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Protein

Probable elongator complex protein 2

Gene

elp2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.By similarity

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 2
Short name:
ELP2
Gene namesi
Name:elp2
ORF Names:DDB_G0275651
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275651. elp2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003277841 – 901Probable elongator complex protein 2Add BLAST901

Proteomic databases

PaxDbiQ86H45.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231759.

Structurei

3D structure databases

ProteinModelPortaliQ86H45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 50WD 1Add BLAST40
Repeati53 – 104WD 2Add BLAST52
Repeati113 – 155WD 3Add BLAST43
Repeati173 – 214WD 4Add BLAST42
Repeati225 – 274WD 5Add BLAST50
Repeati327 – 377WD 6Add BLAST51
Repeati387 – 426WD 7Add BLAST40
Repeati435 – 474WD 8Add BLAST40
Repeati495 – 535WD 9Add BLAST41
Repeati653 – 697WD 10Add BLAST45
Repeati700 – 739WD 11Add BLAST40
Repeati749 – 788WD 12Add BLAST40
Repeati796 – 844WD 13Add BLAST49
Repeati859 – 897WD 14Add BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 249Poly-Glu10
Compositional biasi470 – 475Poly-Asn6
Compositional biasi579 – 589Poly-AsnAdd BLAST11
Compositional biasi608 – 613Poly-Gly6

Sequence similaritiesi

Belongs to the WD repeat ELP2 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1063. Eukaryota.
ENOG410XRF0. LUCA.
InParanoidiQ86H45.
KOiK11374.
OMAiLHLWKQN.
PhylomeDBiQ86H45.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 6 hits.
SMARTiView protein in SMART
SM00320. WD40. 12 hits.
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.

Sequencei

Sequence statusi: Complete.

Q86H45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSSDVDFI SVGCNCLGDC LVWGQNKLAA YGAQNFIALF DPIQSKVLAT
60 70 80 90 100
LPGHKDRVNH ICWVPNINEE YKNRYSSYEN ELLSCSSDNT IISWKQIKGG
110 120 130 140 150
LNYQYKVVEV LKGHSDSVTN ISVLDFPDGS LLMCSTSADN TVKLWRRESL
160 170 180 190 200
TKENIDTDTL PKWECIQTID FTPKCMECSS LAFIPGTTIP LLAVGGLEPK
210 220 230 240 250
IHIYIQNLDS TTATLQFKKL MSLQGHQDWI RSLSFKTINE GEGEGEEEEL
260 270 280 290 300
ILASSSQDFK IRLWKISKFT AEKQKQQQLD ESGNGGANLL GSLSTQLSGV
310 320 330 340 350
TSLSTKGYLF NCNSVKYIIL LDAVLSGHDD WVYSIHWSPA RRDQETGKKI
360 370 380 390 400
QEQMLISASM DKTAIVWRPD RTTGIWIDES RVGDMGGNIL GQYGAVFSPC
410 420 430 440 450
SQYILSHGYN GAFHFWKQNT NQKSSFWEPQ IVVSGHFGPV QDLMWSPDYS
460 470 480 490 500
YFISCSTDRT LRLFSEWKRN NNNNNLENNK EQQIISWNEI ARPQIHGYDL
510 520 530 540 550
ECFTFINKKT HVIVSGAEEK IMRAFVGSQN FVDTLLNISK VQPVNDGTQR
560 570 580 590 600
PLAANQPSLG LSNKPYFTGG SDYNENIDNN NNNNNNNGNG EENTEDSIKM
610 620 630 640 650
KMGGGDEGGG GEGMDTGYFE DEIPFNPEVL SEPPFEEHLL QSSLWPEIHK
660 670 680 690 700
FYGHGNEIVA VACSADGMYL ASTCRASSAD QATVRIWNVS NWKECANLKG
710 720 730 740 750
HTLTVVNLSF SHNSKYLLGV SRDRMWTLWE RSASNSEEPF VKVISAPKSH
760 770 780 790 800
GRIIWSGSWS HDDKFFATGA RDKLVKVWNL DNIKDIKNAC ASTLPAFGSG
810 820 830 840 850
VTCVEFAPKS SKFTGEHGDH LLAVGEDDGK ITIWKSTTST SNPKSLDWTC
860 870 880 890 900
VHTISPLISH TLDVRRIRWR DTPTINGNSL TYQIVTCSVD HSVRIFNIKF

D
Length:901
Mass (Da):100,804
Last modified:June 1, 2003 - v1
Checksum:i7A9F21E538983317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69576.1.
RefSeqiXP_643531.1. XM_638439.1.

Genome annotation databases

EnsemblProtistsiEAL69576; EAL69576; DDB_G0275651.
GeneIDi8620113.
KEGGiddi:DDB_G0275651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69576.1.
RefSeqiXP_643531.1. XM_638439.1.

3D structure databases

ProteinModelPortaliQ86H45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231759.

Proteomic databases

PaxDbiQ86H45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL69576; EAL69576; DDB_G0275651.
GeneIDi8620113.
KEGGiddi:DDB_G0275651.

Organism-specific databases

dictyBaseiDDB_G0275651. elp2.

Phylogenomic databases

eggNOGiKOG1063. Eukaryota.
ENOG410XRF0. LUCA.
InParanoidiQ86H45.
KOiK11374.
OMAiLHLWKQN.
PhylomeDBiQ86H45.

Miscellaneous databases

PROiPR:Q86H45.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 6 hits.
SMARTiView protein in SMART
SM00320. WD40. 12 hits.
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiView protein in PROSITE
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiELP2_DICDI
AccessioniPrimary (citable) accession number: Q86H45
Secondary accession number(s): Q552Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.