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Q86SS6

- SYT9_HUMAN

UniProt

Q86SS6 - SYT9_HUMAN

Protein

Synaptotagmin-9

Gene

SYT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi251 – 2511Calcium 1By similarity
    Metal bindingi251 – 2511Calcium 2By similarity
    Metal bindingi257 – 2571Calcium 1By similarity
    Metal bindingi309 – 3091Calcium 1By similarity
    Metal bindingi309 – 3091Calcium 2By similarity
    Metal bindingi310 – 3101Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi311 – 3111Calcium 1By similarity
    Metal bindingi311 – 3111Calcium 2By similarity
    Metal bindingi311 – 3111Calcium 3By similarity
    Metal bindingi314 – 3141Calcium 3By similarity
    Metal bindingi317 – 3171Calcium 2By similarity
    Metal bindingi317 – 3171Calcium 3By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
    2. regulation of insulin secretion Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-9
    Alternative name(s):
    Synaptotagmin IX
    Short name:
    SytIX
    Gene namesi
    Name:SYT9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19265. SYT9.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dense core granule Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. secretory granule membrane Source: Ensembl
    5. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Synaptotagmin-9PRO_0000183962Add
    BLAST

    Proteomic databases

    PaxDbiQ86SS6.
    PRIDEiQ86SS6.

    PTM databases

    PhosphoSiteiQ86SS6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ86SS6.
    BgeeiQ86SS6.
    CleanExiHS_SYT9.
    GenevestigatoriQ86SS6.

    Organism-specific databases

    HPAiHPA041827.
    HPA045447.

    Interactioni

    Protein-protein interaction databases

    BioGridi126802. 4 interactions.
    STRINGi9606.ENSP00000324419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SS6.
    SMRiQ86SS6. Positions 221-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252VesicularSequence AnalysisAdd
    BLAST
    Topological domaini74 – 491418CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini222 – 323102C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini354 – 457104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG292488.
    HOGENOMiHOG000232128.
    HOVERGENiHBG005010.
    InParanoidiQ86SS6.
    OMAiDFPRECV.
    OrthoDBiEOG78PV8W.
    PhylomeDBiQ86SS6.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028691. SYT9.
    [Graphical view]
    PANTHERiPTHR10024:SF174. PTHR10024:SF174. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86SS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI    50
    SVSLLTLVVT ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN 100
    YMDTETNEQE NSEDFLDPPT PCPDSSMKIS HTSPDIPLST QTGIQENCAH 150
    GVRVQRQVTE PTSSARHNSI RRQLNLSNPD FNIQQLQKQE QLTGIGRIKP 200
    ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK IHKAVNLPAK 250
    DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA 300
    RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN 350
    VDLGELMFSL CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG 400
    RRLKKRKTST KRNTLNPVYN EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN 450
    EIIGVCQVGN EAERLGRDHW SEMLSYPRKP IAHWHSLVEK R 491
    Length:491
    Mass (Da):56,188
    Last modified:June 1, 2003 - v1
    Checksum:iA9808E5E49153BB3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541V → M.1 Publication
    Corresponds to variant rs78477754 [ dbSNP | Ensembl ].
    VAR_065760
    Natural varianti238 – 2381I → V.1 Publication
    VAR_065761
    Natural varianti353 – 3531L → V.1 Publication
    Corresponds to variant rs117876446 [ dbSNP | Ensembl ].
    VAR_065762
    Natural varianti445 – 4451D → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036390

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046367 mRNA. Translation: AAH46367.1.
    CCDSiCCDS7778.1.
    RefSeqiNP_783860.1. NM_175733.3.
    UniGeneiHs.177193.

    Genome annotation databases

    EnsembliENST00000318881; ENSP00000324419; ENSG00000170743.
    GeneIDi143425.
    KEGGihsa:143425.
    UCSCiuc001mfe.3. human.

    Polymorphism databases

    DMDMi33112457.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC046367 mRNA. Translation: AAH46367.1 .
    CCDSi CCDS7778.1.
    RefSeqi NP_783860.1. NM_175733.3.
    UniGenei Hs.177193.

    3D structure databases

    ProteinModelPortali Q86SS6.
    SMRi Q86SS6. Positions 221-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126802. 4 interactions.
    STRINGi 9606.ENSP00000324419.

    PTM databases

    PhosphoSitei Q86SS6.

    Polymorphism databases

    DMDMi 33112457.

    Proteomic databases

    PaxDbi Q86SS6.
    PRIDEi Q86SS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318881 ; ENSP00000324419 ; ENSG00000170743 .
    GeneIDi 143425.
    KEGGi hsa:143425.
    UCSCi uc001mfe.3. human.

    Organism-specific databases

    CTDi 143425.
    GeneCardsi GC11P007273.
    HGNCi HGNC:19265. SYT9.
    HPAi HPA041827.
    HPA045447.
    MIMi 613528. gene.
    neXtProti NX_Q86SS6.
    PharmGKBi PA134984583.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292488.
    HOGENOMi HOG000232128.
    HOVERGENi HBG005010.
    InParanoidi Q86SS6.
    OMAi DFPRECV.
    OrthoDBi EOG78PV8W.
    PhylomeDBi Q86SS6.
    TreeFami TF315600.

    Miscellaneous databases

    GeneWikii SYT9.
    GenomeRNAii 143425.
    NextBioi 84707.
    PROi Q86SS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86SS6.
    Bgeei Q86SS6.
    CleanExi HS_SYT9.
    Genevestigatori Q86SS6.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028691. SYT9.
    [Graphical view ]
    PANTHERi PTHR10024:SF174. PTHR10024:SF174. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.
    3. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
      Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
      Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS MET-154; VAL-238 AND VAL-353.

    Entry informationi

    Entry nameiSYT9_HUMAN
    AccessioniPrimary (citable) accession number: Q86SS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3