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Q86SK9

- SCD5_HUMAN

UniProt

Q86SK9 - SCD5_HUMAN

Protein

Stearoyl-CoA desaturase 5

Gene

SCD5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position.1 Publication

    Catalytic activityi

    Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

    Cofactori

    Iron.By similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. stearoyl-CoA 9-desaturase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi1.14.19.1. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stearoyl-CoA desaturase 5 (EC:1.14.19.1)
    Alternative name(s):
    Acyl-CoA-desaturase 4
    HSCD5
    Stearoyl-CoA 9-desaturase
    Gene namesi
    Name:SCD5
    Synonyms:ACOD4, SCD4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:21088. SCD5.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134934692.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Stearoyl-CoA desaturase 5PRO_0000312653Add
    BLAST

    Proteomic databases

    MaxQBiQ86SK9.
    PaxDbiQ86SK9.
    PRIDEiQ86SK9.

    PTM databases

    PhosphoSiteiQ86SK9.

    Expressioni

    Tissue specificityi

    Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.2 Publications

    Gene expression databases

    ArrayExpressiQ86SK9.
    BgeeiQ86SK9.
    CleanExiHS_SCD5.
    GenevestigatoriQ86SK9.

    Organism-specific databases

    HPAiHPA042380.

    Interactioni

    Protein-protein interaction databases

    BioGridi123034. 1 interaction.
    STRINGi9606.ENSP00000316329.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 996Histidine box-1By similarity
    Motifi131 – 1355Histidine box-2By similarity
    Motifi272 – 2765Histidine box-3By similarity

    Domaini

    The histidine box domains may contain the active site and/or be involved in metal ion binding.By similarity

    Sequence similaritiesi

    Belongs to the fatty acid desaturase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1398.
    HOGENOMiHOG000270352.
    HOVERGENiHBG003367.
    InParanoidiQ86SK9.
    KOiK00507.
    OMAiAHIGWLM.
    OrthoDBiEOG7ZPNKS.
    PhylomeDBiQ86SK9.
    TreeFamiTF313251.

    Family and domain databases

    InterProiIPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view]
    PfamiPF00487. FA_desaturase. 1 hit.
    [Graphical view]
    PRINTSiPR00075. FACDDSATRASE.
    PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86SK9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGPATDAGK IPFCDAKEEI RAGLESSEGG GGPERPGARG QRQNIVWRNV    50
    VLMSLLHLGA VYSLVLIPKA KPLTLLWAYF CFLLAALGVT AGAHRLWSHR 100
    SYRAKLPLRI FLAVANSMAF QNDIFEWSRD HRAHHKYSET DADPHNARRG 150
    FFFSHIGWLF VRKHRDVIEK GRKLDVTDLL ADPVVRIQRK YYKISVVLMC 200
    FVVPTLVPWY IWGESLWNSY FLASILRYTI SLNISWLVNS AAHMYGNRPY 250
    DKHISPRQNP LVALGAIGEG FHNYHHTFPF DYSASEFGLN FNPTTWFIDF 300
    MCWLGLATDR KRATKPMIEA RKARTGDSSA 330
    Length:330
    Mass (Da):37,610
    Last modified:December 4, 2007 - v2
    Checksum:i50652E942C19DB82
    GO
    Isoform 2 (identifier: Q86SK9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         190-330: KYYKISVVLM...RKARTGDSSA → NTQHIQKEGR...RALSVSLEVF

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):28,983
    Checksum:iB8A6129F645C0ADE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821F → L in BAB14961. (PubMed:14702039)Curated
    Sequence conflicti127 – 1271W → R in AAP31443. (PubMed:12727354)Curated
    Sequence conflicti127 – 1271W → R in BAB14961. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei190 – 330141KYYKI…GDSSA → NTQHIQKEGRALNQEAACEM LREWHQGHILKVTLPGLHIL ALLHTHCNHSEKCCLMLRAL SVSLEVF in isoform 2. 1 PublicationVSP_029883Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF389338 mRNA. Translation: AAP31443.1.
    AK024685 mRNA. Translation: BAB14961.1.
    AC073413 Genomic DNA. Translation: AAY40977.1.
    CH471057 Genomic DNA. Translation: EAX05903.1.
    CH471057 Genomic DNA. Translation: EAX05904.1.
    BC137429 mRNA. Translation: AAI37430.1.
    BC137432 mRNA. Translation: AAI37433.1.
    AL831891 mRNA. Translation: CAD38567.1.
    CCDSiCCDS34024.1. [Q86SK9-1]
    CCDS3595.1. [Q86SK9-2]
    RefSeqiNP_001032671.2. NM_001037582.2. [Q86SK9-1]
    NP_079182.2. NM_024906.2. [Q86SK9-2]
    UniGeneiHs.379191.

    Genome annotation databases

    EnsembliENST00000273908; ENSP00000273908; ENSG00000145284. [Q86SK9-2]
    ENST00000319540; ENSP00000316329; ENSG00000145284. [Q86SK9-1]
    GeneIDi79966.
    KEGGihsa:79966.
    UCSCiuc003hna.2. human. [Q86SK9-1]
    uc003hnb.4. human. [Q86SK9-2]

    Polymorphism databases

    DMDMi162416247.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF389338 mRNA. Translation: AAP31443.1 .
    AK024685 mRNA. Translation: BAB14961.1 .
    AC073413 Genomic DNA. Translation: AAY40977.1 .
    CH471057 Genomic DNA. Translation: EAX05903.1 .
    CH471057 Genomic DNA. Translation: EAX05904.1 .
    BC137429 mRNA. Translation: AAI37430.1 .
    BC137432 mRNA. Translation: AAI37433.1 .
    AL831891 mRNA. Translation: CAD38567.1 .
    CCDSi CCDS34024.1. [Q86SK9-1 ]
    CCDS3595.1. [Q86SK9-2 ]
    RefSeqi NP_001032671.2. NM_001037582.2. [Q86SK9-1 ]
    NP_079182.2. NM_024906.2. [Q86SK9-2 ]
    UniGenei Hs.379191.

    3D structure databases

    ProteinModelPortali Q86SK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123034. 1 interaction.
    STRINGi 9606.ENSP00000316329.

    Chemistry

    BindingDBi Q86SK9.
    ChEMBLi CHEMBL1275210.

    PTM databases

    PhosphoSitei Q86SK9.

    Polymorphism databases

    DMDMi 162416247.

    Proteomic databases

    MaxQBi Q86SK9.
    PaxDbi Q86SK9.
    PRIDEi Q86SK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273908 ; ENSP00000273908 ; ENSG00000145284 . [Q86SK9-2 ]
    ENST00000319540 ; ENSP00000316329 ; ENSG00000145284 . [Q86SK9-1 ]
    GeneIDi 79966.
    KEGGi hsa:79966.
    UCSCi uc003hna.2. human. [Q86SK9-1 ]
    uc003hnb.4. human. [Q86SK9-2 ]

    Organism-specific databases

    CTDi 79966.
    GeneCardsi GC04M083550.
    HGNCi HGNC:21088. SCD5.
    HPAi HPA042380.
    MIMi 608370. gene.
    neXtProti NX_Q86SK9.
    PharmGKBi PA134934692.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1398.
    HOGENOMi HOG000270352.
    HOVERGENi HBG003367.
    InParanoidi Q86SK9.
    KOi K00507.
    OMAi AHIGWLM.
    OrthoDBi EOG7ZPNKS.
    PhylomeDBi Q86SK9.
    TreeFami TF313251.

    Enzyme and pathway databases

    BRENDAi 1.14.19.1. 2681.

    Miscellaneous databases

    GenomeRNAii 79966.
    NextBioi 69971.
    PROi Q86SK9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86SK9.
    Bgeei Q86SK9.
    CleanExi HS_SCD5.
    Genevestigatori Q86SK9.

    Family and domain databases

    InterProi IPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view ]
    Pfami PF00487. FA_desaturase. 1 hit.
    [Graphical view ]
    PRINTSi PR00075. FACDDSATRASE.
    PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel gene disrupted by a pericentric inversion inv(4)(p13.1q21.1) in a family with cleft lip."
      Beiraghi S., Zhou M., Talmadge C.B., Went-Sumegi N., Davis J.R., Huang D., Saal H., Seemayer T.A., Sumegi J.
      Gene 309:11-21(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endothelial cell.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 171-330.
      Tissue: Brain.
    7. "Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates."
      Wang J., Yu L., Schmidt R.E., Su C., Huang X., Gould K., Cao G.
      Biochem. Biophys. Res. Commun. 332:735-742(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCD5_HUMAN
    AccessioniPrimary (citable) accession number: Q86SK9
    Secondary accession number(s): B2RPG0
    , Q4W5Q5, Q8NDS0, Q9H7D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3