Q86SM5 (MRGRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mas-related G-protein coupled receptor member G

Alternative name(s):
G-protein coupled receptor 169

Gene names

Name:	MRGPRG
Synonyms:	GPR169, MRGG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Mas-related G-protein coupled receptor member G		PRO_0000069767
Regions
	Topological domain	1 – 13	13	Extracellular Potential
	Transmembrane	14 – 34	21	Helical; Name=1; Potential
	Topological domain	35 – 42	8	Cytoplasmic Potential
	Transmembrane	43 – 63	21	Helical; Name=2; Potential
	Topological domain	64 – 78	15	Extracellular Potential
	Transmembrane	79 – 99	21	Helical; Name=3; Potential
	Topological domain	100 – 120	21	Cytoplasmic Potential
	Transmembrane	121 – 141	21	Helical; Name=4; Potential
	Topological domain	142 – 163	22	Extracellular Potential
	Transmembrane	164 – 184	21	Helical; Name=5; Potential
	Topological domain	185 – 195	11	Cytoplasmic Potential
	Transmembrane	196 – 216	21	Helical; Name=6; Potential
	Topological domain	217 – 221	5	Extracellular Potential
	Transmembrane	222 – 242	21	Helical; Name=7; Potential
	Topological domain	243 – 289	47	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q86SM5 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: DE8457DC94F3E2C6	FASTA	289	31,518
	10 20 30 40 50 60 MFGLFGLWRT FDSVVFYLTL IVGLGGPVGN GLVLWNLGFR IKKGPFSIYL LHLAAADFLF 70 80 90 100 110 120 LSCRVGFSVA QAALGAQDTL YFVLTFLWFA VGLWLLAAFS VERCLSDLFP ACYQGCRPRH 130 140 150 160 170 180 ASAVLCALVW TPTLPAVPLP ANACGLLRNS ACPLVCPRYH VASVTWFLVL ARVAWTAGVV 190 200 210 220 230 240 LFVWVTCCST RPRPRLYGIV LGALLLLFFC GLPSVFYWSL QPLLNFLLPV FSPLATLLAC 250 260 270 280 VNSSSKPLIY SGLGRQPGKR EPLRSVLRRA LGEGAELGAR GQSLPMGLL

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-54.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC109309 Genomic DNA. No translation available. AY255583 mRNA. Translation: AAO85095.1.
IPI	IPI00333751.
RefSeq	NP_001157849.1. NM_001164377.1.
UniGene	Hs.730306.
3D structure databases
ProteinModelPortal	Q86SM5.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	115502419.
Proteomic databases
PaxDb	Q86SM5.
PRIDE	Q86SM5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332314; ENSP00000330612; ENSG00000182170.
GeneID	386746.
KEGG	hsa:386746.
UCSC	uc001lxp.2. human.
Organism-specific databases
CTD	386746.
GeneCards	GC11M003195.
H-InvDB	HIX0022396. HIX0035937.
HGNC	HGNC:24829. MRGPRG.
MIM	607234. gene.
neXtProt	NX_Q86SM5.
PharmGKB	PA134953683.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84039.
HOGENOM	HOG000015412.
HOVERGEN	HBG102287.
InParanoid	Q86SM5.
KO	K08395.
OMA	CVNSSSK.
OrthoDB	EOG42BX9F.
Gene expression databases
Bgee	Q86SM5.
CleanEx	HS_MRGPRG.
Genevestigator	Q86SM5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR026234. MRGPCRFAMILY. IPR027336. MRGPCRG. [Graphical view]
PANTHER	PTHR11334. PTHR11334. 1 hit. PTHR11334:SF2. PTHR11334:SF2. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR02108. MRGPCRFAMILY.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	101093.
SOURCE	Search...

Entry information

Entry name

MRGRG_HUMAN

Accession

Primary (citable) accession number: Q86SM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	October 3, 2006
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.