Q86SH4 (PRNT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative testis-specific prion protein

Alternative name(s):
Protein M8

Gene names

Name:

PRNT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Specifically expressed in adult testis. Ref.1
Miscellaneous	This putative protein is only present in primates and not in other mammals.
Caution	Could be the product of a pseudogene. According to Ref.5, no evidence has been tendered concerning the existence of this protein. According to Ref.1, it is related to the prion family because it is found in the same genomic cluster as PRNP and PRND. However, it does not share any sequence similarity with these 2 proteins.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 94	76	Putative testis-specific prion protein		PRO_0000320163
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	50	1	T → S. Corresponds to variant rs7270737 [ dbSNP | Ensembl ].		VAR_039151

Sequences

	Sequence		Length	Mass (Da)
	Q86SH4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7A6726D67325D115	FASTA	94	10,756
	10 20 30 40 50 60 MQHSLVFFFA VILHLSHLLH LDASIHPFRL PFSSKPFLLI PMSNTTLPHT AWPLSFLHQT 70 80 90 VSTLKAVAVT HSLWHLQIPV DCQACNRKSK KIYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human prion protein (PrP) gene locus." Makrinou E., Collinge J., Antoniou M. Mamm. Genome 13:696-703(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Comparative genomic organization of the human and bovine PRNP locus." Choi S.-H., Kim I.-C., Kim D.-S., Kim D.-W., Chae S.-H., Choi H.-H., Choi I., Yeo J.-S., Song M.-N., Park H.-S. Genomics 87:598-607(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHYLOGENY.
[5]	"The prion protein family: diversity, rivalry, and dysfunction." Watts J.C., Westaway D. Biochim. Biophys. Acta 1772:654-672(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHYLOGENY.
[6]	"Comparative genomic analysis of prion genes." Premzl M., Gamulin V. BMC Genomics 8:1-1(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHYLOGENY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ427539 mRNA. Translation: CAD20690.1. AJ427540 mRNA. Translation: CAD20691.1. AL133396 Genomic DNA. Translation: CAX15126.1. CH471133 Genomic DNA. Translation: EAX10447.1.
IPI	IPI00218954.
UniGene	Hs.126516.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000404306.
Proteomic databases
PRIDE	Q86SH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326539; ENSP00000321242; ENSG00000180259. ENST00000418528; ENSP00000409280; ENSG00000180259. ENST00000423718; ENSP00000404306; ENSG00000180259.
Organism-specific databases
GeneCards	GC20M004660.
HGNC	HGNC:18046. PRNT.
HPA	HPA045000.
neXtProt	NX_Q86SH4.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000232079.
HOVERGEN	HBG067398.
InParanoid	Q86SH4.
OrthoDB	EOG48SGW6.
PhylomeDB	Q86SH4.
Gene expression databases
Bgee	Q86SH4.
CleanEx	HS_PRNT.
Genevestigator	Q86SH4.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PRNT_HUMAN

Accession

Primary (citable) accession number: Q86SH4
Secondary accession number(s): B2RPD9, B7ZBI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.