Q86QU2 (KGX51_CENSC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel toxin gamma-KTx 5.1

Alternative name(s):
CsErgTx5
Short name=CsErg5
Short name=ErgTx5
Ergtoxin-like protein 5

Gene names

Name:

ERG5

Organism

Centruroides sculpturatus (Bark scorpion)

Taxonomic identifier

218467 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides

Protein attributes

Sequence length	47 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Blocks ERG-potassium channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.
Sequence similarities	Belongs to the ergtoxin family. Gamma-KTx 5 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 47	47	Potassium channel toxin gamma-KTx 5.1		PRO_0000066858
Amino acid modifications
	Disulfide bond	5 ↔ 23		By similarity
	Disulfide bond	11 ↔ 34		By similarity
	Disulfide bond	20 ↔ 39		By similarity
	Disulfide bond	24 ↔ 41		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86QU2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 97F44AF20B6CA086	FASTA	47	5,271
	10 20 30 40 DRDSCVDKSR CAKYGYYGQC EVCCKKAGHN GGTCMFFKCM CVNSKMN

References

[1]

"A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides." Corona M., Gurrola G.B., Merino E., Cassulini R.R., Valdez-Cruz N.A., Garcia B., Ramirez-Dominguez M.E., Coronas F.I., Zamudio F.Z., Wanke E., Possani L.D. FEBS Lett. 532:121-126(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY159351 mRNA. Translation: AAO22229.1.
3D structure databases
ProteinModelPortal	Q86QU2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR012622. Ergtoxin. IPR003614. Scorpion_toxin-like. [Graphical view]
Pfam	PF08086. Toxin_17. 1 hit. [Graphical view]
ProDom	PD736966. Ergtoxin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS60026. ERGTX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGX51_CENSC

Accession

Primary (citable) accession number: Q86QU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program