Q86T13 (CLC14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-type lectin domain family 14 member A

Alternative name(s):
Epidermal growth factor receptor 5
Short name=EGFR-5

Gene names

Name:	CLEC14A
Synonyms:	C14orf27, EGFR5
ORF Names:	UNQ236/PRO269

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 1 C-type lectin domain. Contains 1 EGF-like domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain Signal Transmembrane Transmembrane helix
Ligand	Lectin
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.6
	Chain	22 – 490	469	C-type lectin domain family 14 member A		PRO_0000017377
Regions
	Topological domain	22 – 397	376	Extracellular Potential
	Transmembrane	398 – 418	21	Helical; Potential
	Topological domain	419 – 490	72	Cytoplasmic Potential
	Domain	33 – 173	141	C-type lectin
	Domain	245 – 287	43	EGF-like
Amino acid modifications
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	381	1	N-linked (GlcNAc...) Potential
	Disulfide bond	143 ↔ 162		By similarity
Experimental info
	Sequence conflict	432	1	Q → H in AAS77882. Ref.1
	Sequence conflict	437	1	S → F in AAS77882. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q86T13 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: CE453A274CD39BF6	FASTA	490	51,636
	10 20 30 40 50 60 MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA EEACILRGGA 70 80 90 100 110 120 LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR SHCTLENEPL RGFSWLSSDP 130 140 150 160 170 180 GGLESDTLQW VEEPQRSCTA RRCAVLQATG GVEPAGWKEM RCHLRANGYL CKYQFEVLCP 190 200 210 220 230 240 APRPGAASNL SYRAPFQLHS AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG 250 260 270 280 290 300 DVLCPCPGRY LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG 310 320 330 340 350 360 VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG SQSTMSTLQM 370 380 390 400 410 420 SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF IFVSTAVVVL VILTMTVLGL 430 440 450 460 470 480 VKLCFHESPS SQPRKESMGP PGLESDPEPA ALGSSSAHCT NNGVKVGDCD LRDRAEGALL 490 AESPLGSSDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel human ceg1 gene cDNA." Fu J.Q., Wang L., Chen W., Ci H.L., Li Y.P. Shi Yan Sheng Wu Xue Bao 37:409-417(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-36.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY573061 mRNA. Translation: AAS77882.1. AY606132 mRNA. Translation: AAT92280.1. BX248017 mRNA. Translation: CAD62342.1. AY358395 mRNA. Translation: AAQ88761.1. AL161751 Genomic DNA. No translation available. BC031567 mRNA. Translation: AAH31567.2.
IPI	IPI00240345.
RefSeq	NP_778230.1. NM_175060.2.
UniGene	Hs.525307.
3D structure databases
ProteinModelPortal	Q86T13.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353013.
PTM databases
PhosphoSite	Q86T13.
Polymorphism databases
DMDM	34582300.
Proteomic databases
PaxDb	Q86T13.
PRIDE	Q86T13.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342213; ENSP00000353013; ENSG00000176435.
GeneID	161198.
KEGG	hsa:161198.
UCSC	uc001wum.1. human.
Organism-specific databases
CTD	161198.
GeneCards	GC14M038723.
HGNC	HGNC:19832. CLEC14A.
HPA	HPA039468.
neXtProt	NX_Q86T13.
PharmGKB	PA134890576.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46168.
HOGENOM	HOG000111782.
HOVERGEN	HBG051004.
InParanoid	Q86T13.
OMA	FWVALER.
OrthoDB	EOG4P8FJ7.
PhylomeDB	Q86T13.
Gene expression databases
Bgee	Q86T13.
CleanEx	HS_CLEC14A.
Genevestigator	Q86T13.
GermOnline	ENSG00000176435. Homo sapiens.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR000742. EG-like_dom. [Graphical view]
SMART	SM00034. CLECT. 1 hit. SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. 1 hit. PS50026. EGF_3. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	161198.
NextBio	88033.

Entry information

Entry name

CLC14_HUMAN

Accession

Primary (citable) accession number: Q86T13
Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 9, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.