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Q86T13

- CLC14_HUMAN

UniProt

Q86T13 - CLC14_HUMAN

Protein

C-type lectin domain family 14 member A

Gene

CLEC14A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 14 member A
    Alternative name(s):
    Epidermal growth factor receptor 5
    Short name:
    EGFR-5
    Gene namesi
    Name:CLEC14A
    Synonyms:C14orf27, EGFR5
    ORF Names:UNQ236/PRO269
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19832. CLEC14A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134890576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 490469C-type lectin domain family 14 member APRO_0000017377Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ86T13.
    PRIDEiQ86T13.

    PTM databases

    PhosphoSiteiQ86T13.

    Expressioni

    Gene expression databases

    BgeeiQ86T13.
    CleanExiHS_CLEC14A.
    GenevestigatoriQ86T13.

    Organism-specific databases

    HPAiHPA039468.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353013.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86T13.
    SMRiQ86T13. Positions 34-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 397376ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 49072CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 173141C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini245 – 28743EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46168.
    HOGENOMiHOG000111782.
    HOVERGENiHBG051004.
    InParanoidiQ86T13.
    KOiK17528.
    OMAiFWVALER.
    OrthoDBiEOG7GFB4S.
    PhylomeDBiQ86T13.
    TreeFamiTF330714.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86T13-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA    50
    EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR 100
    SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG 150
    GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS 200
    AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY 250
    LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG 300
    VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG 350
    SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF 400
    IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA 450
    ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA 490
    Length:490
    Mass (Da):51,636
    Last modified:June 1, 2003 - v1
    Checksum:iCE453A274CD39BF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti432 – 4321Q → H in AAS77882. (PubMed:15636369)Curated
    Sequence conflicti437 – 4371S → F in AAS77882. (PubMed:15636369)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY573061 mRNA. Translation: AAS77882.1.
    AY606132 mRNA. Translation: AAT92280.1.
    BX248017 mRNA. Translation: CAD62342.1.
    AY358395 mRNA. Translation: AAQ88761.1.
    AL161751 Genomic DNA. No translation available.
    BC031567 mRNA. Translation: AAH31567.2.
    CCDSiCCDS9667.1.
    RefSeqiNP_778230.1. NM_175060.2.
    UniGeneiHs.525307.

    Genome annotation databases

    EnsembliENST00000342213; ENSP00000353013; ENSG00000176435.
    GeneIDi161198.
    KEGGihsa:161198.
    UCSCiuc001wum.2. human.

    Polymorphism databases

    DMDMi34582300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY573061 mRNA. Translation: AAS77882.1 .
    AY606132 mRNA. Translation: AAT92280.1 .
    BX248017 mRNA. Translation: CAD62342.1 .
    AY358395 mRNA. Translation: AAQ88761.1 .
    AL161751 Genomic DNA. No translation available.
    BC031567 mRNA. Translation: AAH31567.2 .
    CCDSi CCDS9667.1.
    RefSeqi NP_778230.1. NM_175060.2.
    UniGenei Hs.525307.

    3D structure databases

    ProteinModelPortali Q86T13.
    SMRi Q86T13. Positions 34-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353013.

    PTM databases

    PhosphoSitei Q86T13.

    Polymorphism databases

    DMDMi 34582300.

    Proteomic databases

    PaxDbi Q86T13.
    PRIDEi Q86T13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342213 ; ENSP00000353013 ; ENSG00000176435 .
    GeneIDi 161198.
    KEGGi hsa:161198.
    UCSCi uc001wum.2. human.

    Organism-specific databases

    CTDi 161198.
    GeneCardsi GC14M038723.
    HGNCi HGNC:19832. CLEC14A.
    HPAi HPA039468.
    neXtProti NX_Q86T13.
    PharmGKBi PA134890576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46168.
    HOGENOMi HOG000111782.
    HOVERGENi HBG051004.
    InParanoidi Q86T13.
    KOi K17528.
    OMAi FWVALER.
    OrthoDBi EOG7GFB4S.
    PhylomeDBi Q86T13.
    TreeFami TF330714.

    Miscellaneous databases

    GenomeRNAii 161198.
    NextBioi 88033.
    PROi Q86T13.

    Gene expression databases

    Bgeei Q86T13.
    CleanExi HS_CLEC14A.
    Genevestigatori Q86T13.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel human ceg1 gene cDNA."
      Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P.
      Shi Yan Sheng Wu Xue Bao 37:409-417(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-36.

    Entry informationi

    Entry nameiCLC14_HUMAN
    AccessioniPrimary (citable) accession number: Q86T13
    Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 9, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3