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Protein

Protein S100-A7A

Gene

S100A7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18Zinc 11
Metal bindingi28Zinc 21
Metal bindingi38Zinc 21
Metal bindingi66Zinc 21
Metal bindingi87Zinc 11
Metal bindingi91Zinc 11

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein self-association Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30950-MONOMER.
ReactomeiR-HSA-6799990. Metal sequestration by antimicrobial proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7A
Alternative name(s):
S100 calcium-binding protein A15
S100 calcium-binding protein A7-like 1
S100 calcium-binding protein A7A
Gene namesi
Name:S100A7A
Synonyms:S100A15, S100A7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21657. S100A7A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi338324.
OpenTargetsiENSG00000184330.
PharmGKBiPA162402333.

Polymorphism and mutation databases

BioMutaiS100A7A.
DMDMi37088296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439912 – 101Protein S100-A7AAdd BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ86SG5.
PaxDbiQ86SG5.
PeptideAtlasiQ86SG5.
PRIDEiQ86SG5.

PTM databases

iPTMnetiQ86SG5.
PhosphoSitePlusiQ86SG5.

Expressioni

Tissue specificityi

Overexpressed in psoriasis.

Gene expression databases

BgeeiENSG00000184330.
CleanExiHS_S100A7A.
GenevisibleiQ86SG5. HS.

Organism-specific databases

HPAiHPA006997.

Interactioni

GO - Molecular functioni

  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi130711. 6 interactors.
STRINGi9606.ENSP00000329008.

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 20Combined sources16
Helixi29 – 39Combined sources11
Helixi41 – 49Combined sources9
Helixi54 – 62Combined sources9
Beta strandi67 – 70Combined sources4
Helixi72 – 90Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQIX-ray1.70A1-101[»]
ProteinModelPortaliQ86SG5.
SMRiQ86SG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ86SG5.
OMAiCHTSSEN.
OrthoDBiEOG091G0Y5T.
PhylomeDBiQ86SG5.
TreeFamiTF341148.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK
60 70 80 90 100
GIHYLATVFE KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS

Q
Length:101
Mass (Da):11,305
Last modified:January 23, 2007 - v3
Checksum:iA311A921414C9732
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06104823R → H.Corresponds to variant rs55985140dbSNPEnsembl.1
Natural variantiVAR_04846884A → T.Corresponds to variant rs3006414dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189117 Genomic DNA. Translation: AAO40032.1.
AY189118 mRNA. Translation: AAO40033.1.
AY189119 mRNA. Translation: AAO40034.1.
AL591704 Genomic DNA. Translation: CAI19499.1.
CH471121 Genomic DNA. Translation: EAW53328.1.
CH471121 Genomic DNA. Translation: EAW53329.1.
BR000043 Genomic DNA. Translation: FAA00014.1.
CCDSiCCDS30872.1.
RefSeqiNP_789793.1. NM_176823.3.
UniGeneiHs.442337.

Genome annotation databases

EnsembliENST00000329256; ENSP00000329008; ENSG00000184330.
ENST00000368728; ENSP00000357717; ENSG00000184330.
ENST00000368729; ENSP00000357718; ENSG00000184330.
GeneIDi338324.
KEGGihsa:338324.
UCSCiuc001fbt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189117 Genomic DNA. Translation: AAO40032.1.
AY189118 mRNA. Translation: AAO40033.1.
AY189119 mRNA. Translation: AAO40034.1.
AL591704 Genomic DNA. Translation: CAI19499.1.
CH471121 Genomic DNA. Translation: EAW53328.1.
CH471121 Genomic DNA. Translation: EAW53329.1.
BR000043 Genomic DNA. Translation: FAA00014.1.
CCDSiCCDS30872.1.
RefSeqiNP_789793.1. NM_176823.3.
UniGeneiHs.442337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQIX-ray1.70A1-101[»]
ProteinModelPortaliQ86SG5.
SMRiQ86SG5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130711. 6 interactors.
STRINGi9606.ENSP00000329008.

PTM databases

iPTMnetiQ86SG5.
PhosphoSitePlusiQ86SG5.

Polymorphism and mutation databases

BioMutaiS100A7A.
DMDMi37088296.

Proteomic databases

MaxQBiQ86SG5.
PaxDbiQ86SG5.
PeptideAtlasiQ86SG5.
PRIDEiQ86SG5.

Protocols and materials databases

DNASUi338324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329256; ENSP00000329008; ENSG00000184330.
ENST00000368728; ENSP00000357717; ENSG00000184330.
ENST00000368729; ENSP00000357718; ENSG00000184330.
GeneIDi338324.
KEGGihsa:338324.
UCSCiuc001fbt.1. human.

Organism-specific databases

CTDi338324.
DisGeNETi338324.
GeneCardsiS100A7A.
HGNCiHGNC:21657. S100A7A.
HPAiHPA006997.
neXtProtiNX_Q86SG5.
OpenTargetsiENSG00000184330.
PharmGKBiPA162402333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ86SG5.
OMAiCHTSSEN.
OrthoDBiEOG091G0Y5T.
PhylomeDBiQ86SG5.
TreeFamiTF341148.

Enzyme and pathway databases

BioCyciZFISH:G66-30950-MONOMER.
ReactomeiR-HSA-6799990. Metal sequestration by antimicrobial proteins.

Miscellaneous databases

GeneWikiiS100A15.
GenomeRNAii338324.
PROiQ86SG5.

Gene expression databases

BgeeiENSG00000184330.
CleanExiHS_S100A7A.
GenevisibleiQ86SG5. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1A7A_HUMAN
AccessioniPrimary (citable) accession number: Q86SG5
Secondary accession number(s): D3DV38, Q5SY69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.