Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat domain-containing protein 23

Gene

ANKRD23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

GO - Molecular functioni

  • titin binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 23
Alternative name(s):
Diabetes-related ankyrin repeat protein
Muscle ankyrin repeat protein 3
Gene namesi
Name:ANKRD23
Synonyms:DARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24470. ANKRD23.

Subcellular locationi

  • Nucleus

  • Note: Sarcomeric I-band and some intercalated disks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi200539.
OpenTargetsiENSG00000163126.
PharmGKBiPA134960626.

Polymorphism and mutation databases

BioMutaiANKRD23.
DMDMi74723447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406661 – 305Ankyrin repeat domain-containing protein 23Add BLAST305

Proteomic databases

PaxDbiQ86SG2.
PeptideAtlasiQ86SG2.
PRIDEiQ86SG2.

PTM databases

PhosphoSitePlusiQ86SG2.

Expressioni

Tissue specificityi

Mainly expressed in heart, skeletal muscle and brown adipose tissues.1 Publication

Gene expression databases

BgeeiENSG00000163126.
CleanExiHS_ANKRD23.
GenevisibleiQ86SG2. HS.

Organism-specific databases

HPAiHPA036201.

Interactioni

Subunit structurei

Interacts with titin/TTN and MYPN.1 Publication

GO - Molecular functioni

  • titin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi128333. 2 interactors.
IntActiQ86SG2. 1 interactor.
STRINGi9606.ENSP00000321679.

Structurei

3D structure databases

ProteinModelPortaliQ86SG2.
SMRiQ86SG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati143 – 172ANK 1Add BLAST30
Repeati176 – 205ANK 2Add BLAST30
Repeati209 – 238ANK 3Add BLAST30
Repeati242 – 271ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 195Interaction with TTN1 PublicationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 72Sequence analysisAdd BLAST32

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ86SG2.
OMAiHWACLKG.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ86SG2.
TreeFamiTF331650.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFISIQQLV SGERVEGKVL GFGHGVPDPG AWPSDWRRGP QEAVAREKLK
60 70 80 90 100
LEEEKKKKLE RFNSTRFNLD NLADLENLVQ RRKKRLRHRV PPRKPEPLVK
110 120 130 140 150
PQSQAQVEPV GLEMFLKAAA ENQEYLIDKY LTDGGDPNAH DKLHRTALHW
160 170 180 190 200
ACLKGHSQLV NKLLVAGATV DARDLLDRTP VFWACRGGHL VILKQLLNQG
210 220 230 240 250
ARVNARDKIG STPLHVAVRT RHPDCLEHLI ECGAHLNAQD KEGDTALHEA
260 270 280 290 300
VRHGSYKAMK LLLLYGAELG VRNAASVTPV QLARDWQRGI REALQAHVAH

PRTRC
Length:305
Mass (Da):34,297
Last modified:June 1, 2003 - v1
Checksum:iA9BB41D0532F932D
GO
Isoform 2 (identifier: Q86SG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-142: Missing.

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):29,683
Checksum:i6860A432B7513062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57K → N in CAC86120 (Ref. 6) Curated1
Sequence conflicti277V → L in BAC03915 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019424101 – 142Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492401 mRNA. Translation: AAO24067.1.
AY196212 mRNA. Translation: AAO40750.1.
AK092564 mRNA. Translation: BAC03915.1.
AC092636 Genomic DNA. Translation: AAY14965.1.
BC107056 mRNA. Translation: AAI07057.1.
AJ315766 mRNA. Translation: CAC86120.1.
CCDSiCCDS2027.1. [Q86SG2-1]
RefSeqiNP_659431.5. NM_144994.7. [Q86SG2-1]
UniGeneiHs.643430.

Genome annotation databases

EnsembliENST00000318357; ENSP00000321679; ENSG00000163126. [Q86SG2-1]
ENST00000331001; ENSP00000333108; ENSG00000163126. [Q86SG2-2]
ENST00000418232; ENSP00000398987; ENSG00000163126. [Q86SG2-1]
GeneIDi200539.
KEGGihsa:200539.
UCSCiuc002sxa.4. human. [Q86SG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492401 mRNA. Translation: AAO24067.1.
AY196212 mRNA. Translation: AAO40750.1.
AK092564 mRNA. Translation: BAC03915.1.
AC092636 Genomic DNA. Translation: AAY14965.1.
BC107056 mRNA. Translation: AAI07057.1.
AJ315766 mRNA. Translation: CAC86120.1.
CCDSiCCDS2027.1. [Q86SG2-1]
RefSeqiNP_659431.5. NM_144994.7. [Q86SG2-1]
UniGeneiHs.643430.

3D structure databases

ProteinModelPortaliQ86SG2.
SMRiQ86SG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128333. 2 interactors.
IntActiQ86SG2. 1 interactor.
STRINGi9606.ENSP00000321679.

PTM databases

PhosphoSitePlusiQ86SG2.

Polymorphism and mutation databases

BioMutaiANKRD23.
DMDMi74723447.

Proteomic databases

PaxDbiQ86SG2.
PeptideAtlasiQ86SG2.
PRIDEiQ86SG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318357; ENSP00000321679; ENSG00000163126. [Q86SG2-1]
ENST00000331001; ENSP00000333108; ENSG00000163126. [Q86SG2-2]
ENST00000418232; ENSP00000398987; ENSG00000163126. [Q86SG2-1]
GeneIDi200539.
KEGGihsa:200539.
UCSCiuc002sxa.4. human. [Q86SG2-1]

Organism-specific databases

CTDi200539.
DisGeNETi200539.
GeneCardsiANKRD23.
HGNCiHGNC:24470. ANKRD23.
HPAiHPA036201.
MIMi610736. gene.
neXtProtiNX_Q86SG2.
OpenTargetsiENSG00000163126.
PharmGKBiPA134960626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00860000133710.
HOGENOMiHOG000236321.
HOVERGENiHBG071561.
InParanoidiQ86SG2.
OMAiHWACLKG.
OrthoDBiEOG091G0DCN.
PhylomeDBiQ86SG2.
TreeFamiTF331650.

Miscellaneous databases

GeneWikiiANKRD23.
GenomeRNAii200539.
PROiQ86SG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163126.
CleanExiHS_ANKRD23.
GenevisibleiQ86SG2. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF13606. Ank_3. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR23_HUMAN
AccessioniPrimary (citable) accession number: Q86SG2
Secondary accession number(s): Q711K7, Q8NAJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.