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Protein

Signal peptidase complex catalytic subunit sec11

Gene

sec11

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit sec11 (EC:3.4.21.89)
Gene namesi
Name:sec11
ORF Names:DDB_G0276359
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276359. sec11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini44 – 179136LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Signal peptidase complex catalytic subunit sec11PRO_0000330653Add
BLAST

Proteomic databases

PaxDbiQ86JD4.
PRIDEiQ86JD4.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of four members: sec11, spcs1, spcs2 and spcs3.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0237791.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
InParanoidiQ86JD4.
KOiK13280.
OMAiGQLWLEK.
PhylomeDBiQ86JD4.

Family and domain databases

InterProiIPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86JD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIISKINP FSSIPKHQIA QQIVNFGLIV ATALMIWKGL MIFSGSESPI
60 70 80 90 100
VVVLSGSMIP AFFRGDLLYL NMEDGPFRVG EIVVFKIEGK EIPIVHRILQ
110 120 130 140 150
IHEKEDGLYD IRTKGDNNNV DDVGLYSPGQ RWLSRDHIIG RAKGFLPSVG
160 170
MVTIVMHDYP QLKFFLVFVL AVFVLSTRE
Length:179
Mass (Da):20,145
Last modified:June 1, 2003 - v1
Checksum:iBF5DE6066C1F2D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000014 Genomic DNA. Translation: EAL69260.1.
RefSeqiXP_643198.1. XM_638106.1.

Genome annotation databases

EnsemblProtistsiDDB0237791; DDB0237791; DDB_G0276359.
GeneIDi8620472.
KEGGiddi:DDB_G0276359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000014 Genomic DNA. Translation: EAL69260.1.
RefSeqiXP_643198.1. XM_638106.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237791.

Protein family/group databases

MEROPSiS26.022.

Proteomic databases

PaxDbiQ86JD4.
PRIDEiQ86JD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0237791; DDB0237791; DDB_G0276359.
GeneIDi8620472.
KEGGiddi:DDB_G0276359.

Organism-specific databases

dictyBaseiDDB_G0276359. sec11.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
InParanoidiQ86JD4.
KOiK13280.
OMAiGQLWLEK.
PhylomeDBiQ86JD4.

Miscellaneous databases

PROiQ86JD4.

Family and domain databases

InterProiIPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC11_DICDI
AccessioniPrimary (citable) accession number: Q86JD4
Secondary accession number(s): Q551R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.