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Q86BS6 (METL_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyltransferase-like protein
EC=2.1.1.-
Gene names
Name:metl
ORF Names:CG13929
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable methyltransferase.

Subunit structure

Interacts with Psn. Ref.4

Tissue specificity

Widely expressed. Expressed in ovaries, head, thorax and abdomen of adult flies, and in the CNS of third instar larvae. Isoform 2 is predominantly expressed in larvae and in adult tissues that have been tested. Ref.4

Developmental stage

Expressed throughout embryogenesis, as well as in larvae and adults.

Sequence similarities

Belongs to the methyltransferase superfamily. METL family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionS-adenosylmethionine-dependent methyltransferase activity

Inferred from sequence or structural similarity Ref.4. Source: FlyBase

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q86BS6-1)

Also known as: B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q86BS6-2)

Also known as: Metl-a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
Isoform 3 (identifier: Q86BS6-3)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLTTSSSTML...LTDAREVFEF → MSDNPAAENEKRPQFGTRLLTDADDVFKH
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Methyltransferase-like protein
PRO_0000204456

Natural variations

Alternative sequence1 – 7979Missing in isoform 2.
VSP_008484
Alternative sequence1 – 5252MLTTS…EVFEF → MSDNPAAENEKRPQFGTRLL TDADDVFKH in isoform 3.
VSP_008483

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (B) [UniParc].

Last modified October 3, 2003. Version 2.
Checksum: 3EFBB4FDC1C7311D

FASTA32538,132
        10         20         30         40         50         60 
MLTTSSSTML GKYGWQILRR LASKSWEHTR QRKKPSGAGS RVLTDAREVF EFNAWDHVQW 

        70         80         90        100        110        120 
DEEQELAAKA AVAKNSTSKM EAEQKERFQT DAPKFWDSFY GIHDNRFFKD RHWLFTEFPE 

       130        140        150        160        170        180 
LAPLAADSAV LQPRSIFELG CGVGNTILPL LQYSSEPQLK VFGCDFSARA IEILRSQRQF 

       190        200        210        220        230        240 
DEKRCEVFVM DATLDHWQVP FEENSQDIIV MIFVLSAIEP KKMQRVLDNC YRYLRPGGLL 

       250        260        270        280        290        300 
LFRDYGRYDL AQLRFKSGKC MEDNFYVRGD GTMVYFFTEE ELRGMMTQAG LQEEQLIVDR 

       310        320 
RLQVNRCRGL KMYRVWIQTK FRKPL

« Hide

Isoform 2 (Metl-a) [UniParc].

Checksum: 9AFF16BBE87D84A2
Show »

FASTA24629,154
Isoform 3 (A) [UniParc].

Checksum: 5BB538AB11E52015
Show »

FASTA30235,448

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Strain: Berkeley.
Tissue: Embryo.
[4]"Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins."
Zhang S.X., Guo Y., Boulianne G.L.
Gene 280:135-144(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH PSN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014296 Genomic DNA. Translation: AAF47531.2.
AE014296 Genomic DNA. Translation: AAF47532.2.
AY051875 mRNA. Translation: AAK93299.1.
RefSeqNP_647636.3. NM_139379.4.
NP_728647.2. NM_167907.3.
UniGeneDm.4455.

3D structure databases

ProteinModelPortalQ86BS6.
SMRQ86BS6. Positions 110-297.
ModBaseSearch...

Protein-protein interaction databases

IntActQ86BS6. 2 interactions.
MINTMINT-764262.

Proteomic databases

PaxDbQ86BS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0072814; FBpp0072696; FBgn0035247.
GeneID38197.
KEGGdme:Dmel_CG13929.
UCSCCG13929-RA. d. melanogaster.

Organism-specific databases

CTD38197.
FlyBaseFBgn0035247. metl.

Phylogenomic databases

eggNOGNOG258359.
GeneTreeENSGT00520000055554.
InParanoidQ86BS6.
OMARPQFGTR.
OrthoDBEOG4QZ62H.
PhylomeDBQ86BS6.

Gene expression databases

BgeeQ86BS6.
GermOnlineCG13929. Drosophila melanogaster.

Family and domain databases

InterProIPR013217. Methyltransf_12.
IPR026113. MeTrfase.
[Graphical view]
PANTHERPTHR22809. PTHR22809. 1 hit.
PfamPF08242. Methyltransf_12. 1 hit.
[Graphical view]
PIRSFPIRSF037755. Mettl2_prd. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi38197.
NextBio807465.

Entry information

Entry nameMETL_DROME
AccessionPrimary (citable) accession number: Q86BS6
Secondary accession number(s): Q960S9, Q9W0C0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents