ID   Q86T07_HUMAN            Unreviewed;       367 AA.
AC   Q86T07;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=Chromogranin-A {ECO:0000256|ARBA:ARBA00040787};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAD62591.1};
RN   [1] {ECO:0000313|EMBL:CAD62591.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adult brain {ECO:0000313|EMBL:CAD62591.1};
RA   Li W.B., Gruber C., Jessee J., Polayes D.;
RT   "Full-length cDNA libraries and normalization.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAD62591.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adult brain {ECO:0000313|EMBL:CAD62591.1};
RA   Genoscope;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Strongly inhibits glucose induced insulin release from the
CC       pancreas. {ECO:0000256|ARBA:ARBA00037544}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC       {ECO:0000256|ARBA:ARBA00004398}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the chromogranin/secretogranin protein family.
CC       {ECO:0000256|ARBA:ARBA00005723}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX248263; CAD62591.1; -; mRNA.
DR   RefSeq; NP_001266.1; NM_001275.3.
DR   RefSeq; NP_001288619.1; NM_001301690.1.
DR   AlphaFoldDB; Q86T07; -.
DR   DNASU; 1113; -.
DR   GeneID; 1113; -.
DR   KEGG; hsa:1113; -.
DR   CTD; 1113; -.
DR   PharmGKB; PA26461; -.
DR   OrthoDB; 4262934at2759; -.
DR   BioGRID-ORCS; 1113; 178 hits in 1147 CRISPR screens.
DR   GenomeRNAi; 1113; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001819; Chromogranin_AB.
DR   InterPro; IPR018054; Chromogranin_CS.
DR   InterPro; IPR001990; Granin.
DR   PANTHER; PTHR10583; CHROMOGRANIN; 1.
DR   PANTHER; PTHR10583:SF1; CHROMOGRANIN-A; 1.
DR   Pfam; PF01271; Granin; 2.
DR   PRINTS; PR00659; CHROMOGRANIN.
DR   PROSITE; PS00422; GRANINS_1; 1.
DR   PROSITE; PS00423; GRANINS_2; 1.
DR   Genevisible; Q86T07; HS.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAD62591.1"
SQ   SEQUENCE   367 AA;  40456 MW;  86024ED83D2EF724 CRC64;
     EPRAGELAGG STDRRTHAEA LRPQPRAGAT AARPRPPVQP PLARCLGARP HTASCSAPGS
     AMRSAAVLAL LLCAGQVTAL PVNSPMNKGD TEVMKCIVEV ISDTLSKPSP MPVSQECFET
     LRGDERILSI LRHQNLLKEL QDLALQGAKE RAHQQKKHSG FEDELSEVLE NQSSQAELKG
     RSEALAVDGA GKPGAEEAQD PEGKGEQEHS QQKEEEEEMA VVPQGLFRGG KSGELEQEEE
     RLSKEWEDSK RWSKMDQLAK ELTAEKRLEG QEEEEDNRDS SMKLSFRARA YGFRGPGPQL
     RRGWRPSSRE DSLEAGLPLQ VRGYPEEKKE EEGSANRRPE DQELESLSAI EAELEKVAHQ
     LQALRRG
//