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Q86SM8

- MRGRE_HUMAN

UniProt

Q86SM8 - MRGRE_HUMAN

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Protein

Mas-related G-protein coupled receptor member E

Gene

MRGPRE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
G-protein coupled receptor 167
Gene namesi
Name:MRGPRE
Synonyms:GPR167, MRGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30694. MRGPRE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini42 – 5918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 10626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14114CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 17614ExtracellularSequence AnalysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini198 – 21720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini239 – 2413ExtracellularSequence Analysis
Transmembranei242 – 26221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini263 – 31250CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Mas-related G-protein coupled receptor member EPRO_0000069760Add
BLAST

Proteomic databases

PaxDbiQ86SM8.
PRIDEiQ86SM8.

Expressioni

Gene expression databases

BgeeiQ86SM8.
CleanExiHS_MRGPRE.
GenevestigatoriQ86SM8.

Organism-specific databases

HPAiHPA046556.

Structurei

3D structure databases

ProteinModelPortaliQ86SM8.
SMRiQ86SM8. Positions 27-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47650.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ86SM8.
KOiK08393.
OMAiPFGIYWL.
PhylomeDBiQ86SM8.
TreeFamiTF336336.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS
60 70 80 90 100
SNVYRNPFAI YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA
110 120 130 140 150
TLRFFCYIVG LSLLAAVSVE QCLAALFPAW YSCRRPRHLT TCVCALTWAL
160 170 180 190 200
CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV AAVLLALLCC TMCGASLMLL
210 220 230 240 250
LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR NLLWYIPHYF
260 270 280 290 300
YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
310
ETSRRGLVDI AA
Length:312
Mass (Da):34,286
Last modified:July 9, 2014 - v3
Checksum:i42CC3B3C8D1AF974
GO

Sequence cautioni

The sequence AAI04890.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI12204.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161G → S.
Corresponds to variant rs12295710 [ dbSNP | Ensembl ].
VAR_059325
Natural varianti160 – 1601G → S.
Corresponds to variant rs4391795 [ dbSNP | Ensembl ].
VAR_059326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104889 mRNA. Translation: AAI04890.1. Different initiation.
BC112203 mRNA. Translation: AAI12204.1. Different initiation.
AY255572 mRNA. Translation: AAO85084.1.
CCDSiCCDS41603.2.
RefSeqiNP_001034254.2. NM_001039165.2.
UniGeneiHs.745512.

Genome annotation databases

EnsembliENST00000389832; ENSP00000374482; ENSG00000184350.
GeneIDi116534.
KEGGihsa:116534.
UCSCiuc021qcj.1. human.

Polymorphism databases

DMDMi115502418.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104889 mRNA. Translation: AAI04890.1 . Different initiation.
BC112203 mRNA. Translation: AAI12204.1 . Different initiation.
AY255572 mRNA. Translation: AAO85084.1 .
CCDSi CCDS41603.2.
RefSeqi NP_001034254.2. NM_001039165.2.
UniGenei Hs.745512.

3D structure databases

ProteinModelPortali Q86SM8.
SMRi Q86SM8. Positions 27-160.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 115502418.

Proteomic databases

PaxDbi Q86SM8.
PRIDEi Q86SM8.

Protocols and materials databases

DNASUi 116534.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389832 ; ENSP00000374482 ; ENSG00000184350 .
GeneIDi 116534.
KEGGi hsa:116534.
UCSCi uc021qcj.1. human.

Organism-specific databases

CTDi 116534.
GeneCardsi GC11M003248.
H-InvDB HIX0171334.
HGNCi HGNC:30694. MRGPRE.
HPAi HPA046556.
MIMi 607232. gene.
neXtProti NX_Q86SM8.
PharmGKBi PA134939296.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47650.
HOGENOMi HOG000015412.
HOVERGENi HBG102287.
InParanoidi Q86SM8.
KOi K08393.
OMAi PFGIYWL.
PhylomeDBi Q86SM8.
TreeFami TF336336.

Miscellaneous databases

GeneWikii MRGPRE.
GenomeRNAii 116534.
NextBioi 79966.
PROi Q86SM8.
SOURCEi Search...

Gene expression databases

Bgeei Q86SM8.
CleanExi HS_MRGPRE.
Genevestigatori Q86SM8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view ]
PANTHERi PTHR11334. PTHR11334. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-202.

Entry informationi

Entry nameiMRGRE_HUMAN
AccessioniPrimary (citable) accession number: Q86SM8
Secondary accession number(s): Q2M1V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 9, 2014
Last modified: November 26, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3