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Protein

Polycomb group RING finger protein 5

Gene

PCGF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotation1 PublicationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8939243. RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 5
Alternative name(s):
RING finger protein 159
Gene namesi
Name:PCGF5
Synonyms:RNF159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000180628.14.
HGNCiHGNC:28264. PCGF5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180628.
PharmGKBiPA134929149.

Polymorphism and mutation databases

BioMutaiPCGF5.
DMDMi74750353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778681 – 256Polycomb group RING finger protein 5Add BLAST256

Proteomic databases

EPDiQ86SE9.
MaxQBiQ86SE9.
PaxDbiQ86SE9.
PeptideAtlasiQ86SE9.
PRIDEiQ86SE9.

PTM databases

PhosphoSitePlusiQ86SE9.

Expressioni

Gene expression databases

BgeeiENSG00000180628.
CleanExiHS_PCGF5.
GenevisibleiQ86SE9. HS.

Organism-specific databases

HPAiHPA038349.

Interactioni

Subunit structurei

Component of a PRC1-like complex that contains PCGF5, RNF2 and UBE2D3 (PubMed:21282530, PubMed:26151332). Interacts with RNF2; the interaction is direct (PubMed:26151332). Interacts with CBX6, CBX7 and CBX8 (PubMed:21282530). Interacts with AUTS2; the interaction is direct (PubMed:25519132). Identified in a complex that contains AUTS2, PCGF5, CSNK2B and RNF2 (PubMed:25519132).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124057. 43 interactors.
DIPiDIP-61356N.
IntActiQ86SE9. 48 interactors.
MINTiMINT-4726289.
STRINGi9606.ENSP00000337500.

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 12Combined sources4
Helixi13 – 16Combined sources4
Turni19 – 21Combined sources3
Beta strandi22 – 24Combined sources3
Beta strandi26 – 31Combined sources6
Turni32 – 35Combined sources4
Beta strandi36 – 39Combined sources4
Helixi40 – 46Combined sources7
Turni47 – 49Combined sources3
Turni54 – 56Combined sources3
Helixi65 – 68Combined sources4
Beta strandi69 – 71Combined sources3
Helixi73 – 82Combined sources10
Helixi86 – 98Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4S3OX-ray2.00C/F1-109[»]
ProteinModelPortaliQ86SE9.
SMRiQ86SE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotation1 PublicationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ86SE9.
KOiK11489.
OMAiFNHFITC.
OrthoDBiEOG091G0EC9.
PhylomeDBiQ86SE9.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF16207. RAWUL. 1 hit.
SMARTiView protein in SMART
SM00184. RING. 1 hit.
PROSITEiView protein in PROSITE
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86SE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS
60 70 80 90 100
NDCPRCGNQV HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK
110 120 130 140 150
NKPQENGQDD TSKADKPKVD EEGDENEDDK DYHRSDPQIA ICLDCLRNNG
160 170 180 190 200
QSGDNVVKGL MKKFIRCSTR VTVGTIKKFL SLKLKLPSSY ELDVLCNGEI
210 220 230 240 250
MGKDHTMEFI YMTRWRLRGE NFRCLNCSAS QVCSQDGPLY QSYPMVLQYR

PRIDFG
Length:256
Mass (Da):29,714
Last modified:June 1, 2003 - v1
Checksum:iE5AC78F2A3BBBED5
GO
Isoform 2 (identifier: Q86SE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-49: FCKTCIVQHFED → SAESYWMSTWMS
     50-256: Missing.

Note: No experimental confirmation available.
Show »
Length:49
Mass (Da):5,779
Checksum:i92ED2ED8C317B0BF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02311838 – 49FCKTC…QHFED → SAESYWMSTWMS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02311950 – 256Missing in isoform 2. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303014 mRNA. Translation: BAH13878.1.
AL832003 mRNA. Translation: CAD89905.1.
AL832496 mRNA. Translation: CAD91165.1.
CH471066 Genomic DNA. Translation: EAW50112.1.
CH471066 Genomic DNA. Translation: EAW50113.1.
BC007377 mRNA. Translation: AAH07377.1.
BC051845 mRNA. Translation: AAH51845.1.
CCDSiCCDS7413.1. [Q86SE9-1]
RefSeqiNP_001243478.1. NM_001256549.1. [Q86SE9-1]
NP_001244030.1. NM_001257101.1. [Q86SE9-1]
NP_115749.2. NM_032373.4. [Q86SE9-1]
XP_011538573.1. XM_011540271.2. [Q86SE9-1]
XP_016872265.1. XM_017016776.1. [Q86SE9-1]
UniGeneiHs.500512.

Genome annotation databases

EnsembliENST00000336126; ENSP00000337500; ENSG00000180628. [Q86SE9-1]
ENST00000543648; ENSP00000445704; ENSG00000180628. [Q86SE9-1]
ENST00000614189; ENSP00000479492; ENSG00000180628. [Q86SE9-1]
GeneIDi84333.
KEGGihsa:84333.
UCSCiuc001khh.5. human. [Q86SE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPCGF5_HUMAN
AccessioniPrimary (citable) accession number: Q86SE9
Secondary accession number(s): B7Z892
, D3DR33, Q6PK47, Q86TD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references