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Protein

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Gene

TMEM55B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331By similarity

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Source: FlyBase

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:HS15363-MONOMER.
BRENDAi3.1.3.78. 2681.

Chemistry

SwissLipidsiSLP:000000850.

Names & Taxonomyi

Protein namesi
Recommended name:
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (EC:3.1.3.78)
Short name:
Type 1 PtdIns-4,5-P2 4-Ptase
Alternative name(s):
PtdIns-4,5-P2 4-Ptase I
Transmembrane protein 55B
Gene namesi
Name:TMEM55B
Synonyms:C14orf9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19299. TMEM55B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome membrane Source: FlyBase
  • lysosomal membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919069.

Polymorphism and mutation databases

BioMutaiTMEM55B.
DMDMi33112243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatasePRO_0000072579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86T03.
MaxQBiQ86T03.
PaxDbiQ86T03.
PeptideAtlasiQ86T03.
PRIDEiQ86T03.

PTM databases

iPTMnetiQ86T03.
PhosphoSiteiQ86T03.
SwissPalmiQ86T03.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000165782.
CleanExiHS_TMEM55B.
ExpressionAtlasiQ86T03. baseline and differential.
GenevisibleiQ86T03. HS.

Organism-specific databases

HPAiHPA048528.
HPA069252.

Interactioni

Protein-protein interaction databases

BioGridi124764. 11 interactions.
IntActiQ86T03. 8 interactions.
STRINGi9606.ENSP00000381102.

Structurei

3D structure databases

ProteinModelPortaliQ86T03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1397CX5R motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 3721Gly-richAdd
BLAST
Compositional biasi34 – 8047Pro-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4684. Eukaryota.
ENOG410XSVD. LUCA.
GeneTreeiENSGT00390000003680.
HOGENOMiHOG000231722.
HOVERGENiHBG080409.
InParanoidiQ86T03.
KOiK13084.
OMAiCMRVSQP.
OrthoDBiEOG091G0HQD.
PhylomeDBiQ86T03.
TreeFamiTF316367.

Family and domain databases

InterProiIPR019178. PtdIns-P2-Ptase.
[Graphical view]
PANTHERiPTHR21014. PTHR21014. 1 hit.
PfamiPF09788. Tmemb_55A. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86T03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADGERSPL LSEPIDGGAG GNGLVGPGGS GAGPGGGLTP SAPPYGAAFP
60 70 80 90 100
PFPEGHPAVL PGEDPPPYSP LTSPDSGSAP MITCRVCQSL INVEGKMHQH
110 120 130 140 150
VVKCGVCNEA TPIKNAPPGK KYVRCPCNCL LICKVTSQRI ACPRPYCKRI
160 170 180 190 200
INLGPVHPGP LSPEPQPMGV RVICGHCKNT FLWTEFTDRT LARCPHCRKV
210 220 230 240 250
SSIGRRYPRK RCICCFLLGL LLAVTATGLA FGTWKHARRY GGIYAAWAFV
260 270
ILLAVLCLGR ALYWACMKVS HPVQNFS
Length:277
Mass (Da):29,470
Last modified:June 1, 2003 - v1
Checksum:iA85FE1F736366CBC
GO
Isoform 2 (identifier: Q86T03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: A → AGKHAPPQ

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):30,185
Checksum:i7EA24D2735640FDF
GO
Isoform 3 (identifier: Q86T03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-224: AFPPFPEGHP...CFLLGLLLAV → GKHAPPQGKP...TTVEHQWGCK
     225-277: Missing.

Note: May be due to intron retention.
Show »
Length:149
Mass (Da):15,191
Checksum:i89AC50824E6CFF55
GO

Sequence cautioni

The sequence CAB70896 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAD62347 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081P → T in AAH20947 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 471A → AGKHAPPQ in isoform 2. 1 PublicationVSP_007815
Alternative sequencei48 – 224177AFPPF…LLLAV → GKHAPPQGKPGRVRGAPRGT LKAGEGAGPRAEAGPSRQVR DCCTCDWARLPSLRNRDHSL GTEGGSEQPDRSANYEKPSE LGQRVEDQKDFPTTVEHQWG CK in isoform 3. 1 PublicationVSP_007816Add
BLAST
Alternative sequencei225 – 27753Missing in isoform 3. 1 PublicationVSP_007817Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161490 mRNA. Translation: CAD61939.1.
BX248025 mRNA. Translation: CAD62347.1. Different initiation.
AK314021 mRNA. Translation: BAG36732.1.
AL137727 mRNA. Translation: CAB70896.1. Different initiation.
CH471078 Genomic DNA. Translation: EAW66461.1.
BC002867 mRNA. Translation: AAH02867.2.
BC020947 mRNA. Translation: AAH20947.1.
CCDSiCCDS41911.1. [Q86T03-2]
CCDS9551.1. [Q86T03-1]
PIRiT46382.
RefSeqiNP_001094284.1. NM_001100814.2. [Q86T03-2]
NP_653169.2. NM_144568.3. [Q86T03-1]
UniGeneiHs.7001.

Genome annotation databases

EnsembliENST00000250489; ENSP00000250489; ENSG00000165782. [Q86T03-1]
ENST00000398020; ENSP00000381102; ENSG00000165782. [Q86T03-2]
GeneIDi90809.
KEGGihsa:90809.
UCSCiuc001vxk.4. human. [Q86T03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161490 mRNA. Translation: CAD61939.1.
BX248025 mRNA. Translation: CAD62347.1. Different initiation.
AK314021 mRNA. Translation: BAG36732.1.
AL137727 mRNA. Translation: CAB70896.1. Different initiation.
CH471078 Genomic DNA. Translation: EAW66461.1.
BC002867 mRNA. Translation: AAH02867.2.
BC020947 mRNA. Translation: AAH20947.1.
CCDSiCCDS41911.1. [Q86T03-2]
CCDS9551.1. [Q86T03-1]
PIRiT46382.
RefSeqiNP_001094284.1. NM_001100814.2. [Q86T03-2]
NP_653169.2. NM_144568.3. [Q86T03-1]
UniGeneiHs.7001.

3D structure databases

ProteinModelPortaliQ86T03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124764. 11 interactions.
IntActiQ86T03. 8 interactions.
STRINGi9606.ENSP00000381102.

Chemistry

SwissLipidsiSLP:000000850.

PTM databases

iPTMnetiQ86T03.
PhosphoSiteiQ86T03.
SwissPalmiQ86T03.

Polymorphism and mutation databases

BioMutaiTMEM55B.
DMDMi33112243.

Proteomic databases

EPDiQ86T03.
MaxQBiQ86T03.
PaxDbiQ86T03.
PeptideAtlasiQ86T03.
PRIDEiQ86T03.

Protocols and materials databases

DNASUi90809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250489; ENSP00000250489; ENSG00000165782. [Q86T03-1]
ENST00000398020; ENSP00000381102; ENSG00000165782. [Q86T03-2]
GeneIDi90809.
KEGGihsa:90809.
UCSCiuc001vxk.4. human. [Q86T03-1]

Organism-specific databases

CTDi90809.
GeneCardsiTMEM55B.
HGNCiHGNC:19299. TMEM55B.
HPAiHPA048528.
HPA069252.
MIMi609865. gene.
neXtProtiNX_Q86T03.
PharmGKBiPA134919069.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4684. Eukaryota.
ENOG410XSVD. LUCA.
GeneTreeiENSGT00390000003680.
HOGENOMiHOG000231722.
HOVERGENiHBG080409.
InParanoidiQ86T03.
KOiK13084.
OMAiCMRVSQP.
OrthoDBiEOG091G0HQD.
PhylomeDBiQ86T03.
TreeFamiTF316367.

Enzyme and pathway databases

BioCyciMetaCyc:HS15363-MONOMER.
BRENDAi3.1.3.78. 2681.

Miscellaneous databases

GenomeRNAii90809.
PROiQ86T03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165782.
CleanExiHS_TMEM55B.
ExpressionAtlasiQ86T03. baseline and differential.
GenevisibleiQ86T03. HS.

Family and domain databases

InterProiIPR019178. PtdIns-P2-Ptase.
[Graphical view]
PANTHERiPTHR21014. PTHR21014. 1 hit.
PfamiPF09788. Tmemb_55A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM55B_HUMAN
AccessioniPrimary (citable) accession number: Q86T03
Secondary accession number(s): B2RA35
, Q86U09, Q8WUC0, Q9BU67, Q9NSU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.