Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amphoterin-induced protein 2

Gene

AMIGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • negative regulation of apoptotic process Source: InterPro
  • negative regulation of programmed cell death Source: UniProtKB
  • positive regulation of synapse assembly Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Differentially expressed in gastric adenocarcinomas
Short name:
DEGA
Gene namesi
Name:AMIGO2Imported
Synonyms:ALI1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24073. AMIGO2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini40 – 398ExtracellularSequence analysisAdd BLAST359
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 522CytoplasmicSequence analysisAdd BLAST103

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi347902.
OpenTargetsiENSG00000139211.
PharmGKBiPA142672626.

Polymorphism and mutation databases

BioMutaiAMIGO2.
DMDMi68052338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_000001450940 – 522Amphoterin-induced protein 2Sequence analysisAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 47PROSITE-ProRule annotation
Disulfide bondi45 ↔ 54PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi232 ↔ 260PROSITE-ProRule annotation
Disulfide bondi234 ↔ 282PROSITE-ProRule annotation
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi310 ↔ 363PROSITE-ProRule annotation
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi384N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ86SJ2.
MaxQBiQ86SJ2.
PaxDbiQ86SJ2.
PeptideAtlasiQ86SJ2.
PRIDEiQ86SJ2.

PTM databases

iPTMnetiQ86SJ2.
PhosphoSitePlusiQ86SJ2.
SwissPalmiQ86SJ2.

Expressioni

Tissue specificityi

Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.1 Publication

Gene expression databases

BgeeiENSG00000139211.
CleanExiHS_AMIGO2.
ExpressionAtlasiQ86SJ2. baseline and differential.
GenevisibleiQ86SJ2. HS.

Organism-specific databases

HPAiHPA054004.
HPA059601.

Interactioni

Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3866830,EBI-766279

Protein-protein interaction databases

BioGridi131497. 5 interactors.
IntActiQ86SJ2. 1 interactor.
STRINGi9606.ENSP00000266581.

Structurei

3D structure databases

ProteinModelPortaliQ86SJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 68LRRNTAdd BLAST29
Repeati69 – 90LRR 1Add BLAST22
Repeati94 – 115LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Domaini228 – 284LRRCTAdd BLAST57
Domaini289 – 379Ig-like C2-typeSequence analysisAdd BLAST91

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86SJ2.
OMAiSCIAMNR.
OrthoDBiEOG091G05D4.
PhylomeDBiQ86SJ2.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031286. AMIGO2.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF209. PTHR24368:SF209. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD
60 70 80 90 100
IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL
110 120 130 140 150
RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN
160 170 180 190 200
NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS
210 220 230 240 250
YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS
260 270 280 290 300
VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA
310 320 330 340 350
QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI
360 370 380 390 400
ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF
410 420 430 440 450
TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA
460 470 480 490 500
SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST
510 520
RGKSDSDSVN SVFSDTPFVA ST
Length:522
Mass (Da):57,934
Last modified:June 1, 2003 - v1
Checksum:i20A86E3D82C05B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237005 mRNA. Translation: AAO48946.1.
AB079074 mRNA. Translation: BAC81188.1.
AB080610 mRNA. Translation: BAC81189.1.
AY454159 mRNA. Translation: AAR83271.1.
AL833007 mRNA. Translation: CAH56293.1.
BC014103 mRNA. Translation: AAH14103.2.
BC047595 mRNA. Translation: AAH47595.1.
BC095477 mRNA. Translation: AAH95477.1.
CCDSiCCDS8751.1.
RefSeqiNP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.3.
UniGeneiHs.121520.

Genome annotation databases

EnsembliENST00000266581; ENSP00000266581; ENSG00000139211.
ENST00000429635; ENSP00000406020; ENSG00000139211.
ENST00000550413; ENSP00000449034; ENSG00000139211.
GeneIDi347902.
KEGGihsa:347902.
UCSCiuc001rpk.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237005 mRNA. Translation: AAO48946.1.
AB079074 mRNA. Translation: BAC81188.1.
AB080610 mRNA. Translation: BAC81189.1.
AY454159 mRNA. Translation: AAR83271.1.
AL833007 mRNA. Translation: CAH56293.1.
BC014103 mRNA. Translation: AAH14103.2.
BC047595 mRNA. Translation: AAH47595.1.
BC095477 mRNA. Translation: AAH95477.1.
CCDSiCCDS8751.1.
RefSeqiNP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.3.
UniGeneiHs.121520.

3D structure databases

ProteinModelPortaliQ86SJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131497. 5 interactors.
IntActiQ86SJ2. 1 interactor.
STRINGi9606.ENSP00000266581.

PTM databases

iPTMnetiQ86SJ2.
PhosphoSitePlusiQ86SJ2.
SwissPalmiQ86SJ2.

Polymorphism and mutation databases

BioMutaiAMIGO2.
DMDMi68052338.

Proteomic databases

EPDiQ86SJ2.
MaxQBiQ86SJ2.
PaxDbiQ86SJ2.
PeptideAtlasiQ86SJ2.
PRIDEiQ86SJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266581; ENSP00000266581; ENSG00000139211.
ENST00000429635; ENSP00000406020; ENSG00000139211.
ENST00000550413; ENSP00000449034; ENSG00000139211.
GeneIDi347902.
KEGGihsa:347902.
UCSCiuc001rpk.4. human.

Organism-specific databases

CTDi347902.
DisGeNETi347902.
GeneCardsiAMIGO2.
HGNCiHGNC:24073. AMIGO2.
HPAiHPA054004.
HPA059601.
MIMi615690. gene.
neXtProtiNX_Q86SJ2.
OpenTargetsiENSG00000139211.
PharmGKBiPA142672626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGN4. Eukaryota.
ENOG410ZZH4. LUCA.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86SJ2.
OMAiSCIAMNR.
OrthoDBiEOG091G05D4.
PhylomeDBiQ86SJ2.
TreeFamiTF326838.

Miscellaneous databases

GenomeRNAii347902.
PROiQ86SJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139211.
CleanExiHS_AMIGO2.
ExpressionAtlasiQ86SJ2. baseline and differential.
GenevisibleiQ86SJ2. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR031283. AMIGO.
IPR031286. AMIGO2.
IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PANTHERiPTHR24368. PTHR24368. 1 hit.
PTHR24368:SF209. PTHR24368:SF209. 1 hit.
PfamiPF00047. ig. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 5 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMGO2_HUMAN
AccessioniPrimary (citable) accession number: Q86SJ2
Secondary accession number(s): Q4VBP6, Q7Z4A0, Q96CN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.