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Protein

Probable valine--tRNA ligase, cytoplasmic

Gene

valS1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei671 – 6711ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable valine--tRNA ligase, cytoplasmic (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:valS1
ORF Names:DDB_G0277733
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277733. valS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10721072Probable valine--tRNA ligase, cytoplasmicPRO_0000327760Add
BLAST

Proteomic databases

PaxDbiQ86KU2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231269.

Structurei

3D structure databases

ProteinModelPortaliQ86KU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 9081Sequence analysisAdd
BLAST
Coiled coili1003 – 106967Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi151 – 16111"HIGH" regionBy similarityAdd
BLAST
Motifi668 – 6725"KMSKS" regionBy similarity

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
InParanoidiQ86KU2.
KOiK01873.
OMAiIWQWRNE.
PhylomeDBiQ86KU2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86KU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPKPTQPI KEIDEETKRK NEEKKKAKEA EKAEKLAKMK EKEAKQAAAK
60 70 80 90 100
EKELQNKLKK EQEKKEKEAE EKEKQEAEEK IVREHIEKIL KTPKGEKKDV
110 120 130 140 150
SSLLSSYHPT AVESIWYDYW LDNGYFSPEK QMEIQPHVVK DKKFVIVIPP
160 170 180 190 200
PNVTGSLHLG HALTNSIQDA VVRYHRMKGE VCLWVPGTDH AGIATQVVVE
210 220 230 240 250
KKIWKENKIT RHDLGREGFI KKVWEWKGEY GARIQGQLKK MGSSVDWSRE
260 270 280 290 300
VFTMDDQRSK AVNTAFIRMF NDGLIVRTTR LVNWSCALKT AISDIEVDFI
310 320 330 340 350
DLEKHTKMSV PGHQGQYDFG VLFEFAYQVE GSGEELVVAT TRIETMLADT
360 370 380 390 400
AIAIHPDDTR YTHLHGKFAI HPLNGRKIPI ITDSVLVDKD FGTGVVKITP
410 420 430 440 450
SHDPNDYETA LRHGLEFINL FTDEGLINEN GGERFAGMKR FDARNAVVEA
460 470 480 490 500
LKEKNLFKGM KDNKMRLGLC SRSKDVIEPM IKPQWYVKCD DMAARAVKAV
510 520 530 540 550
RDGDLKITPK THEVTWYRWL EGIKDWCVSR QLWWGHRIPA YHCIIKGVKS
560 570 580 590 600
NPYDTNQWVV GANQEEATQN AIEKFKLSSK DDILSLEQDP DVLDTWFSSG
610 620 630 640 650
LFPFSVMGWP EQTQDMQDYY PTSLLETGSD ILFFWVARMV MMGQQLTGKL
660 670 680 690 700
PFEQVFLHAM VRDSHGRKMS KSLGNVIDPN DVIKGISLDE LIAKLYEGNL
710 720 730 740 750
DSKEIEKATS GVKSDFPTGI AECGTDAMRF ALCAYTSQGR DINLDIQRVV
760 770 780 790 800
GYRNFCNKIW NATRFAHMKL GDSFKPESFD ASKLLQQSNA INLWILNAAQ
810 820 830 840 850
RAITLSEEGF KEYDFSKVTT AIYSFWLNEM CDVYLEMTKS IFSLEEDSPI
860 870 880 890 900
KQKTKETLYT CIDIGLRLLH PFMPYLTEEL YQSLPRRPED VIPTIMLCPY
910 920 930 940 950
PQSQSCWANS DIEEEMKQCQ DIIKSIRSLR ATYTIPASKK LHTYLHVKNQ
960 970 980 990 1000
ENLERFTKNS SFIRVLAYAS ELEVSISDES RPGCIVNVVN ENVSTLLDVR
1010 1020 1030 1040 1050
GSVDFNLEIA RLETKKQQLV KNYETLVSKT TIPSYDKVPQ NIRDDNTQKI
1060 1070
KALDEEINIT NKTIESFTKL NI
Length:1,072
Mass (Da):122,834
Last modified:June 1, 2003 - v1
Checksum:i110221A2569A41A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000022 Genomic DNA. Translation: EAL68540.1.
RefSeqiXP_642469.1. XM_637377.1.

Genome annotation databases

EnsemblProtistsiDDB0231269; DDB0231269; DDB_G0277733.
GeneIDi8621180.
KEGGiddi:DDB_G0277733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000022 Genomic DNA. Translation: EAL68540.1.
RefSeqiXP_642469.1. XM_637377.1.

3D structure databases

ProteinModelPortaliQ86KU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231269.

Proteomic databases

PaxDbiQ86KU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231269; DDB0231269; DDB_G0277733.
GeneIDi8621180.
KEGGiddi:DDB_G0277733.

Organism-specific databases

dictyBaseiDDB_G0277733. valS1.

Phylogenomic databases

eggNOGiKOG0432. Eukaryota.
COG0525. LUCA.
InParanoidiQ86KU2.
KOiK01873.
OMAiIWQWRNE.
PhylomeDBiQ86KU2.

Miscellaneous databases

PROiQ86KU2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSYVC_DICDI
AccessioniPrimary (citable) accession number: Q86KU2
Secondary accession number(s): Q54Z84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.