Reviewed,
UniProtKB/Swiss-Prot Q86IV5 (CTNA_DICDI)
Last modified
September 23, 2008.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Countin-1 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 258 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion. |
| Subunit structure | Component of the counting factor (CF) complex, which includes cf60, cf50, cf45-1 and ctnA. |
| Subcellular location | |
| Developmental stage | Highly expressed in the vegetative cells and decreases during subsequent developmental stages (6-24 hours). |
| Miscellaneous | Cells lacking cntA form a fewer number of larger aggregates. |
| Sequence similarities | Belongs to the countin family. Contains 1 saposin B-type domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| PTM | Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | ||||||||
| Chain | 22 – 258 | 237 | Countin-1 | |||||||
Regions | ||||||||||
| Domain | 22 – 106 | 85 | Saposin B-type | |||||||
Amino acid modifications | ||||||||||
| Glycosylation | 121 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 215 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 25 ↔ 102 | By similarity | ||||||||
| Disulfide bond | 28 ↔ 96 | By similarity | ||||||||
| Disulfide bond | 56 ↔ 69 | By similarity | ||||||||
Experimental info | ||||||||||
| Sequence conflict | 45 | 1 | Missing in AAD53482. Ref.1 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A cell-counting factor regulating structure size in Dictyostelium." Brock D.A., Gomer R.H. Genes Dev. 13:1960-1969(1999) [PubMed: 10444594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-41, IDENTIFICATION IN THE COUNTIN COMPLEX, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, FUNCTION, KNOCKOUT. |
| [2] | "Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [3] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [4] | "A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion." Roisin-Bouffay C., Jang W., Caprette D.R., Gomer R.H. Mol. Cell 6:953-959(2000) [PubMed: 11090633] [Abstract] Cited for: FUNCTION. |
| [5] | "Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum." Okuwa T., Katayama T., Takano A., Kodaira K., Yasukawa H. Dev. Growth Differ. 43:735-744(2001) [PubMed: 11737154] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE. |
Cross-references
Sequence databases | |
|---|---|
| AF140780 Genomic DNA. Translation: AAD53482.1. AC116986 Genomic DNA. Translation: AAO51901.1. AAFI02000012 Genomic DNA. Translation: EAL70191.1. | |
| RefSeq | XP_643887.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3395201. |
| KEGG | ddi:DDB_0185089. |
Organism-specific databases | |
| dictyBase | DDB0185089. ctnA. |
Family and domain databases | |
| InterPro | IPR008139. SaposinB. [Graphical view] |
| SMART | SM00741. SapB. 1 hit. [Graphical view] |
| PROSITE | PS50015. SAP_B. 1 hit. [Graphical view] |
| ProDom | Q86IV5. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | CTNA_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q86IV5 Secondary accession number(s): Q556C3, Q9U7C4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


