UniProtKB - Q86QV2 (KGX34_CENGR)
(max 400 entries)x
Your basket is currently empty.
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Potassium channel toxin gamma-KTx 3.4
Gene
N/A
Organism
Centruroides gracilis (Slenderbrown scorpion) (Florida bark scorpion)
Status
Functioni
Blocks Kv11/ERG potassium channels.By similarity
GO - Molecular functioni
- potassium channel inhibitor activity Source: InterPro
GO - Biological processi
- defense response Source: InterPro
- pathogenesis Source: InterPro
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin gamma-KTx 3.41 PublicationAlternative name(s): CgErgTx2Curated Short name: CgErg21 Publication Short name: ErgTx21 Publication Ergtoxin-like protein1 Publication |
| Organismi | Centruroides gracilis (Slenderbrown scorpion) (Florida bark scorpion) |
| Taxonomic identifieri | 217898 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
- Secreted By similarity
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000066848 | 1 – 42 | Potassium channel toxin gamma-KTx 3.4Add BLAST | 42 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 5 ↔ 23 | By similarity | ||
| Disulfide bondi | 11 ↔ 34 | By similarity | ||
| Disulfide bondi | 20 ↔ 39 | By similarity | ||
| Disulfide bondi | 24 ↔ 41 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
| ProteinModelPortali | Q86QV2. |
| SMRi | Q86QV2. |
| ModBasei | Search... |
| MobiDBi | Search... |
Family & Domainsi
Domaini
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Has the CSalpha/beta fold, which comprises one or two short alpha helices connected to anti-parallel beta-sheets stabilized by three or four disulfide bonds.By similarity
Sequence similaritiesi
Keywords - Domaini
KnottinFamily and domain databases
| Gene3Di | 3.30.30.10. 1 hit. |
| InterProi | View protein in InterPro IPR012622. Ergtoxin. IPR003614. Scorpion_toxin-like. |
| Pfami | View protein in Pfam PF08086. Toxin_17. 1 hit. |
| ProDomi | View protein in ProDom or Entries sharing at least one domain PD736966. Ergtoxin. 1 hit. |
| SUPFAMi | SSF57095. SSF57095. 1 hit. |
| PROSITEi | View protein in PROSITE PS60026. ERGTX. 1 hit. |
Sequencei
Sequence statusi: Complete.
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY159341 mRNA. Translation: AAO22219.1. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KGX34_CENGR | |
| Accessioni | Q86QV2Primary (citable) accession number: Q86QV2 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
| Last sequence update: | June 1, 2003 | |
| Last modified: | May 10, 2017 | |
| This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Documents
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
