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Q86SJ2

- AMGO2_HUMAN

UniProt

Q86SJ2 - AMGO2_HUMAN

Protein

Amphoterin-induced protein 2

Gene

AMIGO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. heterophilic cell-cell adhesion Source: UniProtKB
    2. homophilic cell adhesion Source: UniProtKB
    3. negative regulation of apoptotic process Source: Ensembl
    4. negative regulation of programmed cell death Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amphoterin-induced protein 2
    Alternative name(s):
    AMIGO-2
    Alivin-1
    Differentially expressed in gastric adenocarcinomas
    Short name:
    DEGA
    Gene namesi
    Name:AMIGO2Imported
    Synonyms:ALI1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24073. AMIGO2.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Nucleus By similarity
    Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672626.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 522483Amphoterin-induced protein 2Sequence AnalysisPRO_0000014509Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 47PROSITE-ProRule annotation
    Disulfide bondi45 ↔ 54PROSITE-ProRule annotation
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi232 ↔ 260PROSITE-ProRule annotation
    Disulfide bondi234 ↔ 282PROSITE-ProRule annotation
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi310 ↔ 363PROSITE-ProRule annotation
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ86SJ2.
    PaxDbiQ86SJ2.
    PeptideAtlasiQ86SJ2.
    PRIDEiQ86SJ2.

    Expressioni

    Tissue specificityi

    Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.1 Publication

    Gene expression databases

    ArrayExpressiQ86SJ2.
    BgeeiQ86SJ2.
    CleanExiHS_AMIGO2.
    GenevestigatoriQ86SJ2.

    Organism-specific databases

    HPAiHPA054004.

    Interactioni

    Subunit structurei

    Binds itself as well as AMIGO1 and AMIGO3.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CACNA1AO005552EBI-3866830,EBI-766279

    Protein-protein interaction databases

    BioGridi131497. 5 interactions.
    IntActiQ86SJ2. 1 interaction.
    STRINGi9606.ENSP00000266581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86SJ2.
    SMRiQ86SJ2. Positions 41-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini40 – 398359ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 522103CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 6829LRRNTAdd
    BLAST
    Repeati69 – 9022LRR 1Add
    BLAST
    Repeati94 – 11522LRR 2Add
    BLAST
    Repeati118 – 13922LRR 3Add
    BLAST
    Repeati142 – 16322LRR 4Add
    BLAST
    Repeati166 – 18722LRR 5Add
    BLAST
    Repeati193 – 21422LRR 6Add
    BLAST
    Domaini228 – 28457LRRCTAdd
    BLAST
    Domaini289 – 37991Ig-like C2-typeSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 6 LRR (leucine-rich) repeats.Sequence Analysis
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146733.
    HOGENOMiHOG000231327.
    HOVERGENiHBG080231.
    InParanoidiQ86SJ2.
    OMAiSCIAMNR.
    OrthoDBiEOG71CFKP.
    PhylomeDBiQ86SJ2.
    TreeFamiTF326838.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86SJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD    50
    IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL 100
    RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN 150
    NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS 200
    YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS 250
    VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA 300
    QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI 350
    ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF 400
    TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA 450
    SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST 500
    RGKSDSDSVN SVFSDTPFVA ST 522
    Length:522
    Mass (Da):57,934
    Last modified:June 1, 2003 - v1
    Checksum:i20A86E3D82C05B9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237005 mRNA. Translation: AAO48946.1.
    AB079074 mRNA. Translation: BAC81188.1.
    AB080610 mRNA. Translation: BAC81189.1.
    AY454159 mRNA. Translation: AAR83271.1.
    AL833007 mRNA. Translation: CAH56293.1.
    BC014103 mRNA. Translation: AAH14103.2.
    BC047595 mRNA. Translation: AAH47595.1.
    BC095477 mRNA. Translation: AAH95477.1.
    CCDSiCCDS8751.1.
    RefSeqiNP_001137140.1. NM_001143668.1.
    NP_862830.1. NM_181847.4.
    XP_005268894.1. XM_005268837.1.
    UniGeneiHs.121520.

    Genome annotation databases

    EnsembliENST00000266581; ENSP00000266581; ENSG00000139211.
    ENST00000429635; ENSP00000406020; ENSG00000139211.
    ENST00000550413; ENSP00000449034; ENSG00000139211.
    GeneIDi347902.
    KEGGihsa:347902.
    UCSCiuc001rpk.3. human.

    Polymorphism databases

    DMDMi68052338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY237005 mRNA. Translation: AAO48946.1 .
    AB079074 mRNA. Translation: BAC81188.1 .
    AB080610 mRNA. Translation: BAC81189.1 .
    AY454159 mRNA. Translation: AAR83271.1 .
    AL833007 mRNA. Translation: CAH56293.1 .
    BC014103 mRNA. Translation: AAH14103.2 .
    BC047595 mRNA. Translation: AAH47595.1 .
    BC095477 mRNA. Translation: AAH95477.1 .
    CCDSi CCDS8751.1.
    RefSeqi NP_001137140.1. NM_001143668.1.
    NP_862830.1. NM_181847.4.
    XP_005268894.1. XM_005268837.1.
    UniGenei Hs.121520.

    3D structure databases

    ProteinModelPortali Q86SJ2.
    SMRi Q86SJ2. Positions 41-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131497. 5 interactions.
    IntActi Q86SJ2. 1 interaction.
    STRINGi 9606.ENSP00000266581.

    Polymorphism databases

    DMDMi 68052338.

    Proteomic databases

    MaxQBi Q86SJ2.
    PaxDbi Q86SJ2.
    PeptideAtlasi Q86SJ2.
    PRIDEi Q86SJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266581 ; ENSP00000266581 ; ENSG00000139211 .
    ENST00000429635 ; ENSP00000406020 ; ENSG00000139211 .
    ENST00000550413 ; ENSP00000449034 ; ENSG00000139211 .
    GeneIDi 347902.
    KEGGi hsa:347902.
    UCSCi uc001rpk.3. human.

    Organism-specific databases

    CTDi 347902.
    GeneCardsi GC12M047469.
    HGNCi HGNC:24073. AMIGO2.
    HPAi HPA054004.
    MIMi 615690. gene.
    neXtProti NX_Q86SJ2.
    PharmGKBi PA142672626.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146733.
    HOGENOMi HOG000231327.
    HOVERGENi HBG080231.
    InParanoidi Q86SJ2.
    OMAi SCIAMNR.
    OrthoDBi EOG71CFKP.
    PhylomeDBi Q86SJ2.
    TreeFami TF326838.

    Miscellaneous databases

    GenomeRNAii 347902.
    NextBioi 99311.
    PROi Q86SJ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q86SJ2.
    Bgeei Q86SJ2.
    CleanExi HS_AMIGO2.
    Genevestigatori Q86SJ2.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS51450. LRR. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats."
      Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.
      J. Cell Biol. 160:963-973(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fibrosarcoma1 Publication.
    2. "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons."
      Ono T., Sekino-Suzuki N., Kikkawa Y., Yonekawa H., Kawashima S.
      J. Neurosci. 23:5887-5896(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: BrainImported.
    3. "DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity."
      Rabenau K.E., O'Toole J.M., Bassi R., Kotanides H., Witte L., Ludwig D.L., Pereira D.S.
      Oncogene 23:5056-5067(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Stomach.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported and UterusImported.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiAMGO2_HUMAN
    AccessioniPrimary (citable) accession number: Q86SJ2
    Secondary accession number(s): Q4VBP6, Q7Z4A0, Q96CN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3