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Q86M34

- HEXB_ENTHI

UniProt

Q86M34 - HEXB_ENTHI

Protein

Beta-hexosaminidase subunit beta

Gene

HEXB

Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Hexoaminidase complex may contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components.1 Publication

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase subunit beta (EC:3.2.1.52)
    Alternative name(s):
    Beta-GlcNAcase subunit beta
    Beta-N-acetylhexosaminidase subunit beta
    N-acetyl-beta-glucosaminidase subunit beta
    Gene namesi
    Name:HEXB
    OrganismiEntamoeba histolytica
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

    Subcellular locationi

    Cytoplasmic granule 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 13131 PublicationAdd
    BLAST
    Chaini14 – 565552Beta-hexosaminidase subunit betaPRO_0000012012Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86M34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86M34-1 [UniParc]FASTAAdd to Basket

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    MIVLLLLISY CFAGNGVNVK NQLLLMPYPT TVNAQFGSND CVEATSNIKM    50
    VLSNNCQNDP NCLSFMTFNF NHTITYPLQR QRNLEDFRVS IFAPIDIEEM 100
    KGNVVYSANT VNIELTGNNI EEIYPPLKIG IDESYSLDVT KEGIKISATT 150
    VYGARLGLET LIQMLRPYQG KYIIKHIPIM IEDKPRLQWR GLMIDVARNS 200
    FSRSAFVKII NAMAAIKANV LHIHLSDAQT FMFESKEYPE LSKKGAFFQN 250
    KVLTQSFIKQ LVQYGAKRGV IVYPEIDTPA HTASWNAGYP GVVADIWDYI 300
    VSSSMRYGEN VLALNPANEK TFSIIDALMK EMGEVFGNDY VHFGGDEVWT 350
    GAWSKAKEYP AILEWMNKKG INTLKELEAY FNKYAQEQII KNGKTPVCWE 400
    EVYQKGSADK KTIIQVWNNV NLLKEAATAG YKVILSAGYY LDMQMPLCSD 450
    YVADSCTNPN HMWVWTNRDM YRNDPIKELD YATKQNVLGG EACSWDESVD 500
    EQNFFDRVFQ RFSAVAERFW SSEDITDPES HEVRANYVRC LGLRRNFLKG 550
    TGPLYHSYCQ LPEDI 565
    Length:565
    Mass (Da):64,372
    Last modified:June 1, 2003 - v1
    Checksum:iDABBBA0B932BBA4F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417748 Genomic DNA. Translation: CAD10500.3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ417748 Genomic DNA. Translation: CAD10500.3 .

    3D structure databases

    ProteinModelPortali Q86M34.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG3525.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The beta-N-acetylhexosaminidase of Entamoeba histolytica is composed of two homologous chains and has been localized to cytoplasmic granules."
      Riekenberg S., Flockenhaus B., Vahrmann A., Mueller M.C.M., Leippe M., Kiess M., Scholze H.H.
      Mol. Biochem. Parasitol. 138:217-225(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 14-33; 146-155 AND 307-316, FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH HEXA.
      Strain: ATCC 30459 / HM-1:IMSS.

    Entry informationi

    Entry nameiHEXB_ENTHI
    AccessioniPrimary (citable) accession number: Q86M34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3