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Protein

Protein S100-A7A

Gene

S100A7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Zinc 1
Metal bindingi28 – 281Zinc 2
Metal bindingi38 – 381Zinc 2
Metal bindingi66 – 661Zinc 2
Metal bindingi87 – 871Zinc 1
Metal bindingi91 – 911Zinc 1

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein self-association Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7A
Alternative name(s):
S100 calcium-binding protein A15
S100 calcium-binding protein A7-like 1
S100 calcium-binding protein A7A
Gene namesi
Name:S100A7A
Synonyms:S100A15, S100A7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21657. S100A7A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402333.

Polymorphism and mutation databases

BioMutaiS100A7A.
DMDMi37088296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 101100Protein S100-A7APRO_0000143991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ86SG5.
PRIDEiQ86SG5.

PTM databases

iPTMnetiQ86SG5.
PhosphoSiteiQ86SG5.

Expressioni

Tissue specificityi

Overexpressed in psoriasis.

Gene expression databases

BgeeiQ86SG5.
CleanExiHS_S100A7A.
GenevisibleiQ86SG5. HS.

Organism-specific databases

HPAiHPA006997.

Interactioni

GO - Molecular functioni

  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi130711. 6 interactions.
STRINGi9606.ENSP00000329008.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2016Combined sources
Helixi29 – 3911Combined sources
Helixi41 – 499Combined sources
Helixi54 – 629Combined sources
Beta strandi67 – 704Combined sources
Helixi72 – 9019Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AQIX-ray1.70A1-101[»]
ProteinModelPortaliQ86SG5.
SMRiQ86SG5. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ86SG5.
OMAiCHTSSEN.
OrthoDBiEOG79SF08.
PhylomeDBiQ86SG5.
TreeFamiTF341148.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK
60 70 80 90 100
GIHYLATVFE KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS

Q
Length:101
Mass (Da):11,305
Last modified:January 23, 2007 - v3
Checksum:iA311A921414C9732
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231R → H.
Corresponds to variant rs55985140 [ dbSNP | Ensembl ].
VAR_061048
Natural varianti84 – 841A → T.
Corresponds to variant rs3006414 [ dbSNP | Ensembl ].
VAR_048468

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189117 Genomic DNA. Translation: AAO40032.1.
AY189118 mRNA. Translation: AAO40033.1.
AY189119 mRNA. Translation: AAO40034.1.
AL591704 Genomic DNA. Translation: CAI19499.1.
CH471121 Genomic DNA. Translation: EAW53328.1.
CH471121 Genomic DNA. Translation: EAW53329.1.
BR000043 Genomic DNA. Translation: FAA00014.1.
CCDSiCCDS30872.1.
RefSeqiNP_789793.1. NM_176823.3.
XP_006711350.1. XM_006711287.2.
UniGeneiHs.442337.

Genome annotation databases

EnsembliENST00000329256; ENSP00000329008; ENSG00000184330.
ENST00000368728; ENSP00000357717; ENSG00000184330.
ENST00000368729; ENSP00000357718; ENSG00000184330.
GeneIDi338324.
KEGGihsa:338324.
UCSCiuc001fbt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189117 Genomic DNA. Translation: AAO40032.1.
AY189118 mRNA. Translation: AAO40033.1.
AY189119 mRNA. Translation: AAO40034.1.
AL591704 Genomic DNA. Translation: CAI19499.1.
CH471121 Genomic DNA. Translation: EAW53328.1.
CH471121 Genomic DNA. Translation: EAW53329.1.
BR000043 Genomic DNA. Translation: FAA00014.1.
CCDSiCCDS30872.1.
RefSeqiNP_789793.1. NM_176823.3.
XP_006711350.1. XM_006711287.2.
UniGeneiHs.442337.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AQIX-ray1.70A1-101[»]
ProteinModelPortaliQ86SG5.
SMRiQ86SG5. Positions 2-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130711. 6 interactions.
STRINGi9606.ENSP00000329008.

PTM databases

iPTMnetiQ86SG5.
PhosphoSiteiQ86SG5.

Polymorphism and mutation databases

BioMutaiS100A7A.
DMDMi37088296.

Proteomic databases

PaxDbiQ86SG5.
PRIDEiQ86SG5.

Protocols and materials databases

DNASUi338324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329256; ENSP00000329008; ENSG00000184330.
ENST00000368728; ENSP00000357717; ENSG00000184330.
ENST00000368729; ENSP00000357718; ENSG00000184330.
GeneIDi338324.
KEGGihsa:338324.
UCSCiuc001fbt.1. human.

Organism-specific databases

CTDi338324.
GeneCardsiS100A7A.
HGNCiHGNC:21657. S100A7A.
HPAiHPA006997.
neXtProtiNX_Q86SG5.
PharmGKBiPA162402333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ86SG5.
OMAiCHTSSEN.
OrthoDBiEOG79SF08.
PhylomeDBiQ86SG5.
TreeFamiTF341148.

Miscellaneous databases

GeneWikiiS100A15.
GenomeRNAii338324.
PROiQ86SG5.

Gene expression databases

BgeeiQ86SG5.
CleanExiHS_S100A7A.
GenevisibleiQ86SG5. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF64. PTHR11639:SF64. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family."
    Wolf R., Mirmohammadsadegh A., Walz M., Lysa B., Tartler U., Remus R., Hengge U., Michel G., Ruzicka T.
    FASEB J. 17:1969-1971(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Epidermis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21."
    Kulski J.K., Lim C.P., Dunn D.S., Bellgard M.
    J. Mol. Evol. 56:397-406(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOMIC ORGANIZATION.
  5. "Structural characterization of S100A15 reveals a novel zinc coordination site among S100 proteins and altered surface chemistry with functional implications for receptor binding."
    Murray J.I., Tonkin M.L., Whiting A.L., Peng F., Farnell B., Cullen J.T., Hof F., Boulanger M.J.
    BMC Struct. Biol. 12:16-16(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), CALCIUM-BINDING SITES, ZINC-BINDING SITES.

Entry informationi

Entry nameiS1A7A_HUMAN
AccessioniPrimary (citable) accession number: Q86SG5
Secondary accession number(s): D3DV38, Q5SY69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.