Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q86SM8

- MRGRE_HUMAN

UniProt

Q86SM8 - MRGRE_HUMAN

Protein

Mas-related G-protein coupled receptor member E

Gene

MRGPRE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (09 Jul 2014)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mas-related G-protein coupled receptor member E
    Alternative name(s):
    G-protein coupled receptor 167
    Gene namesi
    Name:MRGPRE
    Synonyms:GPR167, MRGE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30694. MRGPRE.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939296.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Mas-related G-protein coupled receptor member EPRO_0000069760Add
    BLAST

    Proteomic databases

    PaxDbiQ86SM8.
    PRIDEiQ86SM8.

    Expressioni

    Gene expression databases

    BgeeiQ86SM8.
    CleanExiHS_MRGPRE.
    GenevestigatoriQ86SM8.

    Organism-specific databases

    HPAiHPA046556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SM8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 10626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini239 – 2413ExtracellularSequence Analysis
    Topological domaini263 – 31250CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei218 – 23821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47650.
    HOGENOMiHOG000015412.
    HOVERGENiHBG102287.
    InParanoidiQ86SM8.
    KOiK08393.
    OMAiPFGIYWL.
    PhylomeDBiQ86SM8.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026230. MRGPCRE.
    IPR026234. MRGPCRFAMILY.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR02111. MRGPCRE.
    PR02108. MRGPCRFAMILY.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86SM8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS    50
    SNVYRNPFAI YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA 100
    TLRFFCYIVG LSLLAAVSVE QCLAALFPAW YSCRRPRHLT TCVCALTWAL 150
    CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV AAVLLALLCC TMCGASLMLL 200
    LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR NLLWYIPHYF 250
    YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR 300
    ETSRRGLVDI AA 312
    Length:312
    Mass (Da):34,286
    Last modified:July 9, 2014 - v3
    Checksum:i42CC3B3C8D1AF974
    GO

    Sequence cautioni

    The sequence AAI04890.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI12204.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161G → S.
    Corresponds to variant rs12295710 [ dbSNP | Ensembl ].
    VAR_059325
    Natural varianti160 – 1601G → S.
    Corresponds to variant rs4391795 [ dbSNP | Ensembl ].
    VAR_059326

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104889 mRNA. Translation: AAI04890.1. Different initiation.
    BC112203 mRNA. Translation: AAI12204.1. Different initiation.
    AY255572 mRNA. Translation: AAO85084.1.
    CCDSiCCDS41603.2.
    RefSeqiNP_001034254.2. NM_001039165.2.
    UniGeneiHs.745512.

    Genome annotation databases

    EnsembliENST00000389832; ENSP00000374482; ENSG00000184350.
    GeneIDi116534.
    KEGGihsa:116534.
    UCSCiuc021qcj.1. human.

    Polymorphism databases

    DMDMi115502418.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC104889 mRNA. Translation: AAI04890.1 . Different initiation.
    BC112203 mRNA. Translation: AAI12204.1 . Different initiation.
    AY255572 mRNA. Translation: AAO85084.1 .
    CCDSi CCDS41603.2.
    RefSeqi NP_001034254.2. NM_001039165.2.
    UniGenei Hs.745512.

    3D structure databases

    ProteinModelPortali Q86SM8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 115502418.

    Proteomic databases

    PaxDbi Q86SM8.
    PRIDEi Q86SM8.

    Protocols and materials databases

    DNASUi 116534.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000389832 ; ENSP00000374482 ; ENSG00000184350 .
    GeneIDi 116534.
    KEGGi hsa:116534.
    UCSCi uc021qcj.1. human.

    Organism-specific databases

    CTDi 116534.
    GeneCardsi GC11M003248.
    H-InvDB HIX0171334.
    HGNCi HGNC:30694. MRGPRE.
    HPAi HPA046556.
    MIMi 607232. gene.
    neXtProti NX_Q86SM8.
    PharmGKBi PA134939296.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47650.
    HOGENOMi HOG000015412.
    HOVERGENi HBG102287.
    InParanoidi Q86SM8.
    KOi K08393.
    OMAi PFGIYWL.
    PhylomeDBi Q86SM8.
    TreeFami TF336336.

    Miscellaneous databases

    GeneWikii MRGPRE.
    GenomeRNAii 116534.
    NextBioi 79966.
    PROi Q86SM8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86SM8.
    CleanExi HS_MRGPRE.
    Genevestigatori Q86SM8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026230. MRGPCRE.
    IPR026234. MRGPCRFAMILY.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR02111. MRGPCRE.
    PR02108. MRGPCRFAMILY.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-202.

    Entry informationi

    Entry nameiMRGRE_HUMAN
    AccessioniPrimary (citable) accession number: Q86SM8
    Secondary accession number(s): Q2M1V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: July 9, 2014
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3