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Protein

Mas-related G-protein coupled receptor member E

Gene

MRGPRE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
G-protein coupled receptor 167
Gene namesi
Name:MRGPRE
Synonyms:GPR167, MRGE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000184350.9
HGNCiHGNC:30694 MRGPRE
MIMi607232 gene
neXtProtiNX_Q86SM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 59CytoplasmicSequence analysisAdd BLAST18
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 106ExtracellularSequence analysisAdd BLAST26
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 141CytoplasmicSequence analysisAdd BLAST14
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 176ExtracellularSequence analysisAdd BLAST14
Transmembranei177 – 197Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini198 – 217CytoplasmicSequence analysisAdd BLAST20
Transmembranei218 – 238Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini239 – 241ExtracellularSequence analysis3
Transmembranei242 – 262Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini263 – 312CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184350
PharmGKBiPA134939296

Polymorphism and mutation databases

BioMutaiMRGPRE
DMDMi115502418

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697601 – 312Mas-related G-protein coupled receptor member EAdd BLAST312

Proteomic databases

PaxDbiQ86SM8
PeptideAtlasiQ86SM8
PRIDEiQ86SM8

PTM databases

PhosphoSitePlusiQ86SM8

Expressioni

Gene expression databases

BgeeiENSG00000184350
CleanExiHS_MRGPRE
ExpressionAtlasiQ86SM8 baseline and differential

Organism-specific databases

HPAiHPA046556

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374482

Structurei

3D structure databases

ProteinModelPortaliQ86SM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JC07 Eukaryota
ENOG4111507 LUCA
GeneTreeiENSGT00550000074531
HOGENOMiHOG000015412
HOVERGENiHBG102287
InParanoidiQ86SM8
KOiK08393
OMAiCADLIFL
OrthoDBiEOG091G0GUJ
PhylomeDBiQ86SM8
TreeFamiTF336336

Family and domain databases

InterProiView protein in InterPro
IPR019430 7TM_GPCR_serpentine_rcpt_Srx
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026230 MRGPCRE
IPR026234 MRGPCRFAMILY
PANTHERiPTHR11334 PTHR11334, 1 hit
PTHR11334:SF26 PTHR11334:SF26, 1 hit
PfamiView protein in Pfam
PF10328 7TM_GPCR_Srx, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR02111 MRGPCRE
PR02108 MRGPCRFAMILY
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q86SM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS
60 70 80 90 100
SNVYRNPFAI YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA
110 120 130 140 150
TLRFFCYIVG LSLLAAVSVE QCLAALFPAW YSCRRPRHLT TCVCALTWAL
160 170 180 190 200
CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV AAVLLALLCC TMCGASLMLL
210 220 230 240 250
LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR NLLWYIPHYF
260 270 280 290 300
YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
310
ETSRRGLVDI AA
Length:312
Mass (Da):34,286
Last modified:July 9, 2014 - v3
Checksum:i42CC3B3C8D1AF974
GO

Sequence cautioni

The sequence AAI04890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI12204 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05932516G → S. Corresponds to variant dbSNP:rs12295710Ensembl.1
Natural variantiVAR_059326160G → S. Corresponds to variant dbSNP:rs4391795Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104889 mRNA Translation: AAI04890.1 Different initiation.
BC112203 mRNA Translation: AAI12204.1 Different initiation.
AY255572 mRNA Translation: AAO85084.1
CCDSiCCDS41603.2
RefSeqiNP_001034254.2, NM_001039165.2
UniGeneiHs.745512

Genome annotation databases

EnsembliENST00000389832; ENSP00000374482; ENSG00000184350
GeneIDi116534
KEGGihsa:116534

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMRGRE_HUMAN
AccessioniPrimary (citable) accession number: Q86SM8
Secondary accession number(s): Q2M1V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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