Reviewed, UniProtKB/Swiss-Prot Q86SG4 (DPCA2_HUMAN)

Names and origin

Protein names

Recommended name:
    Dresden prostate carcinoma protein 2
      Short name=D-PCa-2

Gene names

Name:

C15orf21

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity

Very high expression in prostate and prostate cancer. Faint expression in other tissues. Ref.1

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q86SG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q86SG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEPWAMRALDFA → MKE

Isoform 3 (identifier: Q86SG4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Dresden prostate carcinoma protein 2		PRO_0000079990
Natural variations
	Alternative sequence	1 – 22	22	Missing in isoform 3.		VSP_014624
	Alternative sequence	1 – 12	12	MEPWA…ALDFA → MKE in isoform 2.		VSP_014625
	Natural variant	91	1	C → R: dbSNP rs8042811.		VAR_022865

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: A4BF71B87716B156	FASTA	172	20,403
	10 20 30 40 50 60 MEPWAMRALD FADESGSVSC KDMHLLLWLQ KRIEMHKAEQ CEEEEAMTPR PTKARAPLPS 70 80 90 100 110 120 AYVPPLSLPP CPRERLKGML KEIKPRLSRN CREDPQGCLL NLLLQSHSRS PERPLQRRER 130 140 150 160 170 RYLQRRREKL MLARRGITLQ KMEMPKQTRH RKLKVLEMPS EVCAFLITVY FW
	Isoform 2. Checksum: 68F0740E8B0056FA	FASTA	163	19,372
	10 20 30 40 50 60 MKEDESGSVS CKDMHLLLWL QKRIEMHKAE QCEEEEAMTP RPTKARAPLP SAYVPPLSLP 70 80 90 100 110 120 PCPRERLKGM LKEIKPRLSR NCREDPQGCL LNLLLQSHSR SPERPLQRRE RRYLQRRREK 130 140 150 160 LMLARRGITL QKMEMPKQTR HRKLKVLEMP SEVCAFLITV YFW
	Isoform 3. Checksum: 66195BC581041FE2	FASTA	150	17,975
	10 20 30 40 50 60 MHLLLWLQKR IEMHKAEQCE EEEAMTPRPT KARAPLPSAY VPPLSLPPCP RERLKGMLKE 70 80 90 100 110 120 IKPRLSRNCR EDPQGCLLNL LLQSHSRSPE RPLQRRERRY LQRRREKLML ARRGITLQKM 130 140 150 EMPKQTRHRK LKVLEMPSEV CAFLITVYFW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"D-PCa-2: a novel transcript highly overexpressed in human prostate and prostate cancer." Weigle B., Kiessling A., Ebner R., Fuessel S., Temme A., Meye A., Schmitz M., Rieger M.A., Ockert D., Wirth M.P., Rieber E.P. Int. J. Cancer 109:882-892(2004) [PubMed: 15027122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Prostate.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY271964 mRNA. Translation: AAP12643.1. AY271965 mRNA. Translation: AAP12644.1. AY271966 mRNA. Translation: AAP12645.1. AY271967 mRNA. Translation: AAP12646.1. AK096745 mRNA. Translation: BAC04856.1. BC101266 mRNA. Translation: AAI01267.1.
IPI	IPI00167483. IPI00465134. IPI00465136.
UniGene	Hs.574240
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000179362. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC15P043590.
H-InvDB	HIX0058684.
HGNC	HGNC:26817. C15orf21.
MIM	611314. gene.
PharmGKB	PA134909825.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q86SG4.
HOVERGEN	Q86SG4.
OMA	Q86SG4. CPRERLK.
Gene expression databases
ArrayExpress	Q86SG4.
Bgee	Q86SG4.
CleanEx	HS_C15orf21.
Family and domain databases
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

DPCA2_HUMAN

Accession

Primary (citable) accession number: Q86SG4
Secondary accession number(s): Q495B5, Q86SH8, Q8N8I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	June 1, 2003
Last modified:	May 5, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)