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Q86BS6

- METL_DROME

UniProt

Q86BS6 - METL_DROME

Protein

Methyltransferase-like protein

Gene

metl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (03 Oct 2003)
      Previous versions | rss
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    Functioni

    Probable methyltransferase.

    GO - Molecular functioni

    1. S-adenosylmethionine-dependent methyltransferase activity Source: FlyBase

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyltransferase-like protein (EC:2.1.1.-)
    Gene namesi
    Name:metl
    ORF Names:CG13929
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0035247. metl.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Methyltransferase-like proteinPRO_0000204456Add
    BLAST

    Proteomic databases

    PaxDbiQ86BS6.
    PRIDEiQ86BS6.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in ovaries, head, thorax and abdomen of adult flies, and in the CNS of third instar larvae. Isoform 2 is predominantly expressed in larvae and in adult tissues that have been tested.1 Publication

    Developmental stagei

    Expressed throughout embryogenesis, as well as in larvae and adults.

    Gene expression databases

    BgeeiQ86BS6.

    Interactioni

    Subunit structurei

    Interacts with Psn.1 Publication

    Protein-protein interaction databases

    BioGridi63731. 8 interactions.
    IntActiQ86BS6. 2 interactions.
    MINTiMINT-764262.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86BS6.
    SMRiQ86BS6. Positions 110-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG258359.
    GeneTreeiENSGT00520000055554.
    InParanoidiQ86BS6.
    OMAiRPQFGTR.
    OrthoDBiEOG7VX8ZJ.
    PhylomeDBiQ86BS6.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013217. Methyltransf_12.
    IPR026113. MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR22809. PTHR22809. 1 hit.
    PfamiPF08242. Methyltransf_12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q86BS6-1) [UniParc]FASTAAdd to Basket

    Also known as: B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTTSSSTML GKYGWQILRR LASKSWEHTR QRKKPSGAGS RVLTDAREVF    50
    EFNAWDHVQW DEEQELAAKA AVAKNSTSKM EAEQKERFQT DAPKFWDSFY 100
    GIHDNRFFKD RHWLFTEFPE LAPLAADSAV LQPRSIFELG CGVGNTILPL 150
    LQYSSEPQLK VFGCDFSARA IEILRSQRQF DEKRCEVFVM DATLDHWQVP 200
    FEENSQDIIV MIFVLSAIEP KKMQRVLDNC YRYLRPGGLL LFRDYGRYDL 250
    AQLRFKSGKC MEDNFYVRGD GTMVYFFTEE ELRGMMTQAG LQEEQLIVDR 300
    RLQVNRCRGL KMYRVWIQTK FRKPL 325
    Length:325
    Mass (Da):38,132
    Last modified:October 3, 2003 - v2
    Checksum:i3EFBB4FDC1C7311D
    GO
    Isoform 2 (identifier: Q86BS6-2) [UniParc]FASTAAdd to Basket

    Also known as: Metl-a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.

    Show »
    Length:246
    Mass (Da):29,154
    Checksum:i9AFF16BBE87D84A2
    GO
    Isoform 3 (identifier: Q86BS6-3) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-52: MLTTSSSTML...LTDAREVFEF → MSDNPAAENEKRPQFGTRLLTDADDVFKH

    Note: No experimental confirmation available.

    Show »
    Length:302
    Mass (Da):35,448
    Checksum:i5BB538AB11E52015
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979Missing in isoform 2. CuratedVSP_008484Add
    BLAST
    Alternative sequencei1 – 5252MLTTS…EVFEF → MSDNPAAENEKRPQFGTRLL TDADDVFKH in isoform 3. 1 PublicationVSP_008483Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF47531.2.
    AE014296 Genomic DNA. Translation: AAF47532.2.
    AY051875 mRNA. Translation: AAK93299.1.
    RefSeqiNP_647636.3. NM_139379.4. [Q86BS6-1]
    NP_728647.2. NM_167907.3. [Q86BS6-3]
    UniGeneiDm.4455.

    Genome annotation databases

    EnsemblMetazoaiFBtr0072814; FBpp0072696; FBgn0035247. [Q86BS6-1]
    GeneIDi38197.
    KEGGidme:Dmel_CG13929.
    UCSCiCG13929-RA. d. melanogaster. [Q86BS6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF47531.2 .
    AE014296 Genomic DNA. Translation: AAF47532.2 .
    AY051875 mRNA. Translation: AAK93299.1 .
    RefSeqi NP_647636.3. NM_139379.4. [Q86BS6-1 ]
    NP_728647.2. NM_167907.3. [Q86BS6-3 ]
    UniGenei Dm.4455.

    3D structure databases

    ProteinModelPortali Q86BS6.
    SMRi Q86BS6. Positions 110-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 63731. 8 interactions.
    IntActi Q86BS6. 2 interactions.
    MINTi MINT-764262.

    Proteomic databases

    PaxDbi Q86BS6.
    PRIDEi Q86BS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0072814 ; FBpp0072696 ; FBgn0035247 . [Q86BS6-1 ]
    GeneIDi 38197.
    KEGGi dme:Dmel_CG13929.
    UCSCi CG13929-RA. d. melanogaster. [Q86BS6-1 ]

    Organism-specific databases

    CTDi 38197.
    FlyBasei FBgn0035247. metl.

    Phylogenomic databases

    eggNOGi NOG258359.
    GeneTreei ENSGT00520000055554.
    InParanoidi Q86BS6.
    OMAi RPQFGTR.
    OrthoDBi EOG7VX8ZJ.
    PhylomeDBi Q86BS6.

    Miscellaneous databases

    GenomeRNAii 38197.
    NextBioi 807465.
    PROi Q86BS6.

    Gene expression databases

    Bgeei Q86BS6.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013217. Methyltransf_12.
    IPR026113. MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR22809. PTHR22809. 1 hit.
    Pfami PF08242. Methyltransf_12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037755. Mettl2_prd. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Strain: Berkeley.
      Tissue: Embryo.
    4. "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins."
      Zhang S.X., Guo Y., Boulianne G.L.
      Gene 280:135-144(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH PSN.

    Entry informationi

    Entry nameiMETL_DROME
    AccessioniPrimary (citable) accession number: Q86BS6
    Secondary accession number(s): Q960S9, Q9W0C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: October 3, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3