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Q86BN8

- PTPM1_DROME

UniProt

Q86BN8 - PTPM1_DROME

Protein

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Gene

Plip

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Lipid phosphatase that may mediate dephosphorylation of mitochondrial proteins By similarity. Protein phosphatase that may mediate dephosphorylation of mitochondrial proteins By similarity. Does not dephosphorylate Akt.By similarity

    Catalytic activityi

    Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei141 – 1411Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. phosphatidylglycerophosphatase activity Source: UniProtKB-EC
    2. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: RefGenome
    3. protein tyrosine/serine/threonine phosphatase activity Source: FlyBase
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP catabolic process Source: FlyBase
    2. inositol phosphate dephosphorylation Source: RefGenome
    3. neurogenesis Source: FlyBase
    4. phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
    5. protein dephosphorylation Source: FlyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_180833. Synthesis of PG.
    UniPathwayiUPA00084; UER00504.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC:3.1.3.27)
    Alternative name(s):
    PTEN-like protein
    Protein-tyrosine phosphatase mitochondrial 1-like protein (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Plip
    ORF Names:CG10371
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0039111. Plip.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionSequence AnalysisAdd
    BLAST
    Chaini29 – 200172Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1PRO_0000025426Add
    BLAST

    Proteomic databases

    PaxDbiQ86BN8.
    PRIDEiQ86BN8.

    Expressioni

    Tissue specificityi

    Highly enriched in testis.1 Publication

    Gene expression databases

    BgeeiQ86BN8.

    Interactioni

    Protein-protein interaction databases

    BioGridi67745. 2 interactions.
    MINTiMINT-318143.

    Structurei

    3D structure databases

    ProteinModelPortaliQ86BN8.
    SMRiQ86BN8. Positions 31-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini103 – 18684Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG146651.
    GeneTreeiENSGT00390000014065.
    InParanoidiQ86BN8.
    KOiK14165.
    OMAiNSSQEWK.
    OrthoDBiEOG7KDFCN.
    PhylomeDBiQ86BN8.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: Q86BN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEMSAAMFAR VSFYPTLLYN VLMEKASARN WYDRIDEHVI LGALPFRSQA    50
    NDLIEKENMK AVVSMNEDYE LTAFSNNTEK WRKLGIEFLQ LATTDIFESP 100
    NQEKLFRGVE FINKFLPLKQ RIGGLSSSYQ PENVGSVYVH CKAGRTRSAT 150
    LVGCYLMMKN GWTPDQAVDH MRKCRPHILL HTKQWDALRL FYTNNVETKS 200
    Length:200
    Mass (Da):23,156
    Last modified:June 1, 2003 - v1
    Checksum:iE7B4B6A69CB1CFCD
    GO
    Isoform A (identifier: Q86BN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:194
    Mass (Da):22,535
    Checksum:i7C1D7F373CFF2EA7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti186 – 1861D → G in AAL48664. (PubMed:12537569)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66Missing in isoform A. CuratedVSP_015010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56179.1.
    AE014297 Genomic DNA. Translation: AAN13956.2.
    AY071042 mRNA. Translation: AAL48664.1.
    RefSeqiNP_651180.3. NM_142923.3. [Q86BN8-1]
    NP_732901.1. NM_170090.2. [Q86BN8-2]
    UniGeneiDm.20236.

    Genome annotation databases

    EnsemblMetazoaiFBtr0084453; FBpp0083844; FBgn0039111. [Q86BN8-1]
    GeneIDi42807.
    KEGGidme:Dmel_CG10371.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF56179.1 .
    AE014297 Genomic DNA. Translation: AAN13956.2 .
    AY071042 mRNA. Translation: AAL48664.1 .
    RefSeqi NP_651180.3. NM_142923.3. [Q86BN8-1 ]
    NP_732901.1. NM_170090.2. [Q86BN8-2 ]
    UniGenei Dm.20236.

    3D structure databases

    ProteinModelPortali Q86BN8.
    SMRi Q86BN8. Positions 31-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67745. 2 interactions.
    MINTi MINT-318143.

    Proteomic databases

    PaxDbi Q86BN8.
    PRIDEi Q86BN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0084453 ; FBpp0083844 ; FBgn0039111 . [Q86BN8-1 ]
    GeneIDi 42807.
    KEGGi dme:Dmel_CG10371.

    Organism-specific databases

    CTDi 42807.
    FlyBasei FBgn0039111. Plip.

    Phylogenomic databases

    eggNOGi NOG146651.
    GeneTreei ENSGT00390000014065.
    InParanoidi Q86BN8.
    KOi K14165.
    OMAi NSSQEWK.
    OrthoDBi EOG7KDFCN.
    PhylomeDBi Q86BN8.

    Enzyme and pathway databases

    UniPathwayi UPA00084 ; UER00504 .
    Reactomei REACT_180833. Synthesis of PG.

    Miscellaneous databases

    ChiTaRSi KAT5. drosophila.
    GenomeRNAii 42807.
    NextBioi 830670.
    PROi Q86BN8.

    Gene expression databases

    Bgeei Q86BN8.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: Berkeley.
      Tissue: Embryo.
    4. "A PTEN-like phosphatase with a novel substrate specificity."
      Pagliarini D.J., Worby C.A., Dixon J.E.
      J. Biol. Chem. 279:38590-38596(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF ACTIVITY TOWARD AKT, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPTPM1_DROME
    AccessioniPrimary (citable) accession number: Q86BN8
    Secondary accession number(s): Q8SZ90, Q9VCI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3