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Protein

Polycomb group RING finger protein 5

Gene

PCGF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5740RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 5
Alternative name(s):
RING finger protein 159
Gene namesi
Name:PCGF5
Synonyms:RNF159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28264. PCGF5.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: LIFEdb
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929149.

Polymorphism and mutation databases

BioMutaiPCGF5.
DMDMi74750353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Polycomb group RING finger protein 5PRO_0000277868Add
BLAST

Proteomic databases

EPDiQ86SE9.
MaxQBiQ86SE9.
PaxDbiQ86SE9.
PRIDEiQ86SE9.

PTM databases

PhosphoSiteiQ86SE9.

Expressioni

Gene expression databases

BgeeiQ86SE9.
CleanExiHS_PCGF5.
GenevisibleiQ86SE9. HS.

Organism-specific databases

HPAiHPA038349.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BCORQ6W2J9-43EBI-2827999,EBI-10208579
CBX8Q9HC523EBI-2827999,EBI-712912
PHC2Q8IXK03EBI-2827999,EBI-713786
PRMT6Q96LA82EBI-2827999,EBI-912440
RING1Q065872EBI-2827999,EBI-752313
RNF2Q994962EBI-2827999,EBI-722416
TRAF2Q129333EBI-2827999,EBI-355744

Protein-protein interaction databases

BioGridi124057. 32 interactions.
DIPiDIP-61356N.
IntActiQ86SE9. 27 interactions.
MINTiMINT-4726289.
STRINGi9606.ENSP00000337500.

Structurei

Secondary structure

1
256
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 124Combined sources
Helixi13 – 164Combined sources
Turni19 – 213Combined sources
Beta strandi22 – 243Combined sources
Beta strandi26 – 316Combined sources
Turni32 – 354Combined sources
Beta strandi36 – 394Combined sources
Helixi40 – 467Combined sources
Turni47 – 493Combined sources
Turni54 – 563Combined sources
Helixi65 – 684Combined sources
Beta strandi69 – 713Combined sources
Helixi73 – 8210Combined sources
Helixi86 – 9813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4S3OX-ray2.00C/F1-109[»]
ProteinModelPortaliQ86SE9.
SMRiQ86SE9. Positions 8-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri18 – 5740RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ86SE9.
KOiK11489.
OMAiFNHFITC.
OrthoDBiEOG754HQ5.
PhylomeDBiQ86SE9.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS
60 70 80 90 100
NDCPRCGNQV HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK
110 120 130 140 150
NKPQENGQDD TSKADKPKVD EEGDENEDDK DYHRSDPQIA ICLDCLRNNG
160 170 180 190 200
QSGDNVVKGL MKKFIRCSTR VTVGTIKKFL SLKLKLPSSY ELDVLCNGEI
210 220 230 240 250
MGKDHTMEFI YMTRWRLRGE NFRCLNCSAS QVCSQDGPLY QSYPMVLQYR

PRIDFG
Length:256
Mass (Da):29,714
Last modified:June 1, 2003 - v1
Checksum:iE5AC78F2A3BBBED5
GO
Isoform 2 (identifier: Q86SE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-49: FCKTCIVQHFED → SAESYWMSTWMS
     50-256: Missing.

Note: No experimental confirmation available.
Show »
Length:49
Mass (Da):5,779
Checksum:i92ED2ED8C317B0BF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 4912FCKTC…QHFED → SAESYWMSTWMS in isoform 2. 1 PublicationVSP_023118Add
BLAST
Alternative sequencei50 – 256207Missing in isoform 2. 1 PublicationVSP_023119Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303014 mRNA. Translation: BAH13878.1.
AL832003 mRNA. Translation: CAD89905.1.
AL832496 mRNA. Translation: CAD91165.1.
CH471066 Genomic DNA. Translation: EAW50112.1.
CH471066 Genomic DNA. Translation: EAW50113.1.
BC007377 mRNA. Translation: AAH07377.1.
BC051845 mRNA. Translation: AAH51845.1.
CCDSiCCDS7413.1. [Q86SE9-1]
RefSeqiNP_001243478.1. NM_001256549.1. [Q86SE9-1]
NP_001244030.1. NM_001257101.1. [Q86SE9-1]
NP_115749.2. NM_032373.4. [Q86SE9-1]
XP_011538573.1. XM_011540271.1. [Q86SE9-1]
UniGeneiHs.500512.

Genome annotation databases

EnsembliENST00000336126; ENSP00000337500; ENSG00000180628. [Q86SE9-1]
ENST00000543648; ENSP00000445704; ENSG00000180628. [Q86SE9-1]
ENST00000614189; ENSP00000479492; ENSG00000180628. [Q86SE9-1]
GeneIDi84333.
KEGGihsa:84333.
UCSCiuc001khh.5. human. [Q86SE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303014 mRNA. Translation: BAH13878.1.
AL832003 mRNA. Translation: CAD89905.1.
AL832496 mRNA. Translation: CAD91165.1.
CH471066 Genomic DNA. Translation: EAW50112.1.
CH471066 Genomic DNA. Translation: EAW50113.1.
BC007377 mRNA. Translation: AAH07377.1.
BC051845 mRNA. Translation: AAH51845.1.
CCDSiCCDS7413.1. [Q86SE9-1]
RefSeqiNP_001243478.1. NM_001256549.1. [Q86SE9-1]
NP_001244030.1. NM_001257101.1. [Q86SE9-1]
NP_115749.2. NM_032373.4. [Q86SE9-1]
XP_011538573.1. XM_011540271.1. [Q86SE9-1]
UniGeneiHs.500512.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4S3OX-ray2.00C/F1-109[»]
ProteinModelPortaliQ86SE9.
SMRiQ86SE9. Positions 8-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124057. 32 interactions.
DIPiDIP-61356N.
IntActiQ86SE9. 27 interactions.
MINTiMINT-4726289.
STRINGi9606.ENSP00000337500.

PTM databases

PhosphoSiteiQ86SE9.

Polymorphism and mutation databases

BioMutaiPCGF5.
DMDMi74750353.

Proteomic databases

EPDiQ86SE9.
MaxQBiQ86SE9.
PaxDbiQ86SE9.
PRIDEiQ86SE9.

Protocols and materials databases

DNASUi84333.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336126; ENSP00000337500; ENSG00000180628. [Q86SE9-1]
ENST00000543648; ENSP00000445704; ENSG00000180628. [Q86SE9-1]
ENST00000614189; ENSP00000479492; ENSG00000180628. [Q86SE9-1]
GeneIDi84333.
KEGGihsa:84333.
UCSCiuc001khh.5. human. [Q86SE9-1]

Organism-specific databases

CTDi84333.
GeneCardsiPCGF5.
HGNCiHGNC:28264. PCGF5.
HPAiHPA038349.
neXtProtiNX_Q86SE9.
PharmGKBiPA134929149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ86SE9.
KOiK11489.
OMAiFNHFITC.
OrthoDBiEOG754HQ5.
PhylomeDBiQ86SE9.
TreeFamiTF324206.

Miscellaneous databases

ChiTaRSiPCGF5. human.
GeneWikiiPCGF5.
GenomeRNAii84333.
NextBioi74097.
PROiQ86SE9.

Gene expression databases

BgeeiQ86SE9.
CleanExiHS_PCGF5.
GenevisibleiQ86SE9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial adenocarcinoma and Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Pancreas.
  5. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
    Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX, INTERACTION WITH CBX6; CBX7 AND CBX8, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPCGF5_HUMAN
AccessioniPrimary (citable) accession number: Q86SE9
Secondary accession number(s): B7Z892
, D3DR33, Q6PK47, Q86TD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.