Q86IL4 (TP4AB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein tyrosine phosphatase type IVA B
EC=3.1.3.48

Gene names

ORF Names:

DDB_G0272662

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Lipid-anchor Potential.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Membrane
Molecular function	Hydrolase Protein phosphatase
PTM	Disulfide bond Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Probable protein tyrosine phosphatase type IVA B		PRO_0000329026
	Propeptide	161 – 163	3	Removed in mature form By similarity		PRO_0000396657
Regions
	Domain	80 – 148	69	Tyrosine-protein phosphatase
	Region	105 – 110	6	Phosphate binding By similarity
Sites
	Active site	70	1	Proton donor By similarity
	Active site	104	1	Phosphocysteine intermediate By similarity
	Binding site	110	1	Substrate By similarity
Amino acid modifications
	Modified residue	160	1	Cysteine methyl ester By similarity
	Lipidation	160	1	S-farnesyl cysteine By similarity
	Disulfide bond	49 ↔ 104		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q86IL4 [UniParc]. Last modified January 19, 2010. Version 4. Checksum: 878E96822E4E5084	FASTA	163	18,542
	10 20 30 40 50 60 MDPGRSHIET IIESSTHKFI LFDEPTEETI PYFKDLMKKN SCINIVRCCE INYDASLFEG 70 80 90 100 110 120 VKIHELCFKD GNVPPKDIIE RWLEILKQAF IENGKQKTTV GIHCIAGLGR TPLLVCIALI 130 140 150 160 EDGMKPLQAV EFVRSKRKNA INSPQIKFLK EYKASKKAGC KIM

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000008 Genomic DNA. Translation: EAL70968.2.
RefSeq	XP_644995.2. XM_639903.2.
3D structure databases
HSSP	HSSP built from PDB template 1RXD based on UniProtKB Q93096.
ProteinModelPortal	Q86IL4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0266465; DDB0266465; DDB_G0272662.
GeneID	8618672.
KEGG	ddi:DDB_G0272662.
Organism-specific databases
dictyBase	DDB_G0272662.
Phylogenomic databases
eggNOG	NOG265664.
OMA	TYNTAIL.
ProtClustDB	PTZ00242.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TP4AB_DICDI

Accession

Primary (citable) accession number: Q86IL4
Secondary accession number(s): Q558S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	January 19, 2010
Last modified:	April 3, 2013
This is version 60 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)