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Q86SD8 (KA155_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 15.5
Alternative name(s):
Toxin AaTX2
OrganismAndroctonus australis (Sahara scorpion)
Taxonomic identifier6858 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Protein attributes

Sequence length59 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to potassium channel and affects the potassium ion currents, by occluding the outer entry to the K+ conducting pore. The blockade is partially reversible and affect both open and closed channels By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 5937Potassium channel toxin alpha-KTx 15.5
PRO_0000035311

Sites

Site491Basic residue of the functional dyad By similarity
Site581Aromatic residue of the functional dyad By similarity

Amino acid modifications

Modified residue231Pyrrolidone carboxylic acid By similarity
Disulfide bond30 ↔ 50 By similarity
Disulfide bond35 ↔ 55 By similarity
Disulfide bond39 ↔ 57 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q86SD8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E429B1A5BF99664E

FASTA596,277
        10         20         30         40         50 
MKFSSIILLT LLICSMSIFG NCQVETNKKC QGGSCASVCR RVIGVAAGKC INGRCVCYP 

« Hide

References

[1]"Characterisation of the genes encoding Aa1 isoforms from the scorpion Androctonus australis."
Legros C., Bougis P.E., Martin-Eauclaire M.-F.
Toxicon 41:115-119(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ427744 mRNA. Translation: CAD20743.1.

3D structure databases

ProteinModelPortalQ86SD8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKA155_ANDAU
AccessionPrimary (citable) accession number: Q86SD8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2003
Last modified: October 16, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries