Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology-like domain family B member 2

Gene

PHLDB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • establishment of protein localization Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
  • negative regulation of focal adhesion assembly Source: UniProtKB
  • negative regulation of stress fiber assembly Source: UniProtKB
  • negative regulation of wound healing, spreading of epidermal cells Source: UniProtKB
  • positive regulation of basement membrane assembly involved in embryonic body morphogenesis Source: UniProtKB
  • regulation of epithelial to mesenchymal transition Source: UniProtKB
  • regulation of gastrulation Source: UniProtKB
  • regulation of microtubule cytoskeleton organization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 2
Alternative name(s):
Protein LL5-beta
Gene namesi
Name:PHLDB2
Synonyms:LL5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144824.19
HGNCiHGNC:29573 PHLDB2
MIMi610298 gene
neXtProtiNX_Q86SQ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1162 – 1163KR → AA: Loss of binding to PtdIns(3,4,5)P3. 1 Publication2

Organism-specific databases

DisGeNETi90102
OpenTargetsiENSG00000144824
PharmGKBiPA134884060

Polymorphism and mutation databases

BioMutaiPHLDB2
DMDMi84029396

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538941 – 1253Pleckstrin homology-like domain family B member 2Add BLAST1253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei212PhosphoserineCombined sources1
Modified residuei242PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei334PhosphoserineCombined sources1
Modified residuei348PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1
Modified residuei574PhosphothreonineCombined sources1
Modified residuei898PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ86SQ0
MaxQBiQ86SQ0
PaxDbiQ86SQ0
PeptideAtlasiQ86SQ0
PRIDEiQ86SQ0

PTM databases

iPTMnetiQ86SQ0
PhosphoSitePlusiQ86SQ0

Expressioni

Gene expression databases

BgeeiENSG00000144824
CleanExiHS_PHLDB2
ExpressionAtlasiQ86SQ0 baseline and differential
GenevisibleiQ86SQ0 HS

Organism-specific databases

HPAiHPA035146
HPA035147

Interactioni

Subunit structurei

Interacts with FLNC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP213333EBI-2798483,EBI-350432

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124661, 84 interactors
DIPiDIP-42196N
IntActiQ86SQ0, 40 interactors
MINTiQ86SQ0
STRINGi9606.ENSP00000377502

Structurei

3D structure databases

ProteinModelPortaliQ86SQ0
SMRiQ86SQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1143 – 1246PHPROSITE-ProRule annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili584 – 696Sequence analysisAdd BLAST113
Coiled coili722 – 807Sequence analysisAdd BLAST86
Coiled coili1032 – 1098Sequence analysisAdd BLAST67

Domaini

The PH domain mediates the binding to phosphoinositides.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFMW Eukaryota
ENOG4111JWX LUCA
GeneTreeiENSGT00530000063148
HOVERGENiHBG082124
InParanoidiQ86SQ0
OMAiLNSFHYP
OrthoDBiEOG091G0PU7
PhylomeDBiQ86SQ0
TreeFamiTF329165

Family and domain databases

CDDicd14673 PH_PHLDB1_2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037810 PHLDB1/2/3_PH
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK
60 70 80 90 100
ANGDYSGSYL TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD
110 120 130 140 150
KNIPMKPPTP LLNTTSSLSG YPLGRADFDH YTGRDSERAL RLSEKPPYSK
160 170 180 190 200
YSSRHKSHDN VYSLGGLEGR KASGSLLAMW NGSSLSDAGP PPISRSGAAS
210 220 230 240 250
MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK YSSSSLSHMG
260 270 280 290 300
AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN
310 320 330 340 350
YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA
360 370 380 390 400
SDDFDQASYV GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ
410 420 430 440 450
ASGTPQPALR ERKSSISSIS GRDDLMDYHR RQREERLREQ EMERLERQRL
460 470 480 490 500
ETILSLCAEY TKPDSRLSTG TTVEDVQKIN KELEKLQLSD EESVFEEALM
510 520 530 540 550
SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN DELLSDLTRT
560 570 580 590 600
PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN
610 620 630 640 650
LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL
660 670 680 690 700
NRKIAELEKN IVGEKTKEKV KLDAEREKLE RLQELYSEQK TQLDNCPESM
710 720 730 740 750
REQLQQQLKR DADLLDVESK HFEDLEFQQL EHESRLDEEK ENLTQQLLRE
760 770 780 790 800
VAEYQRNIVS RKEKISALKK QANHIVQQAQ REQDHFVKEK NNLIMMLQRE
810 820 830 840 850
KENLCNLEKK YSSLSGGKGF PVNPNTLKEG YISVNEINEP CGNSTNLSPS
860 870 880 890 900
TQFPADADAV ATEPATAVLA SQPQSKEHFR SLEERKKQHK EGLYLSDTLP
910 920 930 940 950
RKKTTSSISP HFSSATMGRS ITPKAHLPLG QSNSCGSVLP PSLAAMAKDS
960 970 980 990 1000
ESRRMLRGYN HQQMSEGHRQ KSEFYNRTAS ESNVYLNSFH YPDHSYKDQA
1010 1020 1030 1040 1050
FDTLSLDSSD SMETSISACS PDNISSASTS NIARIEEMER LLKQAHAEKT
1060 1070 1080 1090 1100
RLLESREREM EAKKRALEEE KRRREILEKR LQEETSQRQK LIEKEVKIRE
1110 1120 1130 1140 1150
RQRAQARPLT RYLPVRKEDF DLRSHVETAG HNIDTCYHVS ITEKTCRGFL
1160 1170 1180 1190 1200
IKMGGKIKTW KKRWFVFDRN KRTFSYYADK HETKLKGVIY FQAIEEVYYD
1210 1220 1230 1240 1250
HLKNANKSPN PLLTFSVKTH DRIYYMVAPS PEAMRIWMDV IVTGAEGYTH

FLL
Length:1,253
Mass (Da):142,158
Last modified:December 20, 2005 - v2
Checksum:iD0950E96AEE1B020
GO
Isoform 2 (identifier: Q86SQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-710: Missing.

Show »
Length:1,210
Mass (Da):136,886
Checksum:iD05881C68D0A811C
GO
Isoform 3 (identifier: Q86SQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEEEDTKREVPKEDGVGDVQHFDSSKIM
     668-710: Missing.

Show »
Length:1,237
Mass (Da):139,974
Checksum:iBF9C4AF0F1DEC613
GO

Sequence cautioni

The sequence AAH69194 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD93140 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96Y → H in BAC04014 (PubMed:14702039).Curated1
Sequence conflicti346T → A in CAH18447 (PubMed:17974005).Curated1
Sequence conflicti585Q → E in CAD42711 (PubMed:12376540).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024760941P → S1 PublicationCorresponds to variant dbSNP:rs3749298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0167441M → MEEEDTKREVPKEDGVGDVQ HFDSSKIM in isoform 3. 1 Publication1
Alternative sequenceiVSP_016745668 – 710Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ496194 mRNA Translation: CAD42711.1
AF506820 mRNA Translation: AAM33634.1
AB209903 mRNA Translation: BAD93140.1 Different initiation.
CR749654 mRNA Translation: CAH18447.1
CH471052 Genomic DNA Translation: EAW79690.1
BC069194 mRNA Translation: AAH69194.1 Sequence problems.
BC142678 mRNA Translation: AAI42679.1
BC150210 mRNA Translation: AAI50211.1
AK092996 mRNA Translation: BAC04014.1
AK096151 mRNA Translation: BAC04713.1
CCDSiCCDS2962.1 [Q86SQ0-2]
CCDS46885.1 [Q86SQ0-3]
CCDS46886.1 [Q86SQ0-1]
RefSeqiNP_001127909.1, NM_001134437.1 [Q86SQ0-3]
NP_001127910.1, NM_001134438.1 [Q86SQ0-1]
NP_001127911.1, NM_001134439.1 [Q86SQ0-1]
NP_665696.1, NM_145753.2 [Q86SQ0-2]
UniGeneiHs.603252
Hs.679140

Genome annotation databases

EnsembliENST00000393923; ENSP00000377500; ENSG00000144824 [Q86SQ0-3]
ENST00000393925; ENSP00000377502; ENSG00000144824 [Q86SQ0-1]
ENST00000412622; ENSP00000405292; ENSG00000144824 [Q86SQ0-2]
ENST00000431670; ENSP00000405405; ENSG00000144824 [Q86SQ0-1]
ENST00000481953; ENSP00000418319; ENSG00000144824 [Q86SQ0-2]
GeneIDi90102
KEGGihsa:90102
UCSCiuc003dyc.4 human [Q86SQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPHLB2_HUMAN
AccessioniPrimary (citable) accession number: Q86SQ0
Secondary accession number(s): A5PKZ3
, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health