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Protein

Trafficking protein particle complex subunit 6B

Gene

TRAPPC6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000182400.14
HGNCiHGNC:23066 TRAPPC6B
MIMi610397 gene
neXtProtiNX_Q86SZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

MalaCardsiTRAPPC6B
OpenTargetsiENSG00000182400
PharmGKBiPA134973191

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaiTRAPPC6B
DMDMi45477299

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115871 – 158Trafficking protein particle complex subunit 6BAdd BLAST158

Proteomic databases

EPDiQ86SZ2
MaxQBiQ86SZ2
PaxDbiQ86SZ2
PeptideAtlasiQ86SZ2
PRIDEiQ86SZ2

PTM databases

iPTMnetiQ86SZ2
PhosphoSitePlusiQ86SZ2

Expressioni

Gene expression databases

BgeeiENSG00000182400
CleanExiHS_TRAPPC6B
ExpressionAtlasiQ86SZ2 baseline and differential
GenevisibleiQ86SZ2 HS

Organism-specific databases

HPAiHPA047928

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex. Homodimer. Heterodimer with TRAPPC3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC3O436173EBI-6160531,EBI-743566

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125777, 20 interactors
CORUMiQ86SZ2
DIPiDIP-47626N
IntActiQ86SZ2, 6 interactors
MINTiQ86SZ2
STRINGi9606.ENSP00000330289

Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 20Combined sources20
Turni24 – 30Combined sources7
Helixi31 – 48Combined sources18
Helixi62 – 69Combined sources8
Helixi71 – 77Combined sources7
Beta strandi82 – 88Combined sources7
Beta strandi91 – 98Combined sources8
Helixi100 – 102Combined sources3
Helixi116 – 118Combined sources3
Helixi120 – 132Combined sources13
Beta strandi136 – 145Combined sources10
Beta strandi149 – 156Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BJNX-ray1.70A/B1-158[»]
2CFHX-ray2.30C/D1-158[»]
3KXCX-ray2.00C1-158[»]
ProteinModelPortaliQ86SZ2
SMRiQ86SZ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86SZ2

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3316 Eukaryota
ENOG410YUYH LUCA
GeneTreeiENSGT00390000012948
HOGENOMiHOG000200502
HOVERGENiHBG056159
InParanoidiQ86SZ2
KOiK20304
OMAiFLWFPCG
OrthoDBiEOG091G0MJ1
PhylomeDBiQ86SZ2
TreeFamiTF313010

Family and domain databases

CDDicd14944 TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33
PANTHERiPTHR12817 PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEALFLLL HNEMVSGVYK SAEQGEVENG RCITKLENMG FRVGQGLIER
60 70 80 90 100
FTKDTARFKD ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR
110 120 130 140 150
LLTQMSAGKQ YLEHASKYLA FTCGLIRGGL SNLGIKSIVT AEVSSMPACK

FQVMIQKL
Length:158
Mass (Da):17,983
Last modified:June 1, 2003 - v1
Checksum:i5A8B0474548C304B
GO
Isoform 2 (identifier: Q86SZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-117: Missing.

Show »
Length:130
Mass (Da):14,761
Checksum:i780D0777899093DD
GO

Sequence cautioni

The sequence CAD62341 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00965990 – 117Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161510 mRNA Translation: CAD61947.1
BX248013 mRNA Translation: CAD62341.1 Different initiation.
AL833179 mRNA Translation: CAI46185.1
AK056690 mRNA Translation: BAG51784.1
CH471078 Genomic DNA Translation: EAW65823.1
CH471078 Genomic DNA Translation: EAW65824.1
BC047328 mRNA Translation: AAH47328.1
CCDSiCCDS41947.1 [Q86SZ2-1]
CCDS9670.1 [Q86SZ2-2]
RefSeqiNP_001073005.1, NM_001079537.1 [Q86SZ2-1]
NP_803235.1, NM_177452.3 [Q86SZ2-2]
UniGeneiHs.13303

Genome annotation databases

EnsembliENST00000330149; ENSP00000330289; ENSG00000182400 [Q86SZ2-1]
ENST00000347691; ENSP00000335171; ENSG00000182400 [Q86SZ2-2]
GeneIDi122553
KEGGihsa:122553
UCSCiuc001wut.2 human [Q86SZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTPC6B_HUMAN
AccessioniPrimary (citable) accession number: Q86SZ2
Secondary accession number(s): B3KPS2
, Q5JPD6, Q86U35, Q86X35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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