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Q86SS6

- SYT9_HUMAN

UniProt

Q86SS6 - SYT9_HUMAN

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Protein

Synaptotagmin-9

Gene

SYT9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactori

Ca2+By similarityNote: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi251 – 2511Calcium 1By similarity
Metal bindingi251 – 2511Calcium 2By similarity
Metal bindingi257 – 2571Calcium 1By similarity
Metal bindingi309 – 3091Calcium 1By similarity
Metal bindingi309 – 3091Calcium 2By similarity
Metal bindingi310 – 3101Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi311 – 3111Calcium 1By similarity
Metal bindingi311 – 3111Calcium 2By similarity
Metal bindingi311 – 3111Calcium 3By similarity
Metal bindingi314 – 3141Calcium 3By similarity
Metal bindingi317 – 3171Calcium 2By similarity
Metal bindingi317 – 3171Calcium 3By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transporter activity Source: InterPro

GO - Biological processi

  1. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
  2. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-9
Alternative name(s):
Synaptotagmin IX
Short name:
SytIX
Gene namesi
Name:SYT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19265. SYT9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252VesicularSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 491418CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dense core granule Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. secretory granule membrane Source: Ensembl
  5. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Synaptotagmin-9PRO_0000183962Add
BLAST

Proteomic databases

PaxDbiQ86SS6.
PRIDEiQ86SS6.

PTM databases

PhosphoSiteiQ86SS6.

Expressioni

Gene expression databases

BgeeiQ86SS6.
CleanExiHS_SYT9.
ExpressionAtlasiQ86SS6. baseline and differential.
GenevestigatoriQ86SS6.

Organism-specific databases

HPAiHPA041827.
HPA045447.

Interactioni

Protein-protein interaction databases

BioGridi126802. 4 interactions.
STRINGi9606.ENSP00000324419.

Structurei

3D structure databases

ProteinModelPortaliQ86SS6.
SMRiQ86SS6. Positions 221-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini222 – 323102C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini354 – 457104C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292488.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ86SS6.
OMAiDFPRECV.
OrthoDBiEOG78PV8W.
PhylomeDBiQ86SS6.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028691. SYT9.
[Graphical view]
PANTHERiPTHR10024:SF174. PTHR10024:SF174. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI
60 70 80 90 100
SVSLLTLVVT ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN
110 120 130 140 150
YMDTETNEQE NSEDFLDPPT PCPDSSMKIS HTSPDIPLST QTGIQENCAH
160 170 180 190 200
GVRVQRQVTE PTSSARHNSI RRQLNLSNPD FNIQQLQKQE QLTGIGRIKP
210 220 230 240 250
ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK IHKAVNLPAK
260 270 280 290 300
DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA
310 320 330 340 350
RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN
360 370 380 390 400
VDLGELMFSL CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG
410 420 430 440 450
RRLKKRKTST KRNTLNPVYN EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN
460 470 480 490
EIIGVCQVGN EAERLGRDHW SEMLSYPRKP IAHWHSLVEK R
Length:491
Mass (Da):56,188
Last modified:June 1, 2003 - v1
Checksum:iA9808E5E49153BB3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541V → M.1 Publication
Corresponds to variant rs78477754 [ dbSNP | Ensembl ].
VAR_065760
Natural varianti238 – 2381I → V.1 Publication
VAR_065761
Natural varianti353 – 3531L → V.1 Publication
Corresponds to variant rs117876446 [ dbSNP | Ensembl ].
VAR_065762
Natural varianti445 – 4451D → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036390

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA. Translation: AAH46367.1.
CCDSiCCDS7778.1.
RefSeqiNP_783860.1. NM_175733.3.
UniGeneiHs.177193.

Genome annotation databases

EnsembliENST00000318881; ENSP00000324419; ENSG00000170743.
GeneIDi143425.
KEGGihsa:143425.
UCSCiuc001mfe.3. human.

Polymorphism databases

DMDMi33112457.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA. Translation: AAH46367.1 .
CCDSi CCDS7778.1.
RefSeqi NP_783860.1. NM_175733.3.
UniGenei Hs.177193.

3D structure databases

ProteinModelPortali Q86SS6.
SMRi Q86SS6. Positions 221-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126802. 4 interactions.
STRINGi 9606.ENSP00000324419.

PTM databases

PhosphoSitei Q86SS6.

Polymorphism databases

DMDMi 33112457.

Proteomic databases

PaxDbi Q86SS6.
PRIDEi Q86SS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318881 ; ENSP00000324419 ; ENSG00000170743 .
GeneIDi 143425.
KEGGi hsa:143425.
UCSCi uc001mfe.3. human.

Organism-specific databases

CTDi 143425.
GeneCardsi GC11P007273.
HGNCi HGNC:19265. SYT9.
HPAi HPA041827.
HPA045447.
MIMi 613528. gene.
neXtProti NX_Q86SS6.
PharmGKBi PA134984583.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292488.
GeneTreei ENSGT00760000118973.
HOGENOMi HOG000232128.
HOVERGENi HBG005010.
InParanoidi Q86SS6.
OMAi DFPRECV.
OrthoDBi EOG78PV8W.
PhylomeDBi Q86SS6.
TreeFami TF315600.

Miscellaneous databases

GeneWikii SYT9.
GenomeRNAii 143425.
NextBioi 84707.
PROi Q86SS6.
SOURCEi Search...

Gene expression databases

Bgeei Q86SS6.
CleanExi HS_SYT9.
ExpressionAtlasi Q86SS6. baseline and differential.
Genevestigatori Q86SS6.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028691. SYT9.
[Graphical view ]
PANTHERi PTHR10024:SF174. PTHR10024:SF174. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-445.
  3. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
    Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
    Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MET-154; VAL-238 AND VAL-353.

Entry informationi

Entry nameiSYT9_HUMAN
AccessioniPrimary (citable) accession number: Q86SS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3