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Q86SM5

- MRGRG_HUMAN

UniProt

Q86SM5 - MRGRG_HUMAN

Protein

Mas-related G-protein coupled receptor member G

Gene

MRGPRG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mas-related G-protein coupled receptor member G
    Alternative name(s):
    G-protein coupled receptor 169
    Gene namesi
    Name:MRGPRG
    Synonyms:GPR169, MRGG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:24829. MRGPRG.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Mas-related G-protein coupled receptor member GPRO_0000069767Add
    BLAST

    Proteomic databases

    PaxDbiQ86SM5.
    PRIDEiQ86SM5.

    Expressioni

    Gene expression databases

    BgeeiQ86SM5.
    CleanExiHS_MRGPRG.
    GenevestigatoriQ86SM5.

    Organism-specific databases

    HPAiHPA058909.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini35 – 428CytoplasmicSequence Analysis
    Topological domaini64 – 7815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini100 – 12021CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini142 – 16322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 19511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini217 – 2215ExtracellularSequence Analysis
    Topological domaini243 – 28947CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG84039.
    HOGENOMiHOG000015412.
    HOVERGENiHBG102287.
    InParanoidiQ86SM5.
    KOiK08395.
    OMAiWRTFDSV.
    OrthoDBiEOG7F7W9T.
    PhylomeDBiQ86SM5.
    TreeFamiTF336336.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR027336. MRGPCRG.
    [Graphical view]
    PANTHERiPTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF2. PTHR11334:SF2. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86SM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL    50
    LHLAAADFLF LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS 100
    VERCLSDLFP ACYQGCRPRH ASAVLCALVW TPTLPAVPLP ANACGLLRNS 150
    ACPLVCPRYH VASVTWFLVL ARVAWTAGVV LFVWVTCCST RPRPRLYGIV 200
    LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC VNSSSKPLIY 250
    SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL 289
    Length:289
    Mass (Da):31,518
    Last modified:October 3, 2006 - v2
    Checksum:iDE8457DC94F3E2C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC109309 Genomic DNA. No translation available.
    AY255583 mRNA. Translation: AAO85095.1.
    CCDSiCCDS44520.1.
    RefSeqiNP_001157849.1. NM_001164377.1.
    UniGeneiHs.730306.

    Genome annotation databases

    EnsembliENST00000332314; ENSP00000330612; ENSG00000182170.
    GeneIDi386746.
    KEGGihsa:386746.
    UCSCiuc001lxp.2. human.

    Polymorphism databases

    DMDMi115502419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC109309 Genomic DNA. No translation available.
    AY255583 mRNA. Translation: AAO85095.1 .
    CCDSi CCDS44520.1.
    RefSeqi NP_001157849.1. NM_001164377.1.
    UniGenei Hs.730306.

    3D structure databases

    ProteinModelPortali Q86SM5.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 115502419.

    Proteomic databases

    PaxDbi Q86SM5.
    PRIDEi Q86SM5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332314 ; ENSP00000330612 ; ENSG00000182170 .
    GeneIDi 386746.
    KEGGi hsa:386746.
    UCSCi uc001lxp.2. human.

    Organism-specific databases

    CTDi 386746.
    GeneCardsi GC11M003195.
    H-InvDB HIX0022396.
    HIX0035937.
    HGNCi HGNC:24829. MRGPRG.
    HPAi HPA058909.
    MIMi 607234. gene.
    neXtProti NX_Q86SM5.
    PharmGKBi PA134953683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84039.
    HOGENOMi HOG000015412.
    HOVERGENi HBG102287.
    InParanoidi Q86SM5.
    KOi K08395.
    OMAi WRTFDSV.
    OrthoDBi EOG7F7W9T.
    PhylomeDBi Q86SM5.
    TreeFami TF336336.

    Miscellaneous databases

    GeneWikii MRGPRG.
    NextBioi 101093.
    PROi Q86SM5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q86SM5.
    CleanExi HS_MRGPRG.
    Genevestigatori Q86SM5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR026234. MRGPCRFAMILY.
    IPR027336. MRGPCRG.
    [Graphical view ]
    PANTHERi PTHR11334. PTHR11334. 1 hit.
    PTHR11334:SF2. PTHR11334:SF2. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR02108. MRGPCRFAMILY.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54.

    Entry informationi

    Entry nameiMRGRG_HUMAN
    AccessioniPrimary (citable) accession number: Q86SM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3