##gff-version 3 Q86SQ4 UniProtKB Signal peptide 1 37 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Chain 38 1221 . . . ID=PRO_0000012902;Note=Adhesion G-protein coupled receptor G6 Q86SQ4 UniProtKB Chain 38 840 . . . ID=PRO_0000438596;Note=ADGRG6 N-terminal fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Chain 841 1221 . . . ID=PRO_0000438597;Note=ADGRG6 C-terminal fragment;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Topological domain 38 862 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 863 883 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 884 903 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 904 924 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 925 929 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 930 950 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 951 970 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 971 991 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 992 1024 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 1025 1045 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 1046 1069 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 1070 1090 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 1091 1092 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Transmembrane 1093 1113 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Topological domain 1114 1221 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Domain 41 149 . . . Note=CUB;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 Q86SQ4 UniProtKB Domain 154 356 . . . Note=Pentraxin (PTX);Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01172 Q86SQ4 UniProtKB Domain 800 852 . . . Note=GPS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00098 Q86SQ4 UniProtKB Region 41 852 . . . Note=Inhibits receptor signaling in absence of type IV collagen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:C6KFA3 Q86SQ4 UniProtKB Region 41 355 . . . Note=Mediates interaction with type IV collagen;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:C6KFA3 Q86SQ4 UniProtKB Region 473 837 . . . Note=Mediates interaction with laminin-2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6F3F9 Q86SQ4 UniProtKB Region 1156 1176 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q86SQ4 UniProtKB Motif 842 850 . . . Note=Stachel;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25533341;Dbxref=PMID:25533341 Q86SQ4 UniProtKB Site 467 468 . . . Note=Cleavage%3B by furin like-convertase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Site 840 841 . . . Note=Cleavage;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Modified residue 1165 1165 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q86SQ4 UniProtKB Modified residue 1168 1168 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6F3F9 Q86SQ4 UniProtKB Glycosylation 121 121 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 143 143 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 Q86SQ4 UniProtKB Glycosylation 206 206 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 258 258 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 314 314 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 324 324 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15084671;Dbxref=PMID:15084671 Q86SQ4 UniProtKB Glycosylation 353 353 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 438 438 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 Q86SQ4 UniProtKB Glycosylation 445 445 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16335952;Dbxref=PMID:16335952 Q86SQ4 UniProtKB Glycosylation 452 452 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 485 485 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 488 488 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 505 505 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 563 563 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 593 593 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 600 600 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 605 605 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 667 667 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 673 673 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 695 695 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 704 704 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 750 750 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 776 776 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 811 811 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Glycosylation 818 818 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q86SQ4 UniProtKB Disulfide bond 41 67 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 Q86SQ4 UniProtKB Disulfide bond 94 111 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00059 Q86SQ4 UniProtKB Disulfide bond 186 254 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01172 Q86SQ4 UniProtKB Alternative sequence 380 407 . . . ID=VSP_010747;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15189448,ECO:0000303|PubMed:15225624,ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15189448,PMID:15225624,PMID:15489334,PMID:17974005 Q86SQ4 UniProtKB Alternative sequence 1193 1221 . . . ID=VSP_010748;Note=In isoform 3 and isoform 4. NVSYEHSFNKSGSLRQCFHGQVLVKTGPC->SASMDKSLSKLAHADGDQTSIIPVHQVIDKVKGYCNAHSDNFYKNIIMSDTFSHSTKF;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12565841,ECO:0000303|PubMed:15189448,ECO:0000303|PubMed:15225624,ECO:0000303|PubMed:15489334;Dbxref=PMID:12565841,PMID:15189448,PMID:15225624,PMID:15489334 Q86SQ4 UniProtKB Natural variant 123 123 . . . ID=VAR_054128;Note=S->G;Dbxref=dbSNP:rs17280293 Q86SQ4 UniProtKB Natural variant 230 230 . . . ID=VAR_024478;Note=K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs11155242,PMID:15489334 Q86SQ4 UniProtKB Natural variant 741 741 . . . ID=VAR_075146;Note=In LCCS9%3B decreases the autoprocessing/cleavage of the receptor. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26004201;Dbxref=PMID:26004201 Q86SQ4 UniProtKB Natural variant 769 769 . . . ID=VAR_075147;Note=In LCCS9. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26004201;Dbxref=dbSNP:rs793888525,PMID:26004201 Q86SQ4 UniProtKB Natural variant 1057 1057 . . . ID=VAR_076965;Note=Found in patients with aggressive periodontitis%3B impairs cAMP production%3B abrogates osteoblastic differentiation. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27509131;Dbxref=dbSNP:rs536714306,PMID:27509131 Q86SQ4 UniProtKB Natural variant 1127 1127 . . . ID=VAR_054129;Note=Q->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12565841,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15189448,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|Ref.8;Dbxref=dbSNP:rs1262686,PMID:12565841,PMID:14702039,PMID:15189448,PMID:15489334,PMID:17974005 Q86SQ4 UniProtKB Mutagenesis 468 468 . . . Note=No cleavage. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 469 469 . . . Note=No effect on cleavage. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 803 803 . . . Note=No cleavage and not detected at the cell surface. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 813 813 . . . Note=No effect on G-protein-mediated cAMP release. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25533341;Dbxref=PMID:25533341 Q86SQ4 UniProtKB Mutagenesis 815 815 . . . Note=Abolishes G-protein-mediated cAMP release. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25533341;Dbxref=PMID:25533341 Q86SQ4 UniProtKB Mutagenesis 818 818 . . . Note=Abolishes G-protein-mediated cAMP release. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25533341;Dbxref=PMID:25533341 Q86SQ4 UniProtKB Mutagenesis 819 819 . . . Note=Abolishes G-protein-mediated cAMP release. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25533341;Dbxref=PMID:25533341 Q86SQ4 UniProtKB Mutagenesis 822 822 . . . Note=No cleavage and not detected at the cell surface. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 835 835 . . . Note=No cleavage and not detected at the cell surface. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 837 837 . . . Note=No cleavage and not detected at the cell surface. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 841 841 . . . Note=No cleavage but detected at cell surface. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Mutagenesis 841 841 . . . Note=No cleavage and not detected at the cell surface. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15189448;Dbxref=PMID:15189448 Q86SQ4 UniProtKB Sequence conflict 622 622 . . . Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86SQ4 UniProtKB Sequence conflict 623 623 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86SQ4 UniProtKB Sequence conflict 708 708 . . . Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86SQ4 UniProtKB Sequence conflict 763 763 . . . Note=K->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q86SQ4 UniProtKB Sequence conflict 908 908 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305