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Protein

Potassium channel toxin gamma-KTx 1.6

Gene
N/A
Organism
Centruroides exilicauda (Bark scorpion)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks Kv11/ERG potassium channels.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin gamma-KTx 1.61 Publication
Alternative name(s):
CexErgTx1Curated
Short name:
CexErg11 Publication
Ergtoxin-like protein1 Publication
OrganismiCentruroides exilicauda (Bark scorpion)
Taxonomic identifieri6879 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668601 – 42Potassium channel toxin gamma-KTx 1.6Add BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 23By similarity
Disulfide bondi11 ↔ 34By similarity
Disulfide bondi20 ↔ 39By similarity
Disulfide bondi24 ↔ 41By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliQ86QU1.
SMRiQ86QU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Has the CSalpha/beta fold, which comprises one or two short alpha helices connected to anti-parallel beta-sheets stabilized by three or four disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the ergtoxin family. Gamma-KTx 1 subfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiView protein in InterPro
IPR012622. Ergtoxin.
IPR003614. Scorpion_toxin-like.
PfamiView protein in Pfam
PF08086. Toxin_17. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD736966. Ergtoxin. 1 hit.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiView protein in PROSITE
PS60026. ERGTX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86QU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
DRDSCVDKSR CAKYGYYQEC QDCCKKAGHS GGTCMFFKCK CA
Length:42
Mass (Da):4,725
Last modified:June 1, 2003 - v1
Checksum:iB585F51452681BD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY159352 mRNA. Translation: AAO22230.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKGX16_CENEX
AccessioniPrimary (citable) accession number: Q86QU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2003
Last modified: May 10, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families