Q86SQ6 (GP123_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 123

Gene names

Name:	GPR123
Synonyms:	KIAA1828

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Sequence caution	The sequence BAB47457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA integral to membrane Non-traceable author statement Ref.1PubMed 17212699. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	G-protein coupled receptor activity Non-traceable author statement Ref.1PubMed 17212699. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q86SQ6-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q86SQ6-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGHGNHSRL...GPLAACIPTQ
     167-167: Missing.

Isoform 2 (identifier: Q86SQ6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Probable G-protein coupled receptor 123		PRO_0000070337
Regions
	Topological domain	1 – 19	19	Extracellular Potential
	Transmembrane	20 – 40	21	Helical; Name=1; Potential
	Topological domain	41 – 53	13	Cytoplasmic Potential
	Transmembrane	54 – 74	21	Helical; Name=2; Potential
	Topological domain	75 – 84	10	Extracellular Potential
	Transmembrane	85 – 105	21	Helical; Name=3; Potential
	Topological domain	106 – 134	29	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Name=4; Potential
	Topological domain	156 – 175	20	Extracellular Potential
	Transmembrane	176 – 196	21	Helical; Name=5; Potential
	Topological domain	197 – 257	61	Cytoplasmic Potential
	Transmembrane	258 – 278	21	Helical; Name=6; Potential
	Topological domain	279 – 284	6	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=7; Potential
	Topological domain	306 – 560	255	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	75	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 97	97	Missing in isoform 2.		VSP_040207
	Alternative sequence	1	1	M → MRGHGNHSRLKSRCASLGNV HHHQAQMAHGAHCRGGRTPQ SPDSRGPTAGGHTRGRWTYR PIEALINVSFPGAKGGRTAE GEPSWAWVFRSGYLQRQALP GLPVSTRVAACWWQHHPGRD SGFLGPGFIDLLREEPSGRA DGKAAAQKTGRLYLFPTFLG NKLPEAADSFGEIASGNSVI FTSVLQSSHPPGTPPPSARK PSPGAAMLVCEETLELGAQG CWGSTSPRGQAVSLVGGPTA GGSRLGGAGCTMGLLMALQA RRPRDGTWADPRRCSRAVEG SGLTRAALVSPGPSGVEEDT RREGCVLVGSWRSSTHRSRV LIINTPSGRTPWSQGSLGST GRYNQTRAPGSQQQGLCSDA ALHEDFVPEPTPAFFQYPPQ AFSKTKVRDLGRGGLYAFSK EEKVSEAQRVEAYETHGLGL STGRQNPVPSPCKPGCVCQG LALDAEAWPRHPGRRPCAAK EACLGPPGCSGELSLPEEEG IAPGAATAAPAWVPHGRVSR FLTVKLFTYVTMYQCKQERI LRLCISGESGRYVRRSRFRN FAALMVSTGVPGVLQLGARP LRGGGHPYGDSQAGKVVEWR AGDRASGLSAGERRFLSQSE LQTWPRTPHCVGKKVPQPVG AADLAPDTSLCRKEGSSASR SCRPGPGHLTRREEDSFRQL AFPRFEEVTFPPLTAAERAP SVHGGHSLASQGLVLAGRTR SVASGGKQELSGPLAACIPT Q in isoform 1.		VSP_040208
	Alternative sequence	167	1	Missing in isoform 1.		VSP_040209
	Natural variant	183	1	A → S. Corresponds to variant rs34915504 [ dbSNP | Ensembl ].		VAR_055931
	Natural variant	214	1	Q → L. Corresponds to variant rs34679676 [ dbSNP | Ensembl ].		VAR_055932
Isoform 1:
	Natural variant	38	1	T → I in an acute myeloid leukemia sample, somatic mutation.
Experimental info
	Sequence conflict	560	1	V → VW in AAO27353. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 1529EA836A679C5C	FASTA	560	60,885
	10 20 30 40 50 60 MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR KGRHTLLNFC 70 80 90 100 110 120 FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW IGVTARNIYK QVTKKAPLCL 130 140 150 160 170 180 DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT AATNIRNYGT EDEDTAYCWM AWEPSLGAFY 190 200 210 220 230 240 GPAAIITLVT CVYFLGTYVQ LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA 250 260 270 280 290 300 PGASVLQNEH SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL 310 320 330 340 350 360 FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG QPRGFAHPPG 370 380 390 400 410 420 PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH LQEEGAFGHD PHLHGCLQGR 430 440 450 460 470 480 TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM 490 500 510 520 530 540 VTQPEGSDGS PALYSCPTQP GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP 550 560 FGTDGTGNIR TGPWKNETTV
	Isoform 1 [UniParc]. Checksum: AF7FDE6401E30D54	FASTA	1,279	137,203
	10 20 30 40 50 60 MRGHGNHSRL KSRCASLGNV HHHQAQMAHG AHCRGGRTPQ SPDSRGPTAG GHTRGRWTYR 70 80 90 100 110 120 PIEALINVSF PGAKGGRTAE GEPSWAWVFR SGYLQRQALP GLPVSTRVAA CWWQHHPGRD 130 140 150 160 170 180 SGFLGPGFID LLREEPSGRA DGKAAAQKTG RLYLFPTFLG NKLPEAADSF GEIASGNSVI 190 200 210 220 230 240 FTSVLQSSHP PGTPPPSARK PSPGAAMLVC EETLELGAQG CWGSTSPRGQ AVSLVGGPTA 250 260 270 280 290 300 GGSRLGGAGC TMGLLMALQA RRPRDGTWAD PRRCSRAVEG SGLTRAALVS PGPSGVEEDT 310 320 330 340 350 360 RREGCVLVGS WRSSTHRSRV LIINTPSGRT PWSQGSLGST GRYNQTRAPG SQQQGLCSDA 370 380 390 400 410 420 ALHEDFVPEP TPAFFQYPPQ AFSKTKVRDL GRGGLYAFSK EEKVSEAQRV EAYETHGLGL 430 440 450 460 470 480 STGRQNPVPS PCKPGCVCQG LALDAEAWPR HPGRRPCAAK EACLGPPGCS GELSLPEEEG 490 500 510 520 530 540 IAPGAATAAP AWVPHGRVSR FLTVKLFTYV TMYQCKQERI LRLCISGESG RYVRRSRFRN 550 560 570 580 590 600 FAALMVSTGV PGVLQLGARP LRGGGHPYGD SQAGKVVEWR AGDRASGLSA GERRFLSQSE 610 620 630 640 650 660 LQTWPRTPHC VGKKVPQPVG AADLAPDTSL CRKEGSSASR SCRPGPGHLT RREEDSFRQL 670 680 690 700 710 720 AFPRFEEVTF PPLTAAERAP SVHGGHSLAS QGLVLAGRTR SVASGGKQEL SGPLAACIPT 730 740 750 760 770 780 QDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR KGRHTLLNFC 790 800 810 820 830 840 FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW IGVTARNIYK QVTKKAPLCL 850 860 870 880 890 900 DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT AATNIRNYGT EDEDTACWMA WEPSLGAFYG 910 920 930 940 950 960 PAAIITLVTC VYFLGTYVQL RRHPGRRYEL RTQPEEQRRL ATPEGGRGIR PGTPPAHDAP 970 980 990 1000 1010 1020 GASVLQNEHS FQAQLRAAAF TLFLFTATWA FGALAVSQGH FLDMVFSCLY GAFCVTLGLF 1030 1040 1050 1060 1070 1080 VLIHHCAKRE DVWQCWWACC PPRKDAHPAL DANGAALGRA ACLHSPGLGQ PRGFAHPPGP 1090 1100 1110 1120 1130 1140 CKMTNLQAAQ GHASCLSPAT PCCAKMHCEP LTADEAHVHL QEEGAFGHDP HLHGCLQGRT 1150 1160 1170 1180 1190 1200 KPPYFSRHPA EEPEYAYHIP SSLDGSPRSS RTDSPPSSLD GPAGTHTLAC CTQGDPFPMV 1210 1220 1230 1240 1250 1260 TQPEGSDGSP ALYSCPTQPG REAALGPGHL EMLRRTQSLP FGGPSQNGLP KGKLLEGLPF 1270 GTDGTGNIRT GPWKNETTV
	Isoform 2 [UniParc]. Checksum: 620377131CF9B583	FASTA	463	50,101
	10 20 30 40 50 60 MLWIGVTARN IYKQVTKKAP LCLDTDQPPY PRQPLLRFYL VSGGVPFIIC GVTAATNIRN 70 80 90 100 110 120 YGTEDEDTAY CWMAWEPSLG AFYGPAAIIT LVTCVYFLGT YVQLRRHPGR RYELRTQPEE 130 140 150 160 170 180 QRRLATPEGG RGIRPGTPPA HDAPGASVLQ NEHSFQAQLR AAAFTLFLFT ATWAFGALAV 190 200 210 220 230 240 SQGHFLDMVF SCLYGAFCVT LGLFVLIHHC AKREDVWQCW WACCPPRKDA HPALDANGAA 250 260 270 280 290 300 LGRAACLHSP GLGQPRGFAH PPGPCKMTNL QAAQGHASCL SPATPCCAKM HCEPLTADEA 310 320 330 340 350 360 HVHLQEEGAF GHDPHLHGCL QGRTKPPYFS RHPAEEPEYA YHIPSSLDGS PRSSRTDSPP 370 380 390 400 410 420 SSLDGPAGTH TLACCTQGDP FPMVTQPEGS DGSPALYSCP TQPGREAALG PGHLEMLRRT 430 440 450 460 QSLPFGGPSQ NGLPKGKLLE GLPFGTDGTG NIRTGPWKNE TTV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini." Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B. Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete coding sequence of human GPR123." Bonner T.I., Kauffman D., Nagle J.W., Sloger M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-465.
[6]	"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K. Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-38 (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY181241 mRNA. Translation: AAO27353.1. EF536972 mRNA. Translation: ABQ08572.1. AB058731 mRNA. Translation: BAB47457.1. Different initiation. AL445199 Genomic DNA. Translation: CAO03417.1. AY255564 mRNA. Translation: AAO85076.1.
IPI	IPI00255554. IPI00937870. IPI00940547.
RefSeq	NP_001077378.1. NM_001083909.1.
UniGene	Hs.435183.
3D structure databases
ProteinModelPortal	Q86SQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000376384.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q86SQ6.
Polymorphism databases
DMDM	143811399.
Proteomic databases
PaxDb	Q86SQ6.
PRIDE	Q86SQ6.
Protocols and materials databases
DNASU	84435.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000392607; ENSP00000376384; ENSG00000197177.
GeneID	84435.
KEGG	hsa:84435.
UCSC	uc001llw.3. human. uc001llx.4. human.
Organism-specific databases
CTD	84435.
GeneCards	GC10P134884.
HGNC	HGNC:13838. GPR123.
HPA	HPA042773.
MIM	612302. gene.
neXtProt	NX_Q86SQ6.
PharmGKB	PA134910893.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259400.
HOGENOM	HOG000276895.
HOVERGEN	HBG062926.
InParanoid	Q86SQ6.
KO	K08460.
OMA	WADPRRC.
OrthoDB	EOG4M65HR.
Gene expression databases
ArrayExpress	Q86SQ6.
Bgee	Q86SQ6.
CleanEx	HS_GPR123.
Genevestigator	Q86SQ6.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. [Graphical view]
PROSITE	PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84435.
NextBio	74175.
SOURCE	Search...

Entry information

Entry name

GP123_HUMAN

Accession

Primary (citable) accession number: Q86SQ6
Secondary accession number(s): A5HL16 , A6NG50, Q5T234, Q86SN7, Q96JJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	November 30, 2010
Last modified:	April 3, 2013
This is version 92 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.