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Protein

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Gene

pdhB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei85Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

ReactomeiR-DDI-389661. Glyoxylate metabolism and glycine degradation.
R-DDI-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC:1.2.4.1)
Short name:
PDHE1-B
Gene namesi
Name:pdhB
ORF Names:DDB_G0276417
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276417. pdhB.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000032862626 – 356Pyruvate dehydrogenase E1 component subunit beta, mitochondrialAdd BLAST331

Proteomic databases

PaxDbiQ86HX0.
PRIDEiQ86HX0.

Interactioni

Subunit structurei

Tetramer of 2 alpha and 2 beta subunits.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0229442.

Structurei

3D structure databases

ProteinModelPortaliQ86HX0.
SMRiQ86HX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
InParanoidiQ86HX0.
KOiK00162.
OMAiSRMRHHC.
PhylomeDBiQ86HX0.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiView protein in InterPro
IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
PANTHERiPTHR11624:SF94. PTHR11624:SF94. 1 hit.
PfamiView protein in Pfam
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86HX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSILKKIQ PSLLVNFRII TRTYATKEVT VRDAINSALD EELARDEKVF
60 70 80 90 100
IMGEEVAQYN GAYKITKGLF DKYGGDRIID TPITEAGFAG IGVGAAMAGT
110 120 130 140 150
RPIIEFMTFN FAMQAIDHII NSSAKTHYMS GGKVFNPIVW RGPNGPPTAV
160 170 180 190 200
GAQHSQCFAA WYGSVPGLKV VAPWSAADHR GLLKSAIRDD NPVVYLESEL
210 220 230 240 250
LYNYKFDLSD QEQDKEYLVP IGKAKVEREG KDVTIVGFSR IVSNCMEAAE
260 270 280 290 300
ILAKEGISAE VINLRTIRPI DAETIVNSLK KTNKLVTVEE GWAQSGIGAE
310 320 330 340 350
ISALMMEHAF DYLDAPIERI CGADVPMPYA SNLENAAMVQ TQNIVNAAKR

VTQRNK
Length:356
Mass (Da):39,068
Last modified:June 1, 2003 - v1
Checksum:iA259CB6753D1FF3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69162.1.
RefSeqiXP_643119.1. XM_638027.1.

Genome annotation databases

EnsemblProtistsiEAL69162; EAL69162; DDB_G0276417.
GeneIDi8620524.
KEGGiddi:DDB_G0276417.

Similar proteinsi

Entry informationi

Entry nameiODPB_DICDI
AccessioniPrimary (citable) accession number: Q86HX0
Secondary accession number(s): Q551L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase