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Q86GC8

- ACES_CULPI

UniProt

Q86GC8 - ACES_CULPI

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Protein

Acetylcholinesterase

Gene
ACHE1
Organism
Culex pipiens (House mosquito)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Rapidly hydrolyzes choline released into the synapse.

Catalytic activityi

Acetylcholine + H2O = choline + acetate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271Acyl-ester intermediate By similarityBy similarity
Active sitei453 – 4531Charge relay system By similarityBy similarity
Active sitei567 – 5671Charge relay system By similarityBy similarity

GO - Molecular functioni

  1. acetylcholinesterase activity Source: UniProtKB-EC

GO - Biological processi

  1. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Keywords - Biological processi

Neurotransmitter degradation

Protein family/group databases

MEROPSiS09.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholinesterase (EC:3.1.1.7)
Short name:
AChE
Gene namesi
Name:ACHE1
OrganismiCulex pipiens (House mosquito)
Taxonomic identifieri7175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex

Subcellular locationi

Cell junctionsynapse By similarity. Secreted By similarity. Cell membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-SubCell
  3. plasma membrane Source: UniProtKB-SubCell
  4. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 Reviewed predictionAdd
BLAST
Chaini37 – 702666AcetylcholinesterasePRO_0000008602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi195 ↔ 222 By similarityBy similarity
Disulfide bondi381 ↔ 394 By similarityBy similarity
Disulfide bondi529 ↔ 650 By similarityBy similarity
Glycosylationi637 – 6371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ006034-PA.

Structurei

3D structure databases

ProteinModelPortaliQ86GC8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR00878. CHOLNESTRASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86GC8-1 [UniParc]FASTAAdd to Basket

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MEIRGLITRL LGPCHLRHLI LCSLGLYSIL VQSVHCRHHD IGSSVAHQLG    50
SKYSQSSSLS SSSQSSSSLA EEATLNKDSD AFFTPYIGHG DSVRIVDAEL 100
GTLEREHIHS TTTRRRGLTR RESSSDATDS DPLVITTDKG KIRGTTLEAP 150
SGKKVDAWMG IPYAQPPLGP LRFRHPRPAE RWTGVLNATK PPNSCVQIVD 200
TVFGDFPGAT MWNPNTPLSE DCLYINVVVP RPRPKNAAVM LWIFGGGFYS 250
GTATLDVYDH RTLASEENVI VVSLQYRVAS LGFLFLGTPE APGNAGLFDQ 300
NLALRWVRDN IHRFGGDPSR VTLFGESAGA VSVSLHLLSA LSRDLFQRAI 350
LQSGSPTAPW ALVSREEATL RALRLAEAVN CPHDATKLSD AVECLRTKDP 400
NELVDNEWGT LGICEFPFVP VVDGAFLDET PQRSLASGRF KKTDILTGSN 450
TEEGYYFIIY YLTELLRKEE GVTVTREEFL QAVRELNPYV NGAARQAIVF 500
EYTDWIEPDN PNSNRDALDK MVGDYHFTCN VNEFAQRYAE EGNNVFMYLY 550
THRSKGNPWP RWTGVMHGDE INYVFGEPLN SALGYQDDEK DFSRKIMRYW 600
SNFAKTGNPN PSTPSVDLPE WPKHTAHGRH YLELGLNTTF VGRGPRLRQC 650
AFWKKYLPQL VAATSNLQVT PAPSVPCESS STSYRSTLLL IVTLLLVTRF 700
KI 702
Length:702
Mass (Da):78,179
Last modified:August 22, 2003 - v2
Checksum:i4B11ABF5EA824A07
GO

Polymorphismi

Strain SLAB is susceptible to insecticides while strain SR is resistant. Insensitivity to insecticides results from a loss of sensitivity of acetylcholinesterase to organophosphates and carbamates and is due to a variant at position 247.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471G → S in strain: SR; confers resistance to insecticides. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ515147 mRNA. Translation: CAD56155.1.
AJ489456 mRNA. Translation: CAD33707.2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ515147 mRNA. Translation: CAD56155.1 .
AJ489456 mRNA. Translation: CAD33707.2 .

3D structure databases

ProteinModelPortali Q86GC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7176.CPIJ006034-PA.

Protein family/group databases

MEROPSi S09.979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
IPR000997. Cholinesterase.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
PRINTSi PR00878. CHOLNESTRASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SLAB and SR.

Entry informationi

Entry nameiACES_CULPI
AccessioniPrimary (citable) accession number: Q86GC8
Secondary accession number(s): Q86GD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: June 11, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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