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Protein

Ubiquitin-conjugating enzyme E2 pex4

Gene

pex4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPeroxisome biogenesis, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 pex4 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme pex4
Peroxin-4
Peroxisome biogenesis factor 4
Ubiquitin carrier protein pex4
Gene namesi
Name:pex4
ORF Names:DDB_G0274313
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274313 pex4

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003714051 – 149Ubiquitin-conjugating enzyme E2 pex4Add BLAST149

Proteomic databases

PaxDbiQ86IZ3

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0237666

Structurei

3D structure databases

ProteinModelPortaliQ86IZ3
SMRiQ86IZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
InParanoidiQ86IZ3
KOiK10689
OMAiCVRAVRM
PhylomeDBiQ86IZ3

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q86IZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARLMKEYK VLQNEEFEDI LLYPRDESDL YRWVAIIKGP PDTPYENGKF
60 70 80 90 100
ELDISVPTNY PLQPPTIKFV TKIFHPNIHF KTGEICLDLL KTSWSAIYTL
110 120 130 140
QSVCRSIIAL LSLPEADSPL NCDAGNLIRN GDVKGHDSLA RMYTRLYGC
Length:149
Mass (Da):17,011
Last modified:June 1, 2003 - v1
Checksum:i83AF71AB962BD9B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70049.1
RefSeqiXP_643940.1, XM_638848.1

Genome annotation databases

EnsemblProtistsiEAL70049; EAL70049; DDB_G0274313
GeneIDi8619368
KEGGiddi:DDB_G0274313

Similar proteinsi

Entry informationi

Entry nameiUBCX_DICDI
AccessioniPrimary (citable) accession number: Q86IZ3
Secondary accession number(s): Q555X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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