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Q86M34

- HEXB_ENTHI

UniProt

Q86M34 - HEXB_ENTHI

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Protein

Beta-hexosaminidase subunit beta

Gene

HEXB

Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hexoaminidase complex may contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components.1 Publication

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit beta (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase subunit beta
Beta-N-acetylhexosaminidase subunit beta
N-acetyl-beta-glucosaminidase subunit beta
Gene namesi
Name:HEXB
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Subcellular locationi

Cytoplasmic granule 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 13131 PublicationAdd
BLAST
Chaini14 – 565552Beta-hexosaminidase subunit betaPRO_0000012012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliQ86M34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86M34-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVLLLLISY CFAGNGVNVK NQLLLMPYPT TVNAQFGSND CVEATSNIKM
60 70 80 90 100
VLSNNCQNDP NCLSFMTFNF NHTITYPLQR QRNLEDFRVS IFAPIDIEEM
110 120 130 140 150
KGNVVYSANT VNIELTGNNI EEIYPPLKIG IDESYSLDVT KEGIKISATT
160 170 180 190 200
VYGARLGLET LIQMLRPYQG KYIIKHIPIM IEDKPRLQWR GLMIDVARNS
210 220 230 240 250
FSRSAFVKII NAMAAIKANV LHIHLSDAQT FMFESKEYPE LSKKGAFFQN
260 270 280 290 300
KVLTQSFIKQ LVQYGAKRGV IVYPEIDTPA HTASWNAGYP GVVADIWDYI
310 320 330 340 350
VSSSMRYGEN VLALNPANEK TFSIIDALMK EMGEVFGNDY VHFGGDEVWT
360 370 380 390 400
GAWSKAKEYP AILEWMNKKG INTLKELEAY FNKYAQEQII KNGKTPVCWE
410 420 430 440 450
EVYQKGSADK KTIIQVWNNV NLLKEAATAG YKVILSAGYY LDMQMPLCSD
460 470 480 490 500
YVADSCTNPN HMWVWTNRDM YRNDPIKELD YATKQNVLGG EACSWDESVD
510 520 530 540 550
EQNFFDRVFQ RFSAVAERFW SSEDITDPES HEVRANYVRC LGLRRNFLKG
560
TGPLYHSYCQ LPEDI
Length:565
Mass (Da):64,372
Last modified:June 1, 2003 - v1
Checksum:iDABBBA0B932BBA4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ417748 Genomic DNA. Translation: CAD10500.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ417748 Genomic DNA. Translation: CAD10500.3 .

3D structure databases

ProteinModelPortali Q86M34.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG3525.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The beta-N-acetylhexosaminidase of Entamoeba histolytica is composed of two homologous chains and has been localized to cytoplasmic granules."
    Riekenberg S., Flockenhaus B., Vahrmann A., Mueller M.C.M., Leippe M., Kiess M., Scholze H.H.
    Mol. Biochem. Parasitol. 138:217-225(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 14-33; 146-155 AND 307-316, FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH HEXA.
    Strain: ATCC 30459 / HM-1:IMSS.

Entry informationi

Entry nameiHEXB_ENTHI
AccessioniPrimary (citable) accession number: Q86M34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3