Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable protein tyrosine phosphatase type IVA B

Gene

DDB_G0272662

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton donorBy similarity1
Active sitei104Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei110SubstrateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein tyrosine phosphatase type IVA B (EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0272662
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272662.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003290261 – 160Probable protein tyrosine phosphatase type IVA BAdd BLAST160
PropeptideiPRO_0000396657161 – 163Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 104By similarity
Modified residuei160Cysteine methyl esterBy similarity1
Lipidationi160S-farnesyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ86IL4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0266465.

Structurei

3D structure databases

ProteinModelPortaliQ86IL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 148Tyrosine-protein phosphataseAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 110Phosphate bindingBy similarity6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
InParanoidiQ86IL4.
OMAiFTIRVCE.
PhylomeDBiQ86IL4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86IL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGRSHIET IIESSTHKFI LFDEPTEETI PYFKDLMKKN SCINIVRCCE
60 70 80 90 100
INYDASLFEG VKIHELCFKD GNVPPKDIIE RWLEILKQAF IENGKQKTTV
110 120 130 140 150
GIHCIAGLGR TPLLVCIALI EDGMKPLQAV EFVRSKRKNA INSPQIKFLK
160
EYKASKKAGC KIM
Length:163
Mass (Da):18,542
Last modified:January 19, 2010 - v4
Checksum:i878E96822E4E5084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL70968.2.
RefSeqiXP_644995.2. XM_639903.2.

Genome annotation databases

EnsemblProtistsiEAL70968; EAL70968; DDB_G0272662.
GeneIDi8618672.
KEGGiddi:DDB_G0272662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL70968.2.
RefSeqiXP_644995.2. XM_639903.2.

3D structure databases

ProteinModelPortaliQ86IL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266465.

Proteomic databases

PaxDbiQ86IL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70968; EAL70968; DDB_G0272662.
GeneIDi8618672.
KEGGiddi:DDB_G0272662.

Organism-specific databases

dictyBaseiDDB_G0272662.

Phylogenomic databases

eggNOGiKOG2836. Eukaryota.
ENOG4111I7J. LUCA.
InParanoidiQ86IL4.
OMAiFTIRVCE.
PhylomeDBiQ86IL4.

Miscellaneous databases

PROiQ86IL4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTP4AB_DICDI
AccessioniPrimary (citable) accession number: Q86IL4
Secondary accession number(s): Q558S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 19, 2010
Last modified: November 2, 2016
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.