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Protein

Adhesion G protein-coupled receptor A1

Gene

ADGRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor A11 Publication
Alternative name(s):
G-protein coupled receptor 123
Gene namesi
Name:ADGRA1Imported
Synonyms:GPR123, KIAA1828
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13838. ADGRA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularCuratedAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 53CytoplasmicCuratedAdd BLAST13
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 84ExtracellularCurated10
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 134CytoplasmicCuratedAdd BLAST29
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 175ExtracellularCuratedAdd BLAST20
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 257CytoplasmicCuratedAdd BLAST61
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 284ExtracellularCurated6
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 560CytoplasmicCuratedAdd BLAST255

GO - Cellular componenti

  • integral component of membrane Source: GDB

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84435.
OpenTargetsiENSG00000197177.
PharmGKBiPA134910893.

Polymorphism and mutation databases

BioMutaiGPR123.
DMDMi313104230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703371 – 560Adhesion G protein-coupled receptor A1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86SQ6.
PeptideAtlasiQ86SQ6.
PRIDEiQ86SQ6.

PTM databases

iPTMnetiQ86SQ6.
PhosphoSitePlusiQ86SQ6.

Expressioni

Gene expression databases

BgeeiENSG00000197177.
CleanExiHS_GPR123.
GenevisibleiQ86SQ6. HS.

Organism-specific databases

HPAiHPA042773.

Interactioni

Protein-protein interaction databases

IntActiQ86SQ6. 1 interactor.
STRINGi9606.ENSP00000376384.

Structurei

3D structure databases

ProteinModelPortaliQ86SQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000276895.
HOVERGENiHBG062926.
InParanoidiQ86SQ6.
KOiK08460.
OMAiSTHRSRV.
OrthoDBiEOG091G03GB.
PhylomeDBiQ86SQ6.
TreeFamiTF331206.

Family and domain databases

InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q86SQ6-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR
60 70 80 90 100
KGRHTLLNFC FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW
110 120 130 140 150
IGVTARNIYK QVTKKAPLCL DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT
160 170 180 190 200
AATNIRNYGT EDEDTAYCWM AWEPSLGAFY GPAAIITLVT CVYFLGTYVQ
210 220 230 240 250
LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA PGASVLQNEH
260 270 280 290 300
SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL
310 320 330 340 350
FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG
360 370 380 390 400
QPRGFAHPPG PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH
410 420 430 440 450
LQEEGAFGHD PHLHGCLQGR TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS
460 470 480 490 500
SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM VTQPEGSDGS PALYSCPTQP
510 520 530 540 550
GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP FGTDGTGNIR
560
TGPWKNETTV
Length:560
Mass (Da):60,885
Last modified:November 30, 2010 - v3
Checksum:i1529EA836A679C5C
GO
Isoform 1 (identifier: Q86SQ6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGHGNHSRL...GPLAACIPTQ
     167-167: Missing.

Show »
Length:1,279
Mass (Da):137,203
Checksum:iAF7FDE6401E30D54
GO
Isoform 2 (identifier: Q86SQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):50,101
Checksum:i620377131CF9B583
GO

Sequence cautioni

The sequence BAB47457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti560V → VW in AAO27353 (PubMed:12565841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055931183A → S. Corresponds to variant dbSNP:rs34915504Ensembl.1
Natural variantiVAR_055932214Q → L. Corresponds to variant dbSNP:rs34679676Ensembl.1
Isoform 1 (identifier: Q86SQ6-1)
Natural varianti38T → I in an acute myeloid leukemia, somatic mutation. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402071 – 97Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0402081M → MRGHGNHSRLKSRCASLGNV HHHQAQMAHGAHCRGGRTPQ SPDSRGPTAGGHTRGRWTYR PIEALINVSFPGAKGGRTAE GEPSWAWVFRSGYLQRQALP GLPVSTRVAACWWQHHPGRD SGFLGPGFIDLLREEPSGRA DGKAAAQKTGRLYLFPTFLG NKLPEAADSFGEIASGNSVI FTSVLQSSHPPGTPPPSARK PSPGAAMLVCEETLELGAQG CWGSTSPRGQAVSLVGGPTA GGSRLGGAGCTMGLLMALQA RRPRDGTWADPRRCSRAVEG SGLTRAALVSPGPSGVEEDT RREGCVLVGSWRSSTHRSRV LIINTPSGRTPWSQGSLGST GRYNQTRAPGSQQQGLCSDA ALHEDFVPEPTPAFFQYPPQ AFSKTKVRDLGRGGLYAFSK EEKVSEAQRVEAYETHGLGL STGRQNPVPSPCKPGCVCQG LALDAEAWPRHPGRRPCAAK EACLGPPGCSGELSLPEEEG IAPGAATAAPAWVPHGRVSR FLTVKLFTYVTMYQCKQERI LRLCISGESGRYVRRSRFRN FAALMVSTGVPGVLQLGARP LRGGGHPYGDSQAGKVVEWR AGDRASGLSAGERRFLSQSE LQTWPRTPHCVGKKVPQPVG AADLAPDTSLCRKEGSSASR SCRPGPGHLTRREEDSFRQL AFPRFEEVTFPPLTAAERAP SVHGGHSLASQGLVLAGRTR SVASGGKQELSGPLAACIPT Q in isoform 1. 1 Publication1
Alternative sequenceiVSP_040209167Missing in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181241 mRNA. Translation: AAO27353.1.
EF536972 mRNA. Translation: ABQ08572.1.
AB058731 mRNA. Translation: BAB47457.1. Different initiation.
AL445199 Genomic DNA. No translation available.
AY255564 mRNA. Translation: AAO85076.1.
CCDSiCCDS41580.1. [Q86SQ6-3]
CCDS76362.1. [Q86SQ6-2]
RefSeqiNP_001077378.1. NM_001083909.2. [Q86SQ6-3]
NP_001278014.1. NM_001291085.1. [Q86SQ6-2]
XP_005252752.1. XM_005252695.1. [Q86SQ6-1]
UniGeneiHs.435183.

Genome annotation databases

EnsembliENST00000392606; ENSP00000376383; ENSG00000197177. [Q86SQ6-2]
ENST00000392607; ENSP00000376384; ENSG00000197177. [Q86SQ6-3]
ENST00000607359; ENSP00000475778; ENSG00000197177. [Q86SQ6-1]
GeneIDi84435.
KEGGihsa:84435.
UCSCiuc001llw.3. human. [Q86SQ6-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181241 mRNA. Translation: AAO27353.1.
EF536972 mRNA. Translation: ABQ08572.1.
AB058731 mRNA. Translation: BAB47457.1. Different initiation.
AL445199 Genomic DNA. No translation available.
AY255564 mRNA. Translation: AAO85076.1.
CCDSiCCDS41580.1. [Q86SQ6-3]
CCDS76362.1. [Q86SQ6-2]
RefSeqiNP_001077378.1. NM_001083909.2. [Q86SQ6-3]
NP_001278014.1. NM_001291085.1. [Q86SQ6-2]
XP_005252752.1. XM_005252695.1. [Q86SQ6-1]
UniGeneiHs.435183.

3D structure databases

ProteinModelPortaliQ86SQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86SQ6. 1 interactor.
STRINGi9606.ENSP00000376384.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ86SQ6.
PhosphoSitePlusiQ86SQ6.

Polymorphism and mutation databases

BioMutaiGPR123.
DMDMi313104230.

Proteomic databases

PaxDbiQ86SQ6.
PeptideAtlasiQ86SQ6.
PRIDEiQ86SQ6.

Protocols and materials databases

DNASUi84435.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392606; ENSP00000376383; ENSG00000197177. [Q86SQ6-2]
ENST00000392607; ENSP00000376384; ENSG00000197177. [Q86SQ6-3]
ENST00000607359; ENSP00000475778; ENSG00000197177. [Q86SQ6-1]
GeneIDi84435.
KEGGihsa:84435.
UCSCiuc001llw.3. human. [Q86SQ6-3]

Organism-specific databases

CTDi84435.
DisGeNETi84435.
GeneCardsiADGRA1.
HGNCiHGNC:13838. ADGRA1.
HPAiHPA042773.
MIMi612302. gene.
neXtProtiNX_Q86SQ6.
OpenTargetsiENSG00000197177.
PharmGKBiPA134910893.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000276895.
HOVERGENiHBG062926.
InParanoidiQ86SQ6.
KOiK08460.
OMAiSTHRSRV.
OrthoDBiEOG091G03GB.
PhylomeDBiQ86SQ6.
TreeFamiTF331206.

Miscellaneous databases

GeneWikiiGPR123.
GenomeRNAii84435.
PROiPR:Q86SQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197177.
CleanExiHS_GPR123.
GenevisibleiQ86SQ6. HS.

Family and domain databases

InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PROSITEiView protein in PROSITE
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGRA1_HUMAN
AccessioniPrimary (citable) accession number: Q86SQ6
Secondary accession number(s): A5HL16
, A6NG50, Q5T234, Q86SN7, Q96JJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 30, 2010
Last modified: May 10, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.