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Q86SM5 (MRGRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mas-related G-protein coupled receptor member G
Alternative name(s):
G-protein coupled receptor 169
Gene names
Name:MRGPRG
Synonyms:GPR169, MRGG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Mas-related G-protein coupled receptor member G
PRO_0000069767

Regions

Topological domain1 – 1313Extracellular Potential
Transmembrane14 – 3421Helical; Name=1; Potential
Topological domain35 – 428Cytoplasmic Potential
Transmembrane43 – 6321Helical; Name=2; Potential
Topological domain64 – 7815Extracellular Potential
Transmembrane79 – 9921Helical; Name=3; Potential
Topological domain100 – 12021Cytoplasmic Potential
Transmembrane121 – 14121Helical; Name=4; Potential
Topological domain142 – 16322Extracellular Potential
Transmembrane164 – 18421Helical; Name=5; Potential
Topological domain185 – 19511Cytoplasmic Potential
Transmembrane196 – 21621Helical; Name=6; Potential
Topological domain217 – 2215Extracellular Potential
Transmembrane222 – 24221Helical; Name=7; Potential
Topological domain243 – 28947Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q86SM5 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: DE8457DC94F3E2C6

FASTA28931,518
        10         20         30         40         50         60 
MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL LHLAAADFLF 

        70         80         90        100        110        120 
LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS VERCLSDLFP ACYQGCRPRH 

       130        140        150        160        170        180 
ASAVLCALVW TPTLPAVPLP ANACGLLRNS ACPLVCPRYH VASVTWFLVL ARVAWTAGVV 

       190        200        210        220        230        240 
LFVWVTCCST RPRPRLYGIV LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC 

       250        260        270        280 
VNSSSKPLIY SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC109309 Genomic DNA. No translation available.
AY255583 mRNA. Translation: AAO85095.1.
CCDSCCDS44520.1.
RefSeqNP_001157849.1. NM_001164377.1.
UniGeneHs.730306.

3D structure databases

ProteinModelPortalQ86SM5.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM115502419.

Proteomic databases

PaxDbQ86SM5.
PRIDEQ86SM5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332314; ENSP00000330612; ENSG00000182170.
GeneID386746.
KEGGhsa:386746.
UCSCuc001lxp.2. human.

Organism-specific databases

CTD386746.
GeneCardsGC11M003195.
H-InvDBHIX0022396.
HIX0035937.
HGNCHGNC:24829. MRGPRG.
HPAHPA058909.
MIM607234. gene.
neXtProtNX_Q86SM5.
PharmGKBPA134953683.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84039.
HOGENOMHOG000015412.
HOVERGENHBG102287.
InParanoidQ86SM5.
KOK08395.
OMAWRTFDSV.
OrthoDBEOG7F7W9T.
PhylomeDBQ86SM5.
TreeFamTF336336.

Gene expression databases

BgeeQ86SM5.
CleanExHS_MRGPRG.
GenevestigatorQ86SM5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026234. MRGPCRFAMILY.
IPR027336. MRGPCRG.
[Graphical view]
PANTHERPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF2. PTHR11334:SF2. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR02108. MRGPCRFAMILY.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMRGPRG.
NextBio101093.
PROQ86SM5.
SOURCESearch...

Entry information

Entry nameMRGRG_HUMAN
AccessionPrimary (citable) accession number: Q86SM5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries