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Protein

Signal peptidase complex catalytic subunit sec11

Gene

sec11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.010

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit sec11 (EC:3.4.21.89)
Gene namesi
Name:sec11
ORF Names:DDB_G0276359
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276359 sec11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini44 – 179LumenalSequence analysisAdd BLAST136

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306531 – 179Signal peptidase complex catalytic subunit sec11Add BLAST179

Proteomic databases

PaxDbiQ86JD4

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of four members: sec11, spcs1, spcs2 and spcs3.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0237791

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342 Eukaryota
COG0681 LUCA
InParanoidiQ86JD4
KOiK13280
OMAiYIPFVGY
PhylomeDBiQ86JD4

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR015927 Peptidase_S24_S26A/B/C
IPR001733 Peptidase_S26B
IPR037712 SEC11A/SEC11B
PANTHERiPTHR10806 PTHR10806, 1 hit
PTHR10806:SF8 PTHR10806:SF8, 1 hit
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00728 SIGNALPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02228 sigpep_I_arch, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q86JD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIISKINP FSSIPKHQIA QQIVNFGLIV ATALMIWKGL MIFSGSESPI
60 70 80 90 100
VVVLSGSMIP AFFRGDLLYL NMEDGPFRVG EIVVFKIEGK EIPIVHRILQ
110 120 130 140 150
IHEKEDGLYD IRTKGDNNNV DDVGLYSPGQ RWLSRDHIIG RAKGFLPSVG
160 170
MVTIVMHDYP QLKFFLVFVL AVFVLSTRE
Length:179
Mass (Da):20,145
Last modified:June 1, 2003 - v1
Checksum:iBF5DE6066C1F2D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000014 Genomic DNA Translation: EAL69260.1
RefSeqiXP_643198.1, XM_638106.1

Genome annotation databases

EnsemblProtistsiEAL69260; EAL69260; DDB_G0276359
GeneIDi8620472
KEGGiddi:DDB_G0276359

Similar proteinsi

Entry informationi

Entry nameiSEC11_DICDI
AccessioniPrimary (citable) accession number: Q86JD4
Secondary accession number(s): Q551R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health