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Protein

Histone acetyltransferase type B catalytic subunit DDB_G0274269

Gene

DDB_G0274269

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei299Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit DDB_G0274269 (EC:2.3.1.48By similarity)
Gene namesi
ORF Names:DDB_G0274269
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274269.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678311 – 486Histone acetyltransferase type B catalytic subunit DDB_G0274269Add BLAST486

Proteomic databases

PaxDbiQ86J12.

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei218Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0237834.

Structurei

3D structure databases

ProteinModelPortaliQ86J12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini189 – 386N-acetyltransferaseAdd BLAST198

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 262Acetyl-CoA bindingBy similarity3
Regioni267 – 273Acetyl-CoA bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 69Sequence analysisAdd BLAST43
Coiled coili392 – 481Sequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 56Poly-Glu6
Compositional biasi62 – 67Poly-Glu6

Sequence similaritiesi

Belongs to the HAT1 family.Curated
Contains 1 N-acetyltransferase domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
InParanoidiQ86J12.
KOiK11303.
OMAiGENENIV.
PhylomeDBiQ86J12.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 3 hits.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.

Sequencei

Sequence statusi: Complete.

Q86J12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNRIKSSNT LLTFDANEVT NIKLVWDIEE LKNKDNKENK DKENKAHIKD
60 70 80 90 100
EGEEEEQKEK KEEEEKEDDG GPISFHPTYS HQIFNEDKIQ GYEPCKIDIY
110 120 130 140 150
MGAGSLTSYI DTNYTLQSKN LTNVEGEFLK VFSKQDPPIS KQSFYKYIEE
160 170 180 190 200
KEKLFKPIGK KIHEYSIIDK ESGKETEYEI YFGRITDQVV FRYHEKLQIF
210 220 230 240 250
VLWYIDGSSY IWTDDPNWDI FFIFEKRIID GEKRYGITGY STIYNFYHHP
260 270 280 290 300
EQTRARISQY LILPPYQRMG HGKYLFNSIY QYYKTNDGFY GPIYDITIED
310 320 330 340 350
PADEFNLLRN YVDLKNIMDE KLFDNVILDL NANNKSVFEE IRKKLLIPYK
360 370 380 390 400
QSKLCLEIYL FSKFLGTPNS DTKYKEYRIS IKKRLYKQNI GDSEQIEKIK
410 420 430 440 450
QQVAEENQEN LRLEQEELQE LQDIENKKNG TNIKVDIKPK ELTTPPGPEK
460 470 480
NKEEIEKDRL EEILELYKEL EKNYHKTLSS LNLISK
Length:486
Mass (Da):57,832
Last modified:June 1, 2003 - v1
Checksum:iB47394CB3F8294E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70027.1.
RefSeqiXP_643973.1. XM_638881.1.

Genome annotation databases

EnsemblProtistsiEAL70027; EAL70027; DDB_G0274269.
GeneIDi8619399.
KEGGiddi:DDB_G0274269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA. Translation: EAL70027.1.
RefSeqiXP_643973.1. XM_638881.1.

3D structure databases

ProteinModelPortaliQ86J12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0237834.

Proteomic databases

PaxDbiQ86J12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70027; EAL70027; DDB_G0274269.
GeneIDi8619399.
KEGGiddi:DDB_G0274269.

Organism-specific databases

dictyBaseiDDB_G0274269.

Phylogenomic databases

eggNOGiKOG2696. Eukaryota.
ENOG410XPH4. LUCA.
InParanoidiQ86J12.
KOiK11303.
OMAiGENENIV.
PhylomeDBiQ86J12.

Miscellaneous databases

PROiQ86J12.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 3 hits.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHAT11_DICDI
AccessioniPrimary (citable) accession number: Q86J12
Secondary accession number(s): Q555T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.