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Q86BS6

- METL_DROME

UniProt

Q86BS6 - METL_DROME

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Protein
Methyltransferase-like protein
Gene
metl, CG13929
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable methyltransferase.

GO - Molecular functioni

  1. S-adenosylmethionine-dependent methyltransferase activity Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein (EC:2.1.1.-)
Gene namesi
Name:metl
ORF Names:CG13929
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035247. metl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Methyltransferase-like protein
PRO_0000204456Add
BLAST

Proteomic databases

PaxDbiQ86BS6.
PRIDEiQ86BS6.

Expressioni

Tissue specificityi

Widely expressed. Expressed in ovaries, head, thorax and abdomen of adult flies, and in the CNS of third instar larvae. Isoform 2 is predominantly expressed in larvae and in adult tissues that have been tested.1 Publication

Developmental stagei

Expressed throughout embryogenesis, as well as in larvae and adults.

Gene expression databases

BgeeiQ86BS6.

Interactioni

Subunit structurei

Interacts with Psn.1 Publication

Protein-protein interaction databases

BioGridi63731. 8 interactions.
IntActiQ86BS6. 2 interactions.
MINTiMINT-764262.

Structurei

3D structure databases

ProteinModelPortaliQ86BS6.
SMRiQ86BS6. Positions 110-297.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG258359.
GeneTreeiENSGT00520000055554.
InParanoidiQ86BS6.
OMAiRPQFGTR.
OrthoDBiEOG7VX8ZJ.
PhylomeDBiQ86BS6.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013217. Methyltransf_12.
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 1 hit.
PfamiPF08242. Methyltransf_12. 1 hit.
[Graphical view]
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q86BS6-1) [UniParc]FASTAAdd to Basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLTTSSSTML GKYGWQILRR LASKSWEHTR QRKKPSGAGS RVLTDAREVF    50
EFNAWDHVQW DEEQELAAKA AVAKNSTSKM EAEQKERFQT DAPKFWDSFY 100
GIHDNRFFKD RHWLFTEFPE LAPLAADSAV LQPRSIFELG CGVGNTILPL 150
LQYSSEPQLK VFGCDFSARA IEILRSQRQF DEKRCEVFVM DATLDHWQVP 200
FEENSQDIIV MIFVLSAIEP KKMQRVLDNC YRYLRPGGLL LFRDYGRYDL 250
AQLRFKSGKC MEDNFYVRGD GTMVYFFTEE ELRGMMTQAG LQEEQLIVDR 300
RLQVNRCRGL KMYRVWIQTK FRKPL 325
Length:325
Mass (Da):38,132
Last modified:October 3, 2003 - v2
Checksum:i3EFBB4FDC1C7311D
GO
Isoform 2 (identifier: Q86BS6-2) [UniParc]FASTAAdd to Basket

Also known as: Metl-a

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:246
Mass (Da):29,154
Checksum:i9AFF16BBE87D84A2
GO
Isoform 3 (identifier: Q86BS6-3) [UniParc]FASTAAdd to Basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLTTSSSTML...LTDAREVFEF → MSDNPAAENEKRPQFGTRLLTDADDVFKH

Note: No experimental confirmation available.

Show »
Length:302
Mass (Da):35,448
Checksum:i5BB538AB11E52015
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979Missing in isoform 2.
VSP_008484Add
BLAST
Alternative sequencei1 – 5252MLTTS…EVFEF → MSDNPAAENEKRPQFGTRLL TDADDVFKH in isoform 3.
VSP_008483Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF47531.2.
AE014296 Genomic DNA. Translation: AAF47532.2.
AY051875 mRNA. Translation: AAK93299.1.
RefSeqiNP_647636.3. NM_139379.4. [Q86BS6-1]
NP_728647.2. NM_167907.3. [Q86BS6-3]
UniGeneiDm.4455.

Genome annotation databases

EnsemblMetazoaiFBtr0072814; FBpp0072696; FBgn0035247. [Q86BS6-1]
GeneIDi38197.
KEGGidme:Dmel_CG13929.
UCSCiCG13929-RA. d. melanogaster. [Q86BS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF47531.2 .
AE014296 Genomic DNA. Translation: AAF47532.2 .
AY051875 mRNA. Translation: AAK93299.1 .
RefSeqi NP_647636.3. NM_139379.4. [Q86BS6-1 ]
NP_728647.2. NM_167907.3. [Q86BS6-3 ]
UniGenei Dm.4455.

3D structure databases

ProteinModelPortali Q86BS6.
SMRi Q86BS6. Positions 110-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 63731. 8 interactions.
IntActi Q86BS6. 2 interactions.
MINTi MINT-764262.

Proteomic databases

PaxDbi Q86BS6.
PRIDEi Q86BS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0072814 ; FBpp0072696 ; FBgn0035247 . [Q86BS6-1 ]
GeneIDi 38197.
KEGGi dme:Dmel_CG13929.
UCSCi CG13929-RA. d. melanogaster. [Q86BS6-1 ]

Organism-specific databases

CTDi 38197.
FlyBasei FBgn0035247. metl.

Phylogenomic databases

eggNOGi NOG258359.
GeneTreei ENSGT00520000055554.
InParanoidi Q86BS6.
OMAi RPQFGTR.
OrthoDBi EOG7VX8ZJ.
PhylomeDBi Q86BS6.

Miscellaneous databases

GenomeRNAii 38197.
NextBioi 807465.
PROi Q86BS6.

Gene expression databases

Bgeei Q86BS6.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013217. Methyltransf_12.
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR22809. PTHR22809. 1 hit.
Pfami PF08242. Methyltransf_12. 1 hit.
[Graphical view ]
PIRSFi PIRSF037755. Mettl2_prd. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins."
    Zhang S.X., Guo Y., Boulianne G.L.
    Gene 280:135-144(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH PSN.

Entry informationi

Entry nameiMETL_DROME
AccessioniPrimary (citable) accession number: Q86BS6
Secondary accession number(s): Q960S9, Q9W0C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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