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Q86KC1

- LYSG2_DICDI

UniProt

Q86KC1 - LYSG2_DICDI

Protein

Probable GH family 25 lysozyme 2

Gene

DDB_G0274181

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell wall macromolecule catabolic process Source: InterPro
    3. cytolysis Source: UniProtKB-KW
    4. defense response to bacterium Source: UniProtKB-KW
    5. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable GH family 25 lysozyme 2 (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase 2
    Gene namesi
    ORF Names:DDB_G0274181
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0274181.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 212193Probable GH family 25 lysozyme 2PRO_0000330648Add
    BLAST

    Proteomic databases

    PRIDEiQ86KC1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86KC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75899.
    OMAiHQWHGTE.
    PhylomeDBiQ86KC1.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR002053. Glyco_hydro_25.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01183. Glyco_hydro_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q86KC1-1 [UniParc]FASTAAdd to Basket

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    MRFIALLISF FALLKVISAI SGVDISSAST IESFTCLKSA GYDFAIIRAY    50
    ESLGQVDPNG PHSVYNARDA GIEYVDVYMF PCPTCGNGAG QAETMVNYLK 100
    GYNANYGMVW LDIEGPQYWM SQSENVAFFE SLVAGLKAEG AHIGVYTSAS 150
    QWEPIMGGYT GGSEFPLWYA HYDGNPSFSD FSPFNGWSTP SVKQYDDTGD 200
    SCGLGFDLNW YP 212
    Length:212
    Mass (Da):23,202
    Last modified:June 1, 2003 - v1
    Checksum:iB6036D806E5E8281
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000012 Genomic DNA. Translation: EAL69983.1.
    RefSeqiXP_644284.1. XM_639192.1.

    Genome annotation databases

    EnsemblProtistsiDDB0252580; DDB0252580; DDB_G0274181.
    GeneIDi8619712.
    KEGGiddi:DDB_G0274181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000012 Genomic DNA. Translation: EAL69983.1 .
    RefSeqi XP_644284.1. XM_639192.1.

    3D structure databases

    ProteinModelPortali Q86KC1.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q86KC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0252580 ; DDB0252580 ; DDB_G0274181 .
    GeneIDi 8619712.
    KEGGi ddi:DDB_G0274181.

    Organism-specific databases

    dictyBasei DDB_G0274181.

    Phylogenomic databases

    eggNOGi NOG75899.
    OMAi HQWHGTE.
    PhylomeDBi Q86KC1.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR002053. Glyco_hydro_25.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01183. Glyco_hydro_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiLYSG2_DICDI
    AccessioniPrimary (citable) accession number: Q86KC1
    Secondary accession number(s): Q554N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3