Q86SH2 (ZAR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zygote arrest protein 1

Alternative name(s):
Oocyte-specific maternal effect factor

Gene names

Name:

ZAR1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for female fertility. May play a role in the oocyte-to-embryo transition By similarity.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Ovary and testis. Ref.1
Sequence similarities	Belongs to the ZAR1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	bile acid:sodium symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Zygote arrest protein 1		PRO_0000187011

Sequences

	Sequence		Length	Mass (Da)
	Q86SH2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 81CEF693C5BA14A5	FASTA	424	45,873
	10 20 30 40 50 60 MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA SSPCSAGAAS 70 80 90 100 110 120 LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR AGSCDVAVQV SPRIDAAVQC 130 140 150 160 170 180 SLGRRTLQRR ARDPESPAGP GAEGTTGGGS FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA 190 200 210 220 230 240 VYSPLALRRL TAFLEGPGPA AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD 250 260 270 280 290 300 DDGEAQAAVR ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA 310 320 330 340 350 360 VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT NKVYFKQFCR 370 380 390 400 410 420 TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR QDLCGRCKGK RLSCDSTFSF KYII

References

[1]	"Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition." Wu X., Viveiros M.M., Eppig J.J., Bai Y., Fitzpatrick S.L., Matzuk M.M. Nat. Genet. 33:187-191(2003) [PubMed: 12539046] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries." Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M. Biol. Reprod. 69:861-867(2003) [PubMed: 12773403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY191416 mRNA. Translation: AAO24707.1. AY193890 Genomic DNA. Translation: AAO24709.1.
IPI	IPI00328400.
RefSeq	NP_783318.1. NM_175619.1.
UniGene	Hs.276457.
3D structure databases
ProteinModelPortal	Q86SH2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86SH2.
Polymorphism databases
DMDM	45477298.
Proteomic databases
PRIDE	Q86SH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000327939; ENSP00000329803; ENSG00000182223.
GeneID	326340.
KEGG	hsa:326340.
UCSC	uc003gyd.1. human.
Organism-specific databases
CTD	326340.
GeneCards	GC04P048492.
H-InvDB	HIX0031408.
HGNC	HGNC:20436. ZAR1.
MIM	607520. gene.
neXtProt	NX_Q86SH2.
PharmGKB	PA134938240.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16852.
GeneTree	ENSGT00390000012305.
HOGENOM	HBG443602.
HOVERGEN	HBG050367.
InParanoid	Q86SH2.
OMA	VAVYSPV.
OrthoDB	EOG4P2Q2H.
PhylomeDB	Q86SH2.
Gene expression databases
ArrayExpress	Q86SH2.
Bgee	Q86SH2.
CleanEx	HS_ZAR1.
Genevestigator	Q86SH2.
GermOnline	ENSG00000182223. Homo sapiens.
Family and domain databases
InterPro	IPR002657. BilAc/Na_symport. [Graphical view]
PANTHER	PTHR10361. BilAc/Na_symport. 1 hit.
ProtoNet	Search...
Other
NextBio	96650.
SOURCE	Search...

Entry information

Entry name

ZAR1_HUMAN

Accession

Primary (citable) accession number: Q86SH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.