Q86KK2 (FHIT_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bis(5'-adenosyl)-triphosphatase
EC=3.6.1.29

Alternative name(s):
AP3A hydrolase
Short name=AP3Aase
Diadenosine 5',5'''-P1,P3-triphosphate hydrolase
Dinucleosidetriphosphatase
Fragile histidine triad protein homolog

Gene names

Name:	fhit
ORF Names:	DDB_G0274257

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves A-5'-PPP-5'A to yield AMP and ADP By similarity.
Catalytic activity	P(1)-P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 HIT domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	bis(5'-adenosyl)-triphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	Bis(5'-adenosyl)-triphosphatase		PRO_0000342401
Regions
	Domain	1 – 115	115	HIT

Sequences

	Sequence		Length	Mass (Da)
	Q86KK2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2F44495136FBA7C9	FASTA	149	17,499
	10 20 30 40 50 60 MTTTYFGPWL IRQSEIFFTT ELSFALVNLK PVLPGHVLVC PKRIVPRVKD LTKEEFTDLW 70 80 90 100 110 120 LSAQRISSVV EEHFNGDGIT FAIQDGKNAG QTVEHVHIHI IPRKKFDFEN NDQIYNEIEK 130 140 EREPRSYEEM EKESSELRPL FEENKNKTF

References

[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000012 Genomic DNA. Translation: EAL70021.1.
RefSeq	XP_644016.1. XM_638924.1.
3D structure databases
HSSP	HSSP built from PDB template 2FIT based on UniProtKB P49789.
ProteinModelPortal	Q86KK2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q86KK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0167807; DDB0167807; DDB_G0274257.
GeneID	8619446.
GenomeReviews	Gene locus fhit in contig CM000151_GR.
KEGG	ddi:DDB_G0274257.
Organism-specific databases
dictyBase	DDB_G0274257. fhit.
Phylogenomic databases
eggNOG	KOG3379.
GeneTree	EPrGT00050000005158.
HOGENOM	HBG396802.
OMA	TLAIQDG.
PhylomeDB	Q86KK2.
ProtClustDB	CLSZ2497260.
Family and domain databases
InterPro	IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. IPR019808. Histidine_triad_CS. IPR001310. Histidine_triad_HIT. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 1 hit.
KO	K01522.
PANTHER	PTHR23089. HIT. 1 hit.
Pfam	PF01230. HIT. 1 hit. [Graphical view]
PRINTS	PR00332. HISTRIAD.
SUPFAM	SSF54197. His_triad-like_motif. 1 hit.
PROSITE	PS00892. HIT_1. 1 hit. PS51084. HIT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FHIT_DICDI

Accession

Primary (citable) accession number: Q86KK2
Secondary accession number(s): Q555P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)