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Q86SJ2

- AMGO2_HUMAN

UniProt

Q86SJ2 - AMGO2_HUMAN

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Protein

Amphoterin-induced protein 2

Gene

AMIGO2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

GO - Biological processi

  1. heterophilic cell-cell adhesion Source: UniProtKB
  2. homophilic cell adhesion Source: UniProtKB
  3. negative regulation of apoptotic process Source: Ensembl
  4. negative regulation of programmed cell death Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Differentially expressed in gastric adenocarcinomas
Short name:
DEGA
Gene namesi
Name:AMIGO2Imported
Synonyms:ALI1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24073. AMIGO2.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Nucleus By similarity
Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 522483Amphoterin-induced protein 2Sequence AnalysisPRO_0000014509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 47PROSITE-ProRule annotation
Disulfide bondi45 ↔ 54PROSITE-ProRule annotation
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi232 ↔ 260PROSITE-ProRule annotation
Disulfide bondi234 ↔ 282PROSITE-ProRule annotation
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi310 ↔ 363PROSITE-ProRule annotation
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ86SJ2.
PaxDbiQ86SJ2.
PeptideAtlasiQ86SJ2.
PRIDEiQ86SJ2.

Expressioni

Tissue specificityi

Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.1 Publication

Gene expression databases

BgeeiQ86SJ2.
CleanExiHS_AMIGO2.
ExpressionAtlasiQ86SJ2. baseline and differential.
GenevestigatoriQ86SJ2.

Organism-specific databases

HPAiHPA054004.

Interactioni

Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3866830,EBI-766279

Protein-protein interaction databases

BioGridi131497. 5 interactions.
IntActiQ86SJ2. 1 interaction.
STRINGi9606.ENSP00000266581.

Structurei

3D structure databases

ProteinModelPortaliQ86SJ2.
SMRiQ86SJ2. Positions 41-387.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini40 – 398359ExtracellularSequence AnalysisAdd
BLAST
Topological domaini420 – 522103CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 6829LRRNTAdd
BLAST
Repeati69 – 9022LRR 1Add
BLAST
Repeati94 – 11522LRR 2Add
BLAST
Repeati118 – 13922LRR 3Add
BLAST
Repeati142 – 16322LRR 4Add
BLAST
Repeati166 – 18722LRR 5Add
BLAST
Repeati193 – 21422LRR 6Add
BLAST
Domaini228 – 28457LRRCTAdd
BLAST
Domaini289 – 37991Ig-like C2-typeSequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 6 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146733.
GeneTreeiENSGT00530000063545.
HOGENOMiHOG000231327.
HOVERGENiHBG080231.
InParanoidiQ86SJ2.
OMAiSCIAMNR.
OrthoDBiEOG71CFKP.
PhylomeDBiQ86SJ2.
TreeFamiTF326838.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD
60 70 80 90 100
IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL
110 120 130 140 150
RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN
160 170 180 190 200
NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS
210 220 230 240 250
YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS
260 270 280 290 300
VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA
310 320 330 340 350
QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI
360 370 380 390 400
ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF
410 420 430 440 450
TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA
460 470 480 490 500
SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST
510 520
RGKSDSDSVN SVFSDTPFVA ST
Length:522
Mass (Da):57,934
Last modified:June 1, 2003 - v1
Checksum:i20A86E3D82C05B9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237005 mRNA. Translation: AAO48946.1.
AB079074 mRNA. Translation: BAC81188.1.
AB080610 mRNA. Translation: BAC81189.1.
AY454159 mRNA. Translation: AAR83271.1.
AL833007 mRNA. Translation: CAH56293.1.
BC014103 mRNA. Translation: AAH14103.2.
BC047595 mRNA. Translation: AAH47595.1.
BC095477 mRNA. Translation: AAH95477.1.
CCDSiCCDS8751.1.
RefSeqiNP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.1.
UniGeneiHs.121520.

Genome annotation databases

EnsembliENST00000266581; ENSP00000266581; ENSG00000139211.
ENST00000429635; ENSP00000406020; ENSG00000139211.
ENST00000550413; ENSP00000449034; ENSG00000139211.
GeneIDi347902.
KEGGihsa:347902.
UCSCiuc001rpk.3. human.

Polymorphism databases

DMDMi68052338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY237005 mRNA. Translation: AAO48946.1 .
AB079074 mRNA. Translation: BAC81188.1 .
AB080610 mRNA. Translation: BAC81189.1 .
AY454159 mRNA. Translation: AAR83271.1 .
AL833007 mRNA. Translation: CAH56293.1 .
BC014103 mRNA. Translation: AAH14103.2 .
BC047595 mRNA. Translation: AAH47595.1 .
BC095477 mRNA. Translation: AAH95477.1 .
CCDSi CCDS8751.1.
RefSeqi NP_001137140.1. NM_001143668.1.
NP_862830.1. NM_181847.4.
XP_005268894.1. XM_005268837.1.
UniGenei Hs.121520.

3D structure databases

ProteinModelPortali Q86SJ2.
SMRi Q86SJ2. Positions 41-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131497. 5 interactions.
IntActi Q86SJ2. 1 interaction.
STRINGi 9606.ENSP00000266581.

Polymorphism databases

DMDMi 68052338.

Proteomic databases

MaxQBi Q86SJ2.
PaxDbi Q86SJ2.
PeptideAtlasi Q86SJ2.
PRIDEi Q86SJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266581 ; ENSP00000266581 ; ENSG00000139211 .
ENST00000429635 ; ENSP00000406020 ; ENSG00000139211 .
ENST00000550413 ; ENSP00000449034 ; ENSG00000139211 .
GeneIDi 347902.
KEGGi hsa:347902.
UCSCi uc001rpk.3. human.

Organism-specific databases

CTDi 347902.
GeneCardsi GC12M047469.
HGNCi HGNC:24073. AMIGO2.
HPAi HPA054004.
MIMi 615690. gene.
neXtProti NX_Q86SJ2.
PharmGKBi PA142672626.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146733.
GeneTreei ENSGT00530000063545.
HOGENOMi HOG000231327.
HOVERGENi HBG080231.
InParanoidi Q86SJ2.
OMAi SCIAMNR.
OrthoDBi EOG71CFKP.
PhylomeDBi Q86SJ2.
TreeFami TF326838.

Miscellaneous databases

GenomeRNAii 347902.
NextBioi 99311.
PROi Q86SJ2.
SOURCEi Search...

Gene expression databases

Bgeei Q86SJ2.
CleanExi HS_AMIGO2.
ExpressionAtlasi Q86SJ2. baseline and differential.
Genevestigatori Q86SJ2.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats."
    Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.
    J. Cell Biol. 160:963-973(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibrosarcoma1 Publication.
  2. "Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons."
    Ono T., Sekino-Suzuki N., Kikkawa Y., Yonekawa H., Kawashima S.
    J. Neurosci. 23:5887-5896(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: BrainImported.
  3. "DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity."
    Rabenau K.E., O'Toole J.M., Bassi R., Kotanides H., Witte L., Ludwig D.L., Pereira D.S.
    Oncogene 23:5056-5067(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Stomach.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported and UterusImported.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiAMGO2_HUMAN
AccessioniPrimary (citable) accession number: Q86SJ2
Secondary accession number(s): Q4VBP6, Q7Z4A0, Q96CN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3