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Q86SQ4

- GP126_HUMAN

UniProt

Q86SQ4 - GP126_HUMAN

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Protein

G-protein coupled receptor 126

Gene

GPR126

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei467 – 4682Cleavage; by furin like-convertase
Sitei840 – 8412Cleavage

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SignaLinkiQ86SQ4.

Protein family/group databases

MEROPSiS63.020.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 126
Alternative name(s):
Developmentally regulated G-protein-coupled receptor
Vascular inducible G protein-coupled receptor
Gene namesi
Name:GPR126
Synonyms:DREG, VIGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13841. GPR126.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Detected on the cell surface of activated but not resting umbilical vein.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 862825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei863 – 88321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini884 – 90320CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei904 – 92421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini925 – 9295ExtracellularSequence Analysis
Transmembranei930 – 95021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini951 – 97020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei971 – 99121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini992 – 102433ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1025 – 104521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini1046 – 106924CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1070 – 109021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini1091 – 10922ExtracellularSequence Analysis
Transmembranei1093 – 111321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini1114 – 1221108CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi468 – 4681R → A: No cleavage.
Mutagenesisi469 – 4691S → A: No effect on cleavage.
Mutagenesisi803 – 8031C → S: No cleavage and not detected at the cell surface. 1 Publication
Mutagenesisi822 – 8221C → S: No cleavage and not detected at the cell surface. 1 Publication
Mutagenesisi835 – 8351C → S: No cleavage and not detected at the cell surface. 1 Publication
Mutagenesisi837 – 8371C → S: No cleavage and not detected at the cell surface. 1 Publication
Mutagenesisi841 – 8411T → A: No cleavage but detected at cell surface. 1 Publication
Mutagenesisi841 – 8411T → P: No cleavage and not detected the cell surface. 1 Publication

Organism-specific databases

MIMi606255. phenotype.
PharmGKBiPA134878328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence AnalysisAdd
BLAST
Chaini38 – 12211184G-protein coupled receptor 126PRO_0000012902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)1 Publication
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)1 Publication
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)1 Publication
Glycosylationi445 – 4451N-linked (GlcNAc...)1 Publication
Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi667 – 6671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi750 – 7501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence Analysis
Modified residuei1165 – 11651Phosphoserine1 Publication

Post-translational modificationi

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ86SQ4.
PaxDbiQ86SQ4.
PRIDEiQ86SQ4.

PTM databases

PhosphoSiteiQ86SQ4.

Expressioni

Tissue specificityi

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.1 Publication

Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.1 Publication

Gene expression databases

BgeeiQ86SQ4.
CleanExiHS_GPR126.
ExpressionAtlasiQ86SQ4. baseline and differential.
GenevestigatoriQ86SQ4.

Organism-specific databases

HPAiHPA017346.

Interactioni

Protein-protein interaction databases

BioGridi121449. 2 interactions.
STRINGi9606.ENSP00000356581.

Structurei

3D structure databases

ProteinModelPortaliQ86SQ4.
SMRiQ86SQ4. Positions 37-212, 536-840, 863-1115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 149109CUBPROSITE-ProRule annotationAdd
BLAST
Domaini150 – 355206PentaxinAdd
BLAST
Domaini800 – 85253GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1153 – 120553Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118787.
HOVERGENiHBG051778.
InParanoidiQ86SQ4.
KOiK08463.
OMAiNLSCGSY.
OrthoDBiEOG7ZGX28.
PhylomeDBiQ86SQ4.
TreeFamiTF321769.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
2.60.120.200. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00431. CUB. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00042. CUB. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86SQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT
210 220 230 240 250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF
260 270 280 290 300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
310 320 330 340 350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA
360 370 380 390 400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN
410 420 430 440 450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV
460 470 480 490 500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK
510 520 530 540 550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD
560 570 580 590 600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN
610 620 630 640 650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS
660 670 680 690 700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL
710 720 730 740 750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN
760 770 780 790 800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH
810 820 830 840 850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP
860 870 880 890 900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI
910 920 930 940 950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL
960 970 980 990 1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG
1010 1020 1030 1040 1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR
1060 1070 1080 1090 1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS
1110 1120 1130 1140 1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII
1160 1170 1180 1190 1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF
1210 1220
NKSGSLRQCF HGQVLVKTGP C
Length:1,221
Mass (Da):136,695
Last modified:November 25, 2008 - v3
Checksum:i1950DE5AE648F1C4
GO
Isoform 2 (identifier: Q86SQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.

Show »
Length:1,193
Mass (Da):133,671
Checksum:iEDE274EF3096A242
GO
Isoform 3 (identifier: Q86SQ4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,250
Mass (Da):139,901
Checksum:iBDDABA6A755A445B
GO
Isoform 4 (identifier: Q86SQ4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,222
Mass (Da):136,878
Checksum:i7B50E167F0EBBA97
GO

Sequence cautioni

The sequence AAO13250.1 differs from that shown. Reason: Sequencing errors.Curated
The sequence BAB55406.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11393.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAE45930.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI20053.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti622 – 6221N → S in CAE45986. (PubMed:17974005)Curated
Sequence conflicti623 – 6231I → V in CAE45930. (PubMed:17974005)Curated
Sequence conflicti708 – 7081F → S in CAE45986. (PubMed:17974005)Curated
Sequence conflicti763 – 7631K → Q in CAE45930. (PubMed:17974005)Curated
Sequence conflicti908 – 9081L → P in AAH75798. (PubMed:15489334)Curated

Polymorphismi

Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIMi:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231S → G.
Corresponds to variant rs17280293 [ dbSNP | Ensembl ].
VAR_054128
Natural varianti230 – 2301K → Q.1 Publication
Corresponds to variant rs11155242 [ dbSNP | Ensembl ].
VAR_024478
Natural varianti1127 – 11271Q → R.6 Publications
Corresponds to variant rs1262686 [ dbSNP | Ensembl ].
VAR_054129

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei380 – 40728Missing in isoform 2 and isoform 4. 4 PublicationsVSP_010747Add
BLAST
Alternative sequencei1193 – 122129NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsVSP_010748Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216967 mRNA. Translation: AAO13250.1. Sequence problems.
AB183546 mRNA. Translation: BAD27571.1.
AB183547 mRNA. Translation: BAD27572.1.
AB183548 mRNA. Translation: BAD27573.1.
AB183549 mRNA. Translation: BAD27574.1.
BX640971 mRNA. Translation: CAE45986.1.
BX640873 mRNA. Translation: CAE45930.1. Different initiation.
AL033377 Genomic DNA. Translation: CAI20053.1. Sequence problems.
AL360007 Genomic DNA. No translation available.
BC075798 mRNA. Translation: AAH75798.1.
AK027843 mRNA. Translation: BAB55406.1. Different initiation.
AK075087 mRNA. Translation: BAC11393.1. Different initiation.
AY181244 mRNA. Translation: AAO27356.1.
AY426673 mRNA. Translation: AAR88427.1.
CCDSiCCDS47489.1. [Q86SQ4-3]
CCDS47490.1. [Q86SQ4-1]
CCDS47491.1. [Q86SQ4-2]
CCDS55064.1. [Q86SQ4-4]
RefSeqiNP_001027566.1. NM_001032394.2.
NP_001027567.1. NM_001032395.2.
NP_065188.4. NM_020455.5.
NP_940971.1. NM_198569.2.
UniGeneiHs.743302.

Genome annotation databases

EnsembliENST00000230173; ENSP00000230173; ENSG00000112414. [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414. [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414. [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414. [Q86SQ4-3]
GeneIDi57211.
KEGGihsa:57211.
UCSCiuc010khc.3. human. [Q86SQ4-1]
uc010khd.3. human. [Q86SQ4-2]
uc010khe.3. human. [Q86SQ4-3]
uc010khf.3. human. [Q86SQ4-4]

Polymorphism databases

DMDMi215274152.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216967 mRNA. Translation: AAO13250.1 . Sequence problems.
AB183546 mRNA. Translation: BAD27571.1 .
AB183547 mRNA. Translation: BAD27572.1 .
AB183548 mRNA. Translation: BAD27573.1 .
AB183549 mRNA. Translation: BAD27574.1 .
BX640971 mRNA. Translation: CAE45986.1 .
BX640873 mRNA. Translation: CAE45930.1 . Different initiation.
AL033377 Genomic DNA. Translation: CAI20053.1 . Sequence problems.
AL360007 Genomic DNA. No translation available.
BC075798 mRNA. Translation: AAH75798.1 .
AK027843 mRNA. Translation: BAB55406.1 . Different initiation.
AK075087 mRNA. Translation: BAC11393.1 . Different initiation.
AY181244 mRNA. Translation: AAO27356.1 .
AY426673 mRNA. Translation: AAR88427.1 .
CCDSi CCDS47489.1. [Q86SQ4-3 ]
CCDS47490.1. [Q86SQ4-1 ]
CCDS47491.1. [Q86SQ4-2 ]
CCDS55064.1. [Q86SQ4-4 ]
RefSeqi NP_001027566.1. NM_001032394.2.
NP_001027567.1. NM_001032395.2.
NP_065188.4. NM_020455.5.
NP_940971.1. NM_198569.2.
UniGenei Hs.743302.

3D structure databases

ProteinModelPortali Q86SQ4.
SMRi Q86SQ4. Positions 37-212, 536-840, 863-1115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121449. 2 interactions.
STRINGi 9606.ENSP00000356581.

Protein family/group databases

MEROPSi S63.020.
GPCRDBi Search...

PTM databases

PhosphoSitei Q86SQ4.

Polymorphism databases

DMDMi 215274152.

Proteomic databases

MaxQBi Q86SQ4.
PaxDbi Q86SQ4.
PRIDEi Q86SQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230173 ; ENSP00000230173 ; ENSG00000112414 . [Q86SQ4-1 ]
ENST00000296932 ; ENSP00000296932 ; ENSG00000112414 . [Q86SQ4-2 ]
ENST00000367608 ; ENSP00000356580 ; ENSG00000112414 . [Q86SQ4-4 ]
ENST00000367609 ; ENSP00000356581 ; ENSG00000112414 . [Q86SQ4-3 ]
GeneIDi 57211.
KEGGi hsa:57211.
UCSCi uc010khc.3. human. [Q86SQ4-1 ]
uc010khd.3. human. [Q86SQ4-2 ]
uc010khe.3. human. [Q86SQ4-3 ]
uc010khf.3. human. [Q86SQ4-4 ]

Organism-specific databases

CTDi 57211.
GeneCardsi GC06P142622.
HGNCi HGNC:13841. GPR126.
HPAi HPA017346.
MIMi 606255. phenotype.
612243. gene.
neXtProti NX_Q86SQ4.
PharmGKBi PA134878328.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118787.
HOVERGENi HBG051778.
InParanoidi Q86SQ4.
KOi K08463.
OMAi NLSCGSY.
OrthoDBi EOG7ZGX28.
PhylomeDBi Q86SQ4.
TreeFami TF321769.

Enzyme and pathway databases

SignaLinki Q86SQ4.

Miscellaneous databases

ChiTaRSi GPR126. human.
GeneWikii GPR126.
GenomeRNAii 57211.
NextBioi 63312.
PROi Q86SQ4.
SOURCEi Search...

Gene expression databases

Bgeei Q86SQ4.
CleanExi HS_GPR126.
ExpressionAtlasi Q86SQ4. baseline and differential.
Genevestigatori Q86SQ4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
2.60.120.200. 1 hit.
2.60.120.290. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000203. GPS.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00431. CUB. 1 hit.
PF01825. GPS. 1 hit.
PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00042. CUB. 1 hit.
SM00303. GPS. 1 hit.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS01180. CUB. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells."
    Stehlik C., Kroismayr R., Dorfleutner A., Binder B.R., Lipp J.
    FEBS Lett. 569:149-155(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, GLYCOSYLATION.
    Tissue: Vein.
  2. "DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites."
    Moriguchi T., Haraguchi K., Ueda N., Okada M., Furuya T., Akiyama T.
    Genes Cells 9:549-560(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), PROTEIN SEQUENCE OF 469-483 AND 841-845, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-803; CYS-822; CYS-835; CYS-837 AND THR-841, PROTEOLYTIC PROCESSING, CLEAVAGE BY FURIN-LIKE CONVERTASE, VARIANT ARG-1127.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-1127.
    Tissue: Uterus.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS GLN-230 AND ARG-1127.
    Tissue: Placenta.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1221, VARIANT ARG-1127.
    Tissue: Placenta.
  7. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 710-1221 (ISOFORM 3), VARIANT ARG-1127.
  8. Ji D., Cheng J., Wang J., Dong J., Yang Q., Dang X., Liu Y.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1032-1221, VARIANT ARG-1127.
  9. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324.
    Tissue: Bile.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-143; ASN-438 AND ASN-445.
    Tissue: Plasma.
  11. Cited for: INVOLVEMENT IN STATURE AS A QUANTITATIVE TRAIT.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGP126_HUMAN
AccessioniPrimary (citable) accession number: Q86SQ4
Secondary accession number(s): Q5TGN7
, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3