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Protein

Zygote arrest protein 1

Gene

ZAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

BioCyciZFISH:G66-31839-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zygote arrest protein 1
Alternative name(s):
Oocyte-specific maternal effect factor
Gene namesi
Name:ZAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:20436. ZAR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi326340.
OpenTargetsiENSG00000182223.
PharmGKBiPA134938240.

Polymorphism and mutation databases

BioMutaiZAR1.
DMDMi45477298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870111 – 424Zygote arrest protein 1Add BLAST424

Proteomic databases

PaxDbiQ86SH2.
PRIDEiQ86SH2.

PTM databases

iPTMnetiQ86SH2.
PhosphoSitePlusiQ86SH2.

Expressioni

Tissue specificityi

Ovary and testis.1 Publication

Gene expression databases

BgeeiENSG00000182223.
CleanExiHS_ZAR1.
GenevisibleiQ86SH2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329803.

Structurei

3D structure databases

ProteinModelPortaliQ86SH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZAR1 family.Curated

Phylogenomic databases

eggNOGiENOG410IEKQ. Eukaryota.
ENOG4110E36. LUCA.
GeneTreeiENSGT00390000012305.
HOGENOMiHOG000108874.
HOVERGENiHBG050367.
InParanoidiQ86SH2.
KOiK18762.
OMAiGEVWTRK.
OrthoDBiEOG091G090Z.
PhylomeDBiQ86SH2.
TreeFamiTF331383.

Family and domain databases

InterProiIPR026775. Zar1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR31054. PTHR31054. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86SH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA
60 70 80 90 100
SSPCSAGAAS LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR
110 120 130 140 150
AGSCDVAVQV SPRIDAAVQC SLGRRTLQRR ARDPESPAGP GAEGTTGGGS
160 170 180 190 200
FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA VYSPLALRRL TAFLEGPGPA
210 220 230 240 250
AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD DDGEAQAAVR
260 270 280 290 300
ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA
310 320 330 340 350
VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT
360 370 380 390 400
NKVYFKQFCR TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR
410 420
QDLCGRCKGK RLSCDSTFSF KYII
Length:424
Mass (Da):45,873
Last modified:June 1, 2003 - v1
Checksum:i81CEF693C5BA14A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191416 mRNA. Translation: AAO24707.1.
AY193890 Genomic DNA. Translation: AAO24709.1.
CCDSiCCDS3483.1.
RefSeqiNP_783318.1. NM_175619.2.
UniGeneiHs.276457.

Genome annotation databases

EnsembliENST00000327939; ENSP00000329803; ENSG00000182223.
GeneIDi326340.
KEGGihsa:326340.
UCSCiuc003gyd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY191416 mRNA. Translation: AAO24707.1.
AY193890 Genomic DNA. Translation: AAO24709.1.
CCDSiCCDS3483.1.
RefSeqiNP_783318.1. NM_175619.2.
UniGeneiHs.276457.

3D structure databases

ProteinModelPortaliQ86SH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329803.

PTM databases

iPTMnetiQ86SH2.
PhosphoSitePlusiQ86SH2.

Polymorphism and mutation databases

BioMutaiZAR1.
DMDMi45477298.

Proteomic databases

PaxDbiQ86SH2.
PRIDEiQ86SH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327939; ENSP00000329803; ENSG00000182223.
GeneIDi326340.
KEGGihsa:326340.
UCSCiuc003gyd.4. human.

Organism-specific databases

CTDi326340.
DisGeNETi326340.
GeneCardsiZAR1.
HGNCiHGNC:20436. ZAR1.
MIMi607520. gene.
neXtProtiNX_Q86SH2.
OpenTargetsiENSG00000182223.
PharmGKBiPA134938240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKQ. Eukaryota.
ENOG4110E36. LUCA.
GeneTreeiENSGT00390000012305.
HOGENOMiHOG000108874.
HOVERGENiHBG050367.
InParanoidiQ86SH2.
KOiK18762.
OMAiGEVWTRK.
OrthoDBiEOG091G090Z.
PhylomeDBiQ86SH2.
TreeFamiTF331383.

Enzyme and pathway databases

BioCyciZFISH:G66-31839-MONOMER.

Miscellaneous databases

GenomeRNAii326340.
PROiQ86SH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182223.
CleanExiHS_ZAR1.
GenevisibleiQ86SH2. HS.

Family and domain databases

InterProiIPR026775. Zar1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR31054. PTHR31054. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
SMARTiSM01328. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZAR1_HUMAN
AccessioniPrimary (citable) accession number: Q86SH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.