Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q86SM8 (MRGRE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member E
Alternative name(s):
G-protein coupled receptor 167
Gene names
Name:MRGPRE
Synonyms:GPR167, MRGE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Sequence caution

The sequence AAI04890.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI12204.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Mas-related G-protein coupled receptor member E
PRO_0000069760

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 5918Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 10626Extracellular Potential
Transmembrane107 – 12721Helical; Name=3; Potential
Topological domain128 – 14114Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 17614Extracellular Potential
Transmembrane177 – 19721Helical; Name=5; Potential
Topological domain198 – 21720Cytoplasmic Potential
Transmembrane218 – 23821Helical; Name=6; Potential
Topological domain239 – 2413Extracellular Potential
Transmembrane242 – 26221Helical; Name=7; Potential
Topological domain263 – 31250Cytoplasmic Potential

Natural variations

Natural variant161G → S.
Corresponds to variant rs12295710 [ dbSNP | Ensembl ].
VAR_059325
Natural variant1601G → S.
Corresponds to variant rs4391795 [ dbSNP | Ensembl ].
VAR_059326

Sequences

Sequence LengthMass (Da)Tools
Q86SM8 [UniParc].

Last modified July 9, 2014. Version 3.
Checksum: 42CC3B3C8D1AF974

FASTA31234,286
        10         20         30         40         50         60 
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS SNVYRNPFAI 

        70         80         90        100        110        120 
YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA TLRFFCYIVG LSLLAAVSVE 

       130        140        150        160        170        180 
QCLAALFPAW YSCRRPRHLT TCVCALTWAL CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV 

       190        200        210        220        230        240 
AAVLLALLCC TMCGASLMLL LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR 

       250        260        270        280        290        300 
NLLWYIPHYF YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR 

       310 
ETSRRGLVDI AA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-202.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC104889 mRNA. Translation: AAI04890.1. Different initiation.
BC112203 mRNA. Translation: AAI12204.1. Different initiation.
AY255572 mRNA. Translation: AAO85084.1.
RefSeqNP_001034254.2. NM_001039165.2.
UniGeneHs.745512.

3D structure databases

ProteinModelPortalQ86SM8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM115502418.

Proteomic databases

PaxDbQ86SM8.
PRIDEQ86SM8.

Protocols and materials databases

DNASU116534.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000436689; ENSP00000393251; ENSG00000184350.
GeneID116534.
KEGGhsa:116534.
UCSCuc021qcj.1. human.

Organism-specific databases

CTD116534.
GeneCardsGC11M003248.
H-InvDBHIX0171334.
HGNCHGNC:30694. MRGPRE.
HPAHPA046556.
MIM607232. gene.
neXtProtNX_Q86SM8.
PharmGKBPA134939296.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47650.
HOGENOMHOG000015412.
HOVERGENHBG102287.
InParanoidQ86SM8.
KOK08393.
OMAPFGIYWL.
PhylomeDBQ86SM8.
TreeFamTF336336.

Gene expression databases

BgeeQ86SM8.
CleanExHS_MRGPRE.
GenevestigatorQ86SM8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026230. MRGPCRE.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02111. MRGPCRE.
PR02108. MRGPCRFAMILY.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRGPRE.
GenomeRNAi116534.
NextBio79966.
PROQ86SM8.
SOURCESearch...

Entry information

Entry nameMRGRE_HUMAN
AccessionPrimary (citable) accession number: Q86SM8
Secondary accession number(s): Q2M1V7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 9, 2014
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries