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Protein

Mas-related G-protein coupled receptor member E

Gene

MRGPRE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
G-protein coupled receptor 167
Gene namesi
Name:MRGPRE
Synonyms:GPR167, MRGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30694. MRGPRE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 59CytoplasmicSequence analysisAdd BLAST18
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 106ExtracellularSequence analysisAdd BLAST26
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 141CytoplasmicSequence analysisAdd BLAST14
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 176ExtracellularSequence analysisAdd BLAST14
Transmembranei177 – 197Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini198 – 217CytoplasmicSequence analysisAdd BLAST20
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 241ExtracellularSequence analysis3
Transmembranei242 – 262Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini263 – 312CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184350.
PharmGKBiPA134939296.

Polymorphism and mutation databases

BioMutaiMRGPRE.
DMDMi115502418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697601 – 312Mas-related G-protein coupled receptor member EAdd BLAST312

Proteomic databases

PaxDbiQ86SM8.
PRIDEiQ86SM8.

PTM databases

PhosphoSitePlusiQ86SM8.

Expressioni

Gene expression databases

CleanExiHS_MRGPRE.
ExpressionAtlasiQ86SM8. baseline and differential.

Organism-specific databases

HPAiHPA046556.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374482.

Structurei

3D structure databases

ProteinModelPortaliQ86SM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JC07. Eukaryota.
ENOG4111507. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ86SM8.
KOiK08393.
OMAiPFGIYWL.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ86SM8.
TreeFamiTF336336.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS
60 70 80 90 100
SNVYRNPFAI YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA
110 120 130 140 150
TLRFFCYIVG LSLLAAVSVE QCLAALFPAW YSCRRPRHLT TCVCALTWAL
160 170 180 190 200
CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV AAVLLALLCC TMCGASLMLL
210 220 230 240 250
LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR NLLWYIPHYF
260 270 280 290 300
YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
310
ETSRRGLVDI AA
Length:312
Mass (Da):34,286
Last modified:July 9, 2014 - v3
Checksum:i42CC3B3C8D1AF974
GO

Sequence cautioni

The sequence AAI04890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI12204 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05932516G → S.Corresponds to variant rs12295710dbSNPEnsembl.1
Natural variantiVAR_059326160G → S.Corresponds to variant rs4391795dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104889 mRNA. Translation: AAI04890.1. Different initiation.
BC112203 mRNA. Translation: AAI12204.1. Different initiation.
AY255572 mRNA. Translation: AAO85084.1.
CCDSiCCDS41603.2.
RefSeqiNP_001034254.2. NM_001039165.2.
UniGeneiHs.745512.

Genome annotation databases

EnsembliENST00000389832; ENSP00000374482; ENSG00000184350.
GeneIDi116534.
KEGGihsa:116534.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104889 mRNA. Translation: AAI04890.1. Different initiation.
BC112203 mRNA. Translation: AAI12204.1. Different initiation.
AY255572 mRNA. Translation: AAO85084.1.
CCDSiCCDS41603.2.
RefSeqiNP_001034254.2. NM_001039165.2.
UniGeneiHs.745512.

3D structure databases

ProteinModelPortaliQ86SM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374482.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ86SM8.

Polymorphism and mutation databases

BioMutaiMRGPRE.
DMDMi115502418.

Proteomic databases

PaxDbiQ86SM8.
PRIDEiQ86SM8.

Protocols and materials databases

DNASUi116534.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389832; ENSP00000374482; ENSG00000184350.
GeneIDi116534.
KEGGihsa:116534.

Organism-specific databases

CTDi116534.
GeneCardsiMRGPRE.
H-InvDBHIX0171334.
HGNCiHGNC:30694. MRGPRE.
HPAiHPA046556.
MIMi607232. gene.
neXtProtiNX_Q86SM8.
OpenTargetsiENSG00000184350.
PharmGKBiPA134939296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JC07. Eukaryota.
ENOG4111507. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ86SM8.
KOiK08393.
OMAiPFGIYWL.
OrthoDBiEOG091G0GUJ.
PhylomeDBiQ86SM8.
TreeFamiTF336336.

Enzyme and pathway databases

BioCyciZFISH:G66-32692-MONOMER.

Miscellaneous databases

GeneWikiiMRGPRE.
GenomeRNAii116534.
PROiQ86SM8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_MRGPRE.
ExpressionAtlasiQ86SM8. baseline and differential.

Family and domain databases

InterProiIPR019430. 7TM_GPCR_serpentine_rcpt_Srx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF10328. 7TM_GPCR_Srx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRE_HUMAN
AccessioniPrimary (citable) accession number: Q86SM8
Secondary accession number(s): Q2M1V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 9, 2014
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.