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Q86T26

- TM11B_HUMAN

UniProt

Q86T26 - TM11B_HUMAN

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Protein

Transmembrane protease serine 11B

Gene

TMPRSS11B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable serine protease.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251Charge relay systemBy similarity
Active sitei270 – 2701Charge relay systemBy similarity
Active sitei366 – 3661Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.365.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11B (EC:3.4.21.-)
Alternative name(s):
Airway trypsin-like protease 5
Gene namesi
Name:TMPRSS11B
Synonyms:HATL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25398. TMPRSS11B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini39 – 416378ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Transmembrane protease serine 11BPRO_0000299319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi210 ↔ 226PROSITE-ProRule annotation
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi335 ↔ 351PROSITE-ProRule annotation
Disulfide bondi362 ↔ 391PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86T26.
PRIDEiQ86T26.

Expressioni

Gene expression databases

BgeeiQ86T26.
CleanExiHS_TMPRSS11B.
GenevestigatoriQ86T26.

Organism-specific databases

HPAiHPA042951.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330475.

Structurei

3D structure databases

ProteinModelPortaliQ86T26.
SMRiQ86T26. Positions 42-147, 155-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 160118SEAPROSITE-ProRule annotationAdd
BLAST
Domaini185 – 415231Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ86T26.
KOiK09751.
OMAiYYYQGDF.
OrthoDBiEOG75B84T.
PhylomeDBiQ86T26.
TreeFamiTF351684.

Family and domain databases

Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86T26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD
60 70 80 90 100
FHISGVTYND NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI
110 120 130 140 150
KLLPNANGSN VQLQLKFKFP PAEGVSMRTK IKAKLHQMLK NNMASWNAVP
160 170 180 190 200
ASIKLMEISK AASEMLTNNC CGRQVANSII TGNKIVNGKS SLEGAWPWQA
210 220 230 240 250
SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF GIVVNKPYMT
260 270 280 290 300
RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE
310 320 330 340 350
NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML
360 370 380 390 400
CAGFMSGEAD ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY
410
TRVTSYRNWI TSKTGL
Length:416
Mass (Da):46,337
Last modified:January 11, 2011 - v3
Checksum:i0A9C369EA6F348A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421I → V.3 Publications
Corresponds to variant rs12331141 [ dbSNP | Ensembl ].
VAR_034798
Natural varianti325 – 3251D → A.2 Publications
Corresponds to variant rs2319796 [ dbSNP | Ensembl ].
VAR_047675
Natural varianti348 – 3481T → S.2 Publications
Corresponds to variant rs2319797 [ dbSNP | Ensembl ].
VAR_034799

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290904 mRNA. Translation: BAF83593.1.
AL833167 mRNA. Translation: CAD91168.1.
BX537945 mRNA. Translation: CAD97913.1.
AC098799 Genomic DNA. No translation available.
BC126195 mRNA. Translation: AAI26196.1.
CCDSiCCDS3521.1.
RefSeqiNP_872308.2. NM_182502.3.
UniGeneiHs.407122.

Genome annotation databases

EnsembliENST00000332644; ENSP00000330475; ENSG00000185873.
GeneIDi132724.
KEGGihsa:132724.
UCSCiuc003hdw.4. human.

Polymorphism databases

DMDMi317373502.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290904 mRNA. Translation: BAF83593.1 .
AL833167 mRNA. Translation: CAD91168.1 .
BX537945 mRNA. Translation: CAD97913.1 .
AC098799 Genomic DNA. No translation available.
BC126195 mRNA. Translation: AAI26196.1 .
CCDSi CCDS3521.1.
RefSeqi NP_872308.2. NM_182502.3.
UniGenei Hs.407122.

3D structure databases

ProteinModelPortali Q86T26.
SMRi Q86T26. Positions 42-147, 155-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000330475.

Protein family/group databases

MEROPSi S01.365.

Polymorphism databases

DMDMi 317373502.

Proteomic databases

PaxDbi Q86T26.
PRIDEi Q86T26.

Protocols and materials databases

DNASUi 132724.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332644 ; ENSP00000330475 ; ENSG00000185873 .
GeneIDi 132724.
KEGGi hsa:132724.
UCSCi uc003hdw.4. human.

Organism-specific databases

CTDi 132724.
GeneCardsi GC04M069092.
HGNCi HGNC:25398. TMPRSS11B.
HPAi HPA042951.
neXtProti NX_Q86T26.
PharmGKBi PA142670727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118962.
HOGENOMi HOG000251823.
HOVERGENi HBG013304.
InParanoidi Q86T26.
KOi K09751.
OMAi YYYQGDF.
OrthoDBi EOG75B84T.
PhylomeDBi Q86T26.
TreeFami TF351684.

Miscellaneous databases

ChiTaRSi TMPRSS11B. human.
GenomeRNAii 132724.
NextBioi 83134.
PROi Q86T26.

Gene expression databases

Bgeei Q86T26.
CleanExi HS_TMPRSS11B.
Genevestigatori Q86T26.

Family and domain databases

Gene3Di 3.30.70.960. 1 hit.
InterProi IPR017329. Pept_S1A_HAT/DESC1.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEi PS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-242.
    Tissue: Esophagus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-242; ALA-325 AND SER-348.
    Tissue: Cervix.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-242; ALA-325 AND SER-348.

Entry informationi

Entry nameiTM11B_HUMAN
AccessioniPrimary (citable) accession number: Q86T26
Secondary accession number(s): A8K4D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3