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Q86SQ6

- GP123_HUMAN

UniProt

Q86SQ6 - GP123_HUMAN

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Protein

Probable G-protein coupled receptor 123

Gene

GPR123

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 123
Gene namesi
Name:GPR123
Synonyms:KIAA1828
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:13838. GPR123.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 5313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 8410ExtracellularSequence Analysis
Transmembranei85 – 10521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini106 – 13429CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei135 – 15521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini156 – 17520ExtracellularSequence AnalysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini197 – 25761CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini279 – 2846ExtracellularSequence Analysis
Transmembranei285 – 30521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini306 – 560255CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Probable G-protein coupled receptor 123PRO_0000070337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86SQ6.
PRIDEiQ86SQ6.

PTM databases

PhosphoSiteiQ86SQ6.

Expressioni

Gene expression databases

BgeeiQ86SQ6.
CleanExiHS_GPR123.
GenevestigatoriQ86SQ6.

Organism-specific databases

HPAiHPA042773.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376384.

Structurei

3D structure databases

ProteinModelPortaliQ86SQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259400.
GeneTreeiENSGT00390000016104.
HOGENOMiHOG000276895.
HOVERGENiHBG062926.
InParanoidiQ86SQ6.
KOiK08460.
OMAiSTHRSRV.
OrthoDBiEOG7RV9F8.
PhylomeDBiQ86SQ6.
TreeFamiTF331206.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PROSITEiPS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 3 (identifier: Q86SQ6-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR
60 70 80 90 100
KGRHTLLNFC FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW
110 120 130 140 150
IGVTARNIYK QVTKKAPLCL DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT
160 170 180 190 200
AATNIRNYGT EDEDTAYCWM AWEPSLGAFY GPAAIITLVT CVYFLGTYVQ
210 220 230 240 250
LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA PGASVLQNEH
260 270 280 290 300
SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL
310 320 330 340 350
FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG
360 370 380 390 400
QPRGFAHPPG PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH
410 420 430 440 450
LQEEGAFGHD PHLHGCLQGR TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS
460 470 480 490 500
SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM VTQPEGSDGS PALYSCPTQP
510 520 530 540 550
GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP FGTDGTGNIR
560
TGPWKNETTV
Length:560
Mass (Da):60,885
Last modified:November 30, 2010 - v3
Checksum:i1529EA836A679C5C
GO
Isoform 1 (identifier: Q86SQ6-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGHGNHSRL...GPLAACIPTQ
     167-167: Missing.

Show »
Length:1,279
Mass (Da):137,203
Checksum:iAF7FDE6401E30D54
GO
Isoform 2 (identifier: Q86SQ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.

Show »
Length:463
Mass (Da):50,101
Checksum:i620377131CF9B583
GO

Sequence cautioni

The sequence BAB47457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti560 – 5601V → VW in AAO27353. (PubMed:12565841)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti183 – 1831A → S.
Corresponds to variant rs34915504 [ dbSNP | Ensembl ].
VAR_055931
Natural varianti214 – 2141Q → L.
Corresponds to variant rs34679676 [ dbSNP | Ensembl ].
VAR_055932
Isoform 1 (identifier: Q86SQ6-1)
Natural varianti38 – 381T → I in an acute myeloid leukemia sample, somatic mutation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_040207Add
BLAST
Alternative sequencei1 – 11M → MRGHGNHSRLKSRCASLGNV HHHQAQMAHGAHCRGGRTPQ SPDSRGPTAGGHTRGRWTYR PIEALINVSFPGAKGGRTAE GEPSWAWVFRSGYLQRQALP GLPVSTRVAACWWQHHPGRD SGFLGPGFIDLLREEPSGRA DGKAAAQKTGRLYLFPTFLG NKLPEAADSFGEIASGNSVI FTSVLQSSHPPGTPPPSARK PSPGAAMLVCEETLELGAQG CWGSTSPRGQAVSLVGGPTA GGSRLGGAGCTMGLLMALQA RRPRDGTWADPRRCSRAVEG SGLTRAALVSPGPSGVEEDT RREGCVLVGSWRSSTHRSRV LIINTPSGRTPWSQGSLGST GRYNQTRAPGSQQQGLCSDA ALHEDFVPEPTPAFFQYPPQ AFSKTKVRDLGRGGLYAFSK EEKVSEAQRVEAYETHGLGL STGRQNPVPSPCKPGCVCQG LALDAEAWPRHPGRRPCAAK EACLGPPGCSGELSLPEEEG IAPGAATAAPAWVPHGRVSR FLTVKLFTYVTMYQCKQERI LRLCISGESGRYVRRSRFRN FAALMVSTGVPGVLQLGARP LRGGGHPYGDSQAGKVVEWR AGDRASGLSAGERRFLSQSE LQTWPRTPHCVGKKVPQPVG AADLAPDTSLCRKEGSSASR SCRPGPGHLTRREEDSFRQL AFPRFEEVTFPPLTAAERAP SVHGGHSLASQGLVLAGRTR SVASGGKQELSGPLAACIPT Q in isoform 1. 1 PublicationVSP_040208
Alternative sequencei167 – 1671Missing in isoform 1. 1 PublicationVSP_040209

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181241 mRNA. Translation: AAO27353.1.
EF536972 mRNA. Translation: ABQ08572.1.
AB058731 mRNA. Translation: BAB47457.1. Different initiation.
AL445199 Genomic DNA. Translation: CAO03417.1.
AY255564 mRNA. Translation: AAO85076.1.
CCDSiCCDS41580.1. [Q86SQ6-3]
RefSeqiNP_001077378.1. NM_001083909.2. [Q86SQ6-3]
NP_001278014.1. NM_001291085.1. [Q86SQ6-2]
XP_005252752.1. XM_005252695.1. [Q86SQ6-1]
UniGeneiHs.435183.

Genome annotation databases

EnsembliENST00000392606; ENSP00000376383; ENSG00000197177. [Q86SQ6-2]
ENST00000392607; ENSP00000376384; ENSG00000197177. [Q86SQ6-3]
ENST00000607359; ENSP00000475778; ENSG00000197177. [Q86SQ6-1]
GeneIDi84435.
KEGGihsa:84435.
UCSCiuc001llw.3. human. [Q86SQ6-1]
uc001llx.4. human. [Q86SQ6-3]

Polymorphism databases

DMDMi313104230.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181241 mRNA. Translation: AAO27353.1 .
EF536972 mRNA. Translation: ABQ08572.1 .
AB058731 mRNA. Translation: BAB47457.1 . Different initiation.
AL445199 Genomic DNA. Translation: CAO03417.1 .
AY255564 mRNA. Translation: AAO85076.1 .
CCDSi CCDS41580.1. [Q86SQ6-3 ]
RefSeqi NP_001077378.1. NM_001083909.2. [Q86SQ6-3 ]
NP_001278014.1. NM_001291085.1. [Q86SQ6-2 ]
XP_005252752.1. XM_005252695.1. [Q86SQ6-1 ]
UniGenei Hs.435183.

3D structure databases

ProteinModelPortali Q86SQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000376384.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q86SQ6.

Polymorphism databases

DMDMi 313104230.

Proteomic databases

PaxDbi Q86SQ6.
PRIDEi Q86SQ6.

Protocols and materials databases

DNASUi 84435.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392606 ; ENSP00000376383 ; ENSG00000197177 . [Q86SQ6-2 ]
ENST00000392607 ; ENSP00000376384 ; ENSG00000197177 . [Q86SQ6-3 ]
ENST00000607359 ; ENSP00000475778 ; ENSG00000197177 . [Q86SQ6-1 ]
GeneIDi 84435.
KEGGi hsa:84435.
UCSCi uc001llw.3. human. [Q86SQ6-1 ]
uc001llx.4. human. [Q86SQ6-3 ]

Organism-specific databases

CTDi 84435.
GeneCardsi GC10P134884.
HGNCi HGNC:13838. GPR123.
HPAi HPA042773.
MIMi 612302. gene.
neXtProti NX_Q86SQ6.
PharmGKBi PA134910893.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259400.
GeneTreei ENSGT00390000016104.
HOGENOMi HOG000276895.
HOVERGENi HBG062926.
InParanoidi Q86SQ6.
KOi K08460.
OMAi STHRSRV.
OrthoDBi EOG7RV9F8.
PhylomeDBi Q86SQ6.
TreeFami TF331206.

Miscellaneous databases

GeneWikii GPR123.
GenomeRNAii 84435.
NextBioi 74175.
PROi Q86SQ6.
SOURCEi Search...

Gene expression databases

Bgeei Q86SQ6.
CleanExi HS_GPR123.
Genevestigatori Q86SQ6.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
[Graphical view ]
PROSITEi PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete coding sequence of human GPR123."
    Bonner T.I., Kauffman D., Nagle J.W., Sloger M.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-465.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-38 (ISOFORM 1).

Entry informationi

Entry nameiGP123_HUMAN
AccessioniPrimary (citable) accession number: Q86SQ6
Secondary accession number(s): A5HL16
, A6NG50, Q5T234, Q86SN7, Q96JJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3