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Q86H45

- ELP2_DICDI

UniProt

Q86H45 - ELP2_DICDI

Protein

Probable elongator complex protein 2

Gene

elp2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.By similarity

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: dictyBase
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable elongator complex protein 2
    Short name:
    ELP2
    Gene namesi
    Name:elp2
    ORF Names:DDB_G0275651
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0275651. elp2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. transcription elongation factor complex Source: dictyBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 901901Probable elongator complex protein 2PRO_0000327784Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86H45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 5040WD 1Add
    BLAST
    Repeati53 – 10452WD 2Add
    BLAST
    Repeati113 – 15543WD 3Add
    BLAST
    Repeati173 – 21442WD 4Add
    BLAST
    Repeati225 – 27450WD 5Add
    BLAST
    Repeati327 – 37751WD 6Add
    BLAST
    Repeati387 – 42640WD 7Add
    BLAST
    Repeati435 – 47440WD 8Add
    BLAST
    Repeati495 – 53541WD 9Add
    BLAST
    Repeati653 – 69745WD 10Add
    BLAST
    Repeati700 – 73940WD 11Add
    BLAST
    Repeati749 – 78840WD 12Add
    BLAST
    Repeati796 – 84449WD 13Add
    BLAST
    Repeati859 – 89739WD 14Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi240 – 24910Poly-Glu
    Compositional biasi470 – 4756Poly-Asn
    Compositional biasi579 – 58911Poly-AsnAdd
    BLAST
    Compositional biasi608 – 6136Poly-Gly

    Sequence similaritiesi

    Belongs to the WD repeat ELP2 family.Curated
    Contains 14 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    KOiK11374.
    OMAiDQVPEIN.
    PhylomeDBiQ86H45.

    Family and domain databases

    Gene3Di2.130.10.10. 4 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 10 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 12 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 5 hits.
    PROSITEiPS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q86H45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVSSDVDFI SVGCNCLGDC LVWGQNKLAA YGAQNFIALF DPIQSKVLAT    50
    LPGHKDRVNH ICWVPNINEE YKNRYSSYEN ELLSCSSDNT IISWKQIKGG 100
    LNYQYKVVEV LKGHSDSVTN ISVLDFPDGS LLMCSTSADN TVKLWRRESL 150
    TKENIDTDTL PKWECIQTID FTPKCMECSS LAFIPGTTIP LLAVGGLEPK 200
    IHIYIQNLDS TTATLQFKKL MSLQGHQDWI RSLSFKTINE GEGEGEEEEL 250
    ILASSSQDFK IRLWKISKFT AEKQKQQQLD ESGNGGANLL GSLSTQLSGV 300
    TSLSTKGYLF NCNSVKYIIL LDAVLSGHDD WVYSIHWSPA RRDQETGKKI 350
    QEQMLISASM DKTAIVWRPD RTTGIWIDES RVGDMGGNIL GQYGAVFSPC 400
    SQYILSHGYN GAFHFWKQNT NQKSSFWEPQ IVVSGHFGPV QDLMWSPDYS 450
    YFISCSTDRT LRLFSEWKRN NNNNNLENNK EQQIISWNEI ARPQIHGYDL 500
    ECFTFINKKT HVIVSGAEEK IMRAFVGSQN FVDTLLNISK VQPVNDGTQR 550
    PLAANQPSLG LSNKPYFTGG SDYNENIDNN NNNNNNNGNG EENTEDSIKM 600
    KMGGGDEGGG GEGMDTGYFE DEIPFNPEVL SEPPFEEHLL QSSLWPEIHK 650
    FYGHGNEIVA VACSADGMYL ASTCRASSAD QATVRIWNVS NWKECANLKG 700
    HTLTVVNLSF SHNSKYLLGV SRDRMWTLWE RSASNSEEPF VKVISAPKSH 750
    GRIIWSGSWS HDDKFFATGA RDKLVKVWNL DNIKDIKNAC ASTLPAFGSG 800
    VTCVEFAPKS SKFTGEHGDH LLAVGEDDGK ITIWKSTTST SNPKSLDWTC 850
    VHTISPLISH TLDVRRIRWR DTPTINGNSL TYQIVTCSVD HSVRIFNIKF 900
    D 901
    Length:901
    Mass (Da):100,804
    Last modified:June 1, 2003 - v1
    Checksum:i7A9F21E538983317
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69576.1.
    RefSeqiXP_643531.1. XM_638439.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231759; DDB0231759; DDB_G0275651.
    GeneIDi8620113.
    KEGGiddi:DDB_G0275651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69576.1 .
    RefSeqi XP_643531.1. XM_638439.1.

    3D structure databases

    ProteinModelPortali Q86H45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231759 ; DDB0231759 ; DDB_G0275651 .
    GeneIDi 8620113.
    KEGGi ddi:DDB_G0275651.

    Organism-specific databases

    dictyBasei DDB_G0275651. elp2.

    Phylogenomic databases

    eggNOGi COG2319.
    KOi K11374.
    OMAi DQVPEIN.
    PhylomeDBi Q86H45.

    Miscellaneous databases

    PROi Q86H45.

    Family and domain databases

    Gene3Di 2.130.10.10. 4 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 10 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 12 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 5 hits.
    PROSITEi PS50082. WD_REPEATS_2. 4 hits.
    PS50294. WD_REPEATS_REGION. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiELP2_DICDI
    AccessioniPrimary (citable) accession number: Q86H45
    Secondary accession number(s): Q552Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3