Q86SD8 (KA155_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin alpha-KTx 15.5 Alternative name(s): Toxin AaTX2
Organism	Androctonus australis (Sahara scorpion)
Taxonomic identifier	6858 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus

Protein attributes

Sequence length	59 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to potassium channel and affects the potassium ion currents, by occluding the outer entry to the K+ conducting pore. The blockade is partially reversible and affect both open and closed channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond Pyrrolidone carboxylic acid
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 59	37	Potassium channel toxin alpha-KTx 15.5		PRO_0000035311
Sites
	Site	49	1	Basic residue of the functional dyad By similarity
	Site	58	1	Aromatic residue of the functional dyad By similarity
Amino acid modifications
	Modified residue	23	1	Pyrrolidone carboxylic acid By similarity
	Disulfide bond	30 ↔ 50		By similarity
	Disulfide bond	35 ↔ 55		By similarity
	Disulfide bond	39 ↔ 57		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86SD8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E429B1A5BF99664E	FASTA	59	6,277
	10 20 30 40 50 MKFSSIILLT LLICSMSIFG NCQVETNKKC QGGSCASVCR RVIGVAAGKC INGRCVCYP

References

[1]	"Characterisation of the genes encoding Aa1 isoforms from the scorpion Androctonus australis." Legros C., Bougis P.E., Martin-Eauclaire M.-F. Toxicon 41:115-119(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ427744 mRNA. Translation: CAD20743.1.
3D structure databases
ProteinModelPortal	Q86SD8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA155_ANDAU

Accession

Primary (citable) accession number: Q86SD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program