Synaptotagmin-9 - Homo sapiens (Human)

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Q86SS6 (SYT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Synaptotagmin-9

Alternative name(s):
Synaptotagmin IX
Short name=SytIX

Gene names

Name:

SYT9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in Ca²⁺-dependent exocytosis of secretory vesicles through Ca²⁺ and phospholipid binding to the C2 domain or may serve as Ca²⁺ sensors in the process of vesicular trafficking and exocytosis.
Cofactor	Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the synaptotagmin family. Contains 2 C2 domains.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of calcium ion-dependent exocytosis Inferred from electronic annotation. Source: Compara regulation of insulin secretion Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW dense core granule Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW secretory granule membrane Inferred from electronic annotation. Source: Compara synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 491

491

Synaptotagmin-9

PRO_0000183962

Regions

Topological domain

1 – 52

Vesicular Potential

Transmembrane

53 – 73

Helical; Potential

Topological domain

74 – 491

418

Cytoplasmic Potential

Domain

222 – 323

102

C2 1

Domain

354 – 457

104

C2 2

Sites

Metal binding

251

Calcium 1 By similarity

Metal binding

251

Calcium 2 By similarity

Metal binding

257

Calcium 1 By similarity

Metal binding

309

Calcium 1 By similarity

Metal binding

309

Calcium 2 By similarity

Metal binding

310

Calcium 1; via carbonyl oxygen By similarity

Metal binding

311

Calcium 1 By similarity

Metal binding

311

Calcium 2 By similarity

Metal binding

311

Calcium 3 By similarity

Metal binding

314

Calcium 3 By similarity

Metal binding

317

Calcium 2 By similarity

Metal binding

317

Calcium 3 By similarity

Amino acid modifications

Modified residue

308

Phosphotyrosine By similarity

Natural variations

Natural variant

154

V → M. Ref.3

VAR_065760

Natural variant

238

I → V. Ref.3

VAR_065761

Natural variant

353

L → V. Ref.3

VAR_065762

Natural variant

445

D → N in a colorectal cancer sample; somatic mutation. Ref.2

VAR_036390

Sequences

Sequence

Length

Mass (Da)

Tools

Q86SS6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A9808E5E49153BB3
Show »

FASTA

491

56,188

        10         20         30         40         50         60 
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI SVSLLTLVVT 

        70         80         90        100        110        120 
ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN YMDTETNEQE NSEDFLDPPT 

       130        140        150        160        170        180 
PCPDSSMKIS HTSPDIPLST QTGIQENCAH GVRVQRQVTE PTSSARHNSI RRQLNLSNPD 

       190        200        210        220        230        240 
FNIQQLQKQE QLTGIGRIKP ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK 

       250        260        270        280        290        300 
IHKAVNLPAK DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA 

       310        320        330        340        350        360 
RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN VDLGELMFSL 

       370        380        390        400        410        420 
CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG RRLKKRKTST KRNTLNPVYN 

       430        440        450        460        470        480 
EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN EIIGVCQVGN EAERLGRDHW SEMLSYPRKP 

       490 
IAHWHSLVEK R

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.
[3]	"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis." Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A. Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS MET-154; VAL-238 AND VAL-353.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC046367 mRNA. Translation: AAH46367.1.
IPI	IPI00386377.
RefSeq	NP_783860.1. NM_175733.3.
UniGene	Hs.177193.
3D structure databases
ProteinModelPortal	Q86SS6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000324419.
PTM databases
PhosphoSite	Q86SS6.
Polymorphism databases
DMDM	33112457.
Proteomic databases
PaxDb	Q86SS6.
PRIDE	Q86SS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318881; ENSP00000324419; ENSG00000170743.
GeneID	143425.
KEGG	hsa:143425.
UCSC	uc001mfe.3. human.
Organism-specific databases
CTD	143425.
GeneCards	GC11P007273.
HGNC	HGNC:19265. SYT9.
HPA	HPA041827. HPA045447.
MIM	613528. gene.
neXtProt	NX_Q86SS6.
PharmGKB	PA134984583.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG292488.
HOGENOM	HOG000232128.
HOVERGEN	HBG005010.
InParanoid	Q86SS6.
OMA	CWVPWRE.
OrthoDB	EOG4SF95S.
PhylomeDB	Q86SS6.
Gene expression databases
ArrayExpress	Q86SS6.
Bgee	Q86SS6.
CleanEx	HS_SYT9.
Genevestigator	Q86SS6.
GermOnline	ENSG00000170743. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR020477. C2_dom. IPR018029. C2_membr_targeting. IPR001565. Synaptotagmin. [Graphical view]
Pfam	PF00168. C2. 2 hits. [Graphical view]
PRINTS	PR00360. C2DOMAIN. PR00399. SYNAPTOTAGMN.
SMART	SM00239. C2. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	143425.
NextBio	84707.
SOURCE	Search...

Entry information

Entry name

SYT9_HUMAN

Accession

Primary (citable) accession number: Q86SS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents