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Protein

Transmembrane protease serine 11B

Gene

TMPRSS11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine protease.1 Publication

Enzyme regulationi

Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei225Charge relay systemBy similarity1
Active sitei270Charge relay systemBy similarity1
Active sitei366Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.365

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11B (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 5
Gene namesi
Name:TMPRSS11B
Synonyms:HATL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000185873.7
HGNCiHGNC:25398 TMPRSS11B
neXtProtiNX_Q86T26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 416ExtracellularSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi132724
OpenTargetsiENSG00000185873
PharmGKBiPA142670727

Polymorphism and mutation databases

BioMutaiTMPRSS11B
DMDMi317373502

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993191 – 416Transmembrane protease serine 11BAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi210 ↔ 226PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 351PROSITE-ProRule annotation
Disulfide bondi362 ↔ 391PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ86T26
PaxDbiQ86T26
PeptideAtlasiQ86T26
PRIDEiQ86T26

PTM databases

PhosphoSitePlusiQ86T26

Expressioni

Gene expression databases

BgeeiENSG00000185873
CleanExiHS_TMPRSS11B
GenevisibleiQ86T26 HS

Interactioni

Protein-protein interaction databases

BioGridi12633471 interactors.
STRINGi9606.ENSP00000330475

Structurei

3D structure databases

ProteinModelPortaliQ86T26
SMRiQ86T26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 160SEAPROSITE-ProRule annotationAdd BLAST118
Domaini185 – 415Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140784
HOGENOMiHOG000251823
HOVERGENiHBG013304
InParanoidiQ86T26
KOiK09751
OMAiADACQND
OrthoDBiEOG091G0AH5
PhylomeDBiQ86T26
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.9601 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Q86T26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD
60 70 80 90 100
FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI
110 120 130 140 150
KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP
160 170 180 190 200
ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA
210 220 230 240 250
SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GIVVNKPYMT
260 270 280 290 300
RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE
310 320 330 340 350
NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML
360 370 380 390 400
CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY
410
TRVTSYRNWI TSKTGL
Length:416
Mass (Da):46,337
Last modified:January 11, 2011 - v3
Checksum:i0A9C369EA6F348A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034798242I → V3 PublicationsCorresponds to variant dbSNP:rs12331141Ensembl.1
Natural variantiVAR_047675325D → A2 PublicationsCorresponds to variant dbSNP:rs2319796Ensembl.1
Natural variantiVAR_034799348T → S2 PublicationsCorresponds to variant dbSNP:rs2319797Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290904 mRNA Translation: BAF83593.1
AL833167 mRNA Translation: CAD91168.1
BX537945 mRNA Translation: CAD97913.1
AC098799 Genomic DNA No translation available.
BC126195 mRNA Translation: AAI26196.1
CCDSiCCDS3521.1
RefSeqiNP_872308.2, NM_182502.3
XP_011529910.1, XM_011531608.2
UniGeneiHs.407122

Genome annotation databases

EnsembliENST00000332644; ENSP00000330475; ENSG00000185873
GeneIDi132724
KEGGihsa:132724
UCSCiuc003hdw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM11B_HUMAN
AccessioniPrimary (citable) accession number: Q86T26
Secondary accession number(s): A8K4D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: February 28, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome