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Q86H45

- ELP2_DICDI

UniProt

Q86H45 - ELP2_DICDI

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Protein

Probable elongator complex protein 2

Gene

elp2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.By similarity

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: dictyBase
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 2
Short name:
ELP2
Gene namesi
Name:elp2
ORF Names:DDB_G0275651
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275651. elp2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. transcription elongation factor complex Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901Probable elongator complex protein 2PRO_0000327784Add
BLAST

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231759.

Structurei

3D structure databases

ProteinModelPortaliQ86H45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5040WD 1Add
BLAST
Repeati53 – 10452WD 2Add
BLAST
Repeati113 – 15543WD 3Add
BLAST
Repeati173 – 21442WD 4Add
BLAST
Repeati225 – 27450WD 5Add
BLAST
Repeati327 – 37751WD 6Add
BLAST
Repeati387 – 42640WD 7Add
BLAST
Repeati435 – 47440WD 8Add
BLAST
Repeati495 – 53541WD 9Add
BLAST
Repeati653 – 69745WD 10Add
BLAST
Repeati700 – 73940WD 11Add
BLAST
Repeati749 – 78840WD 12Add
BLAST
Repeati796 – 84449WD 13Add
BLAST
Repeati859 – 89739WD 14Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi240 – 24910Poly-Glu
Compositional biasi470 – 4756Poly-Asn
Compositional biasi579 – 58911Poly-AsnAdd
BLAST
Compositional biasi608 – 6136Poly-Gly

Sequence similaritiesi

Belongs to the WD repeat ELP2 family.Curated
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
InParanoidiQ86H45.
KOiK11374.
OMAiDQVPEIN.
PhylomeDBiQ86H45.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 10 hits.
[Graphical view]
SMARTiSM00320. WD40. 12 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q86H45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVSSDVDFI SVGCNCLGDC LVWGQNKLAA YGAQNFIALF DPIQSKVLAT
60 70 80 90 100
LPGHKDRVNH ICWVPNINEE YKNRYSSYEN ELLSCSSDNT IISWKQIKGG
110 120 130 140 150
LNYQYKVVEV LKGHSDSVTN ISVLDFPDGS LLMCSTSADN TVKLWRRESL
160 170 180 190 200
TKENIDTDTL PKWECIQTID FTPKCMECSS LAFIPGTTIP LLAVGGLEPK
210 220 230 240 250
IHIYIQNLDS TTATLQFKKL MSLQGHQDWI RSLSFKTINE GEGEGEEEEL
260 270 280 290 300
ILASSSQDFK IRLWKISKFT AEKQKQQQLD ESGNGGANLL GSLSTQLSGV
310 320 330 340 350
TSLSTKGYLF NCNSVKYIIL LDAVLSGHDD WVYSIHWSPA RRDQETGKKI
360 370 380 390 400
QEQMLISASM DKTAIVWRPD RTTGIWIDES RVGDMGGNIL GQYGAVFSPC
410 420 430 440 450
SQYILSHGYN GAFHFWKQNT NQKSSFWEPQ IVVSGHFGPV QDLMWSPDYS
460 470 480 490 500
YFISCSTDRT LRLFSEWKRN NNNNNLENNK EQQIISWNEI ARPQIHGYDL
510 520 530 540 550
ECFTFINKKT HVIVSGAEEK IMRAFVGSQN FVDTLLNISK VQPVNDGTQR
560 570 580 590 600
PLAANQPSLG LSNKPYFTGG SDYNENIDNN NNNNNNNGNG EENTEDSIKM
610 620 630 640 650
KMGGGDEGGG GEGMDTGYFE DEIPFNPEVL SEPPFEEHLL QSSLWPEIHK
660 670 680 690 700
FYGHGNEIVA VACSADGMYL ASTCRASSAD QATVRIWNVS NWKECANLKG
710 720 730 740 750
HTLTVVNLSF SHNSKYLLGV SRDRMWTLWE RSASNSEEPF VKVISAPKSH
760 770 780 790 800
GRIIWSGSWS HDDKFFATGA RDKLVKVWNL DNIKDIKNAC ASTLPAFGSG
810 820 830 840 850
VTCVEFAPKS SKFTGEHGDH LLAVGEDDGK ITIWKSTTST SNPKSLDWTC
860 870 880 890 900
VHTISPLISH TLDVRRIRWR DTPTINGNSL TYQIVTCSVD HSVRIFNIKF

D
Length:901
Mass (Da):100,804
Last modified:June 1, 2003 - v1
Checksum:i7A9F21E538983317
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69576.1.
RefSeqiXP_643531.1. XM_638439.1.

Genome annotation databases

EnsemblProtistsiDDB0231759; DDB0231759; DDB_G0275651.
GeneIDi8620113.
KEGGiddi:DDB_G0275651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69576.1 .
RefSeqi XP_643531.1. XM_638439.1.

3D structure databases

ProteinModelPortali Q86H45.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231759 ; DDB0231759 ; DDB_G0275651 .
GeneIDi 8620113.
KEGGi ddi:DDB_G0275651.

Organism-specific databases

dictyBasei DDB_G0275651. elp2.

Phylogenomic databases

eggNOGi COG2319.
InParanoidi Q86H45.
KOi K11374.
OMAi DQVPEIN.
PhylomeDBi Q86H45.

Miscellaneous databases

PROi Q86H45.

Family and domain databases

Gene3Di 2.130.10.10. 4 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 10 hits.
[Graphical view ]
SMARTi SM00320. WD40. 12 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 5 hits.
PROSITEi PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiELP2_DICDI
AccessioniPrimary (citable) accession number: Q86H45
Secondary accession number(s): Q552Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3