Reviewed, UniProtKB/Swiss-Prot Q86H62 (GLRX3_DICDI)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-3 homolog

Gene names

Name:	glrx3
ORF Names:	DDB_G0275555

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May play a role in regulating the function of the thioredoxin system By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.
Sequence similarities	Contains 1 glutaredoxin domain. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Glutaredoxin-3 homolog		PRO_0000348929
Regions
	Domain	1 – 125	125	Thioredoxin
	Domain	144 – 240	97	Glutaredoxin

Sequences

	Sequence		Length	Mass (Da)
	Q86H62-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 6A80609256E93335	FASTA	240	27,479
	10 20 30 40 50 60 MANTINTNEE FENILKDNKF LVVMFWADWS KPSTQMRDVF DQLAKQATNQ ANNKLLFLKV 70 80 90 100 110 120 EAEKVHQISG RYNVKSVPTC IFLNQGKLVQ SVVGANPSEL ALQTNNFSKT CDTLPLEEQQ 130 140 150 160 170 180 QQQQSEEIIN KIKLDQEQEK KLLNERLEKL VNQSPVMLFM KGNPEKPQCG FSNKTVTILK 190 200 210 220 230 240 ENGFEFGSFD ILQDQAVRNG LKEYSNWPTY PQLYINGKLV GGYDIIKDLN EEGELIDLKP

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC116960 Genomic DNA. Translation: AAO53174.1. AAFI02000013 Genomic DNA. Translation: EAL69528.1.
RefSeq	XP_643475.1.
3D structure databases
HSSP	HSSP built from PDB template 1ERW based on UniProtKB P10599.
ModBase	Search...
Genome annotation databases
GeneID	3394576.
KEGG	ddi:DDBDRAFT_0167363.
Organism-specific databases
dictyBase	DDB_G0275555. glrx3.
Phylogenomic databases
OMA	Q86H62. SISHAST.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR004480. Glutredox-rel. IPR017936. Thioredoxin-like. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00365. Glutredox-rel. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX3_DICDI

Accession

Primary (citable) accession number: Q86H62
Secondary accession number(s): Q553E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)