Reviewed,
UniProtKB/Swiss-Prot Q86H28 (PROD_DICDI)
Last modified
February 9, 2010.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Proline dehydrogenase, mitochondrial EC=1.5.99.8 Alternative name(s): Proline oxidase | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 572 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Converts proline to delta-1-pyrroline-5-carboxylate By similarity. |
| Catalytic activity | L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the proline oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Proline metabolism |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW proline catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | proline dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential | |||||||
| Chain | ? – 572 | Proline dehydrogenase, mitochondrial | PRO_0000329318 | ||||||
Regions | |||||||||
| Compositional bias | 10 – 140 | 131 | Asn-rich | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAFI02000013 Genomic DNA. Translation: EAL69585.1. |
| RefSeq | XP_643510.1. |
3D structure databases | |
| SMR | Q86H28. Positions 146-549. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q86H28. |
Genome annotation databases | |
| GeneID | 8620091. |
| KEGG | ddi:DDBDRAFT_0167252. |
Organism-specific databases | |
| dictyBase | DDB_G0275669. prodh. |
Phylogenomic databases | |
| eggNOG | KOG0186. |
| OMA | SKYMPYG. |
| PhylomeDB | Q86H28. |
Enzyme and pathway databases | |
| BRENDA | 1.5.99.8. 424. |
Family and domain databases | |
| InterPro | IPR002872. Proline_DH. IPR015659. Proline_oxidase. [Graphical view] |
| PANTHER | PTHR13914. Proline_oxidase. 1 hit. |
| Pfam | PF01619. Pro_dh. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PROD_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q86H28 Secondary accession number(s): Q553B0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


