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Q86H45 (ELP2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable elongator complex protein 2

Short name=ELP2
Gene names
Name:elp2
ORF Names:DDB_G0275651
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length901 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the WD repeat ELP2 family.

Contains 14 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 901901Probable elongator complex protein 2
PRO_0000327784

Regions

Repeat11 – 5040WD 1
Repeat53 – 10452WD 2
Repeat113 – 15543WD 3
Repeat173 – 21442WD 4
Repeat225 – 27450WD 5
Repeat327 – 37751WD 6
Repeat387 – 42640WD 7
Repeat435 – 47440WD 8
Repeat495 – 53541WD 9
Repeat653 – 69745WD 10
Repeat700 – 73940WD 11
Repeat749 – 78840WD 12
Repeat796 – 84449WD 13
Repeat859 – 89739WD 14
Compositional bias240 – 24910Poly-Glu
Compositional bias470 – 4756Poly-Asn
Compositional bias579 – 58911Poly-Asn
Compositional bias608 – 6136Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
Q86H45 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7A9F21E538983317

FASTA901100,804
        10         20         30         40         50         60 
MNVSSDVDFI SVGCNCLGDC LVWGQNKLAA YGAQNFIALF DPIQSKVLAT LPGHKDRVNH 

        70         80         90        100        110        120 
ICWVPNINEE YKNRYSSYEN ELLSCSSDNT IISWKQIKGG LNYQYKVVEV LKGHSDSVTN 

       130        140        150        160        170        180 
ISVLDFPDGS LLMCSTSADN TVKLWRRESL TKENIDTDTL PKWECIQTID FTPKCMECSS 

       190        200        210        220        230        240 
LAFIPGTTIP LLAVGGLEPK IHIYIQNLDS TTATLQFKKL MSLQGHQDWI RSLSFKTINE 

       250        260        270        280        290        300 
GEGEGEEEEL ILASSSQDFK IRLWKISKFT AEKQKQQQLD ESGNGGANLL GSLSTQLSGV 

       310        320        330        340        350        360 
TSLSTKGYLF NCNSVKYIIL LDAVLSGHDD WVYSIHWSPA RRDQETGKKI QEQMLISASM 

       370        380        390        400        410        420 
DKTAIVWRPD RTTGIWIDES RVGDMGGNIL GQYGAVFSPC SQYILSHGYN GAFHFWKQNT 

       430        440        450        460        470        480 
NQKSSFWEPQ IVVSGHFGPV QDLMWSPDYS YFISCSTDRT LRLFSEWKRN NNNNNLENNK 

       490        500        510        520        530        540 
EQQIISWNEI ARPQIHGYDL ECFTFINKKT HVIVSGAEEK IMRAFVGSQN FVDTLLNISK 

       550        560        570        580        590        600 
VQPVNDGTQR PLAANQPSLG LSNKPYFTGG SDYNENIDNN NNNNNNNGNG EENTEDSIKM 

       610        620        630        640        650        660 
KMGGGDEGGG GEGMDTGYFE DEIPFNPEVL SEPPFEEHLL QSSLWPEIHK FYGHGNEIVA 

       670        680        690        700        710        720 
VACSADGMYL ASTCRASSAD QATVRIWNVS NWKECANLKG HTLTVVNLSF SHNSKYLLGV 

       730        740        750        760        770        780 
SRDRMWTLWE RSASNSEEPF VKVISAPKSH GRIIWSGSWS HDDKFFATGA RDKLVKVWNL 

       790        800        810        820        830        840 
DNIKDIKNAC ASTLPAFGSG VTCVEFAPKS SKFTGEHGDH LLAVGEDDGK ITIWKSTTST 

       850        860        870        880        890        900 
SNPKSLDWTC VHTISPLISH TLDVRRIRWR DTPTINGNSL TYQIVTCSVD HSVRIFNIKF 


D 

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References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000013 Genomic DNA. Translation: EAL69576.1.

3D structure databases

ProteinModelPortalQ86H45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231759; DDB0231759; DDB_G0275651.
KEGGddi:DDB_G0275651.

Organism-specific databases

dictyBaseDDB_G0275651. elp2.

Phylogenomic databases

eggNOGCOG2319.
KOK11374.
OMANRQRFGD.
PhylomeDBQ86H45.
ProtClustDBCLSZ2430953.

Family and domain databases

Gene3D2.130.10.10. 4 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 10 hits.
[Graphical view]
SMARTSM00320. WD40. 12 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 5 hits.
PROSITEPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ86H45.

Entry information

Entry nameELP2_DICDI
AccessionPrimary (citable) accession number: Q86H45
Secondary accession number(s): Q552Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase