Unreviewed, UniProtKB/TrEMBL Q86PA9 (Q86PA9_DROME)

Names and origin

Protein names

Submitted name:
    LD34308p EMBL AAO25003.1

Gene names

Name:	smo EMBL AAO25003.1
ORF Names:	CG11561 FlyBase FBgn0003444

Organism

Drosophila melanogaster (Fruit fly) EMBL AAO25003.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1036 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. Spearmint SPM000024

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Spearmint SPM000024
Molecular function	Developmental protein Spearmint SPM000024 G-protein coupled receptor Spearmint SPM000024 Receptor Transducer
PTM	Disulfide bond Spearmint SPM000024
Gene Ontology (GO)
Biological process	Bolwig's organ morphogenesis Inferred from mutant phenotype. Source: FlyBase G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW Wnt receptor signaling pathway Traceable author statement. Source: FlyBase anterior/posterior lineage restriction, imaginal disc Traceable author statement. Source: FlyBase blastoderm segmentation Inferred from mutant phenotype. Source: FlyBase eye-antennal disc morphogenesis Inferred from genetic interaction. Source: FlyBase ovarian follicle cell development Inferred from mutant phenotype. Source: FlyBase regulation of mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase smoothened signaling pathway Inferred from mutant phenotype. Source: FlyBase somatic stem cell maintenance Inferred from mutant phenotype. Source: FlyBase wing disc anterior/posterior pattern formation Traceable author statement. Source: FlyBase
Cellular component	endosome Traceable author statement. Source: FlyBase integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: FlyBase
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW hedgehog receptor activity Non-traceable author statement. Source: FlyBase non-G-protein coupled 7TM receptor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q86PA9-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7484DD40A47DAC3B	FASTA	1,036	116,538
	10 20 30 40 50 60 MQYLNFPRMP NIMMFLEVAI LCLWVVADAS ASSAKFGSTT PASAQQSDVE LEPINGTLNY 70 80 90 100 110 120 RLYAKKGRDD KPWFDGLDSR HIQCVRRARC YPTSNATNTC FGSKLPYELS SLDLTDFHTE 130 140 150 160 170 180 KELNDKLNDY YALKHVPKCW AAIQPFLCAV FKPKCEKING EDMVYLPSYE MCRITMEPCR 190 200 210 220 230 240 ILYNTTFFPK FLRCNETLFP TKCTNGARGM KFNGTGQCLS PLVPTDTSAS YYPGIEGCGV 250 260 270 280 290 300 RCKDPLYTDD EHRQIHKLIG WAGSICLLSN LFVVSTFFID WKNANKYPAV IVFYINLCFL 310 320 330 340 350 360 IACVGWLLQF TSGSREDIVC RKDGTLRHSE PTAGENLSCI VIFVLVYYFL TAGMVWFVFL 370 380 390 400 410 420 TYAWHWRAMG HVQDRIDKKG SYFHLVAWSL PLVLTITTMA FSEVDGNSIV GICFVGYINH 430 440 450 460 470 480 SMRAGLLLGP LCGVILIGGY FITRGMVMLF GLKHFANDIK STSASNKIHL IIMRMGVCAL 490 500 510 520 530 540 LTLVFILVAI ACHVTEFRHA DEWAQSFRQF IICKISSVFE EKSSCRIENR PSVGVLQLHL 550 560 570 580 590 600 LCLFSSGIVM STWCWTPSSI ETWKRYIRKK CGKEVVEEVK MPKHKVIAQT WAKRKDFEDK 610 620 630 640 650 660 GRLSITLYNT HTDPVGLNFD VNDLNSSETN DISSTWAAYL PQCVKRRMAL TGAATGNSSS 670 680 690 700 710 720 HGPRKNSLDS EISVSVRHVS VESRRNSVDS QVSVKIAEMK TKVASRSRGK HGGSSSNRRT 730 740 750 760 770 780 QRRRDYIAAA TGKSSRRRES STSVESQVIA LNKTTYPNAS HKVGVFAHHS SKKQHNYTSS 790 800 810 820 830 840 MKRRTANAGL DPSILNEFLQ KNGDFIFPFL QNQDMSSSSE EDNSRASQKI QDLNVVVKQQ 850 860 870 880 890 900 EISEDDHDGI KIEELPNSKQ VALENFLKNI KKSNESNSNR HSRNSARSQS KKSQKRHLKN 910 920 930 940 950 960 PAADLDFRKD CVKYRSNDSL SCSSEELDVA LDVGSLLNSS FSGISMGKPH SRNSKTSCDV 970 980 990 1000 1010 1020 GIQANPFELV PSYGEDELQQ AMRLLNAASR QRTEAANEDF GGTELQGLLG HSHRHQREPT 1030 FMSESDKLKM LLLPSK

References

[1]

Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAO25003.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT003246 mRNA. Translation: AAO25003.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q86PA9.
Genome annotation databases
Ensembl	FBgn0003444. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0003444. smo.
Gene expression databases
ArrayExpress	Q86PA9.
Family and domain databases
InterPro	IPR000539. Frizzled. IPR000024. Frizzled_Cys-rich. IPR015526. Frizzled_related. IPR017981. GPCR_2-like. [Graphical view]
Gene3D	G3DSA:1.10.2000.10. Frizzled_Cys-rich. 1 hit.
PANTHER	PTHR11309. Fz_related. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q86PA9_DROME

Accession

Primary (citable) accession number: Q86PA9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)