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Protein

Methyltransferase-like protein

Gene

metl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase.

GO - Molecular functioni

  • S-adenosylmethionine-dependent methyltransferase activity Source: FlyBase

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein (EC:2.1.1.-)
Gene namesi
Name:metl
ORF Names:CG13929
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035247. metl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002044561 – 325Methyltransferase-like proteinAdd BLAST325

Proteomic databases

PaxDbiQ86BS6.
PRIDEiQ86BS6.

Expressioni

Tissue specificityi

Widely expressed. Expressed in ovaries, head, thorax and abdomen of adult flies, and in the CNS of third instar larvae. Isoform 2 is predominantly expressed in larvae and in adult tissues that have been tested.1 Publication

Developmental stagei

Expressed throughout embryogenesis, as well as in larvae and adults.

Gene expression databases

BgeeiFBgn0035247.
ExpressionAtlasiQ86BS6. differential.
GenevisibleiQ86BS6. DM.

Interactioni

Subunit structurei

Interacts with Psn.1 Publication

Protein-protein interaction databases

BioGridi63731. 8 interactors.
IntActiQ86BS6. 3 interactors.
MINTiMINT-764262.
STRINGi7227.FBpp0072696.

Structurei

3D structure databases

ProteinModelPortaliQ86BS6.
SMRiQ86BS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
InParanoidiQ86BS6.
OMAiVFEFNAW.
OrthoDBiEOG091G1235.
PhylomeDBiQ86BS6.

Family and domain databases

InterProiView protein in InterPro
IPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR22809. PTHR22809. 1 hit.
PIRSFiPIRSF037755. Mettl2_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q86BS6-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTTSSSTML GKYGWQILRR LASKSWEHTR QRKKPSGAGS RVLTDAREVF
60 70 80 90 100
EFNAWDHVQW DEEQELAAKA AVAKNSTSKM EAEQKERFQT DAPKFWDSFY
110 120 130 140 150
GIHDNRFFKD RHWLFTEFPE LAPLAADSAV LQPRSIFELG CGVGNTILPL
160 170 180 190 200
LQYSSEPQLK VFGCDFSARA IEILRSQRQF DEKRCEVFVM DATLDHWQVP
210 220 230 240 250
FEENSQDIIV MIFVLSAIEP KKMQRVLDNC YRYLRPGGLL LFRDYGRYDL
260 270 280 290 300
AQLRFKSGKC MEDNFYVRGD GTMVYFFTEE ELRGMMTQAG LQEEQLIVDR
310 320
RLQVNRCRGL KMYRVWIQTK FRKPL
Length:325
Mass (Da):38,132
Last modified:October 3, 2003 - v2
Checksum:i3EFBB4FDC1C7311D
GO
Isoform 2 (identifier: Q86BS6-2) [UniParc]FASTAAdd to basket
Also known as: Metl-a

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:246
Mass (Da):29,154
Checksum:i9AFF16BBE87D84A2
GO
Isoform 3 (identifier: Q86BS6-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MLTTSSSTML...LTDAREVFEF → MSDNPAAENEKRPQFGTRLLTDADDVFKH

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):35,448
Checksum:i5BB538AB11E52015
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0084841 – 79Missing in isoform 2. CuratedAdd BLAST79
Alternative sequenceiVSP_0084831 – 52MLTTS…EVFEF → MSDNPAAENEKRPQFGTRLL TDADDVFKH in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47531.2.
AE014296 Genomic DNA. Translation: AAF47532.2.
AY051875 mRNA. Translation: AAK93299.1.
RefSeqiNP_647636.3. NM_139379.4. [Q86BS6-1]
NP_728647.2. NM_167907.3. [Q86BS6-3]
UniGeneiDm.4455.

Genome annotation databases

EnsemblMetazoaiFBtr0072813; FBpp0072695; FBgn0035247. [Q86BS6-3]
FBtr0072814; FBpp0072696; FBgn0035247. [Q86BS6-1]
GeneIDi38197.
KEGGidme:Dmel_CG13929.
UCSCiCG13929-RA. d. melanogaster. [Q86BS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMETL_DROME
AccessioniPrimary (citable) accession number: Q86BS6
Secondary accession number(s): Q960S9, Q9W0C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: August 30, 2017
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families