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Q86SK9

- SCD5_HUMAN

UniProt

Q86SK9 - SCD5_HUMAN

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Protein
Stearoyl-CoA desaturase 5
Gene
SCD5, ACOD4, SCD4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.1 Publication

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactori

Iron By similarity.

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. stearoyl-CoA 9-desaturase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.19.1. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Stearoyl-CoA desaturase 5 (EC:1.14.19.1)
Alternative name(s):
Acyl-CoA-desaturase 4
HSCD5
Stearoyl-CoA 9-desaturase
Gene namesi
Name:SCD5
Synonyms:ACOD4, SCD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:21088. SCD5.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021Helical; Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei194 – 21421Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23823Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934692.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Stearoyl-CoA desaturase 5
PRO_0000312653Add
BLAST

Proteomic databases

MaxQBiQ86SK9.
PaxDbiQ86SK9.
PRIDEiQ86SK9.

PTM databases

PhosphoSiteiQ86SK9.

Expressioni

Tissue specificityi

Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.2 Publications

Gene expression databases

ArrayExpressiQ86SK9.
BgeeiQ86SK9.
CleanExiHS_SCD5.
GenevestigatoriQ86SK9.

Organism-specific databases

HPAiHPA042380.

Interactioni

Protein-protein interaction databases

BioGridi123034. 1 interaction.
STRINGi9606.ENSP00000316329.

Structurei

3D structure databases

ProteinModelPortaliQ86SK9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Histidine box-1 By similarity
Motifi131 – 1355Histidine box-2 By similarity
Motifi272 – 2765Histidine box-3 By similarity

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1398.
HOGENOMiHOG000270352.
HOVERGENiHBG003367.
InParanoidiQ86SK9.
KOiK00507.
OMAiAHIGWLM.
OrthoDBiEOG7ZPNKS.
PhylomeDBiQ86SK9.
TreeFamiTF313251.

Family and domain databases

InterProiIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamiPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSiPR00075. FACDDSATRASE.
PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86SK9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGPATDAGK IPFCDAKEEI RAGLESSEGG GGPERPGARG QRQNIVWRNV    50
VLMSLLHLGA VYSLVLIPKA KPLTLLWAYF CFLLAALGVT AGAHRLWSHR 100
SYRAKLPLRI FLAVANSMAF QNDIFEWSRD HRAHHKYSET DADPHNARRG 150
FFFSHIGWLF VRKHRDVIEK GRKLDVTDLL ADPVVRIQRK YYKISVVLMC 200
FVVPTLVPWY IWGESLWNSY FLASILRYTI SLNISWLVNS AAHMYGNRPY 250
DKHISPRQNP LVALGAIGEG FHNYHHTFPF DYSASEFGLN FNPTTWFIDF 300
MCWLGLATDR KRATKPMIEA RKARTGDSSA 330
Length:330
Mass (Da):37,610
Last modified:December 4, 2007 - v2
Checksum:i50652E942C19DB82
GO
Isoform 2 (identifier: Q86SK9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-330: KYYKISVVLM...RKARTGDSSA → NTQHIQKEGR...RALSVSLEVF

Note: No experimental confirmation available.

Show »
Length:256
Mass (Da):28,983
Checksum:iB8A6129F645C0ADE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei190 – 330141KYYKI…GDSSA → NTQHIQKEGRALNQEAACEM LREWHQGHILKVTLPGLHIL ALLHTHCNHSEKCCLMLRAL SVSLEVF in isoform 2.
VSP_029883Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821F → L in BAB14961. 1 Publication
Sequence conflicti127 – 1271W → R in AAP31443. 1 Publication
Sequence conflicti127 – 1271W → R in BAB14961. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF389338 mRNA. Translation: AAP31443.1.
AK024685 mRNA. Translation: BAB14961.1.
AC073413 Genomic DNA. Translation: AAY40977.1.
CH471057 Genomic DNA. Translation: EAX05903.1.
CH471057 Genomic DNA. Translation: EAX05904.1.
BC137429 mRNA. Translation: AAI37430.1.
BC137432 mRNA. Translation: AAI37433.1.
AL831891 mRNA. Translation: CAD38567.1.
CCDSiCCDS34024.1. [Q86SK9-1]
CCDS3595.1. [Q86SK9-2]
RefSeqiNP_001032671.2. NM_001037582.2. [Q86SK9-1]
NP_079182.2. NM_024906.2. [Q86SK9-2]
UniGeneiHs.379191.

Genome annotation databases

EnsembliENST00000273908; ENSP00000273908; ENSG00000145284. [Q86SK9-2]
ENST00000319540; ENSP00000316329; ENSG00000145284. [Q86SK9-1]
GeneIDi79966.
KEGGihsa:79966.
UCSCiuc003hna.2. human. [Q86SK9-1]
uc003hnb.4. human. [Q86SK9-2]

Polymorphism databases

DMDMi162416247.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF389338 mRNA. Translation: AAP31443.1 .
AK024685 mRNA. Translation: BAB14961.1 .
AC073413 Genomic DNA. Translation: AAY40977.1 .
CH471057 Genomic DNA. Translation: EAX05903.1 .
CH471057 Genomic DNA. Translation: EAX05904.1 .
BC137429 mRNA. Translation: AAI37430.1 .
BC137432 mRNA. Translation: AAI37433.1 .
AL831891 mRNA. Translation: CAD38567.1 .
CCDSi CCDS34024.1. [Q86SK9-1 ]
CCDS3595.1. [Q86SK9-2 ]
RefSeqi NP_001032671.2. NM_001037582.2. [Q86SK9-1 ]
NP_079182.2. NM_024906.2. [Q86SK9-2 ]
UniGenei Hs.379191.

3D structure databases

ProteinModelPortali Q86SK9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123034. 1 interaction.
STRINGi 9606.ENSP00000316329.

Chemistry

BindingDBi Q86SK9.
ChEMBLi CHEMBL1275210.

PTM databases

PhosphoSitei Q86SK9.

Polymorphism databases

DMDMi 162416247.

Proteomic databases

MaxQBi Q86SK9.
PaxDbi Q86SK9.
PRIDEi Q86SK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273908 ; ENSP00000273908 ; ENSG00000145284 . [Q86SK9-2 ]
ENST00000319540 ; ENSP00000316329 ; ENSG00000145284 . [Q86SK9-1 ]
GeneIDi 79966.
KEGGi hsa:79966.
UCSCi uc003hna.2. human. [Q86SK9-1 ]
uc003hnb.4. human. [Q86SK9-2 ]

Organism-specific databases

CTDi 79966.
GeneCardsi GC04M083550.
HGNCi HGNC:21088. SCD5.
HPAi HPA042380.
MIMi 608370. gene.
neXtProti NX_Q86SK9.
PharmGKBi PA134934692.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1398.
HOGENOMi HOG000270352.
HOVERGENi HBG003367.
InParanoidi Q86SK9.
KOi K00507.
OMAi AHIGWLM.
OrthoDBi EOG7ZPNKS.
PhylomeDBi Q86SK9.
TreeFami TF313251.

Enzyme and pathway databases

BRENDAi 1.14.19.1. 2681.

Miscellaneous databases

GenomeRNAii 79966.
NextBioi 69971.
PROi Q86SK9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86SK9.
Bgeei Q86SK9.
CleanExi HS_SCD5.
Genevestigatori Q86SK9.

Family and domain databases

InterProi IPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view ]
Pfami PF00487. FA_desaturase. 1 hit.
[Graphical view ]
PRINTSi PR00075. FACDDSATRASE.
PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip."
    Beiraghi S., Zhou M., Talmadge C.B., Went-Sumegi N., Davis J.R., Huang D., Saal H., Seemayer T.A., Sumegi J.
    Gene 309:11-21(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endothelial cell.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 171-330.
    Tissue: Brain.
  7. "Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates."
    Wang J., Yu L., Schmidt R.E., Su C., Huang X., Gould K., Cao G.
    Biochem. Biophys. Res. Commun. 332:735-742(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCD5_HUMAN
AccessioniPrimary (citable) accession number: Q86SK9
Secondary accession number(s): B2RPG0
, Q4W5Q5, Q8NDS0, Q9H7D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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