Q86SX3 (CN080_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C14orf80

Gene names

Name:

C14orf80

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence CAD62351.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD62363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD62611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86SX3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86SX3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     196-297: Missing.

Isoform 3 (identifier: Q86SX3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKFDRPEA → MSGQRGDWVQ
     196-297: Missing.

Isoform 4 (identifier: Q86SX3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     144-195: Missing.
     229-297: Missing.

Isoform 5 (identifier: Q86SX3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MGRRRQRVDPAAGARAGALPEAIAALSRSLPSGPSPEIFRRAKFDRPEA → MSGQRGDW
     196-297: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Uncharacterized protein C14orf80		PRO_0000330692
Regions
	Coiled coil	355 – 387	33	Potential
	Coiled coil	452 – 480	29	Potential
Natural variations
	Alternative sequence	1 – 126	126	Missing in isoform 4.		VSP_033062
	Alternative sequence	1 – 49	49	MGRRR…DRPEA → MSGQRGDWVQ in isoform 3.		VSP_033063
	Alternative sequence	1 – 49	49	MGRRR…DRPEA → MSGQRGDW in isoform 5.		VSP_045690
	Alternative sequence	144 – 195	52	Missing in isoform 4.		VSP_033064
	Alternative sequence	196 – 297	102	Missing in isoform 2, isoform 3 and isoform 5.		VSP_033065
	Alternative sequence	229 – 297	69	Missing in isoform 4.		VSP_033066

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 29, 2008. Version 2. Checksum: 3E34FACE82E0EACF	FASTA	495	54,231
	10 20 30 40 50 60 MGRRRQRVDP AAGARAGALP EAIAALSRSL PSGPSPEIFR RAKFDRPEAT SALWQLLFRV 70 80 90 100 110 120 LSPLPAGNAL ASLALEVQAR LVKSALCSQG YPRLALAQLP EDGSQGSREL LLALSWLLAR 130 140 150 160 170 180 GPVPEQMLAQ ARVPLGDEMT VCQCEALASP GPPAPHMEAE GPVDVRHVQW LMGKLRFRWR 190 200 210 220 230 240 QLVSSQQEQC ALLSKIHLYT RGCHSDQSLS HLSVTEAEML RDPEGGQQVS GAGAAQNLDL 250 260 270 280 290 300 AYPKCLHSFC TPGMGPRTFW NDLWLVCEQP GLLPGDWAAP LDPGGASACS LLSPFRALLR 310 320 330 340 350 360 TLERENQRLE AVLAWRRSEL VFWRWMDTVL GTCAPEVPAA ASQPTFLPWV PERGGGELDL 370 380 390 400 410 420 VVRELQALEE ELREAAERRR AAWEAKAGGC GRGPEWSAAR RASREAVEKE LGALQQCWER 430 440 450 460 470 480 DGGPAQPHGP HRLVRREDGA AGDRDLRAAV VIRTLRSQEA CLEAVLRRLQ GQCRQELARL 490 VGARPGLIWI PPPGR
	Isoform 2 [UniParc]. Checksum: 631EE5AEFA077F5E	FASTA	393	43,354
	10 20 30 40 50 60 MGRRRQRVDP AAGARAGALP EAIAALSRSL PSGPSPEIFR RAKFDRPEAT SALWQLLFRV 70 80 90 100 110 120 LSPLPAGNAL ASLALEVQAR LVKSALCSQG YPRLALAQLP EDGSQGSREL LLALSWLLAR 130 140 150 160 170 180 GPVPEQMLAQ ARVPLGDEMT VCQCEALASP GPPAPHMEAE GPVDVRHVQW LMGKLRFRWR 190 200 210 220 230 240 QLVSSQQEQC ALLSKLLRTL ERENQRLEAV LAWRRSELVF WRWMDTVLGT CAPEVPAAAS 250 260 270 280 290 300 QPTFLPWVPE RGGGELDLVV RELQALEEEL REAAERRRAA WEAKAGGCGR GPEWSAARRA 310 320 330 340 350 360 SREAVEKELG ALQQCWERDG GPAQPHGPHR LVRREDGAAG DRDLRAAVVI RTLRSQEACL 370 380 390 EAVLRRLQGQ CRQELARLVG ARPGLIWIPP PGR
	Isoform 3 [UniParc]. Checksum: 007C4A3DF6F200CB	FASTA	354	39,259
	10 20 30 40 50 60 MSGQRGDWVQ TSALWQLLFR VLSPLPAGNA LASLALEVQA RLVKSALCSQ GYPRLALAQL 70 80 90 100 110 120 PEDGSQGSRE LLLALSWLLA RGPVPEQMLA QARVPLGDEM TVCQCEALAS PGPPAPHMEA 130 140 150 160 170 180 EGPVDVRHVQ WLMGKLRFRW RQLVSSQQEQ CALLSKLLRT LERENQRLEA VLAWRRSELV 190 200 210 220 230 240 FWRWMDTVLG TCAPEVPAAA SQPTFLPWVP ERGGGELDLV VRELQALEEE LREAAERRRA 250 260 270 280 290 300 AWEAKAGGCG RGPEWSAARR ASREAVEKEL GALQQCWERD GGPAQPHGPH RLVRREDGAA 310 320 330 340 350 GDRDLRAAVV IRTLRSQEAC LEAVLRRLQG QCRQELARLV GARPGLIWIP PPGR
	Isoform 4 [UniParc]. Checksum: 322285EC56B4EBDC	FASTA	248	27,737
	10 20 30 40 50 60 MLAQARVPLG DEMTVCQIHL YTRGCHSDQS LSHLSVTEAE MLRDPEGGQQ LLRTLERENQ 70 80 90 100 110 120 RLEAVLAWRR SELVFWRWMD TVLGTCAPEV PAAASQPTFL PWVPERGGGE LDLVVRELQA 130 140 150 160 170 180 LEEELREAAE RRRAAWEAKA GGCGRGPEWS AARRASREAV EKELGALQQC WERDGGPAQP 190 200 210 220 230 240 HGPHRLVRRE DGAAGDRDLR AAVVIRTLRS QEACLEAVLR RLQGQCRQEL ARLVGARPGL IWIPPPGR
	Isoform 5 [UniParc]. Checksum: 5C79B45957535B4E	FASTA	352	39,032
	10 20 30 40 50 60 MSGQRGDWTS ALWQLLFRVL SPLPAGNALA SLALEVQARL VKSALCSQGY PRLALAQLPE 70 80 90 100 110 120 DGSQGSRELL LALSWLLARG PVPEQMLAQA RVPLGDEMTV CQCEALASPG PPAPHMEAEG 130 140 150 160 170 180 PVDVRHVQWL MGKLRFRWRQ LVSSQQEQCA LLSKLLRTLE RENQRLEAVL AWRRSELVFW 190 200 210 220 230 240 RWMDTVLGTC APEVPAAASQ PTFLPWVPER GGGELDLVVR ELQALEEELR EAAERRRAAW 250 260 270 280 290 300 EAKAGGCGRG PEWSAARRAS REAVEKELGA LQQCWERDGG PAQPHGPHRL VRREDGAAGD 310 320 330 340 350 RDLRAAVVIR TLRSQEACLE AVLRRLQGQC RQELARLVGA RPGLIWIPPP GR

References

[1]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 5). Tissue: Cervix carcinoma and Placenta.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Uterus.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 327-495. Tissue: Spleen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX161477 mRNA. Translation: CAD61932.1. BX248038 mRNA. Translation: CAD62351.1. Different initiation. BX248074 mRNA. Translation: CAD62363.1. Different initiation. BX248283 mRNA. Translation: CAD62611.1. Different initiation. AL928654 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81929.1. BC016028 mRNA. Translation: AAH16028.1. AK024506 mRNA. Translation: BAB15796.1.
IPI	IPI00384141. IPI00384142. IPI00742988. IPI00791279. IPI01021027.
RefSeq	NP_001128348.1. NM_001134876.1. NP_001128349.1. NM_001134877.1. NP_001185912.1. NM_001198983.1.
UniGene	Hs.720306.
3D structure databases
ProteinModelPortal	Q86SX3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q86SX3. 1 interaction.
STRING	9606.ENSP00000376307.
PTM databases
PhosphoSite	Q86SX3.
Polymorphism databases
DMDM	187470846.
Proteomic databases
PaxDb	Q86SX3.
PRIDE	Q86SX3.
Protocols and materials databases
DNASU	283643.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329886; ENSP00000333010; ENSG00000185347. ENST00000334656; ENSP00000333959; ENSG00000185347. ENST00000354560; ENSP00000346568; ENSG00000185347. ENST00000392523; ENSP00000376308; ENSG00000185347. ENST00000392527; ENSP00000376312; ENSG00000185347. ENST00000450383; ENSP00000391436; ENSG00000185347.
GeneID	283643.
KEGG	hsa:283643.
UCSC	uc001yrj.3. human. uc001yrm.3. human. uc001yro.3. human. uc010tys.2. human.
Organism-specific databases
CTD	283643.
GeneCards	GC14P105953.
HGNC	HGNC:20127. C14orf80.
HPA	HPA039050.
neXtProt	NX_Q86SX3.
PharmGKB	PA134885988.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43941.
HOGENOM	HOG000111821.
HOVERGEN	HBG107730.
InParanoid	Q86SX3.
OMA	FWQWMDT.
Gene expression databases
ArrayExpress	Q86SX3.
Bgee	Q86SX3.
Genevestigator	Q86SX3.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	283643.
NextBio	94117.

Entry information

Entry name

CN080_HUMAN

Accession

Primary (citable) accession number: Q86SX3
Secondary accession number(s): B5MDG3 , Q86TT3, Q86TT4, Q86TT5, Q96B41, Q9H7H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.