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Protein

Countin-1

Gene

ctnA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell-counting factor that limits the maximum size of the multicellular structure. May down-regulate the expression of gp24, which mediates cell adhesion.3 Publications

GO - Molecular functioni

  • signal transducer activity Source: dictyBase

GO - Biological processi

  • actin filament polymerization Source: dictyBase
  • cell motility Source: dictyBase
  • glucose homeostasis Source: dictyBase
  • multicellular organism development Source: dictyBase
  • negative regulation of aggregate size involved in sorocarp development Source: dictyBase
  • negative regulation of cell adhesion Source: dictyBase
  • negative regulation of cGMP biosynthetic process Source: dictyBase
  • regulation of glucose-6-phosphatase activity Source: dictyBase
  • regulation of glycolytic process Source: dictyBase
Complete GO annotation...

Protein family/group databases

TCDBi1.C.35.4.1. the amoebapore (amoebapore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Countin-1
Gene namesi
Name:ctnA
ORF Names:DDB_G0274597
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274597. ctnA.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Cells form a fewer number of larger aggregates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 258237Countin-1PRO_0000327908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 102PROSITE-ProRule annotation
Disulfide bondi28 ↔ 96PROSITE-ProRule annotation
Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
Glycosylationi121 – 1211N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi215 – 2151N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86IV5.
PRIDEiQ86IV5.

Expressioni

Developmental stagei

Highly expressed in the vegetative cells and decreases during subsequent developmental stages (6-24 hours).2 Publications

Interactioni

Subunit structurei

Component of the counting factor (CF) complex, which includes cf60, cf50, cf45-1 and ctnA.4 Publications

Protein-protein interaction databases

STRINGi44689.DDB0185089.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10685Saposin B-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the countin family.Curated
Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17V. Eukaryota.
ENOG4111W08. LUCA.
InParanoidiQ86IV5.
OMAiSKHPHSQ.
PhylomeDBiQ86IV5.

Family and domain databases

InterProiIPR008139. SaposinB_dom.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86IV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLFSLILA LFLVNSAVVS SLDSCSICVD FVGNSLNDLL NIILNSGVIG
60 70 80 90 100
TCGDLCSAVP GGQIVDTVCD LLCDYVGVDE FIKLISDVDP DPIYICEKIS
110 120 130 140 150
VCKTNDNAAA SLDLVQINPQ NGTVGGTFTL SIAYTVTNTI ATGQLAFNII
160 170 180 190 200
DPTGNAFGDA VLLVQQSPEQ YTQQFQFQAT PSEQESFPNG LYTVQALVCE
210 220 230 240 250
GSCGSPHPNT YTLANGTTTF TISGADSSSM SGAGSFSGSS QSTQTGAASG

SGSGFALF
Length:258
Mass (Da):26,659
Last modified:June 1, 2003 - v1
Checksum:i725F37870E78356A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451Missing in AAD53482 (PubMed:10444594).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140780 Genomic DNA. Translation: AAD53482.1.
AAFI02000012 Genomic DNA. Translation: EAL70191.1.
RefSeqiXP_643887.1. XM_638795.1.

Genome annotation databases

EnsemblProtistsiDDB0185089; DDB0185089; DDB_G0274597.
GeneIDi8619313.
KEGGiddi:DDB_G0274597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140780 Genomic DNA. Translation: AAD53482.1.
AAFI02000012 Genomic DNA. Translation: EAL70191.1.
RefSeqiXP_643887.1. XM_638795.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0185089.

Protein family/group databases

TCDBi1.C.35.4.1. the amoebapore (amoebapore) family.

Proteomic databases

PaxDbiQ86IV5.
PRIDEiQ86IV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0185089; DDB0185089; DDB_G0274597.
GeneIDi8619313.
KEGGiddi:DDB_G0274597.

Organism-specific databases

dictyBaseiDDB_G0274597. ctnA.

Phylogenomic databases

eggNOGiENOG410J17V. Eukaryota.
ENOG4111W08. LUCA.
InParanoidiQ86IV5.
OMAiSKHPHSQ.
PhylomeDBiQ86IV5.

Miscellaneous databases

PROiQ86IV5.

Family and domain databases

InterProiIPR008139. SaposinB_dom.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTNA_DICDI
AccessioniPrimary (citable) accession number: Q86IV5
Secondary accession number(s): Q556C3, Q9U7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.