Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptotagmin-9

Gene

SYT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi251Calcium 1By similarity1
Metal bindingi251Calcium 2By similarity1
Metal bindingi257Calcium 1By similarity1
Metal bindingi309Calcium 1By similarity1
Metal bindingi309Calcium 2By similarity1
Metal bindingi310Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi311Calcium 1By similarity1
Metal bindingi311Calcium 2By similarity1
Metal bindingi311Calcium 3By similarity1
Metal bindingi314Calcium 3By similarity1
Metal bindingi317Calcium 2By similarity1
Metal bindingi317Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-9
Alternative name(s):
Synaptotagmin IX
Short name:
SytIX
Gene namesi
Name:SYT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19265. SYT9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52VesicularSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 491CytoplasmicSequence analysisAdd BLAST418

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi143425.
OpenTargetsiENSG00000170743.
PharmGKBiPA134984583.

Polymorphism and mutation databases

BioMutaiSYT9.
DMDMi33112457.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839621 – 491Synaptotagmin-9Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphothreonineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ86SS6.
MaxQBiQ86SS6.
PaxDbiQ86SS6.
PeptideAtlasiQ86SS6.
PRIDEiQ86SS6.

PTM databases

iPTMnetiQ86SS6.
PhosphoSitePlusiQ86SS6.

Expressioni

Gene expression databases

BgeeiENSG00000170743.
CleanExiHS_SYT9.
ExpressionAtlasiQ86SS6. baseline and differential.
GenevisibleiQ86SS6. HS.

Organism-specific databases

HPAiHPA041827.
HPA045447.

Interactioni

Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126802. 4 interactors.
STRINGi9606.ENSP00000324419.

Structurei

3D structure databases

ProteinModelPortaliQ86SS6.
SMRiQ86SS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 323C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini354 – 457C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 31Cysteine motifBy similarityAdd BLAST23

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XQZ9. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ86SS6.
KOiK19909.
OMAiCWVPLSG.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ86SS6.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028691. SYT9.
[Graphical view]
PANTHERiPTHR10024:SF180. PTHR10024:SF180. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI
60 70 80 90 100
SVSLLTLVVT ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN
110 120 130 140 150
YMDTETNEQE NSEDFLDPPT PCPDSSMKIS HTSPDIPLST QTGIQENCAH
160 170 180 190 200
GVRVQRQVTE PTSSARHNSI RRQLNLSNPD FNIQQLQKQE QLTGIGRIKP
210 220 230 240 250
ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK IHKAVNLPAK
260 270 280 290 300
DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA
310 320 330 340 350
RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN
360 370 380 390 400
VDLGELMFSL CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG
410 420 430 440 450
RRLKKRKTST KRNTLNPVYN EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN
460 470 480 490
EIIGVCQVGN EAERLGRDHW SEMLSYPRKP IAHWHSLVEK R
Length:491
Mass (Da):56,188
Last modified:June 1, 2003 - v1
Checksum:iA9808E5E49153BB3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065760154V → M.1 PublicationCorresponds to variant rs78477754dbSNPEnsembl.1
Natural variantiVAR_065761238I → V.1 Publication1
Natural variantiVAR_065762353L → V.1 PublicationCorresponds to variant rs117876446dbSNPEnsembl.1
Natural variantiVAR_036390445D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA. Translation: AAH46367.1.
CCDSiCCDS7778.1.
RefSeqiNP_783860.1. NM_175733.3.
UniGeneiHs.177193.

Genome annotation databases

EnsembliENST00000318881; ENSP00000324419; ENSG00000170743.
GeneIDi143425.
KEGGihsa:143425.
UCSCiuc001mfe.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA. Translation: AAH46367.1.
CCDSiCCDS7778.1.
RefSeqiNP_783860.1. NM_175733.3.
UniGeneiHs.177193.

3D structure databases

ProteinModelPortaliQ86SS6.
SMRiQ86SS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126802. 4 interactors.
STRINGi9606.ENSP00000324419.

PTM databases

iPTMnetiQ86SS6.
PhosphoSitePlusiQ86SS6.

Polymorphism and mutation databases

BioMutaiSYT9.
DMDMi33112457.

Proteomic databases

EPDiQ86SS6.
MaxQBiQ86SS6.
PaxDbiQ86SS6.
PeptideAtlasiQ86SS6.
PRIDEiQ86SS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318881; ENSP00000324419; ENSG00000170743.
GeneIDi143425.
KEGGihsa:143425.
UCSCiuc001mfe.4. human.

Organism-specific databases

CTDi143425.
DisGeNETi143425.
GeneCardsiSYT9.
HGNCiHGNC:19265. SYT9.
HPAiHPA041827.
HPA045447.
MIMi613528. gene.
neXtProtiNX_Q86SS6.
OpenTargetsiENSG00000170743.
PharmGKBiPA134984583.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XQZ9. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ86SS6.
KOiK19909.
OMAiCWVPLSG.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ86SS6.
TreeFamiTF315600.

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

GeneWikiiSYT9.
GenomeRNAii143425.
PROiQ86SS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170743.
CleanExiHS_SYT9.
ExpressionAtlasiQ86SS6. baseline and differential.
GenevisibleiQ86SS6. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028691. SYT9.
[Graphical view]
PANTHERiPTHR10024:SF180. PTHR10024:SF180. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYT9_HUMAN
AccessioniPrimary (citable) accession number: Q86SS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.