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Q86SJ2

- AMGO2_HUMAN

UniProt

Q86SJ2 - AMGO2_HUMAN

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Protein
Amphoterin-induced protein 2
Gene
AMIGO2, ALI1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.By similarity1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. heterophilic cell-cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: UniProtKB
  3. negative regulation of apoptotic process Source: Ensembl
  4. negative regulation of programmed cell death Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Differentially expressed in gastric adenocarcinomas
Short name:
DEGA
Gene namesi
Name:AMIGO2
Synonyms:ALI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24073. AMIGO2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Nucleus By similarity
Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 398359Extracellular Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Reviewed prediction
Add
BLAST
Topological domaini420 – 522103Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939 Reviewed prediction
Add
BLAST
Chaini40 – 522483Amphoterin-induced protein 2
PRO_0000014509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 47 By similarity
Disulfide bondi45 ↔ 54 By similarity
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi232 ↔ 260 By similarity
Disulfide bondi234 ↔ 282 By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi310 ↔ 363 By similarity
Glycosylationi345 – 3451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi384 – 3841N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ86SJ2.
PaxDbiQ86SJ2.
PeptideAtlasiQ86SJ2.
PRIDEiQ86SJ2.

Expressioni

Tissue specificityi

Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.1 Publication

Gene expression databases

ArrayExpressiQ86SJ2.
BgeeiQ86SJ2.
CleanExiHS_AMIGO2.
GenevestigatoriQ86SJ2.

Organism-specific databases

HPAiHPA054004.

Interactioni

Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3866830,EBI-766279

Protein-protein interaction databases

BioGridi131497. 5 interactions.
IntActiQ86SJ2. 1 interaction.
STRINGi9606.ENSP00000266581.

Structurei

3D structure databases

ProteinModelPortaliQ86SJ2.
SMRiQ86SJ2. Positions 41-387.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 6829LRRNT
Add
BLAST
Repeati69 – 9022LRR 1
Add
BLAST
Repeati94 – 11522LRR 2
Add
BLAST
Repeati118 – 13922LRR 3
Add
BLAST
Repeati142 – 16322LRR 4
Add
BLAST
Repeati166 – 18722LRR 5
Add
BLAST
Repeati193 – 21422LRR 6
Add
BLAST
Domaini228 – 28457LRRCT
Add
BLAST
Domaini289 – 37991Ig-like C2-type
Add
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146733.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86SJ2.
OMAiSCIAMNR.
OrthoDBiEOG71CFKP.
PhylomeDBiQ86SJ2.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD    50
IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL 100
RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN 150
NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS 200
YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS 250
VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA 300
QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI 350
ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF 400
TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA 450
SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST 500
RGKSDSDSVN SVFSDTPFVA ST 522
Length:522
Mass (Da):57,934
Last modified:June 1, 2003 - v1
Checksum:i20A86E3D82C05B9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237005 mRNA. Translation: AAO48946.1.
AB079074 mRNA. Translation: BAC81188.1.
AB080610 mRNA. Translation: BAC81189.1.
AY454159 mRNA. Translation: AAR83271.1.
AL833007 mRNA. Translation: CAH56293.1.
BC014103 mRNA. Translation: AAH14103.2.
BC047595 mRNA. Translation: AAH47595.1.
BC095477 mRNA. Translation: AAH95477.1.
CCDSiCCDS8751.1.
RefSeqiNP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.1.
UniGeneiHs.121520.

Genome annotation databases

EnsembliENST00000266581; ENSP00000266581; ENSG00000139211.
ENST00000321382; ENSP00000320848; ENSG00000139211.
ENST00000429635; ENSP00000406020; ENSG00000139211.
ENST00000550413; ENSP00000449034; ENSG00000139211.
GeneIDi347902.
KEGGihsa:347902.
UCSCiuc001rpk.3. human.

Polymorphism databases

DMDMi68052338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237005 mRNA. Translation: AAO48946.1 .
AB079074 mRNA. Translation: BAC81188.1 .
AB080610 mRNA. Translation: BAC81189.1 .
AY454159 mRNA. Translation: AAR83271.1 .
AL833007 mRNA. Translation: CAH56293.1 .
BC014103 mRNA. Translation: AAH14103.2 .
BC047595 mRNA. Translation: AAH47595.1 .
BC095477 mRNA. Translation: AAH95477.1 .
CCDSi CCDS8751.1.
RefSeqi NP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.1.
UniGenei Hs.121520.

3D structure databases

ProteinModelPortali Q86SJ2.
SMRi Q86SJ2. Positions 41-387.
ModBasei Search...

Protein-protein interaction databases

BioGridi 131497. 5 interactions.
IntActi Q86SJ2. 1 interaction.
STRINGi 9606.ENSP00000266581.

Polymorphism databases

DMDMi 68052338.

Proteomic databases

MaxQBi Q86SJ2.
PaxDbi Q86SJ2.
PeptideAtlasi Q86SJ2.
PRIDEi Q86SJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266581 ; ENSP00000266581 ; ENSG00000139211 .
ENST00000321382 ; ENSP00000320848 ; ENSG00000139211 .
ENST00000429635 ; ENSP00000406020 ; ENSG00000139211 .
ENST00000550413 ; ENSP00000449034 ; ENSG00000139211 .
GeneIDi 347902.
KEGGi hsa:347902.
UCSCi uc001rpk.3. human.

Organism-specific databases

CTDi 347902.
GeneCardsi GC12M047469.
HGNCi HGNC:24073. AMIGO2.
HPAi HPA054004.
MIMi 615690. gene.
neXtProti NX_Q86SJ2.
PharmGKBi PA142672626.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146733.
HOGENOMi HOG000231327.
HOVERGENi HBG080231.
InParanoidi Q86SJ2.
OMAi SCIAMNR.
OrthoDBi EOG71CFKP.
PhylomeDBi Q86SJ2.
TreeFami TF326838.

Miscellaneous databases

GenomeRNAii 347902.
NextBioi 99311.
PROi Q86SJ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q86SJ2.
Bgeei Q86SJ2.
CleanExi HS_AMIGO2.
Genevestigatori Q86SJ2.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats."
    Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.
    J. Cell Biol. 160:963-973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibrosarcoma.
  2. "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons."
    Ono T., Sekino-Suzuki N., Kikkawa Y., Yonekawa H., Kawashima S.
    J. Neurosci. 23:5887-5896(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity."
    Rabenau K.E., O'Toole J.M., Bassi R., Kotanides H., Witte L., Ludwig D.L., Pereira D.S.
    Oncogene 23:5056-5067(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis and Uterus.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiAMGO2_HUMAN
AccessioniPrimary (citable) accession number: Q86SJ2
Secondary accession number(s): Q4VBP6, Q7Z4A0, Q96CN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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