Q86J12 (HAT11_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone acetyltransferase type B catalytic subunit DDB_G0274269
EC=2.3.1.48

Gene names

ORF Names:

DDB_G0274269

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Sequence similarities	Belongs to the HAT1 family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Domain	Coiled coil
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin silencing at telomere Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Histone acetyltransferase type B catalytic subunit DDB_G0274269		PRO_0000367831
Regions
	Domain	189 – 386	198	N-acetyltransferase
	Coiled coil	27 – 69	43	Potential
	Coiled coil	392 – 481	90	Potential
	Compositional bias	51 – 56	6	Poly-Glu
	Compositional bias	62 – 67	6	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q86J12 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B47394CB3F8294E7	FASTA	486	57,832
	10 20 30 40 50 60 MTNRIKSSNT LLTFDANEVT NIKLVWDIEE LKNKDNKENK DKENKAHIKD EGEEEEQKEK 70 80 90 100 110 120 KEEEEKEDDG GPISFHPTYS HQIFNEDKIQ GYEPCKIDIY MGAGSLTSYI DTNYTLQSKN 130 140 150 160 170 180 LTNVEGEFLK VFSKQDPPIS KQSFYKYIEE KEKLFKPIGK KIHEYSIIDK ESGKETEYEI 190 200 210 220 230 240 YFGRITDQVV FRYHEKLQIF VLWYIDGSSY IWTDDPNWDI FFIFEKRIID GEKRYGITGY 250 260 270 280 290 300 STIYNFYHHP EQTRARISQY LILPPYQRMG HGKYLFNSIY QYYKTNDGFY GPIYDITIED 310 320 330 340 350 360 PADEFNLLRN YVDLKNIMDE KLFDNVILDL NANNKSVFEE IRKKLLIPYK QSKLCLEIYL 370 380 390 400 410 420 FSKFLGTPNS DTKYKEYRIS IKKRLYKQNI GDSEQIEKIK QQVAEENQEN LRLEQEELQE 430 440 450 460 470 480 LQDIENKKNG TNIKVDIKPK ELTTPPGPEK NKEEIEKDRL EEILELYKEL EKNYHKTLSS LNLISK

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000012 Genomic DNA. Translation: EAL70027.1.
RefSeq	XP_643973.1. XM_638881.1.
3D structure databases
HSSP	HSSP built from PDB template 1BOB based on UniProtKB Q12341.
ProteinModelPortal	Q86J12.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237834; DDB0237834; DDB_G0274269.
GeneID	8619399.
KEGG	ddi:DDB_G0274269.
Organism-specific databases
dictyBase	DDB_G0274269.
Phylogenomic databases
eggNOG	NOG326277.
KO	K11303.
ProtClustDB	CLSZ2430988.
Family and domain databases
Gene3D	3.40.630.30. 1 hit. 3.90.360.10. 2 hits.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view]
PANTHER	PTHR12046. PTHR12046. 1 hit.
Pfam	PF10394. Hat1_N. 1 hit. [Graphical view]
PIRSF	PIRSF038084. HAT-B_cat. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT11_DICDI

Accession

Primary (citable) accession number: Q86J12
Secondary accession number(s): Q555T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 1, 2003
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)