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Q86T13 (CLC14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type lectin domain family 14 member A
Alternative name(s):
Epidermal growth factor receptor 5
Short name=EGFR-5
Gene names
Name:CLEC14A
Synonyms:C14orf27, EGFR5
ORF Names:UNQ236/PRO269
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.6
Chain22 – 490469C-type lectin domain family 14 member A
PRO_0000017377

Regions

Topological domain22 – 397376Extracellular Potential
Transmembrane398 – 41821Helical; Potential
Topological domain419 – 49072Cytoplasmic Potential
Domain33 – 173141C-type lectin
Domain245 – 28743EGF-like

Amino acid modifications

Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Disulfide bond143 ↔ 162 By similarity

Experimental info

Sequence conflict4321Q → H in AAS77882. Ref.1
Sequence conflict4371S → F in AAS77882. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q86T13 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CE453A274CD39BF6

FASTA49051,636
        10         20         30         40         50         60 
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA 

        70         80         90        100        110        120 
LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP 

       130        140        150        160        170        180 
GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP 

       190        200        210        220        230        240 
APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG 

       250        260        270        280        290        300 
DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG 

       310        320        330        340        350        360 
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM 

       370        380        390        400        410        420 
SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL 

       430        440        450        460        470        480 
VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL 

       490 
AESPLGSSDA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel human ceg1 gene cDNA."
Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P.
Shi Yan Sheng Wu Xue Bao 37:409-417(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY573061 mRNA. Translation: AAS77882.1.
AY606132 mRNA. Translation: AAT92280.1.
BX248017 mRNA. Translation: CAD62342.1.
AY358395 mRNA. Translation: AAQ88761.1.
AL161751 Genomic DNA. No translation available.
BC031567 mRNA. Translation: AAH31567.2.
RefSeqNP_778230.1. NM_175060.2.
UniGeneHs.525307.

3D structure databases

ProteinModelPortalQ86T13.
SMRQ86T13. Positions 34-174, 221-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353013.

PTM databases

PhosphoSiteQ86T13.

Polymorphism databases

DMDM34582300.

Proteomic databases

PaxDbQ86T13.
PRIDEQ86T13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342213; ENSP00000353013; ENSG00000176435.
GeneID161198.
KEGGhsa:161198.
UCSCuc001wum.2. human.

Organism-specific databases

CTD161198.
GeneCardsGC14M038723.
HGNCHGNC:19832. CLEC14A.
HPAHPA039468.
neXtProtNX_Q86T13.
PharmGKBPA134890576.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46168.
HOGENOMHOG000111782.
HOVERGENHBG051004.
InParanoidQ86T13.
KOK17528.
OMAFWVALER.
OrthoDBEOG7GFB4S.
PhylomeDBQ86T13.
TreeFamTF330714.

Gene expression databases

BgeeQ86T13.
CleanExHS_CLEC14A.
GenevestigatorQ86T13.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi161198.
NextBio88033.
PROQ86T13.

Entry information

Entry nameCLC14_HUMAN
AccessionPrimary (citable) accession number: Q86T13
Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2003
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM