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Protein

C-type lectin domain family 14 member A

Gene

CLEC14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 14 member A
Alternative name(s):
Epidermal growth factor receptor 5
Short name:
EGFR-5
Gene namesi
Name:CLEC14A
Synonyms:C14orf27, EGFR5
ORF Names:UNQ236/PRO269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19832. CLEC14A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 397376ExtracellularSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Topological domaini419 – 49072CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134890576.

Polymorphism and mutation databases

BioMutaiCLEC14A.
DMDMi34582300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 490469C-type lectin domain family 14 member APRO_0000017377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86T13.
PRIDEiQ86T13.

PTM databases

PhosphoSiteiQ86T13.

Expressioni

Gene expression databases

BgeeiQ86T13.
CleanExiHS_CLEC14A.
GenevisibleiQ86T13. HS.

Organism-specific databases

HPAiHPA039468.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353013.

Structurei

3D structure databases

ProteinModelPortaliQ86T13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 173141C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini245 – 28743EGF-likeAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46168.
GeneTreeiENSGT00780000122106.
HOGENOMiHOG000111782.
HOVERGENiHBG051004.
InParanoidiQ86T13.
KOiK17528.
OMAiFWVALER.
OrthoDBiEOG7GFB4S.
PhylomeDBiQ86T13.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86T13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA
60 70 80 90 100
EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR
110 120 130 140 150
SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG
160 170 180 190 200
GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS
210 220 230 240 250
AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY
260 270 280 290 300
LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
310 320 330 340 350
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG
360 370 380 390 400
SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF
410 420 430 440 450
IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA
460 470 480 490
ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA
Length:490
Mass (Da):51,636
Last modified:June 1, 2003 - v1
Checksum:iCE453A274CD39BF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti432 – 4321Q → H in AAS77882 (PubMed:15636369).Curated
Sequence conflicti437 – 4371S → F in AAS77882 (PubMed:15636369).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA. Translation: AAS77882.1.
AY606132 mRNA. Translation: AAT92280.1.
BX248017 mRNA. Translation: CAD62342.1.
AY358395 mRNA. Translation: AAQ88761.1.
AL161751 Genomic DNA. No translation available.
BC031567 mRNA. Translation: AAH31567.2.
CCDSiCCDS9667.1.
RefSeqiNP_778230.1. NM_175060.2.
UniGeneiHs.525307.

Genome annotation databases

EnsembliENST00000342213; ENSP00000353013; ENSG00000176435.
GeneIDi161198.
KEGGihsa:161198.
UCSCiuc001wum.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA. Translation: AAS77882.1.
AY606132 mRNA. Translation: AAT92280.1.
BX248017 mRNA. Translation: CAD62342.1.
AY358395 mRNA. Translation: AAQ88761.1.
AL161751 Genomic DNA. No translation available.
BC031567 mRNA. Translation: AAH31567.2.
CCDSiCCDS9667.1.
RefSeqiNP_778230.1. NM_175060.2.
UniGeneiHs.525307.

3D structure databases

ProteinModelPortaliQ86T13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353013.

PTM databases

PhosphoSiteiQ86T13.

Polymorphism and mutation databases

BioMutaiCLEC14A.
DMDMi34582300.

Proteomic databases

PaxDbiQ86T13.
PRIDEiQ86T13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342213; ENSP00000353013; ENSG00000176435.
GeneIDi161198.
KEGGihsa:161198.
UCSCiuc001wum.2. human.

Organism-specific databases

CTDi161198.
GeneCardsiGC14M038723.
HGNCiHGNC:19832. CLEC14A.
HPAiHPA039468.
neXtProtiNX_Q86T13.
PharmGKBiPA134890576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46168.
GeneTreeiENSGT00780000122106.
HOGENOMiHOG000111782.
HOVERGENiHBG051004.
InParanoidiQ86T13.
KOiK17528.
OMAiFWVALER.
OrthoDBiEOG7GFB4S.
PhylomeDBiQ86T13.
TreeFamiTF330714.

Miscellaneous databases

ChiTaRSiCLEC14A. human.
GenomeRNAii161198.
NextBioi88033.
PROiQ86T13.

Gene expression databases

BgeeiQ86T13.
CleanExiHS_CLEC14A.
GenevisibleiQ86T13. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel human ceg1 gene cDNA."
    Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P.
    Shi Yan Sheng Wu Xue Bao 37:409-417(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-36.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLC14_HUMAN
AccessioniPrimary (citable) accession number: Q86T13
Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2003
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.