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Protein

Ankyrin repeat domain-containing protein 23

Gene

ANKRD23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

GO - Molecular functioni

  • titin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 23
Alternative name(s):
Diabetes-related ankyrin repeat protein
Muscle ankyrin repeat protein 3
Gene namesi
Name:ANKRD23
Synonyms:DARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24470. ANKRD23.

Subcellular locationi

  • Nucleus

  • Note: Sarcomeric I-band and some intercalated disks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960626.

Polymorphism and mutation databases

BioMutaiANKRD23.
DMDMi74723447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Ankyrin repeat domain-containing protein 23PRO_0000240666Add
BLAST

Proteomic databases

EPDiQ86SG2.
PaxDbiQ86SG2.
PRIDEiQ86SG2.

PTM databases

PhosphoSiteiQ86SG2.

Expressioni

Tissue specificityi

Mainly expressed in heart, skeletal muscle and brown adipose tissues.1 Publication

Gene expression databases

BgeeiQ86SG2.
CleanExiHS_ANKRD23.
GenevisibleiQ86SG2. HS.

Organism-specific databases

HPAiHPA036201.

Interactioni

Subunit structurei

Interacts with titin/TTN and MYPN.1 Publication

GO - Molecular functioni

  • titin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi128333. 2 interactions.
IntActiQ86SG2. 1 interaction.
STRINGi9606.ENSP00000321679.

Structurei

3D structure databases

ProteinModelPortaliQ86SG2.
SMRiQ86SG2. Positions 55-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati143 – 17230ANK 1Add
BLAST
Repeati176 – 20530ANK 2Add
BLAST
Repeati209 – 23830ANK 3Add
BLAST
Repeati242 – 27130ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni178 – 19518Interaction with TTNAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7232Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ86SG2.
OMAiHWACLKG.
OrthoDBiEOG7FJH17.
PhylomeDBiQ86SG2.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFISIQQLV SGERVEGKVL GFGHGVPDPG AWPSDWRRGP QEAVAREKLK
60 70 80 90 100
LEEEKKKKLE RFNSTRFNLD NLADLENLVQ RRKKRLRHRV PPRKPEPLVK
110 120 130 140 150
PQSQAQVEPV GLEMFLKAAA ENQEYLIDKY LTDGGDPNAH DKLHRTALHW
160 170 180 190 200
ACLKGHSQLV NKLLVAGATV DARDLLDRTP VFWACRGGHL VILKQLLNQG
210 220 230 240 250
ARVNARDKIG STPLHVAVRT RHPDCLEHLI ECGAHLNAQD KEGDTALHEA
260 270 280 290 300
VRHGSYKAMK LLLLYGAELG VRNAASVTPV QLARDWQRGI REALQAHVAH

PRTRC
Length:305
Mass (Da):34,297
Last modified:June 1, 2003 - v1
Checksum:iA9BB41D0532F932D
GO
Isoform 2 (identifier: Q86SG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-142: Missing.

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):29,683
Checksum:i6860A432B7513062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571K → N in CAC86120 (Ref. 6) Curated
Sequence conflicti277 – 2771V → L in BAC03915 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 14242Missing in isoform 2. 1 PublicationVSP_019424Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492401 mRNA. Translation: AAO24067.1.
AY196212 mRNA. Translation: AAO40750.1.
AK092564 mRNA. Translation: BAC03915.1.
AC092636 Genomic DNA. Translation: AAY14965.1.
BC107056 mRNA. Translation: AAI07057.1.
AJ315766 mRNA. Translation: CAC86120.1.
CCDSiCCDS2027.1. [Q86SG2-1]
RefSeqiNP_659431.5. NM_144994.7. [Q86SG2-1]
UniGeneiHs.643430.

Genome annotation databases

EnsembliENST00000318357; ENSP00000321679; ENSG00000163126. [Q86SG2-1]
ENST00000331001; ENSP00000333108; ENSG00000163126. [Q86SG2-2]
ENST00000418232; ENSP00000398987; ENSG00000163126. [Q86SG2-1]
GeneIDi200539.
KEGGihsa:200539.
UCSCiuc002sxa.4. human. [Q86SG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492401 mRNA. Translation: AAO24067.1.
AY196212 mRNA. Translation: AAO40750.1.
AK092564 mRNA. Translation: BAC03915.1.
AC092636 Genomic DNA. Translation: AAY14965.1.
BC107056 mRNA. Translation: AAI07057.1.
AJ315766 mRNA. Translation: CAC86120.1.
CCDSiCCDS2027.1. [Q86SG2-1]
RefSeqiNP_659431.5. NM_144994.7. [Q86SG2-1]
UniGeneiHs.643430.

3D structure databases

ProteinModelPortaliQ86SG2.
SMRiQ86SG2. Positions 55-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128333. 2 interactions.
IntActiQ86SG2. 1 interaction.
STRINGi9606.ENSP00000321679.

PTM databases

PhosphoSiteiQ86SG2.

Polymorphism and mutation databases

BioMutaiANKRD23.
DMDMi74723447.

Proteomic databases

EPDiQ86SG2.
PaxDbiQ86SG2.
PRIDEiQ86SG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318357; ENSP00000321679; ENSG00000163126. [Q86SG2-1]
ENST00000331001; ENSP00000333108; ENSG00000163126. [Q86SG2-2]
ENST00000418232; ENSP00000398987; ENSG00000163126. [Q86SG2-1]
GeneIDi200539.
KEGGihsa:200539.
UCSCiuc002sxa.4. human. [Q86SG2-1]

Organism-specific databases

CTDi200539.
GeneCardsiANKRD23.
HGNCiHGNC:24470. ANKRD23.
HPAiHPA036201.
MIMi610736. gene.
neXtProtiNX_Q86SG2.
PharmGKBiPA134960626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129743.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ86SG2.
OMAiHWACLKG.
OrthoDBiEOG7FJH17.
PhylomeDBiQ86SG2.
TreeFamiTF331650.

Miscellaneous databases

GeneWikiiANKRD23.
GenomeRNAii200539.
PROiQ86SG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ86SG2.
CleanExiHS_ANKRD23.
GenevisibleiQ86SG2. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals."
    Ikeda K., Emoto N., Matsuo M., Yokoyama M.
    J. Biol. Chem. 278:3514-3520(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.
  2. "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules."
    Miller M.K., Bang M.-L., Witt C.C., Labeit D., Trombitas C., Watanabe K., Granzier H., McElhinny A.S., Gregorio C.C., Labeit S.
    J. Mol. Biol. 333:951-964(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TTN AND MYPN.
    Tissue: Skeletal muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Full length sequencing of some human and murine muscular transcripts, (Telethon Italy project B41)."
    Ievolella C., Zara I., Frigimelica E., Lanfranchi G.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-305 (ISOFORM 1).
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiANR23_HUMAN
AccessioniPrimary (citable) accession number: Q86SG2
Secondary accession number(s): Q711K7, Q8NAJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.