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Protein

Transmembrane protease serine 11B

Gene

TMPRSS11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease.1 Publication

Enzyme regulationi

Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251Charge relay systemBy similarity
Active sitei270 – 2701Charge relay systemBy similarity
Active sitei366 – 3661Charge relay systemBy similarity

GO - Molecular functioni

  • serine-type endopeptidase activity Source: InterPro
  • serine-type peptidase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.365.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11B (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 5
Gene namesi
Name:TMPRSS11B
Synonyms:HATL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25398. TMPRSS11B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 416378ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670727.

Polymorphism and mutation databases

BioMutaiTMPRSS11B.
DMDMi317373502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Transmembrane protease serine 11BPRO_0000299319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi210 ↔ 226PROSITE-ProRule annotation
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi335 ↔ 351PROSITE-ProRule annotation
Disulfide bondi362 ↔ 391PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86T26.
PRIDEiQ86T26.

Expressioni

Gene expression databases

BgeeiQ86T26.
CleanExiHS_TMPRSS11B.
GenevisibleiQ86T26. HS.

Organism-specific databases

HPAiHPA042951.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330475.

Structurei

3D structure databases

ProteinModelPortaliQ86T26.
SMRiQ86T26. Positions 42-147, 155-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 160118SEAPROSITE-ProRule annotationAdd
BLAST
Domaini185 – 415231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ86T26.
KOiK09751.
OMAiYYYQGDF.
OrthoDBiEOG75B84T.
PhylomeDBiQ86T26.
TreeFamiTF351684.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86T26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD
60 70 80 90 100
FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI
110 120 130 140 150
KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP
160 170 180 190 200
ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA
210 220 230 240 250
SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GIVVNKPYMT
260 270 280 290 300
RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE
310 320 330 340 350
NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML
360 370 380 390 400
CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY
410
TRVTSYRNWI TSKTGL
Length:416
Mass (Da):46,337
Last modified:January 11, 2011 - v3
Checksum:i0A9C369EA6F348A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421I → V.3 Publications
Corresponds to variant rs12331141 [ dbSNP | Ensembl ].
VAR_034798
Natural varianti325 – 3251D → A.2 Publications
Corresponds to variant rs2319796 [ dbSNP | Ensembl ].
VAR_047675
Natural varianti348 – 3481T → S.2 Publications
Corresponds to variant rs2319797 [ dbSNP | Ensembl ].
VAR_034799

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290904 mRNA. Translation: BAF83593.1.
AL833167 mRNA. Translation: CAD91168.1.
BX537945 mRNA. Translation: CAD97913.1.
AC098799 Genomic DNA. No translation available.
BC126195 mRNA. Translation: AAI26196.1.
CCDSiCCDS3521.1.
RefSeqiNP_872308.2. NM_182502.3.
XP_011529910.1. XM_011531608.1.
UniGeneiHs.407122.

Genome annotation databases

EnsembliENST00000332644; ENSP00000330475; ENSG00000185873.
GeneIDi132724.
KEGGihsa:132724.
UCSCiuc003hdw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290904 mRNA. Translation: BAF83593.1.
AL833167 mRNA. Translation: CAD91168.1.
BX537945 mRNA. Translation: CAD97913.1.
AC098799 Genomic DNA. No translation available.
BC126195 mRNA. Translation: AAI26196.1.
CCDSiCCDS3521.1.
RefSeqiNP_872308.2. NM_182502.3.
XP_011529910.1. XM_011531608.1.
UniGeneiHs.407122.

3D structure databases

ProteinModelPortaliQ86T26.
SMRiQ86T26. Positions 42-147, 155-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330475.

Protein family/group databases

MEROPSiS01.365.

Polymorphism and mutation databases

BioMutaiTMPRSS11B.
DMDMi317373502.

Proteomic databases

PaxDbiQ86T26.
PRIDEiQ86T26.

Protocols and materials databases

DNASUi132724.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332644; ENSP00000330475; ENSG00000185873.
GeneIDi132724.
KEGGihsa:132724.
UCSCiuc003hdw.4. human.

Organism-specific databases

CTDi132724.
GeneCardsiGC04M069092.
HGNCiHGNC:25398. TMPRSS11B.
HPAiHPA042951.
neXtProtiNX_Q86T26.
PharmGKBiPA142670727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ86T26.
KOiK09751.
OMAiYYYQGDF.
OrthoDBiEOG75B84T.
PhylomeDBiQ86T26.
TreeFamiTF351684.

Miscellaneous databases

ChiTaRSiTMPRSS11B. human.
GenomeRNAii132724.
NextBioi83134.
PROiQ86T26.

Gene expression databases

BgeeiQ86T26.
CleanExiHS_TMPRSS11B.
GenevisibleiQ86T26. HS.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-242.
    Tissue: Esophagus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-242; ALA-325 AND SER-348.
    Tissue: Cervix.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-242; ALA-325 AND SER-348.
  5. "HATL5: a cell surface serine protease differentially expressed in epithelial cancers."
    Miller G.S., Zoratti G.L., Murray A.S., Bergum C., Tanabe L.M., List K.
    PLoS ONE 9:E87675-E87675(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTM11B_HUMAN
AccessioniPrimary (citable) accession number: Q86T26
Secondary accession number(s): A8K4D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: July 22, 2015
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.