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Protein

Nascent polypeptide-associated complex subunit alpha

Gene

icd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May promote appropriate targeting of ribosome-nascent polypeptide complexes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha
Short name:
NAC-alpha
Alternative name(s):
Alpha-NAC
Gene namesi
Name:icd-2Imported
ORF Names:Y65B4BR.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY65B4BR.5a; CE22740; WBGene00022042; icd-2.
Y65B4BR.5b; CE33239; WBGene00022042; icd-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Nascent polypeptide-associated complex subunit alphaPRO_0000135585Add
BLAST

Proteomic databases

EPDiQ86S66.
PaxDbiQ86S66.
PRIDEiQ86S66.

PTM databases

iPTMnetiQ86S66.

Expressioni

Gene expression databases

ExpressionAtlasiQ86S66. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CELE_F49E8.7H2KZY35EBI-326549,EBI-326535
icd-1Q188855EBI-326549,EBI-326530

Protein-protein interaction databases

BioGridi37146. 6 interactions.
DIPiDIP-25064N.
IntActiQ86S66. 6 interactions.
MINTiMINT-1063140.
STRINGi6239.Y65B4BR.5b.1.

Structurei

3D structure databases

ProteinModelPortaliQ86S66.
SMRiQ86S66. Positions 66-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 12166NAC-A/BPROSITE-ProRule annotationAdd
BLAST
Domaini158 – 19538UBAAdd
BLAST

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated
Contains 1 NAC-A/B (NAC-alpha/beta) domain.PROSITE-ProRule annotation
Contains 1 UBA domain.Curated

Phylogenomic databases

eggNOGiKOG2239. Eukaryota.
COG1308. LUCA.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000239674.
InParanoidiQ86S66.
KOiK03626.
OMAiIKNEAAP.
PhylomeDBiQ86S66.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
PIRSFiPIRSF015901. NAC_alpha. 1 hit.
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: Q86S66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGSTETRQK EVKEPQVDVS DDSDNEAVEQ ELTEEQRRVA EAAGLGDHID
60 70 80 90 100
KQAKQSRSEK KARKLFSKLG LKQVTGVSRV CIRKSKNILF VINKPDVFKS
110 120 130 140 150
PGSDTYIIFG EAKIEDLTQH AQMSAIENLK PTREAPQLKT VEEDENEDVE
160 170 180 190
FKEDSTGIEE KDIELVISQA NTTRNKAIRA LKEADNDIVN AIMSLTM
Note: Gene prediction based on EST data. No experimental confirmation.
Length:197
Mass (Da):22,078
Last modified:June 1, 2003 - v1
Checksum:i8512718E4D7CA97C
GO
Isoform bImported (identifier: Q86S66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-152: Missing.

Note: Gene prediction based on EST data. No experimental confirmation.
Show »
Length:195
Mass (Da):21,802
Checksum:i0158E4BCCC1775B0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei151 – 1522Missing in isoform b. CuratedVSP_014887

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081483 Genomic DNA. Translation: CCD71933.1.
FO081483 Genomic DNA. Translation: CCD71934.1.
RefSeqiNP_490749.1. NM_058348.5. [Q86S66-2]
NP_871846.1. NM_182046.6. [Q86S66-1]
UniGeneiCel.7722.

Genome annotation databases

EnsemblMetazoaiY65B4BR.5b; Y65B4BR.5b; WBGene00022042. [Q86S66-1]
GeneIDi171646.
KEGGicel:CELE_Y65B4BR.5.
UCSCiY65B4BR.5a.1. c. elegans. [Q86S66-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081483 Genomic DNA. Translation: CCD71933.1.
FO081483 Genomic DNA. Translation: CCD71934.1.
RefSeqiNP_490749.1. NM_058348.5. [Q86S66-2]
NP_871846.1. NM_182046.6. [Q86S66-1]
UniGeneiCel.7722.

3D structure databases

ProteinModelPortaliQ86S66.
SMRiQ86S66. Positions 66-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37146. 6 interactions.
DIPiDIP-25064N.
IntActiQ86S66. 6 interactions.
MINTiMINT-1063140.
STRINGi6239.Y65B4BR.5b.1.

PTM databases

iPTMnetiQ86S66.

Proteomic databases

EPDiQ86S66.
PaxDbiQ86S66.
PRIDEiQ86S66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY65B4BR.5b; Y65B4BR.5b; WBGene00022042. [Q86S66-1]
GeneIDi171646.
KEGGicel:CELE_Y65B4BR.5.
UCSCiY65B4BR.5a.1. c. elegans. [Q86S66-1]

Organism-specific databases

CTDi171646.
WormBaseiY65B4BR.5a; CE22740; WBGene00022042; icd-2.
Y65B4BR.5b; CE33239; WBGene00022042; icd-2.

Phylogenomic databases

eggNOGiKOG2239. Eukaryota.
COG1308. LUCA.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000239674.
InParanoidiQ86S66.
KOiK03626.
OMAiIKNEAAP.
PhylomeDBiQ86S66.

Miscellaneous databases

PROiQ86S66.

Gene expression databases

ExpressionAtlasiQ86S66. baseline.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
PIRSFiPIRSF015901. NAC_alpha. 1 hit.
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiNACA_CAEEL
AccessioniPrimary (citable) accession number: Q86S66
Secondary accession number(s): Q9N2Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.