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Protein

Malic enzyme

Gene

Menl-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Prefers magnesium or manganese.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton donorUniRule annotation1
Active sitei205Proton acceptorUniRule annotation1
Metal bindingi277Divalent metal cationUniRule annotation1
Metal bindingi278Divalent metal cationUniRule annotation1
Metal bindingi301Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malic enzymeUniRule annotation
Gene namesi
Name:Menl-1Imported
Synonyms:Menl-2Imported
ORF Names:CG7964Imported, Dmel_CG7964Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0029154. Menl-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei327 – 345HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0029154.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0291083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 292malicInterPro annotationAdd BLAST183
Domaini302 – 553Malic_MInterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the malic enzymes family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1257. Eukaryota.
COG0281. LUCA.
KOiK00029.
OMAiAETWAYP.
OrthoDBiEOG091G04H9.

Family and domain databases

Gene3Di3.40.50.10380. 1 hit.
InterProiView protein in InterPro
IPR015884. Malic_enzyme_CS.
IPR012301. Malic_N_dom.
IPR037062. Malic_N_dom_sf.
IPR012302. Malic_NAD-bd.
IPR001891. Malic_OxRdtase.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF00390. malic. 1 hit.
PF03949. Malic_M. 1 hit.
PIRSFiPIRSF000106. ME. 1 hit.
PRINTSiPR00072. MALOXRDTASE.
SMARTiView protein in SMART
SM01274. malic. 1 hit.
SM00919. Malic_M. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00331. MALIC_ENZYMES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q86NT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFRLLNFG ITRGSSISKT HQSNCECSPN LIKIRPSSSH DTIRVPIEVV
60 70 80 90 100
FSDKCNKALA FTLEERQRLC IHGLMPACVR TYDEQMLAIE SNFHSFESNV
110 120 130 140 150
GRYRYLRALR QGYERLYFQF VSKNVHAVLP IIYTPTVGLA CTVYGMLYRG
160 170 180 190 200
MTGIHITKHD RGHMKQILSN WPMRRSVKAI CVTDGQRILG LGDLGANGMG
210 220 230 240 250
IAVGKMELYT ALAGIPPSML LPICLDVGTN NKSLHEDPLY IGLRDERLKG
260 270 280 290 300
DEYVCFVDEF MEAVVSTFGD QTLIHFEDFA TPNAFMFLNR YQHCYCHFND
310 320 330 340 350
DIQGTAAVGL GGLLGIQRIT KKPLEEHVIV FAGAGSAAMG IAYLLKMELM
360 370 380 390 400
SRGLSEADAA KNIYFYDQDG VLTTARKSIP DILCVFAKNM KETKSLETLV
410 420 430 440 450
EQVKPSIIMG ATSAPGLFTE KIIRTMAASH ERPGIFAFSN PTIKSECTAE
460 470 480 490 500
QAYKFSDGKA IYSAGSPFPP VEFNGKRLTP GQANNCFAFP ALVLATMTVL
510 520 530 540 550
ATRMPDEIFL LAAHELAEFP TNEEMQSGRI YPLVKQANEV AYKIGVKVAK
560 570 580 590 600
YLIENGYAKR NLEPEDVEEY IEKNSYKLTY GSSLAETWAY PKMKPHPSTA
610
GHENKHQKKK
Length:610
Mass (Da):68,064
Last modified:June 1, 2003 - v1
Checksum:iC54F24782E9735D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58000.3.
BT003651 mRNA. Translation: AAO39655.1.
RefSeqiNP_001027428.1. NM_001032257.2.
UniGeneiDm.20804.

Genome annotation databases

EnsemblMetazoaiFBtr0301869; FBpp0291083; FBgn0029154.
GeneIDi3772542.
KEGGidme:Dmel_CG7964.
UCSCiCG7964-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ86NT5_DROME
AccessioniPrimary (citable) accession number: Q86NT5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported