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Protein

Nascent polypeptide-associated complex subunit alpha

Gene

icd-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote appropriate targeting of ribosome-nascent polypeptide complexes.By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha
Short name:
NAC-alpha
Alternative name(s):
Alpha-NAC
Gene namesi
Name:icd-2Imported
ORF Names:Y65B4BR.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY65B4BR.5a ; CE22740 ; WBGene00022042 ; icd-2
Y65B4BR.5b ; CE33239 ; WBGene00022042 ; icd-2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001355851 – 197Nascent polypeptide-associated complex subunit alphaAdd BLAST197

Proteomic databases

EPDiQ86S66
PaxDbiQ86S66
PeptideAtlasiQ86S66
PRIDEiQ86S66

PTM databases

iPTMnetiQ86S66

Expressioni

Gene expression databases

BgeeiWBGene00022042
ExpressionAtlasiQ86S66 baseline and differential

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi37146, 6 interactors
DIPiDIP-25064N
IntActiQ86S66, 6 interactors
STRINGi6239.Y65B4BR.5b.1

Structurei

3D structure databases

ProteinModelPortaliQ86S66
SMRiQ86S66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 121NAC-A/BPROSITE-ProRule annotationAdd BLAST66
Domaini158 – 195UBAAdd BLAST38

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated

Phylogenomic databases

eggNOGiKOG2239 Eukaryota
COG1308 LUCA
GeneTreeiENSGT00440000033468
HOGENOMiHOG000239674
InParanoidiQ86S66
KOiK03626
OMAiMANPRVE
OrthoDBiEOG091G0292
PhylomeDBiQ86S66

Family and domain databases

Gene3Di2.20.70.30, 1 hit
InterProiView protein in InterPro
IPR016641 EGD2/NACA
IPR038187 NAC_A/B_dom_sf
IPR002715 Nas_poly-pep-assoc_cplx_dom
PANTHERiPTHR21713 PTHR21713, 1 hit
PfamiView protein in Pfam
PF01849 NAC, 1 hit
PIRSFiPIRSF015901 NAC_alpha, 1 hit
SMARTiView protein in SMART
SM01407 NAC, 1 hit
PROSITEiView protein in PROSITE
PS51151 NAC_AB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: Q86S66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGSTETRQK EVKEPQVDVS DDSDNEAVEQ ELTEEQRRVA EAAGLGDHID
60 70 80 90 100
KQAKQSRSEK KARKLFSKLG LKQVTGVSRV CIRKSKNILF VINKPDVFKS
110 120 130 140 150
PGSDTYIIFG EAKIEDLTQH AQMSAIENLK PTREAPQLKT VEEDENEDVE
160 170 180 190
FKEDSTGIEE KDIELVISQA NTTRNKAIRA LKEADNDIVN AIMSLTM
Note: Gene prediction based on EST data. No experimental confirmation.
Length:197
Mass (Da):22,078
Last modified:June 1, 2003 - v1
Checksum:i8512718E4D7CA97C
GO
Isoform bImported (identifier: Q86S66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-152: Missing.

Note: Gene prediction based on EST data. No experimental confirmation.
Show »
Length:195
Mass (Da):21,802
Checksum:i0158E4BCCC1775B0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014887151 – 152Missing in isoform b. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081483 Genomic DNA Translation: CCD71933.1
FO081483 Genomic DNA Translation: CCD71934.1
RefSeqiNP_490749.1, NM_058348.5 [Q86S66-2]
NP_871846.1, NM_182046.6 [Q86S66-1]
UniGeneiCel.7722

Genome annotation databases

EnsemblMetazoaiY65B4BR.5b; Y65B4BR.5b; WBGene00022042 [Q86S66-1]
GeneIDi171646
KEGGicel:CELE_Y65B4BR.5
UCSCiY65B4BR.5a.1 c. elegans [Q86S66-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNACA_CAEEL
AccessioniPrimary (citable) accession number: Q86S66
Secondary accession number(s): Q9N2Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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