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Protein

Mas-related G-protein coupled receptor member G

Gene

MRGPRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member G
Alternative name(s):
G-protein coupled receptor 169
Gene namesi
Name:MRGPRG
Synonyms:GPR169, MRGG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24829. MRGPRG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313ExtracellularSequence AnalysisAdd
BLAST
Transmembranei14 – 3421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini35 – 428CytoplasmicSequence Analysis
Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini64 – 7815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei79 – 9921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini100 – 12021CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini142 – 16322ExtracellularSequence AnalysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini185 – 19511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini217 – 2215ExtracellularSequence Analysis
Transmembranei222 – 24221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini243 – 28947CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953683.

Polymorphism and mutation databases

BioMutaiMRGPRG.
DMDMi115502419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Mas-related G-protein coupled receptor member GPRO_0000069767Add
BLAST

Proteomic databases

PaxDbiQ86SM5.
PRIDEiQ86SM5.

Expressioni

Gene expression databases

BgeeiQ86SM5.
CleanExiHS_MRGPRG.

Organism-specific databases

HPAiHPA058909.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000330612.

Structurei

3D structure databases

ProteinModelPortaliQ86SM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG84039.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ86SM5.
KOiK08395.
OMAiQSLPMGL.
OrthoDBiEOG7F7W9T.
PhylomeDBiQ86SM5.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF2. PTHR11334:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL
60 70 80 90 100
LHLAAADFLF LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS
110 120 130 140 150
VERCLSDLFP ACYQGCRPRH ASAVLCALVW TPTLPAVPLP ANACGLLRNS
160 170 180 190 200
ACPLVCPRYH VASVTWFLVL ARVAWTAGVV LFVWVTCCST RPRPRLYGIV
210 220 230 240 250
LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC VNSSSKPLIY
260 270 280
SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL
Length:289
Mass (Da):31,518
Last modified:October 3, 2006 - v2
Checksum:iDE8457DC94F3E2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109309 Genomic DNA. No translation available.
AY255583 mRNA. Translation: AAO85095.1.
CCDSiCCDS44520.1.
RefSeqiNP_001157849.1. NM_001164377.1.
UniGeneiHs.730306.

Genome annotation databases

EnsembliENST00000332314; ENSP00000330612; ENSG00000182170.
GeneIDi386746.
KEGGihsa:386746.
UCSCiuc001lxp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC109309 Genomic DNA. No translation available.
AY255583 mRNA. Translation: AAO85095.1.
CCDSiCCDS44520.1.
RefSeqiNP_001157849.1. NM_001164377.1.
UniGeneiHs.730306.

3D structure databases

ProteinModelPortaliQ86SM5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000330612.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiMRGPRG.
DMDMi115502419.

Proteomic databases

PaxDbiQ86SM5.
PRIDEiQ86SM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332314; ENSP00000330612; ENSG00000182170.
GeneIDi386746.
KEGGihsa:386746.
UCSCiuc001lxp.2. human.

Organism-specific databases

CTDi386746.
GeneCardsiGC11M003243.
H-InvDBHIX0022396.
HIX0035937.
HGNCiHGNC:24829. MRGPRG.
HPAiHPA058909.
MIMi607234. gene.
neXtProtiNX_Q86SM5.
PharmGKBiPA134953683.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84039.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102287.
InParanoidiQ86SM5.
KOiK08395.
OMAiQSLPMGL.
OrthoDBiEOG7F7W9T.
PhylomeDBiQ86SM5.
TreeFamiTF336336.

Miscellaneous databases

GeneWikiiMRGPRG.
GenomeRNAii386746.
NextBioi101093.
PROiQ86SM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ86SM5.
CleanExiHS_MRGPRG.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF2. PTHR11334:SF2. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54.

Entry informationi

Entry nameiMRGRG_HUMAN
AccessioniPrimary (citable) accession number: Q86SM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 3, 2006
Last modified: July 22, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.