Q86SG5 (S1A7A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A7A

Alternative name(s):
S100 calcium-binding protein A15
S100 calcium-binding protein A7-like 1
S100 calcium-binding protein A7A

Gene names

Name:	S100A7A
Synonyms:	S100A15, S100A7L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Overexpressed in psoriasis.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 101	100	Protein S100-A7A		PRO_0000143991
Regions
	Domain	13 – 48	36	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Calcium binding	63 – 74	12	2; high affinity Potential
Sites
	Metal binding	18	1	Zinc By similarity
	Metal binding	87	1	Zinc By similarity
	Metal binding	91	1	Zinc By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
Natural variations
	Natural variant	23	1	R → H. Corresponds to variant rs55985140 [ dbSNP | Ensembl ].		VAR_061048
	Natural variant	84	1	A → T. Corresponds to variant rs3006414 [ dbSNP | Ensembl ].		VAR_048468

Sequences

	Sequence		Length	Mass (Da)
	Q86SG5 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A311A921414C9732	FASTA	101	11,305
	10 20 30 40 50 60 MSNTQAERSI IGMIDMFHKY TGRDGKIEKP SLLTMMKENF PNFLSACDKK GIHYLATVFE 70 80 90 100 KKDKNEDKKI DFSEFLSLLG DIAADYHKQS HGAAPCSGGS Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family." Wolf R., Mirmohammadsadegh A., Walz M., Lysa B., Tartler U., Remus R., Hengge U., Michel G., Ruzicka T. FASEB J. 17:1969-1971(2003) [PubMed: 12923069] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Epidermis.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21." Kulski J.K., Lim C.P., Dunn D.S., Bellgard M. J. Mol. Evol. 56:397-406(2003) [PubMed: 12664160] [Abstract] Cited for: GENOMIC ORGANIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY189117 Genomic DNA. Translation: AAO40032.1. AY189118 mRNA. Translation: AAO40033.1. AY189119 mRNA. Translation: AAO40034.1. AL591704 Genomic DNA. Translation: CAI19499.1. CH471121 Genomic DNA. Translation: EAW53328.1. CH471121 Genomic DNA. Translation: EAW53329.1. BR000043 Genomic DNA. Translation: FAA00014.1.
IPI	IPI00328396.
RefSeq	NP_789793.1. NM_176823.3.
UniGene	Hs.442337.
3D structure databases
ProteinModelPortal	Q86SG5.
SMR	Q86SG5. Positions 2-101.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86SG5.
PTM databases
PhosphoSite	Q86SG5.
Polymorphism databases
DMDM	37088296.
Proteomic databases
PRIDE	Q86SG5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329256; ENSP00000329008; ENSG00000184330. ENST00000368728; ENSP00000357717; ENSG00000184330. ENST00000368729; ENSP00000357718; ENSG00000184330.
GeneID	338324.
KEGG	hsa:338324.
UCSC	uc001fbt.1. human.
Organism-specific databases
CTD	338324.
GeneCards	GC01P153392.
H-InvDB	HIX0028620.
HGNC	HGNC:21657. S100A7A.
HPA	HPA006997.
neXtProt	NX_Q86SG5.
PharmGKB	PA134861790. PA162402333.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21615.
GeneTree	ENSGT00390000017320.
HOGENOM	HBG506094.
HOVERGEN	HBG095357.
InParanoid	Q86SG5.
OMA	GIHYLAT.
OrthoDB	EOG49GKJ6.
PhylomeDB	Q86SG5.
Gene expression databases
ArrayExpress	Q86SG5.
Bgee	Q86SG5.
CleanEx	HS_S100A7A.
Genevestigator	Q86SG5.
GermOnline	ENSG00000184330. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	96937.

Entry information

Entry name

S1A7A_HUMAN

Accession

Primary (citable) accession number: Q86SG5
Secondary accession number(s): D3DV38, Q5SY69

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.