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Q86SS6 (SYT9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-9
Alternative name(s):
Synaptotagmin IX
Short name=SytIX
Gene names
Name:SYT9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Synaptotagmin-9
PRO_0000183962

Regions

Topological domain1 – 5252Vesicular Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 491418Cytoplasmic Potential
Domain222 – 323102C2 1
Domain354 – 457104C2 2

Sites

Metal binding2511Calcium 1 By similarity
Metal binding2511Calcium 2 By similarity
Metal binding2571Calcium 1 By similarity
Metal binding3091Calcium 1 By similarity
Metal binding3091Calcium 2 By similarity
Metal binding3101Calcium 1; via carbonyl oxygen By similarity
Metal binding3111Calcium 1 By similarity
Metal binding3111Calcium 2 By similarity
Metal binding3111Calcium 3 By similarity
Metal binding3141Calcium 3 By similarity
Metal binding3171Calcium 2 By similarity
Metal binding3171Calcium 3 By similarity

Natural variations

Natural variant1541V → M. Ref.3
Corresponds to variant rs78477754 [ dbSNP | Ensembl ].
VAR_065760
Natural variant2381I → V. Ref.3
VAR_065761
Natural variant3531L → V. Ref.3
Corresponds to variant rs117876446 [ dbSNP | Ensembl ].
VAR_065762
Natural variant4451D → N in a colorectal cancer sample; somatic mutation. Ref.2
VAR_036390

Sequences

Sequence LengthMass (Da)Tools
Q86SS6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A9808E5E49153BB3

FASTA49156,188
        10         20         30         40         50         60 
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI SVSLLTLVVT 

        70         80         90        100        110        120 
ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN YMDTETNEQE NSEDFLDPPT 

       130        140        150        160        170        180 
PCPDSSMKIS HTSPDIPLST QTGIQENCAH GVRVQRQVTE PTSSARHNSI RRQLNLSNPD 

       190        200        210        220        230        240 
FNIQQLQKQE QLTGIGRIKP ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK 

       250        260        270        280        290        300 
IHKAVNLPAK DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA 

       310        320        330        340        350        360 
RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN VDLGELMFSL 

       370        380        390        400        410        420 
CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG RRLKKRKTST KRNTLNPVYN 

       430        440        450        460        470        480 
EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN EIIGVCQVGN EAERLGRDHW SEMLSYPRKP 

       490 
IAHWHSLVEK R 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.
[3]"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MET-154; VAL-238 AND VAL-353.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC046367 mRNA. Translation: AAH46367.1.
CCDSCCDS7778.1.
RefSeqNP_783860.1. NM_175733.3.
UniGeneHs.177193.

3D structure databases

ProteinModelPortalQ86SS6.
SMRQ86SS6. Positions 221-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126802. 4 interactions.
STRING9606.ENSP00000324419.

PTM databases

PhosphoSiteQ86SS6.

Polymorphism databases

DMDM33112457.

Proteomic databases

PaxDbQ86SS6.
PRIDEQ86SS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318881; ENSP00000324419; ENSG00000170743.
GeneID143425.
KEGGhsa:143425.
UCSCuc001mfe.3. human.

Organism-specific databases

CTD143425.
GeneCardsGC11P007273.
HGNCHGNC:19265. SYT9.
HPAHPA041827.
HPA045447.
MIM613528. gene.
neXtProtNX_Q86SS6.
PharmGKBPA134984583.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292488.
HOGENOMHOG000232128.
HOVERGENHBG005010.
InParanoidQ86SS6.
OMADFPRECV.
OrthoDBEOG78PV8W.
PhylomeDBQ86SS6.
TreeFamTF315600.

Gene expression databases

ArrayExpressQ86SS6.
BgeeQ86SS6.
CleanExHS_SYT9.
GenevestigatorQ86SS6.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028691. SYT9.
[Graphical view]
PANTHERPTHR10024:SF174. PTHR10024:SF174. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSYT9.
GenomeRNAi143425.
NextBio84707.
PROQ86SS6.
SOURCESearch...

Entry information

Entry nameSYT9_HUMAN
AccessionPrimary (citable) accession number: Q86SS6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM