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Protein

Putative Dresden prostate carcinoma protein 2

Gene

HMGN2P46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative Dresden prostate carcinoma protein 2
Short name:
D-PCa-2
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2 pseudogene 46
Gene namesi
Name:HMGN2P46
Synonyms:C15orf21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26817. HMGN2P46.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Putative Dresden prostate carcinoma protein 2PRO_0000079990Add
BLAST

Proteomic databases

PRIDEiQ86SG4.

Expressioni

Tissue specificityi

Very high expression in prostate and prostate cancer. Faint expression in other tissues.1 Publication

Gene expression databases

CleanExiHS_C15orf21.

Interactioni

Protein-protein interaction databases

IntActiQ86SG4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ86SG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000112254.
InParanoidiQ86SG4.
PhylomeDBiQ86SG4.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPWAMRALD FADESGSVSC KDMHLLLWLQ KRIEMHKAEQ CEEEEAMTPR
60 70 80 90 100
PTKARAPLPS AYVPPLSLPP CPRERLKGML KEIKPRLSRN CREDPQGCLL
110 120 130 140 150
NLLLQSHSRS PERPLQRRER RYLQRRREKL MLARRGITLQ KMEMPKQTRH
160 170
RKLKVLEMPS EVCAFLITVY FW
Length:172
Mass (Da):20,403
Last modified:June 1, 2003 - v1
Checksum:iA4BF71B87716B156
GO
Isoform 2 (identifier: Q86SG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEPWAMRALDFA → MKE

Show »
Length:163
Mass (Da):19,372
Checksum:i68F0740E8B0056FA
GO
Isoform 3 (identifier: Q86SG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Show »
Length:150
Mass (Da):17,975
Checksum:i66195BC581041FE2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911C → R.
Corresponds to variant rs8042811 [ dbSNP | Ensembl ].
VAR_022865

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2222Missing in isoform 3. 1 PublicationVSP_014624Add
BLAST
Alternative sequencei1 – 1212MEPWA…ALDFA → MKE in isoform 2. 1 PublicationVSP_014625Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271964 mRNA. Translation: AAP12643.1.
AY271965 mRNA. Translation: AAP12644.1.
AY271966 mRNA. Translation: AAP12645.1.
AY271967 mRNA. Translation: AAP12646.1.
AK096745 mRNA. Translation: BAC04856.1.
AC025580 Genomic DNA. No translation available.
UniGeneiHs.574240.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY271964 mRNA. Translation: AAP12643.1.
AY271965 mRNA. Translation: AAP12644.1.
AY271966 mRNA. Translation: AAP12645.1.
AY271967 mRNA. Translation: AAP12646.1.
AK096745 mRNA. Translation: BAC04856.1.
AC025580 Genomic DNA. No translation available.
UniGeneiHs.574240.

3D structure databases

ProteinModelPortaliQ86SG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ86SG4. 1 interaction.

Proteomic databases

PRIDEiQ86SG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiHMGN2P46.
H-InvDBHIX0021637.
HGNCiHGNC:26817. HMGN2P46.
MIMi611314. gene.
neXtProtiNX_Q86SG4.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000112254.
InParanoidiQ86SG4.
PhylomeDBiQ86SG4.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiHS_C15orf21.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "D-PCa-2: a novel transcript highly overexpressed in human prostate and prostate cancer."
    Weigle B., Kiessling A., Ebner R., Fuessel S., Temme A., Meye A., Schmitz M., Rieger M.A., Ockert D., Wirth M.P., Rieber E.P.
    Int. J. Cancer 109:882-892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDPCA2_HUMAN
AccessioniPrimary (citable) accession number: Q86SG4
Secondary accession number(s): Q495B5, Q86SH8, Q8N8I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: March 16, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.