ID   Q86D85_ANOGA            Unreviewed;       248 AA.
AC   Q86D85; Q7Q6N6;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 138.
DE   SubName: Full=AGAP005749-PA {ECO:0000313|EMBL:EAA11710.2};
DE   SubName: Full=Glutathione transferase o1 {ECO:0000313|EMBL:AAP13482.1};
GN   Name=GSTo1 {ECO:0000313|EMBL:AAP13482.1};
GN   Synonyms=1276420 {ECO:0000313|EnsemblMetazoa:AGAP005749-PA}, GSTO1
GN   {ECO:0000313|EMBL:EAA11710.2};
GN   ORFNames=AgaP_AGAP005749 {ECO:0000313|EMBL:EAA11710.2};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:AAP13482.1};
RN   [1] {ECO:0000313|EMBL:EAA11710.2, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11710.2,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAA11710.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11710.2};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAP13482.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ZAN/U {ECO:0000313|EMBL:AAP13482.1};
RX   PubMed=12914673; DOI=10.1186/1471-2164-4-35;
RA   Ding Y., Ortelli F., Rossiter L.C., Hemingway J., Ranson H.;
RT   "The Anopheles gambiae glutathione transferase supergene family:
RT   annotation, phylogeny and expression profiles.";
RL   BMC Genomics 4:35-35(2003).
RN   [4] {ECO:0000313|EMBL:EAA11710.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11710.2};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [5] {ECO:0000313|EMBL:EAA11710.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11710.2};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5.1-R5.13(2007).
RN   [6] {ECO:0000313|EMBL:EAA11710.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAA11710.2};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EnsemblMetazoa:AGAP005749-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP005749-PA};
RG   EnsemblMetazoa;
RL   Submitted (JAN-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GST superfamily. Omega family.
CC       {ECO:0000256|ARBA:ARBA00011067}.
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DR   EMBL; AY255856; AAP13482.1; -; mRNA.
DR   EMBL; AAAB01008960; EAA11710.2; -; Genomic_DNA.
DR   RefSeq; XP_315763.2; XM_315763.4.
DR   AlphaFoldDB; Q86D85; -.
DR   STRING; 7165.Q86D85; -.
DR   PaxDb; 7165-AGAP005749-PA; -.
DR   EnsemblMetazoa; AGAP005749-RA; AGAP005749-PA; AGAP005749.
DR   GeneID; 1276420; -.
DR   KEGG; aga:AgaP_AGAP005749; -.
DR   CTD; 9446; -.
DR   VEuPathDB; VectorBase:AGAP005749; -.
DR   eggNOG; KOG0406; Eukaryota.
DR   HOGENOM; CLU_011226_9_2_1; -.
DR   InParanoid; Q86D85; -.
DR   OMA; PDADIHP; -.
DR   OrthoDB; 103277at2759; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0045174; F:glutathione dehydrogenase (ascorbate) activity; IBA:GO_Central.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
DR   CDD; cd03184; GST_C_Omega; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR005442; GST_omega.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR43968; -; 1.
DR   PANTHER; PTHR43968:SF6; GLUTATHIONE S-TRANSFERASE OMEGA; 1.
DR   Pfam; PF13410; GST_C_2; 1.
DR   Pfam; PF13417; GST_N_3; 1.
DR   PRINTS; PR01625; GSTRNSFRASEO.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SFLD; SFLDG00358; Main_(cytGST); 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062};
KW   Transferase {ECO:0000313|EMBL:AAP13482.1}.
FT   DOMAIN          20..101
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          108..233
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   248 AA;  28356 MW;  B33197C37F84AE24 CRC64;
     MSNGKHLAKG SSPPSLPDDG KLRLYSMRFC PYAQRVHLML DAKKIPYHAI YINLSEKPEW
     YLEKNPLGKV PALEIPGKEG VTLYESLVLS DYIEEAYSAQ QRKLYPADPF SKAQDRILIE
     RFAGSVIGPY YRILFAADGI PPGAITEFGA GLDIFEKELK ARGTPYFGGD KPGMIDYMIW
     PWCERVDLLK FALGDKYELD KERFGKLLQW RELMEKDDAV KQSFISTEDH TKFLQSRKNG
     ENNYDILA
//