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Protein

Probable protein tyrosine phosphatase type IVA B

Gene

DDB_G0272662

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton donorBy similarity1
Active sitei104Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei110SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-DDI-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein tyrosine phosphatase type IVA B (EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0272662
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272662.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290261 – 160Probable protein tyrosine phosphatase type IVA BAdd BLAST160
PropeptideiPRO_0000396657161 – 163Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 104By similarity
Modified residuei160Cysteine methyl esterBy similarity1
Lipidationi160S-farnesyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ86IL4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0266465.

Structurei

3D structure databases

ProteinModelPortaliQ86IL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 148Tyrosine-protein phosphataseAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 110Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
InParanoidiQ86IL4.
OMAiKFCDDPG.
PhylomeDBiQ86IL4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
SMARTiView protein in SMART
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86IL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGRSHIET IIESSTHKFI LFDEPTEETI PYFKDLMKKN SCINIVRCCE
60 70 80 90 100
INYDASLFEG VKIHELCFKD GNVPPKDIIE RWLEILKQAF IENGKQKTTV
110 120 130 140 150
GIHCIAGLGR TPLLVCIALI EDGMKPLQAV EFVRSKRKNA INSPQIKFLK
160
EYKASKKAGC KIM
Length:163
Mass (Da):18,542
Last modified:January 19, 2010 - v4
Checksum:i878E96822E4E5084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL70968.2.
RefSeqiXP_644995.2. XM_639903.2.

Genome annotation databases

EnsemblProtistsiEAL70968; EAL70968; DDB_G0272662.
GeneIDi8618672.
KEGGiddi:DDB_G0272662.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTP4AB_DICDI
AccessioniPrimary (citable) accession number: Q86IL4
Secondary accession number(s): Q558S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 19, 2010
Last modified: June 7, 2017
This is version 83 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families