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Q86T13

- CLC14_HUMAN

UniProt

Q86T13 - CLC14_HUMAN

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Protein

C-type lectin domain family 14 member A

Gene

CLEC14A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 14 member A
Alternative name(s):
Epidermal growth factor receptor 5
Short name:
EGFR-5
Gene namesi
Name:CLEC14A
Synonyms:C14orf27, EGFR5
ORF Names:UNQ236/PRO269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19832. CLEC14A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 397376ExtracellularSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 49072CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 490469C-type lectin domain family 14 member APRO_0000017377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86T13.
PRIDEiQ86T13.

PTM databases

PhosphoSiteiQ86T13.

Expressioni

Gene expression databases

BgeeiQ86T13.
CleanExiHS_CLEC14A.
GenevestigatoriQ86T13.

Organism-specific databases

HPAiHPA039468.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353013.

Structurei

3D structure databases

ProteinModelPortaliQ86T13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 173141C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini245 – 28743EGF-likeAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46168.
GeneTreeiENSGT00770000120465.
HOGENOMiHOG000111782.
HOVERGENiHBG051004.
InParanoidiQ86T13.
KOiK17528.
OMAiFWVALER.
OrthoDBiEOG7GFB4S.
PhylomeDBiQ86T13.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86T13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA
60 70 80 90 100
EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR
110 120 130 140 150
SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG
160 170 180 190 200
GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS
210 220 230 240 250
AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY
260 270 280 290 300
LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
310 320 330 340 350
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG
360 370 380 390 400
SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF
410 420 430 440 450
IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA
460 470 480 490
ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA
Length:490
Mass (Da):51,636
Last modified:June 1, 2003 - v1
Checksum:iCE453A274CD39BF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti432 – 4321Q → H in AAS77882. (PubMed:15636369)Curated
Sequence conflicti437 – 4371S → F in AAS77882. (PubMed:15636369)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA. Translation: AAS77882.1.
AY606132 mRNA. Translation: AAT92280.1.
BX248017 mRNA. Translation: CAD62342.1.
AY358395 mRNA. Translation: AAQ88761.1.
AL161751 Genomic DNA. No translation available.
BC031567 mRNA. Translation: AAH31567.2.
CCDSiCCDS9667.1.
RefSeqiNP_778230.1. NM_175060.2.
UniGeneiHs.525307.

Genome annotation databases

EnsembliENST00000342213; ENSP00000353013; ENSG00000176435.
GeneIDi161198.
KEGGihsa:161198.
UCSCiuc001wum.2. human.

Polymorphism databases

DMDMi34582300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA. Translation: AAS77882.1 .
AY606132 mRNA. Translation: AAT92280.1 .
BX248017 mRNA. Translation: CAD62342.1 .
AY358395 mRNA. Translation: AAQ88761.1 .
AL161751 Genomic DNA. No translation available.
BC031567 mRNA. Translation: AAH31567.2 .
CCDSi CCDS9667.1.
RefSeqi NP_778230.1. NM_175060.2.
UniGenei Hs.525307.

3D structure databases

ProteinModelPortali Q86T13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353013.

PTM databases

PhosphoSitei Q86T13.

Polymorphism databases

DMDMi 34582300.

Proteomic databases

PaxDbi Q86T13.
PRIDEi Q86T13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342213 ; ENSP00000353013 ; ENSG00000176435 .
GeneIDi 161198.
KEGGi hsa:161198.
UCSCi uc001wum.2. human.

Organism-specific databases

CTDi 161198.
GeneCardsi GC14M038723.
HGNCi HGNC:19832. CLEC14A.
HPAi HPA039468.
neXtProti NX_Q86T13.
PharmGKBi PA134890576.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46168.
GeneTreei ENSGT00770000120465.
HOGENOMi HOG000111782.
HOVERGENi HBG051004.
InParanoidi Q86T13.
KOi K17528.
OMAi FWVALER.
OrthoDBi EOG7GFB4S.
PhylomeDBi Q86T13.
TreeFami TF330714.

Miscellaneous databases

ChiTaRSi CLEC14A. human.
GenomeRNAii 161198.
NextBioi 88033.
PROi Q86T13.

Gene expression databases

Bgeei Q86T13.
CleanExi HS_CLEC14A.
Genevestigatori Q86T13.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human ceg1 gene cDNA."
    Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P.
    Shi Yan Sheng Wu Xue Bao 37:409-417(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.

Entry informationi

Entry nameiCLC14_HUMAN
AccessioniPrimary (citable) accession number: Q86T13
Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3