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Q86SQ4 (GP126_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 126
Alternative name(s):
Developmentally regulated G-protein-coupled receptor
Vascular inducible G protein-coupled receptor
Gene names
Name:GPR126
Synonyms:DREG, VIGR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Detected on the cell surface of activated but not resting umbilical vein. Ref.1 Ref.2

Tissue specificity

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. Ref.1

Induction

Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins. Ref.1

Post-translational modification

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Ref.2

Polymorphism

Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIM:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 CUB domain.

Contains 1 GPS domain.

Contains 1 pentaxin domain.

Sequence caution

The sequence AAO13250.1 differs from that shown. Reason: Sequencing errors.

The sequence BAB55406.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11393.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAE45930.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI20053.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86SQ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86SQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
Isoform 3 (identifier: Q86SQ4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF
Isoform 4 (identifier: Q86SQ4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 12211184G-protein coupled receptor 126
PRO_0000012902

Regions

Topological domain38 – 862825Extracellular Potential
Transmembrane863 – 88321Helical; Name=1; Potential
Topological domain884 – 90320Cytoplasmic Potential
Transmembrane904 – 92421Helical; Name=2; Potential
Topological domain925 – 9295Extracellular Potential
Transmembrane930 – 95021Helical; Name=3; Potential
Topological domain951 – 97020Cytoplasmic Potential
Transmembrane971 – 99121Helical; Name=4; Potential
Topological domain992 – 102433Extracellular Potential
Transmembrane1025 – 104521Helical; Name=5; Potential
Topological domain1046 – 106924Cytoplasmic Potential
Transmembrane1070 – 109021Helical; Name=6; Potential
Topological domain1091 – 10922Extracellular Potential
Transmembrane1093 – 111321Helical; Name=7; Potential
Topological domain1114 – 1221108Cytoplasmic Potential
Domain41 – 149109CUB
Domain150 – 355206Pentaxin
Domain800 – 85253GPS
Compositional bias1153 – 120553Ser-rich

Sites

Site467 – 4682Cleavage; by furin like-convertase
Site840 – 8412Cleavage

Amino acid modifications

Modified residue11651Phosphoserine Ref.12
Glycosylation1211N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Ref.10
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation2581N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Ref.9
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Ref.10
Glycosylation4451N-linked (GlcNAc...) Ref.10
Glycosylation4521N-linked (GlcNAc...) Potential
Glycosylation4851N-linked (GlcNAc...) Potential
Glycosylation4881N-linked (GlcNAc...) Potential
Glycosylation5051N-linked (GlcNAc...) Potential
Glycosylation5631N-linked (GlcNAc...) Potential
Glycosylation5931N-linked (GlcNAc...) Potential
Glycosylation6001N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential
Glycosylation6671N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Glycosylation6951N-linked (GlcNAc...) Potential
Glycosylation7041N-linked (GlcNAc...) Potential
Glycosylation7501N-linked (GlcNAc...) Potential
Glycosylation7761N-linked (GlcNAc...) Potential
Glycosylation8111N-linked (GlcNAc...) Potential
Glycosylation8181N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 67 By similarity
Disulfide bond94 ↔ 111 By similarity

Natural variations

Alternative sequence380 – 40728Missing in isoform 2 and isoform 4.
VSP_010747
Alternative sequence1193 – 122129NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4.
VSP_010748
Natural variant1231S → G.
Corresponds to variant rs17280293 [ dbSNP | Ensembl ].
VAR_054128
Natural variant2301K → Q. Ref.5
Corresponds to variant rs11155242 [ dbSNP | Ensembl ].
VAR_024478
Natural variant11271Q → R. Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8
Corresponds to variant rs1262686 [ dbSNP | Ensembl ].
VAR_054129

Experimental info

Mutagenesis4681R → A: No cleavage.
Mutagenesis4691S → A: No effect on cleavage.
Mutagenesis8031C → S: No cleavage and not detected at the cell surface. Ref.2
Mutagenesis8221C → S: No cleavage and not detected at the cell surface. Ref.2
Mutagenesis8351C → S: No cleavage and not detected at the cell surface. Ref.2
Mutagenesis8371C → S: No cleavage and not detected at the cell surface. Ref.2
Mutagenesis8411T → A: No cleavage but detected at cell surface. Ref.2
Mutagenesis8411T → P: No cleavage and not detected the cell surface. Ref.2
Sequence conflict6221N → S in CAE45986. Ref.3
Sequence conflict6231I → V in CAE45930. Ref.3
Sequence conflict7081F → S in CAE45986. Ref.3
Sequence conflict7631K → Q in CAE45930. Ref.3
Sequence conflict9081L → P in AAH75798. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 1950DE5AE648F1C4

FASTA1,221136,695
        10         20         30         40         50         60 
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 

        70         80         90        100        110        120 
YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 

       130        140        150        160        170        180 
NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 

       190        200        210        220        230        240 
SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 

       250        260        270        280        290        300 
EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 

       310        320        330        340        350        360 
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 

       370        380        390        400        410        420 
IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN RIDKQRNDGI IYRISVVIQN 

       430        440        450        460        470        480 
ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV VNISFHLSAG EDKIKVKRSL EDEPRLVLWA 

       490        500        510        520        530        540 
LLVYNATNNT NLEGKIIQQK LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ 

       550        560        570        580        590        600 
PSEYVLPCPD KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 

       610        620        630        640        650        660 
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS SEALKTIDEL 

       670        680        690        700        710        720 
AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL PSNNESYFQM DFESGQVDPL 

       730        740        750        760        770        780 
ASVILPPNLL ENLSPEDSVL VRRAQFTFFN KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ 

       790        800        810        820        830        840 
NLKDPVQIKI KHTRTQEVHH PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF 

       850        860        870        880        890        900 
THFGVLMDLP RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 

       910        920        930        940        950        960 
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL EAIHMYIALV 

       970        980        990       1000       1010       1020 
KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG KESYGKEKGD EFCWIQDPVI 

      1030       1040       1050       1060       1070       1080 
FYVTCAGYFG VMFFLNIAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT 

      1090       1100       1110       1120       1130       1140 
WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS 

      1150       1160       1170       1180       1190       1200 
DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 

      1210       1220 
NKSGSLRQCF HGQVLVKTGP C 

« Hide

Isoform 2 [UniParc].

Checksum: EDE274EF3096A242
Show »

FASTA1,193133,671
Isoform 3 [UniParc].

Checksum: BDDABA6A755A445B
Show »

FASTA1,250139,901
Isoform 4 [UniParc].

Checksum: 7B50E167F0EBBA97
Show »

FASTA1,222136,878

References

« Hide 'large scale' references
[1]"VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells."
Stehlik C., Kroismayr R., Dorfleutner A., Binder B.R., Lipp J.
FEBS Lett. 569:149-155(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, GLYCOSYLATION.
Tissue: Vein.
[2]"DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites."
Moriguchi T., Haraguchi K., Ueda N., Okada M., Furuya T., Akiyama T.
Genes Cells 9:549-560(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), PROTEIN SEQUENCE OF 469-483 AND 841-845, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-803; CYS-822; CYS-835; CYS-837 AND THR-841, PROTEOLYTIC PROCESSING, CLEAVAGE BY FURIN-LIKE CONVERTASE, VARIANT ARG-1127.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-1127.
Tissue: Uterus.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS GLN-230 AND ARG-1127.
Tissue: Placenta.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1221, VARIANT ARG-1127.
Tissue: Placenta.
[7]"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 710-1221 (ISOFORM 3), VARIANT ARG-1127.
[8]Ji D., Cheng J., Wang J., Dong J., Yang Q., Dang X., Liu Y.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1032-1221, VARIANT ARG-1127.
[9]"A proteomic analysis of human bile."
Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A.
Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324.
Tissue: Bile.
[10]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-143; ASN-438 AND ASN-445.
Tissue: Plasma.
[11]"Identification of ten loci associated with height highlights new biological pathways in human growth."
Lettre G., Jackson A.U., Gieger C., Schumacher F.R., Berndt S.I., Sanna S., Eyheramendy S., Voight B.F., Butler J.L., Guiducci C., Illig T., Hackett R., Heid I.M., Jacobs K.B., Lyssenko V., Uda M., Boehnke M., Chanock S.J. expand/collapse author list , Groop L.C., Hu F.B., Isomaa B., Kraft P., Peltonen L., Salomaa V., Schlessinger D., Hunter D.J., Hayes R.B., Abecasis G.R., Wichmann H.-E., Mohlke K.L., Hirschhorn J.N.
Nat. Genet. 40:584-591(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN STATURE AS A QUANTITATIVE TRAIT.
[12]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF216967 mRNA. Translation: AAO13250.1. Sequence problems.
AB183546 mRNA. Translation: BAD27571.1.
AB183547 mRNA. Translation: BAD27572.1.
AB183548 mRNA. Translation: BAD27573.1.
AB183549 mRNA. Translation: BAD27574.1.
BX640971 mRNA. Translation: CAE45986.1.
BX640873 mRNA. Translation: CAE45930.1. Different initiation.
AL033377 Genomic DNA. Translation: CAI20053.1. Sequence problems.
AL360007 Genomic DNA. No translation available.
BC075798 mRNA. Translation: AAH75798.1.
AK027843 mRNA. Translation: BAB55406.1. Different initiation.
AK075087 mRNA. Translation: BAC11393.1. Different initiation.
AY181244 mRNA. Translation: AAO27356.1.
AY426673 mRNA. Translation: AAR88427.1.
CCDSCCDS47489.1. [Q86SQ4-3]
CCDS47490.1. [Q86SQ4-1]
CCDS47491.1. [Q86SQ4-2]
CCDS55064.1. [Q86SQ4-4]
RefSeqNP_001027566.1. NM_001032394.2.
NP_001027567.1. NM_001032395.2.
NP_065188.4. NM_020455.5.
NP_940971.1. NM_198569.2.
UniGeneHs.743302.

3D structure databases

ProteinModelPortalQ86SQ4.
SMRQ86SQ4. Positions 37-212, 536-840, 863-1115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121449. 2 interactions.
STRING9606.ENSP00000356581.

Protein family/group databases

MEROPSS63.020.
GPCRDBSearch...

PTM databases

PhosphoSiteQ86SQ4.

Polymorphism databases

DMDM215274152.

Proteomic databases

MaxQBQ86SQ4.
PaxDbQ86SQ4.
PRIDEQ86SQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000230173; ENSP00000230173; ENSG00000112414. [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414. [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414. [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414. [Q86SQ4-3]
GeneID57211.
KEGGhsa:57211.
UCSCuc010khc.3. human. [Q86SQ4-1]
uc010khd.3. human. [Q86SQ4-2]
uc010khe.3. human. [Q86SQ4-3]
uc010khf.3. human. [Q86SQ4-4]

Organism-specific databases

CTD57211.
GeneCardsGC06P142622.
HGNCHGNC:13841. GPR126.
HPAHPA017346.
MIM606255. phenotype.
612243. gene.
neXtProtNX_Q86SQ4.
PharmGKBPA134878328.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG051778.
KOK08463.
OMANLSCGSY.
OrthoDBEOG7ZGX28.
PhylomeDBQ86SQ4.
TreeFamTF321769.

Enzyme and pathway databases

SignaLinkQ86SQ4.

Gene expression databases

ArrayExpressQ86SQ4.
BgeeQ86SQ4.
CleanExHS_GPR126.
GenevestigatorQ86SQ4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
2.60.120.200. 1 hit.
2.60.120.290. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000859. CUB_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF00431. CUB. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00042. CUB. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMSSF49854. SSF49854. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR126.
GenomeRNAi57211.
NextBio63312.
PROQ86SQ4.
SOURCESearch...

Entry information

Entry nameGP126_HUMAN
AccessionPrimary (citable) accession number: Q86SQ4
Secondary accession number(s): Q5TGN7 expand/collapse secondary AC list , Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries