ID   MRGRE_HUMAN             Reviewed;         312 AA.
AC   Q86SM8; Q2M1V7;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 3.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Mas-related G-protein coupled receptor member E;
DE   AltName: Full=G-protein coupled receptor 167;
GN   Name=MRGPRE; Synonyms=GPR167, MRGE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-202.
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC   -!- FUNCTION: Orphan receptor. May regulate nociceptor function and/or
CC       development, including the sensation or modulation of pain.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Mas
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI04890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI12204.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC104889; AAI04890.1; ALT_INIT; mRNA.
DR   EMBL; BC112203; AAI12204.1; ALT_INIT; mRNA.
DR   EMBL; AY255572; AAO85084.1; -; mRNA.
DR   CCDS; CCDS41603.2; -.
DR   RefSeq; NP_001034254.2; NM_001039165.2.
DR   AlphaFoldDB; Q86SM8; -.
DR   SMR; Q86SM8; -.
DR   BioGRID; 125519; 1.
DR   STRING; 9606.ENSP00000374482; -.
DR   ChEMBL; CHEMBL4523882; -.
DR   PhosphoSitePlus; Q86SM8; -.
DR   BioMuta; MRGPRE; -.
DR   DMDM; 115502418; -.
DR   PaxDb; 9606-ENSP00000374482; -.
DR   PeptideAtlas; Q86SM8; -.
DR   ProteomicsDB; 69602; -.
DR   Antibodypedia; 23328; 123 antibodies from 23 providers.
DR   DNASU; 116534; -.
DR   Ensembl; ENST00000389832.7; ENSP00000374482.6; ENSG00000184350.11.
DR   GeneID; 116534; -.
DR   KEGG; hsa:116534; -.
DR   MANE-Select; ENST00000389832.7; ENSP00000374482.6; NM_001039165.4; NP_001034254.2.
DR   AGR; HGNC:30694; -.
DR   CTD; 116534; -.
DR   GeneCards; MRGPRE; -.
DR   HGNC; HGNC:30694; MRGPRE.
DR   HPA; ENSG00000184350; Not detected.
DR   MIM; 607232; gene.
DR   neXtProt; NX_Q86SM8; -.
DR   OpenTargets; ENSG00000184350; -.
DR   PharmGKB; PA134939296; -.
DR   VEuPathDB; HostDB:ENSG00000184350; -.
DR   eggNOG; ENOG502TKZN; Eukaryota.
DR   GeneTree; ENSGT01030000234639; -.
DR   HOGENOM; CLU_009579_4_1_1; -.
DR   InParanoid; Q86SM8; -.
DR   OMA; GCHMVAI; -.
DR   OrthoDB; 4640638at2759; -.
DR   PhylomeDB; Q86SM8; -.
DR   TreeFam; TF336336; -.
DR   PathwayCommons; Q86SM8; -.
DR   BioGRID-ORCS; 116534; 15 hits in 1027 CRISPR screens.
DR   GeneWiki; MRGPRE; -.
DR   GenomeRNAi; 116534; -.
DR   Pharos; Q86SM8; Tbio.
DR   PRO; PR:Q86SM8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q86SM8; Protein.
DR   Bgee; ENSG00000184350; Expressed in dorsal root ganglion and 93 other cell types or tissues.
DR   ExpressionAtlas; Q86SM8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR026230; MRGPCRE.
DR   InterPro; IPR026234; MRGPCRFAMILY.
DR   PANTHER; PTHR11334; MAS-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR11334:SF26; MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER E; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR02111; MRGPCRE.
DR   PRINTS; PR02108; MRGPCRFAMILY.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Mas-related G-protein coupled receptor member E"
FT                   /id="PRO_0000069760"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..106
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..176
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..217
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..241
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         16
FT                   /note="G -> S (in dbSNP:rs12295710)"
FT                   /id="VAR_059325"
FT   VARIANT         160
FT                   /note="G -> S (in dbSNP:rs4391795)"
FT                   /id="VAR_059326"
SQ   SEQUENCE   312 AA;  34286 MW;  42CC3B3C8D1AF974 CRC64;
     MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS SNVYRNPFAI
     YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA TLRFFCYIVG LSLLAAVSVE
     QCLAALFPAW YSCRRPRHLT TCVCALTWAL CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV
     AAVLLALLCC TMCGASLMLL LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR
     NLLWYIPHYF YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
     ETSRRGLVDI AA
//