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Protein

Trafficking protein particle complex subunit 6B

Gene

TRAPPC6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23066. TRAPPC6B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134973191.

Polymorphism and mutation databases

BioMutaiTRAPPC6B.
DMDMi45477299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Trafficking protein particle complex subunit 6BPRO_0000211587Add
BLAST

Proteomic databases

EPDiQ86SZ2.
MaxQBiQ86SZ2.
PaxDbiQ86SZ2.
PRIDEiQ86SZ2.

PTM databases

iPTMnetiQ86SZ2.
PhosphoSiteiQ86SZ2.

Expressioni

Gene expression databases

BgeeiQ86SZ2.
CleanExiHS_TRAPPC6B.
ExpressionAtlasiQ86SZ2. baseline and differential.
GenevisibleiQ86SZ2. HS.

Organism-specific databases

HPAiHPA047928.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex. Homodimer. Heterodimer with TRAPPC3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC3O436172EBI-6160531,EBI-743566

Protein-protein interaction databases

BioGridi125777. 17 interactions.
DIPiDIP-47626N.
IntActiQ86SZ2. 4 interactions.
MINTiMINT-3035051.
STRINGi9606.ENSP00000330289.

Structurei

Secondary structure

158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 2020Combined sources
Turni24 – 307Combined sources
Helixi31 – 4818Combined sources
Helixi62 – 698Combined sources
Helixi71 – 777Combined sources
Beta strandi82 – 887Combined sources
Beta strandi91 – 988Combined sources
Helixi100 – 1023Combined sources
Helixi116 – 1183Combined sources
Helixi120 – 13213Combined sources
Beta strandi136 – 14510Combined sources
Beta strandi149 – 1568Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BJNX-ray1.70A/B1-158[»]
2CFHX-ray2.30C/D1-158[»]
3KXCX-ray2.00C1-158[»]
ProteinModelPortaliQ86SZ2.
SMRiQ86SZ2. Positions 2-157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ86SZ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3316. Eukaryota.
ENOG410YUYH. LUCA.
GeneTreeiENSGT00390000012948.
HOGENOMiHOG000200502.
HOVERGENiHBG056159.
InParanoidiQ86SZ2.
OMAiQVMIQKM.
OrthoDBiEOG75TMDD.
PhylomeDBiQ86SZ2.
TreeFamiTF313010.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEALFLLL HNEMVSGVYK SAEQGEVENG RCITKLENMG FRVGQGLIER
60 70 80 90 100
FTKDTARFKD ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR
110 120 130 140 150
LLTQMSAGKQ YLEHASKYLA FTCGLIRGGL SNLGIKSIVT AEVSSMPACK

FQVMIQKL
Length:158
Mass (Da):17,983
Last modified:June 1, 2003 - v1
Checksum:i5A8B0474548C304B
GO
Isoform 2 (identifier: Q86SZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-117: Missing.

Show »
Length:130
Mass (Da):14,761
Checksum:i780D0777899093DD
GO

Sequence cautioni

The sequence CAD62341.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 11728Missing in isoform 2. 2 PublicationsVSP_009659Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161510 mRNA. Translation: CAD61947.1.
BX248013 mRNA. Translation: CAD62341.1. Different initiation.
AL833179 mRNA. Translation: CAI46185.1.
AK056690 mRNA. Translation: BAG51784.1.
CH471078 Genomic DNA. Translation: EAW65823.1.
CH471078 Genomic DNA. Translation: EAW65824.1.
BC047328 mRNA. Translation: AAH47328.1.
CCDSiCCDS41947.1. [Q86SZ2-1]
CCDS9670.1. [Q86SZ2-2]
RefSeqiNP_001073005.1. NM_001079537.1. [Q86SZ2-1]
NP_803235.1. NM_177452.3. [Q86SZ2-2]
UniGeneiHs.13303.

Genome annotation databases

EnsembliENST00000330149; ENSP00000330289; ENSG00000182400. [Q86SZ2-1]
ENST00000347691; ENSP00000335171; ENSG00000182400. [Q86SZ2-2]
GeneIDi122553.
KEGGihsa:122553.
UCSCiuc001wut.2. human. [Q86SZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161510 mRNA. Translation: CAD61947.1.
BX248013 mRNA. Translation: CAD62341.1. Different initiation.
AL833179 mRNA. Translation: CAI46185.1.
AK056690 mRNA. Translation: BAG51784.1.
CH471078 Genomic DNA. Translation: EAW65823.1.
CH471078 Genomic DNA. Translation: EAW65824.1.
BC047328 mRNA. Translation: AAH47328.1.
CCDSiCCDS41947.1. [Q86SZ2-1]
CCDS9670.1. [Q86SZ2-2]
RefSeqiNP_001073005.1. NM_001079537.1. [Q86SZ2-1]
NP_803235.1. NM_177452.3. [Q86SZ2-2]
UniGeneiHs.13303.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BJNX-ray1.70A/B1-158[»]
2CFHX-ray2.30C/D1-158[»]
3KXCX-ray2.00C1-158[»]
ProteinModelPortaliQ86SZ2.
SMRiQ86SZ2. Positions 2-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125777. 17 interactions.
DIPiDIP-47626N.
IntActiQ86SZ2. 4 interactions.
MINTiMINT-3035051.
STRINGi9606.ENSP00000330289.

PTM databases

iPTMnetiQ86SZ2.
PhosphoSiteiQ86SZ2.

Polymorphism and mutation databases

BioMutaiTRAPPC6B.
DMDMi45477299.

Proteomic databases

EPDiQ86SZ2.
MaxQBiQ86SZ2.
PaxDbiQ86SZ2.
PRIDEiQ86SZ2.

Protocols and materials databases

DNASUi122553.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330149; ENSP00000330289; ENSG00000182400. [Q86SZ2-1]
ENST00000347691; ENSP00000335171; ENSG00000182400. [Q86SZ2-2]
GeneIDi122553.
KEGGihsa:122553.
UCSCiuc001wut.2. human. [Q86SZ2-1]

Organism-specific databases

CTDi122553.
GeneCardsiTRAPPC6B.
HGNCiHGNC:23066. TRAPPC6B.
HPAiHPA047928.
MIMi610397. gene.
neXtProtiNX_Q86SZ2.
PharmGKBiPA134973191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3316. Eukaryota.
ENOG410YUYH. LUCA.
GeneTreeiENSGT00390000012948.
HOGENOMiHOG000200502.
HOVERGENiHBG056159.
InParanoidiQ86SZ2.
OMAiQVMIQKM.
OrthoDBiEOG75TMDD.
PhylomeDBiQ86SZ2.
TreeFamiTF313010.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiTRAPPC6B. human.
EvolutionaryTraceiQ86SZ2.
GenomeRNAii122553.
PROiQ86SZ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86SZ2.
CleanExiHS_TRAPPC6B.
ExpressionAtlasiQ86SZ2. baseline and differential.
GenevisibleiQ86SZ2. HS.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix carcinoma and Fetal liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lymph node.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex."
    Kuemmel D., Mueller J.J., Roske Y., Misselwitz R., Buessow K., Heinemann U.
    EMBO Rep. 6:787-793(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT.

Entry informationi

Entry nameiTPC6B_HUMAN
AccessioniPrimary (citable) accession number: Q86SZ2
Secondary accession number(s): B3KPS2
, Q5JPD6, Q86U35, Q86X35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.