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Q86SM8 (MRGRE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
G-protein coupled receptor 167
Gene names
Name:MRGPRE
Synonyms:GPR167, MRGE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Mas-related G-protein coupled receptor member E
PRO_0000069760

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4021Helical; Name=1; Potential
Topological domain41 – 5818Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 10526Extracellular Potential
Transmembrane106 – 12621Helical; Name=3; Potential
Topological domain127 – 14014Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 17514Extracellular Potential
Transmembrane176 – 19621Helical; Name=5; Potential
Topological domain197 – 21620Cytoplasmic Potential
Transmembrane217 – 23721Helical; Name=6; Potential
Topological domain238 – 2403Extracellular Potential
Transmembrane241 – 26121Helical; Name=7; Potential
Topological domain262 – 31150Cytoplasmic Potential

Natural variations

Natural variant151G → S.
Corresponds to variant rs12295710 [ dbSNP | Ensembl ].
VAR_059325
Natural variant1591G → S.
Corresponds to variant rs4391795 [ dbSNP | Ensembl ].
VAR_059326

Sequences

Sequence LengthMass (Da)Tools
Q86SM8 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 60F5293C6FEAD2B0

FASTA31134,155
        10         20         30         40         50         60 
MEPREAGQHV GAANGAQEDV AFNLIILSLT EGLGLGGLLG NGAVLWLLSS NVYRNPFAIY 

        70         80         90        100        110        120 
LLDVACADLI FLGCHMVAIV PDLLQGRLDF PGFVQTSLAT LRFFCYIVGL SLLAAVSVEQ 

       130        140        150        160        170        180 
CLAALFPAWY SCRRPRHLTT CVCALTWALC LLLHLLLSGA CTQFFGEPSR HLCRTLWLVA 

       190        200        210        220        230        240 
AVLLALLCCT MCGASLMLLL RVERGPQRPP PRGFPGLILL TVLLFLFCGL PFGIYWLSRN 

       250        260        270        280        290        300 
LLWYIPHYFY HFSFLMAAVH CAAKPVVYFC LGSAQGRRLP LRLVLQRALG DEAELGAVRE 

       310 
TSRRGLVDIA A 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-201.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC104889 mRNA. Translation: AAI04890.1.
BC112203 mRNA. Translation: AAI12204.1.
AY255572 mRNA. Translation: AAO85084.1.
RefSeqNP_001034254.2. NM_001039165.2.
UniGeneHs.745512.

3D structure databases

ProteinModelPortalQ86SM8.
SMRQ86SM8. Positions 23-50.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM115502418.

Proteomic databases

PaxDbQ86SM8.
PRIDEQ86SM8.

Protocols and materials databases

DNASU116534.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000436689; ENSP00000393251; ENSG00000184350.
GeneID116534.
KEGGhsa:116534.
UCSCuc021qcj.1. human.

Organism-specific databases

CTD116534.
GeneCardsGC11M003248.
H-InvDBHIX0171334.
HGNCHGNC:30694. MRGPRE.
HPAHPA046556.
MIM607232. gene.
neXtProtNX_Q86SM8.
PharmGKBPA134939296.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47650.
HOGENOMHOG000015412.
HOVERGENHBG102287.
InParanoidQ86SM8.
KOK08393.
OMAPFGIYWL.
PhylomeDBQ86SM8.
TreeFamTF336336.

Gene expression databases

BgeeQ86SM8.
CleanExHS_MRGPRE.
GenevestigatorQ86SM8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRGPRE.
GenomeRNAi116534.
NextBio79966.
PROQ86SM8.
SOURCESearch...

Entry information

Entry nameMRGRE_HUMAN
AccessionPrimary (citable) accession number: Q86SM8
Secondary accession number(s): Q2M1V7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries