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Q86SQ4

- GP126_HUMAN

UniProt

Q86SQ4 - GP126_HUMAN

Protein

G-protein coupled receptor 126

Gene

GPR126

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei467 – 4682Cleavage; by furin like-convertase
    Sitei840 – 8412Cleavage

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    SignaLinkiQ86SQ4.

    Protein family/group databases

    MEROPSiS63.020.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 126
    Alternative name(s):
    Developmentally regulated G-protein-coupled receptor
    Vascular inducible G protein-coupled receptor
    Gene namesi
    Name:GPR126
    Synonyms:DREG, VIGR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13841. GPR126.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Detected on the cell surface of activated but not resting umbilical vein.

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi468 – 4681R → A: No cleavage.
    Mutagenesisi469 – 4691S → A: No effect on cleavage.
    Mutagenesisi803 – 8031C → S: No cleavage and not detected at the cell surface. 1 Publication
    Mutagenesisi822 – 8221C → S: No cleavage and not detected at the cell surface. 1 Publication
    Mutagenesisi835 – 8351C → S: No cleavage and not detected at the cell surface. 1 Publication
    Mutagenesisi837 – 8371C → S: No cleavage and not detected at the cell surface. 1 Publication
    Mutagenesisi841 – 8411T → A: No cleavage but detected at cell surface. 1 Publication
    Mutagenesisi841 – 8411T → P: No cleavage and not detected the cell surface. 1 Publication

    Organism-specific databases

    MIMi606255. phenotype.
    PharmGKBiPA134878328.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Chaini38 – 12211184G-protein coupled receptor 126PRO_0000012902Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
    Disulfide bondi94 ↔ 111PROSITE-ProRule annotation
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)2 Publications
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)2 Publications
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)2 Publications
    Glycosylationi445 – 4451N-linked (GlcNAc...)2 Publications
    Glycosylationi452 – 4521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi563 – 5631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi667 – 6671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi695 – 6951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi704 – 7041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi750 – 7501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1165 – 11651Phosphoserine1 Publication

    Post-translational modificationi

    Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ86SQ4.
    PaxDbiQ86SQ4.
    PRIDEiQ86SQ4.

    PTM databases

    PhosphoSiteiQ86SQ4.

    Expressioni

    Tissue specificityi

    Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.1 Publication

    Inductioni

    Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.1 Publication

    Gene expression databases

    ArrayExpressiQ86SQ4.
    BgeeiQ86SQ4.
    CleanExiHS_GPR126.
    GenevestigatoriQ86SQ4.

    Organism-specific databases

    HPAiHPA017346.

    Interactioni

    Protein-protein interaction databases

    BioGridi121449. 2 interactions.
    STRINGi9606.ENSP00000356581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SQ4.
    SMRiQ86SQ4. Positions 37-212, 536-840, 863-1115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini38 – 862825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini884 – 90320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini925 – 9295ExtracellularSequence Analysis
    Topological domaini951 – 97020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini992 – 102433ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1046 – 106924CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1091 – 10922ExtracellularSequence Analysis
    Topological domaini1114 – 1221108CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei863 – 88321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei904 – 92421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei930 – 95021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei971 – 99121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei1025 – 104521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei1070 – 109021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei1093 – 111321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 149109CUBPROSITE-ProRule annotationAdd
    BLAST
    Domaini150 – 355206PentaxinAdd
    BLAST
    Domaini800 – 85253GPSPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1153 – 120553Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CUB domain.PROSITE-ProRule annotation
    Contains 1 GPS domain.PROSITE-ProRule annotation
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG051778.
    KOiK08463.
    OMAiNLSCGSY.
    OrthoDBiEOG7ZGX28.
    PhylomeDBiQ86SQ4.
    TreeFamiTF321769.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    2.60.120.200. 1 hit.
    2.60.120.290. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000859. CUB_dom.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000203. GPS.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF00431. CUB. 1 hit.
    PF01825. GPS. 1 hit.
    PF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00042. CUB. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS01180. CUB. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86SQ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG     50
    TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 100
    LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 150
    VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 200
    AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 250
    EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 300
    VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 350
    ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN 400
    RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV 450
    VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK 500
    LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD 550
    KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 600
    LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS 650
    SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL 700
    PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN 750
    KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH 800
    PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP 850
    RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 900
    LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL 950
    EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG 1000
    KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR 1050
    NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS 1100
    IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII 1150
    KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 1200
    NKSGSLRQCF HGQVLVKTGP C 1221
    Length:1,221
    Mass (Da):136,695
    Last modified:November 25, 2008 - v3
    Checksum:i1950DE5AE648F1C4
    GO
    Isoform 2 (identifier: Q86SQ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-407: Missing.

    Show »
    Length:1,193
    Mass (Da):133,671
    Checksum:iEDE274EF3096A242
    GO
    Isoform 3 (identifier: Q86SQ4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

    Show »
    Length:1,250
    Mass (Da):139,901
    Checksum:iBDDABA6A755A445B
    GO
    Isoform 4 (identifier: Q86SQ4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-407: Missing.
         1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

    Show »
    Length:1,222
    Mass (Da):136,878
    Checksum:i7B50E167F0EBBA97
    GO

    Sequence cautioni

    The sequence AAO13250.1 differs from that shown. Reason: Sequencing errors.
    The sequence BAB55406.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11393.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAE45930.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI20053.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti622 – 6221N → S in CAE45986. (PubMed:17974005)Curated
    Sequence conflicti623 – 6231I → V in CAE45930. (PubMed:17974005)Curated
    Sequence conflicti708 – 7081F → S in CAE45986. (PubMed:17974005)Curated
    Sequence conflicti763 – 7631K → Q in CAE45930. (PubMed:17974005)Curated
    Sequence conflicti908 – 9081L → P in AAH75798. (PubMed:15489334)Curated

    Polymorphismi

    Genetic variations in GPR126 influences stature as a quantitative trait (STQTL) [MIMi:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231S → G.
    Corresponds to variant rs17280293 [ dbSNP | Ensembl ].
    VAR_054128
    Natural varianti230 – 2301K → Q.1 Publication
    Corresponds to variant rs11155242 [ dbSNP | Ensembl ].
    VAR_024478
    Natural varianti1127 – 11271Q → R.6 Publications
    Corresponds to variant rs1262686 [ dbSNP | Ensembl ].
    VAR_054129

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei380 – 40728Missing in isoform 2 and isoform 4. 4 PublicationsVSP_010747Add
    BLAST
    Alternative sequencei1193 – 122129NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsVSP_010748Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216967 mRNA. Translation: AAO13250.1. Sequence problems.
    AB183546 mRNA. Translation: BAD27571.1.
    AB183547 mRNA. Translation: BAD27572.1.
    AB183548 mRNA. Translation: BAD27573.1.
    AB183549 mRNA. Translation: BAD27574.1.
    BX640971 mRNA. Translation: CAE45986.1.
    BX640873 mRNA. Translation: CAE45930.1. Different initiation.
    AL033377 Genomic DNA. Translation: CAI20053.1. Sequence problems.
    AL360007 Genomic DNA. No translation available.
    BC075798 mRNA. Translation: AAH75798.1.
    AK027843 mRNA. Translation: BAB55406.1. Different initiation.
    AK075087 mRNA. Translation: BAC11393.1. Different initiation.
    AY181244 mRNA. Translation: AAO27356.1.
    AY426673 mRNA. Translation: AAR88427.1.
    CCDSiCCDS47489.1. [Q86SQ4-3]
    CCDS47490.1. [Q86SQ4-1]
    CCDS47491.1. [Q86SQ4-2]
    CCDS55064.1. [Q86SQ4-4]
    RefSeqiNP_001027566.1. NM_001032394.2.
    NP_001027567.1. NM_001032395.2.
    NP_065188.4. NM_020455.5.
    NP_940971.1. NM_198569.2.
    UniGeneiHs.743302.

    Genome annotation databases

    EnsembliENST00000230173; ENSP00000230173; ENSG00000112414. [Q86SQ4-1]
    ENST00000296932; ENSP00000296932; ENSG00000112414. [Q86SQ4-2]
    ENST00000367608; ENSP00000356580; ENSG00000112414. [Q86SQ4-4]
    ENST00000367609; ENSP00000356581; ENSG00000112414. [Q86SQ4-3]
    GeneIDi57211.
    KEGGihsa:57211.
    UCSCiuc010khc.3. human. [Q86SQ4-1]
    uc010khd.3. human. [Q86SQ4-2]
    uc010khe.3. human. [Q86SQ4-3]
    uc010khf.3. human. [Q86SQ4-4]

    Polymorphism databases

    DMDMi215274152.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF216967 mRNA. Translation: AAO13250.1 . Sequence problems.
    AB183546 mRNA. Translation: BAD27571.1 .
    AB183547 mRNA. Translation: BAD27572.1 .
    AB183548 mRNA. Translation: BAD27573.1 .
    AB183549 mRNA. Translation: BAD27574.1 .
    BX640971 mRNA. Translation: CAE45986.1 .
    BX640873 mRNA. Translation: CAE45930.1 . Different initiation.
    AL033377 Genomic DNA. Translation: CAI20053.1 . Sequence problems.
    AL360007 Genomic DNA. No translation available.
    BC075798 mRNA. Translation: AAH75798.1 .
    AK027843 mRNA. Translation: BAB55406.1 . Different initiation.
    AK075087 mRNA. Translation: BAC11393.1 . Different initiation.
    AY181244 mRNA. Translation: AAO27356.1 .
    AY426673 mRNA. Translation: AAR88427.1 .
    CCDSi CCDS47489.1. [Q86SQ4-3 ]
    CCDS47490.1. [Q86SQ4-1 ]
    CCDS47491.1. [Q86SQ4-2 ]
    CCDS55064.1. [Q86SQ4-4 ]
    RefSeqi NP_001027566.1. NM_001032394.2.
    NP_001027567.1. NM_001032395.2.
    NP_065188.4. NM_020455.5.
    NP_940971.1. NM_198569.2.
    UniGenei Hs.743302.

    3D structure databases

    ProteinModelPortali Q86SQ4.
    SMRi Q86SQ4. Positions 37-212, 536-840, 863-1115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121449. 2 interactions.
    STRINGi 9606.ENSP00000356581.

    Protein family/group databases

    MEROPSi S63.020.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q86SQ4.

    Polymorphism databases

    DMDMi 215274152.

    Proteomic databases

    MaxQBi Q86SQ4.
    PaxDbi Q86SQ4.
    PRIDEi Q86SQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230173 ; ENSP00000230173 ; ENSG00000112414 . [Q86SQ4-1 ]
    ENST00000296932 ; ENSP00000296932 ; ENSG00000112414 . [Q86SQ4-2 ]
    ENST00000367608 ; ENSP00000356580 ; ENSG00000112414 . [Q86SQ4-4 ]
    ENST00000367609 ; ENSP00000356581 ; ENSG00000112414 . [Q86SQ4-3 ]
    GeneIDi 57211.
    KEGGi hsa:57211.
    UCSCi uc010khc.3. human. [Q86SQ4-1 ]
    uc010khd.3. human. [Q86SQ4-2 ]
    uc010khe.3. human. [Q86SQ4-3 ]
    uc010khf.3. human. [Q86SQ4-4 ]

    Organism-specific databases

    CTDi 57211.
    GeneCardsi GC06P142622.
    HGNCi HGNC:13841. GPR126.
    HPAi HPA017346.
    MIMi 606255. phenotype.
    612243. gene.
    neXtProti NX_Q86SQ4.
    PharmGKBi PA134878328.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG051778.
    KOi K08463.
    OMAi NLSCGSY.
    OrthoDBi EOG7ZGX28.
    PhylomeDBi Q86SQ4.
    TreeFami TF321769.

    Enzyme and pathway databases

    SignaLinki Q86SQ4.

    Miscellaneous databases

    GeneWikii GPR126.
    GenomeRNAii 57211.
    NextBioi 63312.
    PROi Q86SQ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86SQ4.
    Bgeei Q86SQ4.
    CleanExi HS_GPR126.
    Genevestigatori Q86SQ4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    2.60.120.200. 1 hit.
    2.60.120.290. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000859. CUB_dom.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000203. GPS.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF00431. CUB. 1 hit.
    PF01825. GPS. 1 hit.
    PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00042. CUB. 1 hit.
    SM00303. GPS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS01180. CUB. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "VIGR -- a novel inducible adhesion family G-protein coupled receptor in endothelial cells."
      Stehlik C., Kroismayr R., Dorfleutner A., Binder B.R., Lipp J.
      FEBS Lett. 569:149-155(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, GLYCOSYLATION.
      Tissue: Vein.
    2. "DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites."
      Moriguchi T., Haraguchi K., Ueda N., Okada M., Furuya T., Akiyama T.
      Genes Cells 9:549-560(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), PROTEIN SEQUENCE OF 469-483 AND 841-845, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-803; CYS-822; CYS-835; CYS-837 AND THR-841, PROTEOLYTIC PROCESSING, CLEAVAGE BY FURIN-LIKE CONVERTASE, VARIANT ARG-1127.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-1127.
      Tissue: Uterus.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS GLN-230 AND ARG-1127.
      Tissue: Placenta.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-1221, VARIANT ARG-1127.
      Tissue: Placenta.
    7. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
      Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
      Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 710-1221 (ISOFORM 3), VARIANT ARG-1127.
    8. Ji D., Cheng J., Wang J., Dong J., Yang Q., Dang X., Liu Y.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1032-1221, VARIANT ARG-1127.
    9. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-324.
      Tissue: Bile.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-143; ASN-438 AND ASN-445.
      Tissue: Plasma.
    11. Cited for: INVOLVEMENT IN STATURE AS A QUANTITATIVE TRAIT.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiGP126_HUMAN
    AccessioniPrimary (citable) accession number: Q86SQ4
    Secondary accession number(s): Q5TGN7
    , Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3