Q86SQ4 (GP126_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
G-protein coupled receptor 126

Alternative name(s):
Developmentally regulated G-protein-coupled receptor
Vascular inducible G protein-coupled receptor

Gene names

Name:	GPR126
Synonyms:	DREG, VIGR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Detected on the cell surface of activated but not resting umbilical vein. Ref.1 Ref.2
Tissue specificity	Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells. Ref.1
Induction	Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins. Ref.1
Post-translational modification	Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Ref.2
Polymorphism	Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIM:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 CUB domain. Contains 1 GPS domain. Contains 1 pentaxin domain.
Sequence caution	The sequence AAO13250.1 differs from that shown. Reason: Sequencing errors. The sequence BAB55406.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11393.1 differs from that shown. Reason: Erroneous initiation. The sequence CAE45930.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI20053.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Traceable author statement PubMed 15203201. Source: GDB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 15203201. Source: GDB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86SQ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86SQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.

Isoform 3 (identifier: Q86SQ4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Isoform 4 (identifier: Q86SQ4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 1221	1184	G-protein coupled receptor 126		PRO_0000012902
Regions
	Topological domain	38 – 862	825	Extracellular Potential
	Transmembrane	863 – 883	21	Helical; Name=1; Potential
	Topological domain	884 – 903	20	Cytoplasmic Potential
	Transmembrane	904 – 924	21	Helical; Name=2; Potential
	Topological domain	925 – 929	5	Extracellular Potential
	Transmembrane	930 – 950	21	Helical; Name=3; Potential
	Topological domain	951 – 970	20	Cytoplasmic Potential
	Transmembrane	971 – 991	21	Helical; Name=4; Potential
	Topological domain	992 – 1024	33	Extracellular Potential
	Transmembrane	1025 – 1045	21	Helical; Name=5; Potential
	Topological domain	1046 – 1069	24	Cytoplasmic Potential
	Transmembrane	1070 – 1090	21	Helical; Name=6; Potential
	Topological domain	1091 – 1092	2	Extracellular Potential
	Transmembrane	1093 – 1113	21	Helical; Name=7; Potential
	Topological domain	1114 – 1221	108	Cytoplasmic Potential
	Domain	41 – 149	109	CUB
	Domain	150 – 355	206	Pentaxin
	Domain	800 – 852	53	GPS
	Compositional bias	1153 – 1205	53	Ser-rich
Sites
	Site	467 – 468	2	Cleavage; by furin like-convertase
	Site	840 – 841	2	Cleavage
Amino acid modifications
	Modified residue	1165	1	Phosphoserine Ref.12
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	206	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	314	1	N-linked (GlcNAc...) Potential
	Glycosylation	324	1	N-linked (GlcNAc...) Ref.9
	Glycosylation	353	1	N-linked (GlcNAc...) Potential
	Glycosylation	438	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	445	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	452	1	N-linked (GlcNAc...) Potential
	Glycosylation	485	1	N-linked (GlcNAc...) Potential
	Glycosylation	488	1	N-linked (GlcNAc...) Potential
	Glycosylation	505	1	N-linked (GlcNAc...) Potential
	Glycosylation	563	1	N-linked (GlcNAc...) Potential
	Glycosylation	593	1	N-linked (GlcNAc...) Potential
	Glycosylation	600	1	N-linked (GlcNAc...) Potential
	Glycosylation	605	1	N-linked (GlcNAc...) Potential
	Glycosylation	667	1	N-linked (GlcNAc...) Potential
	Glycosylation	673	1	N-linked (GlcNAc...) Potential
	Glycosylation	695	1	N-linked (GlcNAc...) Potential
	Glycosylation	704	1	N-linked (GlcNAc...) Potential
	Glycosylation	750	1	N-linked (GlcNAc...) Potential
	Glycosylation	776	1	N-linked (GlcNAc...) Potential
	Glycosylation	811	1	N-linked (GlcNAc...) Potential
	Glycosylation	818	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 67		By similarity
	Disulfide bond	94 ↔ 111		By similarity
Natural variations
	Alternative sequence	380 – 407	28	Missing in isoform 2 and isoform 4.		VSP_010747
	Alternative sequence	1193 – 1221	29	NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4.		VSP_010748
	Natural variant	123	1	S → G. Corresponds to variant rs17280293 [ dbSNP | Ensembl ].		VAR_054128
	Natural variant	230	1	K → Q. Ref.5 Corresponds to variant rs11155242 [ dbSNP | Ensembl ].		VAR_024478
	Natural variant	1127	1	Q → R. Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8 Corresponds to variant rs1262686 [ dbSNP | Ensembl ].		VAR_054129
Experimental info
	Mutagenesis	468	1	R → A: No cleavage.
	Mutagenesis	469	1	S → A: No effect on cleavage.
	Mutagenesis	803	1	C → S: No cleavage and not detected at the cell surface. Ref.2
	Mutagenesis	822	1	C → S: No cleavage and not detected at the cell surface. Ref.2
	Mutagenesis	835	1	C → S: No cleavage and not detected at the cell surface. Ref.2
	Mutagenesis	837	1	C → S: No cleavage and not detected at the cell surface. Ref.2
	Mutagenesis	841	1	T → A: No cleavage but detected at cell surface. Ref.2
	Mutagenesis	841	1	T → P: No cleavage and not detected the cell surface. Ref.2
	Sequence conflict	622	1	N → S in CAE45986. Ref.3
	Sequence conflict	623	1	I → V in CAE45930. Ref.3
	Sequence conflict	708	1	F → S in CAE45986. Ref.3
	Sequence conflict	763	1	K → Q in CAE45930. Ref.3
	Sequence conflict	908	1	L → P in AAH75798. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 1950DE5AE648F1C4	FASTA	1,221	136,695
	10 20 30 40 50 60 MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 70 80 90 100 110 120 YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 130 140 150 160 170 180 NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 190 200 210 220 230 240 SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 250 260 270 280 290 300 EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 310 320 330 340 350 360 VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 370 380 390 400 410 420 IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN RIDKQRNDGI IYRISVVIQN 430 440 450 460 470 480 ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV VNISFHLSAG EDKIKVKRSL EDEPRLVLWA 490 500 510 520 530 540 LLVYNATNNT NLEGKIIQQK LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ 550 560 570 580 590 600 PSEYVLPCPD KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 610 620 630 640 650 660 LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS SEALKTIDEL 670 680 690 700 710 720 AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL PSNNESYFQM DFESGQVDPL 730 740 750 760 770 780 ASVILPPNLL ENLSPEDSVL VRRAQFTFFN KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ 790 800 810 820 830 840 NLKDPVQIKI KHTRTQEVHH PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF 850 860 870 880 890 900 THFGVLMDLP RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 910 920 930 940 950 960 LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL EAIHMYIALV 970 980 990 1000 1010 1020 KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG KESYGKEKGD EFCWIQDPVI 1030 1040 1050 1060 1070 1080 FYVTCAGYFG VMFFLNIAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT 1090 1100 1110 1120 1130 1140 WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS 1150 1160 1170 1180 1190 1200 DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 1210 1220 NKSGSLRQCF HGQVLVKTGP C
	Isoform 2 [UniParc]. Checksum: EDE274EF3096A242	FASTA	1,193	133,671
	10 20 30 40 50 60 MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 70 80 90 100 110 120 YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 130 140 150 160 170 180 NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 190 200 210 220 230 240 SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 250 260 270 280 290 300 EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 310 320 330 340 350 360 VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 370 380 390 400 410 420 IPLPAAELAS CADLGTLCQD GIIYRISVVI QNILRHPEVK VQSKVAEWLN STFQNWNYTV 430 440 450 460 470 480 YVVNISFHLS AGEDKIKVKR SLEDEPRLVL WALLVYNATN NTNLEGKIIQ QKLLKNNESL 490 500 510 520 530 540 DEGLRLHTVN VRQLGHCLAM EEPKGYYWPS IQPSEYVLPC PDKPGFSASR ICFYNATNPL 550 560 570 580 590 600 VTYWGPVDIS NCLKEANEVA NQILNLTADG QNLTSANITN IVEQVKRIVN KEENIDITLG 610 620 630 640 650 660 STLMNIFSNI LSSSDSDLLE SSSEALKTID ELAFKIDLNS TSHVNITTRN LALSVSSLLP 670 680 690 700 710 720 GTNAISNFSI GLPSNNESYF QMDFESGQVD PLASVILPPN LLENLSPEDS VLVRRAQFTF 730 740 750 760 770 780 FNKTGLFQDV GPQRKTLVSY VMACSIGNIT IQNLKDPVQI KIKHTRTQEV HHPICAFWDL 790 800 810 820 830 840 NKNKSFGGWN TSGCVAHRDS DASETVCLCN HFTHFGVLMD LPRSASQLDA RNTKVLTFIS 850 860 870 880 890 900 YIGCGISAIF SAATLLTYVA FEKLRRDYPS KILMNLSTAL LFLNLLFLLD GWITSFNVDG 910 920 930 940 950 960 LCIAVAVLLH FFLLATFTWM GLEAIHMYIA LVKVFNTYIR RYILKFCIIG WGLPALVVSV 970 980 990 1000 1010 1020 VLASRNNNEV YGKESYGKEK GDEFCWIQDP VIFYVTCAGY FGVMFFLNIA MFIVVMVQIC 1030 1040 1050 1060 1070 1080 GRNGKRSNRT LREEVLRNLR SVVSLTFLLG MTWGFAFFAW GPLNIPFMYL FSIFNSLQGL 1090 1100 1110 1120 1130 1140 FIFIFHCAMK ENVQKQWRQH LCCGRFRLAD NSDWSKTATN IIKKSSDNLG KSLSSSSIGS 1150 1160 1170 1180 1190 NSTYLTSKSK SSSTTYFKRN SHTDNVSYEH SFNKSGSLRQ CFHGQVLVKT GPC
	Isoform 3 [UniParc]. Checksum: BDDABA6A755A445B	FASTA	1,250	139,901
	10 20 30 40 50 60 MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 70 80 90 100 110 120 YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 130 140 150 160 170 180 NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 190 200 210 220 230 240 SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 250 260 270 280 290 300 EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 310 320 330 340 350 360 VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 370 380 390 400 410 420 IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN RIDKQRNDGI IYRISVVIQN 430 440 450 460 470 480 ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV VNISFHLSAG EDKIKVKRSL EDEPRLVLWA 490 500 510 520 530 540 LLVYNATNNT NLEGKIIQQK LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ 550 560 570 580 590 600 PSEYVLPCPD KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 610 620 630 640 650 660 LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS SEALKTIDEL 670 680 690 700 710 720 AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL PSNNESYFQM DFESGQVDPL 730 740 750 760 770 780 ASVILPPNLL ENLSPEDSVL VRRAQFTFFN KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ 790 800 810 820 830 840 NLKDPVQIKI KHTRTQEVHH PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF 850 860 870 880 890 900 THFGVLMDLP RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 910 920 930 940 950 960 LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL EAIHMYIALV 970 980 990 1000 1010 1020 KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG KESYGKEKGD EFCWIQDPVI 1030 1040 1050 1060 1070 1080 FYVTCAGYFG VMFFLNIAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT 1090 1100 1110 1120 1130 1140 WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS 1150 1160 1170 1180 1190 1200 DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDSASMDKSL 1210 1220 1230 1240 1250 SKLAHADGDQ TSIIPVHQVI DKVKGYCNAH SDNFYKNIIM SDTFSHSTKF
	Isoform 4 [UniParc]. Checksum: 7B50E167F0EBBA97	FASTA	1,222	136,878
	10 20 30 40 50 60 MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 70 80 90 100 110 120 YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 130 140 150 160 170 180 NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 190 200 210 220 230 240 SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 250 260 270 280 290 300 EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 310 320 330 340 350 360 VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 370 380 390 400 410 420 IPLPAAELAS CADLGTLCQD GIIYRISVVI QNILRHPEVK VQSKVAEWLN STFQNWNYTV 430 440 450 460 470 480 YVVNISFHLS AGEDKIKVKR SLEDEPRLVL WALLVYNATN NTNLEGKIIQ QKLLKNNESL 490 500 510 520 530 540 DEGLRLHTVN VRQLGHCLAM EEPKGYYWPS IQPSEYVLPC PDKPGFSASR ICFYNATNPL 550 560 570 580 590 600 VTYWGPVDIS NCLKEANEVA NQILNLTADG QNLTSANITN IVEQVKRIVN KEENIDITLG 610 620 630 640 650 660 STLMNIFSNI LSSSDSDLLE SSSEALKTID ELAFKIDLNS TSHVNITTRN LALSVSSLLP 670 680 690 700 710 720 GTNAISNFSI GLPSNNESYF QMDFESGQVD PLASVILPPN LLENLSPEDS VLVRRAQFTF 730 740 750 760 770 780 FNKTGLFQDV GPQRKTLVSY VMACSIGNIT IQNLKDPVQI KIKHTRTQEV HHPICAFWDL 790 800 810 820 830 840 NKNKSFGGWN TSGCVAHRDS DASETVCLCN HFTHFGVLMD LPRSASQLDA RNTKVLTFIS 850 860 870 880 890 900 YIGCGISAIF SAATLLTYVA FEKLRRDYPS KILMNLSTAL LFLNLLFLLD GWITSFNVDG 910 920 930 940 950 960 LCIAVAVLLH FFLLATFTWM GLEAIHMYIA LVKVFNTYIR RYILKFCIIG WGLPALVVSV 970 980 990 1000 1010 1020 VLASRNNNEV YGKESYGKEK GDEFCWIQDP VIFYVTCAGY FGVMFFLNIA MFIVVMVQIC 1030 1040 1050 1060 1070 1080 GRNGKRSNRT LREEVLRNLR SVVSLTFLLG MTWGFAFFAW GPLNIPFMYL FSIFNSLQGL 1090 1100 1110 1120 1130 1140 FIFIFHCAMK ENVQKQWRQH LCCGRFRLAD NSDWSKTATN IIKKSSDNLG KSLSSSSIGS 1150 1160 1170 1180 1190 1200 NSTYLTSKSK SSSTTYFKRN SHTDSASMDK SLSKLAHADG DQTSIIPVHQ VIDKVKGYCN 1210 1220 AHSDNFYKNI IMSDTFSHST KF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells." Stehlik C., Kroismayr R., Dorfleutner A., Binder B.R., Lipp J. FEBS Lett. 569:149-155(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, GLYCOSYLATION. Tissue: Vein.
[2]	"DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites." Moriguchi T., Haraguchi K., Ueda N., Okada M., Furuya T., Akiyama T. Genes Cells 9:549-560(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), PROTEIN SEQUENCE OF 469-483 AND 841-845, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-803; CYS-822; CYS-835; CYS-837 AND THR-841, PROTEOLYTIC PROCESSING, CLEAVAGE BY FURIN-LIKE CONVERTASE, VARIANT ARG-1127.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-1127. Tissue: Uterus.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS GLN-230 AND ARG-1127. Tissue: Placenta.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1221, VARIANT ARG-1127. Tissue: Placenta.
[7]	"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini." Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B. Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 710-1221 (ISOFORM 3), VARIANT ARG-1127.
[8]	Ji D., Cheng J., Wang J., Dong J., Yang Q., Dang X., Liu Y. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1032-1221, VARIANT ARG-1127.
[9]	"A proteomic analysis of human bile." Kristiansen T.Z., Bunkenborg J., Gronborg M., Molina H., Thuluvath P.J., Argani P., Goggins M.G., Maitra A., Pandey A. Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324, MASS SPECTROMETRY. Tissue: Bile.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-143; ASN-438 AND ASN-445, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Identification of ten loci associated with height highlights new biological pathways in human growth." Lettre G., Jackson A.U., Gieger C., Schumacher F.R., Berndt S.I., Sanna S., Eyheramendy S., Voight B.F., Butler J.L., Guiducci C., Illig T., Hackett R., Heid I.M., Jacobs K.B., Lyssenko V., Uda M., Boehnke M., Chanock S.J. , Groop L.C., Hu F.B., Isomaa B., Kraft P., Peltonen L., Salomaa V., Schlessinger D., Hunter D.J., Hayes R.B., Abecasis G.R., Wichmann H.-E., Mohlke K.L., Hirschhorn J.N. Nat. Genet. 40:584-591(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN STATURE AS A QUANTITATIVE TRAIT.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1165, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF216967 mRNA. Translation: AAO13250.1. Sequence problems. AB183546 mRNA. Translation: BAD27571.1. AB183547 mRNA. Translation: BAD27572.1. AB183548 mRNA. Translation: BAD27573.1. AB183549 mRNA. Translation: BAD27574.1. BX640971 mRNA. Translation: CAE45986.1. BX640873 mRNA. Translation: CAE45930.1. Different initiation. AL033377 Genomic DNA. Translation: CAI20053.1. Sequence problems. AL360007 Genomic DNA. No translation available. BC075798 mRNA. Translation: AAH75798.1. AK027843 mRNA. Translation: BAB55406.1. Different initiation. AK075087 mRNA. Translation: BAC11393.1. Different initiation. AY181244 mRNA. Translation: AAO27356.1. AY426673 mRNA. Translation: AAR88427.1.
IPI	IPI00217481. IPI00423340. IPI00423342. IPI00651770.
RefSeq	NP_001027566.1. NM_001032394.2. NP_001027567.1. NM_001032395.2. NP_065188.4. NM_020455.5. NP_940971.1. NM_198569.2.
UniGene	Hs.318894.
3D structure databases
ProteinModelPortal	Q86SQ4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000356581.
Protein family/group databases
MEROPS	S63.020.
GPCRDB	Search...
PTM databases
PhosphoSite	Q86SQ4.
Polymorphism databases
DMDM	215274152.
Proteomic databases
PaxDb	Q86SQ4.
PRIDE	Q86SQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000230173; ENSP00000230173; ENSG00000112414. ENST00000296932; ENSP00000296932; ENSG00000112414. ENST00000367608; ENSP00000356580; ENSG00000112414. ENST00000367609; ENSP00000356581; ENSG00000112414.
GeneID	57211.
KEGG	hsa:57211.
UCSC	uc010khc.3. human. uc010khd.3. human. uc010khe.3. human. uc010khf.3. human.
Organism-specific databases
CTD	57211.
GeneCards	GC06P142622.
HGNC	HGNC:13841. GPR126.
HPA	HPA017346.
MIM	606255. phenotype. 612243. gene.
neXtProt	NX_Q86SQ4.
PharmGKB	PA134878328.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG051778.
KO	K08463.
OMA	HQVIDKV.
Gene expression databases
ArrayExpress	Q86SQ4.
Bgee	Q86SQ4.
CleanEx	HS_GPR126.
Genevestigator	Q86SQ4.
GermOnline	ENSG00000112414. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 1 hit. 2.60.120.290. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000859. CUB_dom. IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF00431. CUB. 1 hit. PF01825. GPS. 1 hit. PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
SMART	SM00042. CUB. 1 hit. SM00303. GPS. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49854. CUB. 1 hit.
PROSITE	PS01180. CUB. 1 hit. PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57211.
NextBio	63312.
SOURCE	Search...

Entry information

Entry name

GP126_HUMAN

Accession

Primary (citable) accession number: Q86SQ4
Secondary accession number(s): Q5TGN7 , Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.