Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 149

Gene

GPR149

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 149
Alternative name(s):
G-protein coupled receptor PGR10
Gene namesi
Name:GPR149
Synonyms:PGR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23627. GPR149.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 6913CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini91 – 10919ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13223Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 15523CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 18913ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini211 – 310100CytoplasmicSequence analysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini332 – 34211ExtracellularSequence analysisAdd
BLAST
Transmembranei343 – 36321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini364 – 731368CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981369.

Polymorphism and mutation databases

BioMutaiGPR149.
DMDMi84029267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Probable G-protein coupled receptor 149PRO_0000069626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86SP6.
PRIDEiQ86SP6.

PTM databases

iPTMnetiQ86SP6.
PhosphoSiteiQ86SP6.

Expressioni

Gene expression databases

BgeeiQ86SP6.
CleanExiHS_GPR149.
ExpressionAtlasiQ86SP6. baseline and differential.

Organism-specific databases

HPAiHPA018020.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374390.

Structurei

3D structure databases

ProteinModelPortaliQ86SP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ86SP6.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG7QC7VP.
PhylomeDBiQ86SP6.
TreeFamiTF331679.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFLSNLST NDSSLWKENH NSTDLLNPPG TLNIYLFCLT CLMTFAALVG
60 70 80 90 100
SIYSLISLLK MQNRTVVSML VASWSVDDLM SVLSVTIFMF LQWPNEVPGY
110 120 130 140 150
FQFLCTTSAL MYLCQGLSSN LKATLLVSYN FYTMHRGVGS QTASRRSGQV
160 170 180 190 200
LGVVLTVWAA SLLLSALPLC GWGAFVRTPW GCLVDCSSSY VLFLSIVYAL
210 220 230 240 250
AFGLLVGLSV PLTHRLLCSE EPPRLHSNYQ EISRGASIPG TPPTAGRVVS
260 270 280 290 300
LSPEDAPGPS LRRSGGCSPS SDTVFGPGAP AAAGAEACRR ENRGTLYGTR
310 320 330 340 350
SFTVSVAQKR FALILALTKV VLWLPMMMHM VVQNVVGFQS LPLETFSFLL
360 370 380 390 400
TLLATTVTPV FVLSKRWTHL PCGCIINCRQ NAYAVASDGK KIKRKGFEFN
410 420 430 440 450
LSFQKSYGIY KIAHEDYYDD DENSIFYHNL MNSECETTKD PQRDNRNIFN
460 470 480 490 500
AIKVEISTTP SLDSSTQRGI NKCTNTDITE AKQDSNNKKD AFSDKTGGDI
510 520 530 540 550
NYEETTFSEG PERRLSHEES QKPDLSDWEW CRSKSERTPR QRSGYALAIP
560 570 580 590 600
LCAFQGTVSL HAPTGKTLSL STYEVSAEGQ KITPASKKIE VYRSKSVGHE
610 620 630 640 650
PNSEDSSSTF VDTSVKIHLE VLEICDNEEA LDTVSIISNI SQSSTQVRSP
660 670 680 690 700
SLRYSRKENR FVSCDLGETA SYSLFLPTSN PDGDINISIP DTVEAHRQNS
710 720 730
KRQHQERDGY QEEIQLLNKA YRKREEESKG S
Length:731
Mass (Da):80,984
Last modified:December 20, 2005 - v2
Checksum:i57A43042CB958A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092946 Genomic DNA. No translation available.
AY255534 mRNA. Translation: AAO85046.1.
CCDSiCCDS43162.1.
RefSeqiNP_001033794.1. NM_001038705.1.
UniGeneiHs.688231.

Genome annotation databases

EnsembliENST00000389740; ENSP00000374390; ENSG00000174948.
GeneIDi344758.
KEGGihsa:344758.
UCSCiuc003faa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092946 Genomic DNA. No translation available.
AY255534 mRNA. Translation: AAO85046.1.
CCDSiCCDS43162.1.
RefSeqiNP_001033794.1. NM_001038705.1.
UniGeneiHs.688231.

3D structure databases

ProteinModelPortaliQ86SP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374390.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ86SP6.
PhosphoSiteiQ86SP6.

Polymorphism and mutation databases

BioMutaiGPR149.
DMDMi84029267.

Proteomic databases

PaxDbiQ86SP6.
PRIDEiQ86SP6.

Protocols and materials databases

DNASUi344758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389740; ENSP00000374390; ENSG00000174948.
GeneIDi344758.
KEGGihsa:344758.
UCSCiuc003faa.3. human.

Organism-specific databases

CTDi344758.
GeneCardsiGPR149.
HGNCiHGNC:23627. GPR149.
HPAiHPA018020.
neXtProtiNX_Q86SP6.
PharmGKBiPA134981369.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00390000003715.
HOGENOMiHOG000112771.
HOVERGENiHBG081566.
InParanoidiQ86SP6.
KOiK08433.
OMAiHEDYYDD.
OrthoDBiEOG7QC7VP.
PhylomeDBiQ86SP6.
TreeFamiTF331679.

Miscellaneous databases

GenomeRNAii344758.
PROiQ86SP6.

Gene expression databases

BgeeiQ86SP6.
CleanExiHS_GPR149.
ExpressionAtlasiQ86SP6. baseline and differential.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 156-589.

Entry informationi

Entry nameiGP149_HUMAN
AccessioniPrimary (citable) accession number: Q86SP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.