Q86SQ0 (PHLB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology-like domain family B member 2

Alternative name(s):
Protein LL5-beta

Gene names

Name:	PHLDB2
Synonyms:	LL5B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1253 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane By similarity. Ref.1
Subunit structure	Interacts with FLNC. Ref.1
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein. Note: Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments. Ref.1
Domain	The PH domain mediates the binding to phosphoinositides.
Sequence similarities	Contains 1 PH domain.
Sequence caution	The sequence AAH69194.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAD93140.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA intermediate filament cytoskeleton Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FLNA	P21333	2	EBI-2798483,EBI-350432

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86SQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86SQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     668-710: Missing.

Isoform 3 (identifier: Q86SQ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEEEDTKREVPKEDGVGDVQHFDSSKIM
     668-710: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1253	1253	Pleckstrin homology-like domain family B member 2		PRO_0000053894
Regions
	Domain	1143 – 1246	104	PH
	Coiled coil	584 – 696	113	Potential
	Coiled coil	722 – 807	86	Potential
	Coiled coil	1032 – 1098	67	Potential
Amino acid modifications
	Modified residue	71	1	Phosphoserine Ref.10
	Modified residue	73	1	Phosphoserine Ref.10
	Modified residue	157	1	Phosphoserine Ref.10 Ref.11 Ref.14
	Modified residue	212	1	Phosphoserine Ref.10
	Modified residue	334	1	Phosphoserine Ref.10
	Modified residue	351	1	Phosphoserine Ref.10
	Modified residue	384	1	Phosphoserine Ref.10
	Modified residue	387	1	Phosphoserine Ref.10
	Modified residue	415	1	Phosphoserine Ref.10
	Modified residue	468	1	Phosphoserine Ref.10
	Modified residue	489	1	Phosphoserine Ref.10 Ref.12
	Modified residue	501	1	Phosphoserine Ref.10 Ref.12
	Modified residue	504	1	Phosphothreonine Ref.12
	Modified residue	513	1	Phosphoserine Ref.10
	Modified residue	550	1	Phosphothreonine Ref.10
	Modified residue	574	1	Phosphothreonine Ref.10
	Modified residue	898	1	Phosphothreonine Ref.10
	Modified residue	980	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1	1	M → MEEEDTKREVPKEDGVGDVQ HFDSSKIM in isoform 3.		VSP_016744
	Alternative sequence	668 – 710	43	Missing in isoform 2 and isoform 3.		VSP_016745
	Natural variant	941	1	P → S. Ref.6 Corresponds to variant rs3749298 [ dbSNP | Ensembl ].		VAR_024760
Experimental info
	Mutagenesis	1162 – 1163	2	KR → AA: Loss of binding to PtdIns(3,4,5)P3. Ref.1
	Sequence conflict	96	1	Y → H in BAC04014. Ref.7
	Sequence conflict	346	1	T → A in CAH18447. Ref.4
	Sequence conflict	585	1	Q → E in CAD42711. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: D0950E96AEE1B020	FASTA	1,253	142,158
	10 20 30 40 50 60 MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK ANGDYSGSYL 70 80 90 100 110 120 TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD KNIPMKPPTP LLNTTSSLSG 130 140 150 160 170 180 YPLGRADFDH YTGRDSERAL RLSEKPPYSK YSSRHKSHDN VYSLGGLEGR KASGSLLAMW 190 200 210 220 230 240 NGSSLSDAGP PPISRSGAAS MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK 250 260 270 280 290 300 YSSSSLSHMG AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN 310 320 330 340 350 360 YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA SDDFDQASYV 370 380 390 400 410 420 GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ ASGTPQPALR ERKSSISSIS 430 440 450 460 470 480 GRDDLMDYHR RQREERLREQ EMERLERQRL ETILSLCAEY TKPDSRLSTG TTVEDVQKIN 490 500 510 520 530 540 KELEKLQLSD EESVFEEALM SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN 550 560 570 580 590 600 DELLSDLTRT PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN 610 620 630 640 650 660 LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL NRKIAELEKN 670 680 690 700 710 720 IVGEKTKEKV KLDAEREKLE RLQELYSEQK TQLDNCPESM REQLQQQLKR DADLLDVESK 730 740 750 760 770 780 HFEDLEFQQL EHESRLDEEK ENLTQQLLRE VAEYQRNIVS RKEKISALKK QANHIVQQAQ 790 800 810 820 830 840 REQDHFVKEK NNLIMMLQRE KENLCNLEKK YSSLSGGKGF PVNPNTLKEG YISVNEINEP 850 860 870 880 890 900 CGNSTNLSPS TQFPADADAV ATEPATAVLA SQPQSKEHFR SLEERKKQHK EGLYLSDTLP 910 920 930 940 950 960 RKKTTSSISP HFSSATMGRS ITPKAHLPLG QSNSCGSVLP PSLAAMAKDS ESRRMLRGYN 970 980 990 1000 1010 1020 HQQMSEGHRQ KSEFYNRTAS ESNVYLNSFH YPDHSYKDQA FDTLSLDSSD SMETSISACS 1030 1040 1050 1060 1070 1080 PDNISSASTS NIARIEEMER LLKQAHAEKT RLLESREREM EAKKRALEEE KRRREILEKR 1090 1100 1110 1120 1130 1140 LQEETSQRQK LIEKEVKIRE RQRAQARPLT RYLPVRKEDF DLRSHVETAG HNIDTCYHVS 1150 1160 1170 1180 1190 1200 ITEKTCRGFL IKMGGKIKTW KKRWFVFDRN KRTFSYYADK HETKLKGVIY FQAIEEVYYD 1210 1220 1230 1240 1250 HLKNANKSPN PLLTFSVKTH DRIYYMVAPS PEAMRIWMDV IVTGAEGYTH FLL
	Isoform 2 [UniParc]. Checksum: D05881C68D0A811C	FASTA	1,210	136,886
	10 20 30 40 50 60 MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK ANGDYSGSYL 70 80 90 100 110 120 TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD KNIPMKPPTP LLNTTSSLSG 130 140 150 160 170 180 YPLGRADFDH YTGRDSERAL RLSEKPPYSK YSSRHKSHDN VYSLGGLEGR KASGSLLAMW 190 200 210 220 230 240 NGSSLSDAGP PPISRSGAAS MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK 250 260 270 280 290 300 YSSSSLSHMG AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN 310 320 330 340 350 360 YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA SDDFDQASYV 370 380 390 400 410 420 GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ ASGTPQPALR ERKSSISSIS 430 440 450 460 470 480 GRDDLMDYHR RQREERLREQ EMERLERQRL ETILSLCAEY TKPDSRLSTG TTVEDVQKIN 490 500 510 520 530 540 KELEKLQLSD EESVFEEALM SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN 550 560 570 580 590 600 DELLSDLTRT PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN 610 620 630 640 650 660 LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL NRKIAELEKN 670 680 690 700 710 720 IVGEKTKDAD LLDVESKHFE DLEFQQLEHE SRLDEEKENL TQQLLREVAE YQRNIVSRKE 730 740 750 760 770 780 KISALKKQAN HIVQQAQREQ DHFVKEKNNL IMMLQREKEN LCNLEKKYSS LSGGKGFPVN 790 800 810 820 830 840 PNTLKEGYIS VNEINEPCGN STNLSPSTQF PADADAVATE PATAVLASQP QSKEHFRSLE 850 860 870 880 890 900 ERKKQHKEGL YLSDTLPRKK TTSSISPHFS SATMGRSITP KAHLPLGQSN SCGSVLPPSL 910 920 930 940 950 960 AAMAKDSESR RMLRGYNHQQ MSEGHRQKSE FYNRTASESN VYLNSFHYPD HSYKDQAFDT 970 980 990 1000 1010 1020 LSLDSSDSME TSISACSPDN ISSASTSNIA RIEEMERLLK QAHAEKTRLL ESREREMEAK 1030 1040 1050 1060 1070 1080 KRALEEEKRR REILEKRLQE ETSQRQKLIE KEVKIRERQR AQARPLTRYL PVRKEDFDLR 1090 1100 1110 1120 1130 1140 SHVETAGHNI DTCYHVSITE KTCRGFLIKM GGKIKTWKKR WFVFDRNKRT FSYYADKHET 1150 1160 1170 1180 1190 1200 KLKGVIYFQA IEEVYYDHLK NANKSPNPLL TFSVKTHDRI YYMVAPSPEA MRIWMDVIVT 1210 GAEGYTHFLL
	Isoform 3 [UniParc]. Checksum: BF9C4AF0F1DEC613	FASTA	1,237	139,974
	10 20 30 40 50 60 MEEEDTKREV PKEDGVGDVQ HFDSSKIMEE HSYIQKELDL QNGSLEEDSV VHSVENDSQN 70 80 90 100 110 120 MMESLSPKKY SSSLRFKANG DYSGSYLTLS QPVPAKRSPS PLGTSVRSSP SLAKIQGSKQ 130 140 150 160 170 180 FSYDGTDKNI PMKPPTPLLN TTSSLSGYPL GRADFDHYTG RDSERALRLS EKPPYSKYSS 190 200 210 220 230 240 RHKSHDNVYS LGGLEGRKAS GSLLAMWNGS SLSDAGPPPI SRSGAASMPS SPKQARKMSI 250 260 270 280 290 300 QDSLALQPKL TRHKELASEN INLRTRKYSS SSLSHMGAYS RSLPRLYRAT ENQLTPLSLP 310 320 330 340 350 360 PRNSLGNSKR TKLGEKDLPH SVIDNDNYLN FSSLSSGALP YKTSASEGNP YVSSTLSVPA 370 380 390 400 410 420 SPRVARKMLL ASTSSCASDD FDQASYVGTN PSHSLLAGES DRVFATRRNF SCGSVEFDEA 430 440 450 460 470 480 DLESLRQASG TPQPALRERK SSISSISGRD DLMDYHRRQR EERLREQEME RLERQRLETI 490 500 510 520 530 540 LSLCAEYTKP DSRLSTGTTV EDVQKINKEL EKLQLSDEES VFEEALMSPD TRYRCHRKDS 550 560 570 580 590 600 LPDADLASCG SLSQSSASFF TPRSTRNDEL LSDLTRTPPP PSSTFPKASS ESSYLSILPK 610 620 630 640 650 660 TPEGISEEQR SQELAAMEET RIVILNNLEE LKQKIKDIND QMDESFRELD MECALLDGEQ 670 680 690 700 710 720 KSETTELMKE KEILDHLNRK IAELEKNIVG EKTKDADLLD VESKHFEDLE FQQLEHESRL 730 740 750 760 770 780 DEEKENLTQQ LLREVAEYQR NIVSRKEKIS ALKKQANHIV QQAQREQDHF VKEKNNLIMM 790 800 810 820 830 840 LQREKENLCN LEKKYSSLSG GKGFPVNPNT LKEGYISVNE INEPCGNSTN LSPSTQFPAD 850 860 870 880 890 900 ADAVATEPAT AVLASQPQSK EHFRSLEERK KQHKEGLYLS DTLPRKKTTS SISPHFSSAT 910 920 930 940 950 960 MGRSITPKAH LPLGQSNSCG SVLPPSLAAM AKDSESRRML RGYNHQQMSE GHRQKSEFYN 970 980 990 1000 1010 1020 RTASESNVYL NSFHYPDHSY KDQAFDTLSL DSSDSMETSI SACSPDNISS ASTSNIARIE 1030 1040 1050 1060 1070 1080 EMERLLKQAH AEKTRLLESR EREMEAKKRA LEEEKRRREI LEKRLQEETS QRQKLIEKEV 1090 1100 1110 1120 1130 1140 KIRERQRAQA RPLTRYLPVR KEDFDLRSHV ETAGHNIDTC YHVSITEKTC RGFLIKMGGK 1150 1160 1170 1180 1190 1200 IKTWKKRWFV FDRNKRTFSY YADKHETKLK GVIYFQAIEE VYYDHLKNAN KSPNPLLTFS 1210 1220 1230 VKTHDRIYYM VAPSPEAMRI WMDVIVTGAE GYTHFLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin." Paranavitane V., Coadwell W.J., Eguinoa A., Hawkins P.T., Stephens L. J. Biol. Chem. 278:1328-1335(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH FLNC, BINDING TO PTDINS(3,4,5)P3, MUTAGENESIS OF 1162-LYS-ARG-1163.
[2]	Guo J.H., Yu L. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Aortic endothelium.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal kidney.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1156 (ISOFORM 2), VARIANT SER-941. Tissue: Lung.
[7]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-788 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-787 (ISOFORM 1). Tissue: Spleen.
[8]	"Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities." Dowler S.J., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R. Biochem. J. 351:19-31(2000) [PubMed] [Europe PMC] [Abstract] Cited for: BINDING TO PHOSPHOINOSITIDES.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-73; SER-157; SER-212; SER-334; SER-351; SER-384; SER-387; SER-415; SER-468; SER-489; SER-501; SER-513; THR-550; THR-574 AND THR-898, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489; SER-501 AND THR-504, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ496194 mRNA. Translation: CAD42711.1. AF506820 mRNA. Translation: AAM33634.1. AB209903 mRNA. Translation: BAD93140.1. Different initiation. CR749654 mRNA. Translation: CAH18447.1. CH471052 Genomic DNA. Translation: EAW79690.1. BC069194 mRNA. Translation: AAH69194.1. Sequence problems. BC142678 mRNA. Translation: AAI42679.1. BC150210 mRNA. Translation: AAI50211.1. AK092996 mRNA. Translation: BAC04014.1. AK096151 mRNA. Translation: BAC04713.1.
IPI	IPI00168459. IPI00410259. IPI00657763.
RefSeq	NP_001127909.1. NM_001134437.1. NP_001127910.1. NM_001134438.1. NP_001127911.1. NM_001134439.1. NP_665696.1. NM_145753.2.
UniGene	Hs.603252. Hs.679140.
3D structure databases
ProteinModelPortal	Q86SQ0.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-42196N.
IntAct	Q86SQ0. 6 interactions.
STRING	9606.ENSP00000377502.
PTM databases
PhosphoSite	Q86SQ0.
Polymorphism databases
DMDM	84029396.
Proteomic databases
PaxDb	Q86SQ0.
PRIDE	Q86SQ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393923; ENSP00000377500; ENSG00000144824. ENST00000393925; ENSP00000377502; ENSG00000144824. ENST00000412622; ENSP00000405292; ENSG00000144824. ENST00000431670; ENSP00000405405; ENSG00000144824. ENST00000481953; ENSP00000418319; ENSG00000144824.
GeneID	90102.
KEGG	hsa:90102.
UCSC	uc003dyc.3. human. uc003dyd.3. human. uc003dyg.3. human.
Organism-specific databases
CTD	90102.
GeneCards	GC03P111451.
HGNC	HGNC:29573. PHLDB2.
HPA	HPA035146.
MIM	610298. gene.
neXtProt	NX_Q86SQ0.
PharmGKB	PA134884060.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86245.
HOVERGEN	HBG082124.
InParanoid	Q86SQ0.
OMA	LNSFHYP.
PhylomeDB	Q86SQ0.
Gene expression databases
ArrayExpress	Q86SQ0.
Bgee	Q86SQ0.
CleanEx	HS_PHLDB2.
Genevestigator	Q86SQ0.
GermOnline	ENSG00000144824. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PHLDB2. human.
GenomeRNAi	90102.
NextBio	76517.
SOURCE	Search...

Entry information

Entry name

PHLB2_HUMAN

Accession

Primary (citable) accession number: Q86SQ0
Secondary accession number(s): A5PKZ3 , Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.