Reviewed, UniProtKB/Swiss-Prot Q86HG0 (GMPPA_DICDI)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase alpha
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase alpha
    GDP-mannose pyrophosphorylase A

Gene names

Name:	gmppA
Synonyms:	mpgB
ORF Names:	DDB_G0271858

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Mannose-1-phosphate guanyltransferase alpha		PRO_0000328172
Regions
	Compositional bias	2 – 6	5	Poly-Thr

Sequences

	Sequence		Length	Mass (Da)
	Q86HG0-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: E1D2AF97E00AE1CE	FASTA	412	45,979
	10 20 30 40 50 60 MTTTTTKAII LVGGPSKGTR FRPLSLDVPK LLFPIAGKPM IYHHIEACSK VENMKEIILI 70 80 90 100 110 120 GFFQESVLSK FISETSKQLN VAIRYINEEK VLGTAGGLYH FRDIILEGGP SEIFVLHSDI 130 140 150 160 170 180 CCAFPLNDLL QFHKQHGRSC TIMGTEIESA YANQYGCLVR DEKTAELLHY AEKPETFVSN 190 200 210 220 230 240 LINCGVYCFS PQFFDVIGKT MIDLKTSGQN ITTDYPEITR KGFDVERLRL EQDIFVPLAG 250 260 270 280 290 300 TGFISVYPYV GFWRQIKNAG SSVYCQELYL NHFAKTKPEV LKKGNNIIGN VIIDSTASVD 310 320 330 340 350 360 PSAIIGPDVY IGPNVKIGKG VRVIHSIILD QTEIKDHACI IYSIIGWQSL IGVWARIEGI 370 380 390 400 410 PNYTPFLYSQ DKRRGVTIFG AGAQANGEII VSNCIVMPHK QLDRNYNNEI IL

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC115682 Genomic DNA. Translation: AAO52636.1. AAFI02000007 Genomic DNA. Translation: EAL71508.1.
RefSeq	XP_645432.1.
3D structure databases
HSSP	HSSP built from PDB template 1HM0 based on UniProtKB Q97R46.
ModBase	Search...
Genome annotation databases
GeneID	3396589.
GenomeReviews	Gene locus gmppA in contig CM000151_GR.
KEGG	ddi:DDB_0231666.
Organism-specific databases
dictyBase	DDB_G0271858. gmppA.
Phylogenomic databases
OMA	SWPGAGT.
Enzyme and pathway databases
BRENDA	2.7.7.13. 424.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPA_DICDI

Accession

Primary (citable) accession number: Q86HG0
Secondary accession number(s): Q55AH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)