Reviewed,
UniProtKB/Swiss-Prot Q86KU6 (MTD1_DICDI)
Last modified
June 16, 2009.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Methylenetetrahydrofolate dehydrogenase [NAD+] EC=1.5.1.15 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 313 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis By similarity. |
| Catalytic activity | 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH. |
| Cofactor | NAD By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism Purine biosynthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid and derivative biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon compound metabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW purine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro methylenetetrahydrofolate dehydrogenase (NAD+) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 313 | 313 | Methylenetetrahydrofolate dehydrogenase [NAD+] | PRO_0000327391 | |||||
Regions | |||||||||
| Nucleotide binding | 187 – 188 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 210 – 211 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 270 – 272 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 152 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AC115612 Genomic DNA. Translation: AAO50895.1. AAFI02000022 Genomic DNA. Translation: EAL68536.1. | |
| RefSeq | XP_642462.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EDZ based on UniProtKB Q02046. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3393645. |
| KEGG | ddi:DDB_0230118. |
Organism-specific databases | |
| dictyBase | DDB_G0277725. thfA. |
Phylogenomic databases | |
| OMA | Q86KU6. VCINFSS. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.15. 424. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000672. THF_DH/CycHdrlase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00763. THF_DHG_CYH. 1 hit. PF02882. THF_DHG_CYH_C. 1 hit. [Graphical view] |
| PRINTS | PR00085. THFDHDRGNASE. |
| ProDom | PD002300. THFDhg/Cyc_hydro. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | MTD1_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q86KU6 Secondary accession number(s): Q54Z91 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


