Q86H45 (ELP2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable elongator complex protein 2
Short name=ELP2

Gene names

Name:	elp2
ORF Names:	DDB_G0275651

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	901 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation By similarity.
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat ELP2 family. Contains 14 WD repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: dictyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription elongation factor complex Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 901	901	Probable elongator complex protein 2		PRO_0000327784
Regions
	Repeat	11 – 50	40	WD 1
	Repeat	53 – 104	52	WD 2
	Repeat	113 – 155	43	WD 3
	Repeat	173 – 214	42	WD 4
	Repeat	225 – 274	50	WD 5
	Repeat	327 – 377	51	WD 6
	Repeat	387 – 426	40	WD 7
	Repeat	435 – 474	40	WD 8
	Repeat	495 – 535	41	WD 9
	Repeat	653 – 697	45	WD 10
	Repeat	700 – 739	40	WD 11
	Repeat	749 – 788	40	WD 12
	Repeat	796 – 844	49	WD 13
	Repeat	859 – 897	39	WD 14
	Compositional bias	240 – 249	10	Poly-Glu
	Compositional bias	470 – 475	6	Poly-Asn
	Compositional bias	579 – 589	11	Poly-Asn
	Compositional bias	608 – 613	6	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q86H45 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7A9F21E538983317	FASTA	901	100,804
	10 20 30 40 50 60 MNVSSDVDFI SVGCNCLGDC LVWGQNKLAA YGAQNFIALF DPIQSKVLAT LPGHKDRVNH 70 80 90 100 110 120 ICWVPNINEE YKNRYSSYEN ELLSCSSDNT IISWKQIKGG LNYQYKVVEV LKGHSDSVTN 130 140 150 160 170 180 ISVLDFPDGS LLMCSTSADN TVKLWRRESL TKENIDTDTL PKWECIQTID FTPKCMECSS 190 200 210 220 230 240 LAFIPGTTIP LLAVGGLEPK IHIYIQNLDS TTATLQFKKL MSLQGHQDWI RSLSFKTINE 250 260 270 280 290 300 GEGEGEEEEL ILASSSQDFK IRLWKISKFT AEKQKQQQLD ESGNGGANLL GSLSTQLSGV 310 320 330 340 350 360 TSLSTKGYLF NCNSVKYIIL LDAVLSGHDD WVYSIHWSPA RRDQETGKKI QEQMLISASM 370 380 390 400 410 420 DKTAIVWRPD RTTGIWIDES RVGDMGGNIL GQYGAVFSPC SQYILSHGYN GAFHFWKQNT 430 440 450 460 470 480 NQKSSFWEPQ IVVSGHFGPV QDLMWSPDYS YFISCSTDRT LRLFSEWKRN NNNNNLENNK 490 500 510 520 530 540 EQQIISWNEI ARPQIHGYDL ECFTFINKKT HVIVSGAEEK IMRAFVGSQN FVDTLLNISK 550 560 570 580 590 600 VQPVNDGTQR PLAANQPSLG LSNKPYFTGG SDYNENIDNN NNNNNNNGNG EENTEDSIKM 610 620 630 640 650 660 KMGGGDEGGG GEGMDTGYFE DEIPFNPEVL SEPPFEEHLL QSSLWPEIHK FYGHGNEIVA 670 680 690 700 710 720 VACSADGMYL ASTCRASSAD QATVRIWNVS NWKECANLKG HTLTVVNLSF SHNSKYLLGV 730 740 750 760 770 780 SRDRMWTLWE RSASNSEEPF VKVISAPKSH GRIIWSGSWS HDDKFFATGA RDKLVKVWNL 790 800 810 820 830 840 DNIKDIKNAC ASTLPAFGSG VTCVEFAPKS SKFTGEHGDH LLAVGEDDGK ITIWKSTTST 850 860 870 880 890 900 SNPKSLDWTC VHTISPLISH TLDVRRIRWR DTPTINGNSL TYQIVTCSVD HSVRIFNIKF D

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000013 Genomic DNA. Translation: EAL69576.1.
RefSeq	XP_643531.1. XM_638439.1.
3D structure databases
ProteinModelPortal	Q86H45.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231759.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231759; DDB0231759; DDB_G0275651.
GeneID	8620113.
KEGG	ddi:DDB_G0275651.
Organism-specific databases
dictyBase	DDB_G0275651. elp2.
Phylogenomic databases
eggNOG	COG2319.
KO	K11374.
OMA	DCLIRIW.
ProtClustDB	CLSZ2430953.
Family and domain databases
Gene3D	2.130.10.10. 4 hits.
InterPro	IPR011047. Quinonprotein_ADH-like_supfam. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 10 hits. [Graphical view]
SMART	SM00320. WD40. 12 hits. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ELP2_DICDI

Accession

Primary (citable) accession number: Q86H45
Secondary accession number(s): Q552Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)