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Protein

Putative testis-specific prion protein

Gene

PRNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative testis-specific prion protein
Alternative name(s):
Protein M8
Gene namesi
Name:PRNT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18046. PRNT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 9476Putative testis-specific prion proteinPRO_0000320163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ86SH4.
PRIDEiQ86SH4.

Expressioni

Tissue specificityi

Specifically expressed in adult testis.1 Publication

Gene expression databases

BgeeiENSG00000180259.
CleanExiHS_PRNT.
GenevisibleiQ86SH4. HS.

Organism-specific databases

HPAiHPA045000.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321242.

Structurei

3D structure databases

ProteinModelPortaliQ86SH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232079.
HOVERGENiHBG067398.
OrthoDBiEOG091G12WE.
PhylomeDBiQ86SH4.

Family and domain databases

InterProiIPR029172. PRNT.
[Graphical view]
PfamiPF15174. PRNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHSLVFFFA VILHLSHLLH LDASIHPFRL PFSSKPFLLI PMSNTTLPHT
60 70 80 90
AWPLSFLHQT VSTLKAVAVT HSLWHLQIPV DCQACNRKSK KIYC
Length:94
Mass (Da):10,756
Last modified:June 1, 2003 - v1
Checksum:i7A6726D67325D115
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501T → S.
Corresponds to variant rs7270737 [ dbSNP | Ensembl ].
VAR_039151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427539 mRNA. Translation: CAD20690.1.
AJ427540 mRNA. Translation: CAD20691.1.
AL133396 Genomic DNA. Translation: CAX15126.1.
CH471133 Genomic DNA. Translation: EAX10447.1.
UniGeneiHs.126516.

Genome annotation databases

EnsembliENST00000326539; ENSP00000321242; ENSG00000180259.
ENST00000418528; ENSP00000409280; ENSG00000180259.
ENST00000423718; ENSP00000404306; ENSG00000180259.
UCSCiuc002wlb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ427539 mRNA. Translation: CAD20690.1.
AJ427540 mRNA. Translation: CAD20691.1.
AL133396 Genomic DNA. Translation: CAX15126.1.
CH471133 Genomic DNA. Translation: EAX10447.1.
UniGeneiHs.126516.

3D structure databases

ProteinModelPortaliQ86SH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321242.

Proteomic databases

PaxDbiQ86SH4.
PRIDEiQ86SH4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326539; ENSP00000321242; ENSG00000180259.
ENST00000418528; ENSP00000409280; ENSG00000180259.
ENST00000423718; ENSP00000404306; ENSG00000180259.
UCSCiuc002wlb.4. human.

Organism-specific databases

GeneCardsiPRNT.
HGNCiHGNC:18046. PRNT.
HPAiHPA045000.
neXtProtiNX_Q86SH4.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000232079.
HOVERGENiHBG067398.
OrthoDBiEOG091G12WE.
PhylomeDBiQ86SH4.

Gene expression databases

BgeeiENSG00000180259.
CleanExiHS_PRNT.
GenevisibleiQ86SH4. HS.

Family and domain databases

InterProiIPR029172. PRNT.
[Graphical view]
PfamiPF15174. PRNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRNT_HUMAN
AccessioniPrimary (citable) accession number: Q86SH4
Secondary accession number(s): B2RPD9, B7ZBI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This putative protein is only present in primates and not in other mammals.

Caution

Could be the product of a pseudogene. According to PubMed:17562432, no evidence has been tendered concerning the existence of this protein.Curated
According to PubMed:12514748, it is related to the prion family because it is found in the same genomic cluster as PRNP and PRND. However, it does not share any sequence similarity with these 2 proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.