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Protein

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Gene

PTPMT1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lipid phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Protein phosphatase that may mediate dephosphorylation of mitochondrial proteins (By similarity). Does not dephosphorylate Akt.By similarity

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • dephosphorylation Source: FlyBase
  • phosphatidylglycerol biosynthetic process Source: UniProtKB-UniPathway
  • protein dephosphorylation Source: FlyBase

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC:3.1.3.27)
Alternative name(s):
PTEN-like phosphatase1 Publication
PTEN-like protein
Protein-tyrosine phosphatase mitochondrial 1-like protein (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:PTPMT1Imported
Synonyms:Plip1 Publication
ORF Names:CG10371Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0039111 PTPMT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000002542629 – 200Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1Add BLAST172

Proteomic databases

PaxDbiQ86BN8
PRIDEiQ86BN8

Expressioni

Tissue specificityi

Highly enriched in testis.1 Publication

Gene expression databases

BgeeiFBgn0039111
ExpressionAtlasiQ86BN8 baseline and differential
GenevisibleiQ86BN8 DM

Interactioni

Protein-protein interaction databases

BioGridi67745, 3 interactors
STRINGi7227.FBpp0083844

Structurei

3D structure databases

ProteinModelPortaliQ86BN8
SMRiQ86BN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 186Tyrosine-protein phosphataseAdd BLAST84

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1719 Eukaryota
ENOG4111IMR LUCA
GeneTreeiENSGT00390000014065
InParanoidiQ86BN8
KOiK14165
OMAiWRTVNEY
OrthoDBiEOG091G0R21
PhylomeDBiQ86BN8

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q86BN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMSAAMFAR VSFYPTLLYN VLMEKASARN WYDRIDEHVI LGALPFRSQA
60 70 80 90 100
NDLIEKENMK AVVSMNEDYE LTAFSNNTEK WRKLGIEFLQ LATTDIFESP
110 120 130 140 150
NQEKLFRGVE FINKFLPLKQ RIGGLSSSYQ PENVGSVYVH CKAGRTRSAT
160 170 180 190 200
LVGCYLMMKN GWTPDQAVDH MRKCRPHILL HTKQWDALRL FYTNNVETKS
Length:200
Mass (Da):23,156
Last modified:June 1, 2003 - v1
Checksum:iE7B4B6A69CB1CFCD
GO
Isoform A (identifier: Q86BN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):22,535
Checksum:i7C1D7F373CFF2EA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186D → G in AAL48664 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0150101 – 6Missing in isoform A. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF56179.1
AE014297 Genomic DNA Translation: AAN13956.2
AY071042 mRNA Translation: AAL48664.1
RefSeqiNP_651180.3, NM_142923.3 [Q86BN8-1]
NP_732901.1, NM_170090.2 [Q86BN8-2]
UniGeneiDm.20236

Genome annotation databases

EnsemblMetazoaiFBtr0084453; FBpp0083844; FBgn0039111 [Q86BN8-1]
FBtr0084454; FBpp0083845; FBgn0039111 [Q86BN8-2]
GeneIDi42807
KEGGidme:Dmel_CG10371

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTPM1_DROME
AccessioniPrimary (citable) accession number: Q86BN8
Secondary accession number(s): Q8SZ90, Q9VCI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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